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Procedure: Liver Transplant

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Total 226 results found since Jan 2013.

Recurrent Autoimmune Liver Diseases After Liver Transplant Recurrent Autoimmune Liver Diseases After Liver Transplant
How often do autoimmune liver diseases recur after liver transplantation, and how might the risk of recurrence be reduced?Alimentary Pharmacology & Therapeutics
Source: Medscape Allergy Headlines - March 7, 2017 Category: Allergy & Immunology Tags: Transplantation Journal Article Source Type: news

Antibiotic allergy 'labels' in Liver Transplant recipients (ALT) Study.
Abstract Patient-reported antibiotic allergies (so-called antibiotic allergy labels [AALs]) are associated with suboptimal prescribing and inferior clinical outcomes, especially in the immunocompromised (1, 2).…. PMID: 28264847 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - March 5, 2017 Category: Microbiology Authors: Khumra S, Chan J, Urbancic K, Worland T, Angus P, Jones B, Grayson ML, Trubiano JA Tags: Antimicrob Agents Chemother Source Type: research

Liver transplantation in patients with primary antibody deficiency
Common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA) are the most common symptomatic primary antibody deficiencies (PADs). Patients with PAD may develop severe liver disease as part of their immunodeficiency syndrome.1 There has been a reluctance to perform liver transplantation (LTX) in these patients due to the risks associated with lifelong immunosuppression and fear of severe infections. Previously, iatrogenic chronic hepatitis C virus (HCV) infection was a leading cause of end-stage liver disease in patients with PAD and the lack of eradication of the virus after transplantation added to the r...
Source: Journal of Allergy and Clinical Immunology - December 5, 2016 Category: Allergy & Immunology Authors: Silje F. J ørgensen, Magnhild E. Macpherson, Kristian Bjøro, Tom H. Karlsen, Henrik M. Reims, Krzysztof Grzyb, Bjarte Fosby, Børre Fevang, Pål Aukrust, Ingvild Nordøy Tags: Letter to the Editor Source Type: research

The Management of Autoimmune Hepatitis Patients with Decompensated Cirrhosis: Real-World Experience and a Comprehensive Review
In this study, we sought to determine the therapeutic effect of corticosteroids in this special group of AIH patients. Eighty-two AIH patients with decompensated cirrhosis were included through a retrospective analysis from January 2009 to September 2015. Sixty-four patients were treated with corticosteroids while 18 patients did not receive any corticosteroids. Clinical, laboratory, and histological characteristics and outcomes were analyzed comparing corticosteroid-treated and untreated groups. Patients that did not receive corticosteroids were older than corticosteroid-treated patients and had a worse survival. In corti...
Source: Clinical Reviews in Allergy and Immunology - August 10, 2016 Category: Allergy & Immunology Source Type: research

Cutaneous manifestations of familial hypercholesterolaemia
A 12-year-boy presented with multiple soft tissue swelling over the buttocks and feet, progressively increasing for last 4 years. Examination revealed multiple tuberous xanthomas of various sizes (2–8 cm diameter) studded over the buttocks (figure 1A; black arrows), multiple planar xanthomas over bilateral elbows and knees (figure 1B, C; white arrows), multiple tendinous xanthomas over the Achilles tendon, dorsum and lateral aspect of both feet (figure 1D; hollow black arrows), small xanthoma over the back of the left ear (figure 1F; hollow white arrow), xanthelasma over the lateral aspect of the right eyel...
Source: Postgraduate Medical Journal - April 24, 2016 Category: Journals (General) Authors: Meher, D., Dutta, D., Misgar, R. A. Tags: Genetics, Immunology (including allergy), Drugs: cardiovascular system, Echocardiography, Childhood nutrition, Diet, Ophthalmology, Ischaemic heart disease, Childhood nutrition (paediatrics), Radiology, Gastrointestinal surgery, Transplantation, Diabetes, Source Type: research

What determines treatment success and future perspectives?
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in most Asian countries due to the high prevalence of hepatitis B viral infection.1 Surgical resection and liver transplantation are regarded as the main curative treatments for HCC. Many patients, however, are not eligible for resection due to locally advanced tumour, underlying liver cirrhosis with suboptimal liver reserve or metastatic disease on presentation.1 Puppala et al2 concisely summarise the modern image-guided therapy options for patients with advanced HCC, such as radiofrequency ablation (RFA), microwave ablation, percutaneo...
Source: Postgraduate Medical Journal - February 25, 2016 Category: Journals (General) Authors: Yau, T., Chiu, J., Cheung, T. T. Tags: Liver disease, Immunology (including allergy), Hepatic cancer, Radiology, Clinical diagnostic tests, Gastrointestinal surgery, Surgical oncology, Transplantation Editorials Source Type: research

Safety evaluation of exosomes derived from human umbilical cord mesenchymal stromal cell
Conclusions hucMSC exosomes are well tolerated in animal models. This study provides evidence for the safety of intravenous infusion in future clinical therapy.
Source: Cytotherapy - February 5, 2016 Category: Cytology Source Type: research

Microbiome Regulation of Autoimmune, Gut and Liver associated Diseases.
Abstract Extensive analysis of the complexity and diversity of microbiota using metagenomics in the gut and other body sites has provided evidence that dysbiosis occurs in many disease states. With the application of next generation sequencing technology this research is starting to uncover the impact of microbiota on metabolic, physiological and immunological pathways and elucidate the cellular and molecular mechanisms involved. To highlight these advances we have focused on autoimmunity and gut and liver related diseases and discuss the opportunities and challenges of translating microbiome research towards its ...
Source: Inflammation and Allergy Drug Targets - January 28, 2016 Category: Allergy & Immunology Authors: Singh B Tags: Inflamm Allergy Drug Targets Source Type: research

A severe case of minocycline-induced DRESS resulting in liver transplantation and autoimmune sequelae
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a drug-induced hypersensitivity reaction that includes rash, hematologic abnormalities, lymphadenopathy, and internal organ involvement. The initial signs of fever, rash, and increased transaminase levels usually resolve once the acute episode subsides. However, physicians need to be aware that there are autoimmune sequelae that can develop long after the initial insult, such as thyroid dysfunction, lupus, and type 1 diabetes mellitus (T1DM).
Source: Annals of Allergy, Asthma and Immunology - January 9, 2016 Category: Allergy & Immunology Authors: Jennifer Lan, Amit Lahoti, D. Betty Lew Tags: Letter Source Type: research

A severe case of minocycline-induced DRESS resulting in liver transplantation and autoimmune sequelae.
PMID: 26782675 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 9, 2016 Category: Allergy & Immunology Authors: Lan J, Lahoti A, Lew DB Tags: Ann Allergy Asthma Immunol Source Type: research

Food allergies developing after solid organ transplant
Abstract The development of food allergy is an increasingly recognized form of morbidity after solid organ transplant. It occurs more commonly in liver transplant recipients, although it has also been reported in heart, lung, kidney, and intestinal transplants. Pediatric transplant recipients are more likely to develop symptoms compared to adults, and reports of frequency vary widely from 5% to 38% in pediatric liver transplant recipients. Multiple mechanisms have been proposed in the literature, although no single mechanism can yet account for all reported observations. As food allergy can have at worst potentially fatal ...
Source: Pediatric Transplantation - November 14, 2015 Category: Transplant Surgery Authors: J. M. Needham, S. K. Nicholas, C. M. Davis Tags: Review Article Source Type: research

Management of tacrolimus‐associated food allergy after liver transplantation
This report describes a case of tacrolimus‐associated food allergy after pediatric living‐donor LT. The patient was a 7‐year‐old Japanese girl who had undergone living‐donor LT at 12 months of age, and whom we first saw in the clinic at age 18 months. She received immunosuppressive therapy by tacrolimus after transplantation. Atopic dermatitis developed in post‐transplant month 18. Stridor, facial edema, lip swelling, and skin erythema after consuming tempura udon containing wheat occurred in post‐transplant month 39, and she was subsequently diagnosed with anaphylactic shock. Eosinophilic leukocyte and s...
Source: Pediatrics International - November 5, 2015 Category: Pediatrics Authors: Naho Obayashi, Mitsuyoshi Suzuki, Tomoaki Yokokura, Nakayuki Naritaka, Satoshi Nakano, Yoshikazu Ohtsuka, Hiroyuki Sugo, Seiji Kawasaki, Toshiaki Shimizu Tags: Patient Report Source Type: research

Prospective evaluation of IgE and eosinophilia in food allergy after liver transplantation
This study further enlightens the pathophysiological mechanism of food allergy (FA) after liver transplantation (LT). However, the interval between the time FA happened and the time of the blood testing for analysis was considerably long. This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - September 27, 2015 Category: Allergy & Immunology Authors: Ozlem Yılmaz Ozbek Tags: Correspondence Source Type: research

Cytokine profile of food‐allergic post‐liver transplant children is identified by high levels of IL‐5 and low IL‐10 secretion from patients' peripheral blood mononuclear cells
This study aimed to reveal the nature of the immune response in post‐transplanted allergic patients and compare them to non‐allergic transplanted as well as allergic and non‐allergic control subjects, with focus on cytokine milieu. Post‐liver transplant patients with and without allergic reactions as well as food‐allergic but otherwise healthy and healthy non‐allergic control patients were recruited. We reviewed patient records and routine laboratory tests and assayed subjects' PBMCs, studying cytokine secretion profile in response to different stimuli. Post‐transplant patients with food allergy showed a uniq...
Source: Pediatric Transplantation - August 18, 2015 Category: Transplant Surgery Authors: Amit Nahum, Avivit Brener, Ettie Granot Tags: Original Article Source Type: research