Liver transplantation in patients with primary antibody deficiency
Common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA) are the most common symptomatic primary antibody deficiencies (PADs). Patients with PAD may develop severe liver disease as part of their immunodeficiency syndrome.1 There has been a reluctance to perform liver transplantation (LTX) in these patients due to the risks associated with lifelong immunosuppression and fear of severe infections. Previously, iatrogenic chronic hepatitis C virus (HCV) infection was a leading cause of end-stage liver disease in patients with PAD and the lack of eradication of the virus after transplantation added to the reluctance to perform LTX in these patients.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Silje F. J ørgensen, Magnhild E. Macpherson, Kristian Bjøro, Tom H. Karlsen, Henrik M. Reims, Krzysztof Grzyb, Bjarte Fosby, Børre Fevang, Pål Aukrust, Ingvild Nordøy Tags: Letter to the Editor Source Type: research
More News: Allergy | Allergy & Immunology | Hepatitis | Hepatitis C | Liver | Liver Disease | Liver Transplant | Transplants | Urology & Nephrology | X-Linked Agammaglobulinemia (XLA)