Microbiome Regulation of Autoimmune, Gut and Liver associated Diseases.

Microbiome Regulation of Autoimmune, Gut and Liver associated Diseases.
Inflamm Allergy Drug Targets. 2016 Jan 28;
Authors: Singh B
Abstract
Extensive analysis of the complexity and diversity of microbiota using metagenomics in the gut and other body sites has provided evidence that dysbiosis occurs in many disease states. With the application of next generation sequencing technology this research is starting to uncover the impact of microbiota on metabolic, physiological and immunological pathways and elucidate the cellular and molecular mechanisms involved. To highlight these advances we have focused on autoimmunity and gut and liver related diseases and discuss the opportunities and challenges of translating microbiome research towards its application in human diseases. Towards this goal we have discussed the application of fecal microbiome transplantation (FMT) for the treatment of multiple chronic gut associated inflammatory diseases such as Clostridium difficile infection (CDI) and inflammatory bowel disease (IBD). The potential role of human migration across continents and cultures leading to alternation in their microbiome and its implication in health and disease has also been discussed.
PMID: 26817477 [PubMed - as supplied by publisher]

Source: Inflammation and Allergy Drug Targets - January 28, 2016 Category: Allergy & Immunology Authors: Singh B Tags: Inflamm Allergy Drug Targets Source Type: research