In lab study, nanoparticle shows promising results for treating severe allergies

For about 1 in 13 children in the U.S., usually harmless foodstuffs such as milk, eggs and peanuts can send the body ’s natural defenses into overdrive.Symptoms of food allergies can vary widely, but at worst, a systemwide allergic response can lead to anaphylaxis, a life-threatening condition characterized by a sudden drop in blood pressure and difficulty breathing.Although there are now some preventive measures for food-induced anaphylaxis, there are not yet any long-lasting solutions — treatments capable of locking the immune system into a state of tolerance, so that it doesn’t respond to allergens.Now, a UCLA research team has developed a possible way to impart long-term relief from allergies by inducing an active state of immune tolerance.The technology uses a nanoparticle — a particle so small that it’s measured on the scale of billionths of a meter — to deliver proteins to specific cells in the liver. Those proteins may trigger an allergic response in other organs in the body, but in the liver, they cause the targeted cells to activate a tolerant immune respon se that switches the allergic response off.A report on the research, published in ACS Nano, indicates that the platform is effective in preventing allergic reactions to an egg protein when ingested or inhaled. The UCLA researchers also showed that delivering a single piece of a protein that triggers allergies is sufficient to ameliorate the allergic reaction.“Huge numbers...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Source: Food and Nutrition Research - Category: Nutrition Authors: Tags: Food Nutr Res Source Type: research
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Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
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Boosting the sensitivity of in vitroβ-lactam allergy diagnostic tests. Chem Commun (Camb). 2020 Oct 14;56(80):11973-11976 Authors: Peña-Mendizabal E, Morais S, Maquieira Á Abstract The synthesis of structurally new haptens and the development of suitable antigens are essential for boosting the sensitivity of drug allergy diagnostic testing. Unprecedented structural antigens for benzylpenicillin and amoxicillin are characterised and evaluated in a cohort of 70 subjects with a turnkey solution based on consumer electronics. PMID: 33033809 [PubMed - in process]
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