CNS involvement in V30M transthyretin amyloidosis: clinical, neuropathological and biochemical findings
Conclusions
Our findings indicate that CNS clinical involvement occurs in ATTR-V30M patients regardless of LT. Longer disease duration after LT can provide the necessary time for transthyretin amyloidosis to progress until it becomes clinically relevant. Highly sensitive imaging methods are needed to identify and monitor brain ATTR. Disease modifying therapies should consider brain TTR as a target.
Source: Journal of Neurology, Neurosurgery and Psychiatry - Category: Neurosurgery Authors: Maia, L. F., Magalhaes, R., Freitas, J., Taipa, R., Pires, M. M., Osorio, H., Dias, D., Pessegueiro, H., Correia, M., Coelho, T. Tags: Genetics, Immunology (including allergy), Neuromuscular disease, Peripheral nerve disease, Neuropathology, Radiology, Radiology (diagnostics) Source Type: research
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