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Procedure: Skin Biopsy
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Total 252 results found since Jan 2013.
A thirst for rarity? an interesting case of hypopituitarism
A previously healthy 69-year-old short statured woman presented with a 4-month history of increased thirst, polyuria, nausea, vomiting, 2-stone weight loss and nocturnal visual hallucinations. Neurological examination was normal, however she had difficulty standing due to postural hypotension with a supine blood pressure of 98/64 mm Hg. Investigations revealed hypopituitarism with secondary hypoadrenalism (baseline cortisol of 45 nmol/l) and hypothyroidism. Neuroimaging showed leptomeningeal enhancement and an infundibular mass lesion, which on biopsy demonstrated a benign non-Langerhan cell histiocytic prol...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Edwards, M., Johnston, J. Tags: Immunology (including allergy), Hypertension, Ophthalmology, Radiology, Surgical diagnostic tests ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research
Can't raise one eye brow: does it ring any norwegian bells?
A 60 year old Nigerian man with diabetes who has lived in Europe for 30 years but regularly revisits Nigeria, presented with 6 months of numbness and weakness in all four limbs and recent right facial weakness. Examination revealed partial right facial and left ulnar nerve palsies with areflexia but no skin lesions. Neurophysiology showed multifocal mixed sensory-motor neuropathy with demyelinating features and prominent facial nerve involvement. He was found to be HIV positive.
Subsequent examination revealed peripheral nerve thickening confirmed on limb MRI. Nerve biopsy showed chronic endoneuritis and perineuritis, but ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Galtrey, C., Schon, F., Modarres, H., Rossor, A., Lockwood, D., Reilly, M., Manji, H. Tags: Immunology (including allergy), HIV/AIDS, Tropical medicine (infectious diseases), Neuropathology, Radiology, Surgical diagnostic tests ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research
Rifamycin induced leukocytoclastic vasculitis. A rare side-effect of anti-tuberculous chemotherapy
We describe a case of leucocytoclastic vasculitis (LCV) caused by rifamycins.A 53 year old female presented with cough, night sweats and upper lobe nodules. Bronchial-alveolar lavage confirmed fully sensitive mycobacterium tuberculosis (TB).She commenced treatment with rifampicin, isoniazid, ethambutol and pyrizinazmide. At 4 weeks she developed an extensive purpuric rash, malaise and joint aches. There was no evidence of other infections or connective tissue disorders on extensive screening. Her inflammatory markers were elevated. A punch biopsy of her shin demonstrated leukocytoclastic vasculitis of the superficial dermi...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Ewence, A., Dodd, J., Tewari, A., Akhras, V., Aul, R. Tags: 10.2 Tuberculosis Source Type: research
How is Swimmer ’ s Itch Diagnosed?
Discussion
Cercarial Dermatitis (CD) is known by many names throughout the world, but is commonly known as swimmer’s itch. It is a water-borne, non-communicable infectious disease that is caused by the larval stage (cercariae) of parasitic schistosomatid flukes. The cercariae causes an allergic maculopapular skin rash in humans that is usually self-limited (usually 4-10 days) but can cause problems for up to 20 days.
CD parasites are considered an emerging disease because of the increased distribution of the problem across the globe. Different parasite species cause the problem. In a normal life cycle that occurs ma...
Source: PediatricEducation.org - November 7, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Circulating CLA+ T ‐cells in atopic dermatitis and their possible role as peripheral biomarkers
This article is protected by copyright. All rights reserved.
Source: Allergy - October 31, 2016 Category: Allergy & Immunology Authors: Tali Czarnowicki, Luis F Santamaria ‐Babí, Emma Guttman‐Yassky Tags: Review Source Type: research
Clinical Picture Systemic mastocytosis with generalised skin involvement
A 63-year-old man presented to the department of dermatology and allergy in January, 2016, with a 32-year history of reddish-brown skin lesions, which had worsened over the preceding year, accompanied by daily abdominal pain, pruritus and flushing, joint pain, and fatigue. Full body examination showed brown patches covering more than 90% of his body, sparing only the palms, soles, and head (figure). Serum tryptase was 70 ·5 μg/L, six times the upper limit of normal, and a skin biopsy sample showed multiple mast cells.
Source: LANCET - October 12, 2016 Category: Journals (General) Authors: Alexander Zink, Alexander B öhner, Anna Schuch, Tilo Biedermann, Knut Brockow Tags: Clinical Picture Source Type: research
New-onset pediatric AD phenotype differs from adult AD
The skin phenotype of new-onset pediatric atopic dermatitis differs substantially from that in adult AD, according to an assessment of biopsy findings in infants and children.
The study findings have important therapeutic implications, especially in light of the fact that much of the work in this...
Source: Skin and Allergy News - September 23, 2016 Category: Dermatology Source Type: news
Erythema Multiforme Associated With Misoprostol: A Case Report
A 33-year-old healthy woman at 6 weeks of gestation without any underlying disease developed erythema multiforme (EM) after misoprostol. She had no history of herpes simplex virus infection and drug allergy to nonsteroidal anti-inflammatory drugs and antibiotic agents. Medical abortion was performed at 6 weeks' gestation. Later day, the patient developed oral lesions as several white bullae lesions in her buccal mucosa and hyperkeratotic lip plaques with mild pain. Then, lesions resolved within approximately 3 weeks. Microscopic finding of oral biopsy from beneath the tongue and lesions was performed. The result was consis...
Source: American Journal of Therapeutics - September 1, 2016 Category: Drugs & Pharmacology Tags: Case Reports Source Type: research
Association of TG2 from mast cells and chronic spontaneous urticaria pathogenesis.
CONCLUSION: Our findings suggest that TG2 expressed in and released from mast cells plays an important role in CSU pathogenesis.
PMID: 27613463 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - August 31, 2016 Category: Allergy & Immunology Authors: Hong GU, Ro JY, Bae Y, Kwon IH, Park GH, Choi YH, Choi JH Tags: Ann Allergy Asthma Immunol Source Type: research
IL-22 capacitates dermal fibroblast responses to TNF in scleroderma
Conclusions
IL-22 capacitates fibroblast responses to TNF and promotes a proinflammatory fibroblast phenotype by favouring TNF-induced keratinocyte activation. These results define a novel role for keratinocyte–fibroblast interactions in the context of skin fibrosis.
Source: Annals of the Rheumatic Diseases - August 9, 2016 Category: Rheumatology Authors: Brembilla, N. C., Dufour, A. M., Alvarez, M., Hugues, S., Montanari, E., Truchetet, M.-E., Lonati, P., Fontao, L., Gabrielli, A., Vettori, S., Valentini, G., Boehncke, W.-H., Meroni, P., Chizzolini, C. Tags: Immunology (including allergy), Connective tissue disease Basic and translational research Source Type: research
No, You Don’t Have To Have Celiac Disease To Have A Wheat Sensitivity
People who don’t have a diagnosis for celiac disease or a wheat allergy may face a lot of scorn and derision for claiming to be sensitive to wheat products, skipping pasta and bread.
But a new study by scientists at Columbia University may explain why certain grain products can cause intestinal discomfort in some people, even if they don’t have a widely-recognized medical condition.
It may also present doctors with a new way to test for this non-celiac wheat sensitivity, which for now has no diagnostic measure and must be assessed clinically, according to a person’s symptoms.
Not everyone who feels ...
Source: Healthy Living - The Huffington Post - July 29, 2016 Category: Consumer Health News Source Type: news
Immediate Wheal Reactivity to Autologous Sweat in Atopic Dermatitis Is Associated with Clinical Severity, Serum Total and Specific IgE and Sweat Tryptase Activity
Conclusion: Reactivity to autologous sweat correlates with the clinical severity of AD, and tryptase may be one of the factors involved in the sweat-induced wheal. Int Arch Allergy Immunol 2016;170:84-91
Source: International Archives of Allergy and Immunology - July 21, 2016 Category: Allergy & Immunology Source Type: research
Decreased expression of neuropilin-1 as a novel key factor contributing to peripheral microvasculopathy and defective angiogenesis in systemic sclerosis
Conclusion
In SSc, NRP1 deficiency may be an additional factor in the perturbed VEGF-A/VEGFR-2 system contributing to peripheral microvasculopathy and defective angiogenesis.
Source: Annals of the Rheumatic Diseases - July 7, 2016 Category: Rheumatology Authors: Romano, E., Chora, I., Manetti, M., Mazzotta, C., Rosa, I., Bellando-Randone, S., Blagojevic, J., Soares, R., Avouac, J., Allanore, Y., Ibba-Manneschi, L., Matucci-Cerinic, M., Guiducci, S. Tags: Genetics, Immunology (including allergy), Pathology, Radiology, Connective tissue disease, Surgical diagnostic tests, Clinical diagnostic tests Basic and translational research Source Type: research
Hypersensitivity reactions to heparins
This article provides an update on hypersensitivity reactions to heparins and novel oral anticoagulants, with special emphasis on diagnostic methods and management of patients.
Recent findings: Although heparins are drugs widely used, hypersensitivity reactions are uncommon. Cutaneous delayed hypersensitivity reactions after subcutaneous administration affects up to 7.5% of patients. Heparin-induced thrombocytopenia is another unusual but severe condition in which early recognition is crucial. Immediate hypersensitivity reactions to heparins have been also reported, but with the novel oral anticoagulants are much more unc...
Source: Current Opinion in Allergy and Clinical Immunology - July 1, 2016 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Bernard Y-H. Thong and Miguel Blanca Source Type: research
The coexistence of eosinophilic esophagitis with allergic rhinitis.
CONCLUSIONS: The most common symptom among patients with EoE is reflux. In AR patients with EoE, serum IgE levels were higher compared to those without EoE. In AR patients with reflux symptoms, high serum IgE levels, and especially in patients whose tests are positive for allergy to mites, referral to a gastroenterologist for EoE evaluation may be recommended.
PMID: 27338057 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 25, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
