Decreased expression of neuropilin-1 as a novel key factor contributing to peripheral microvasculopathy and defective angiogenesis in systemic sclerosis

Conclusion
In SSc, NRP1 deficiency may be an additional factor in the perturbed VEGF-A/VEGFR-2 system contributing to peripheral microvasculopathy and defective angiogenesis.

Source: Annals of the Rheumatic Diseases - July 7, 2016 Category: Rheumatology Authors: Romano, E., Chora, I., Manetti, M., Mazzotta, C., Rosa, I., Bellando-Randone, S., Blagojevic, J., Soares, R., Avouac, J., Allanore, Y., Ibba-Manneschi, L., Matucci-Cerinic, M., Guiducci, S. Tags: Genetics, Immunology (including allergy), Pathology, Radiology, Connective tissue disease, Surgical diagnostic tests, Clinical diagnostic tests Basic and translational research Source Type: research