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Total 482 results found since Jan 2013.
Relationship between Bacillus Calmette Guerin Vaccination Policy and Coronavirus Disease-2019 (COVID-19) Incidence
Iran J Allergy Asthma Immunol. 2021 Feb 11;20(1):106-113. doi: 10.18502/ijaai.v20i1.5417.ABSTRACTBacillus Calmette Guerin (BCG) was designed for protecting children against tuberculosis. Also, it can protect against other infectious diseases through the induction of trained immunity. Due to its heterologous protective effects, the BCG vaccine has been proposed as atreatment option for coronavirus disease-2019 (COVID-19). Epidemiological studies have found that countries without BCG vaccination policy have experienced higher mortality rates related toCOVID-19 infection than those with BCG vaccination policy. However, there ...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 27, 2021 Category: Allergy & Immunology Authors: Soheila Alyasin Zahra Kanannejad Hossein Esmaeilzadeh Hesamedin Nabavizadeh Mohammad Amin Ghatee Reza Amin Source Type: research
We May Never Eliminate COVID-19. But We Can Learn to Live With It
When does a pandemic end? Is it when life regains a semblance of normality?
Is it when the world reaches herd immunity, the benchmark at which enough people are immune to an infectious disease to stop its widespread circulation? Or is it when the disease is defeated, the last patient cured and the pathogen retired to the history books?
The last scenario, in the case of COVID-19, is likely a ways off, if it ever arrives. The virus has infected more than 100 million people worldwide and killed more than 2 million. New viral variants even more contagious than those that started the pandemic are spreading across the world. And...
Source: TIME: Health - February 4, 2021 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Cover Story COVID-19 feature Magazine Source Type: news
Severe Cutaneous Adverse Reactions to Anti-tuberculosis Drugs in Korean Patients.
CONCLUSIONS: DRESS was more common among the ATD-related SCAR cases. Although treatment with most ATDs carries the risk of SCAR development, the use of rifampin was most frequently involved in the occurrence of SCARs. Multiple hypersensitivity was frequently observed in ATD-related SCARs.
PMID: 33474859 [PubMed]
Source: Allergy, Asthma and Immunology Research - January 23, 2021 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
M411 active tuberculosis (tb) masquerading as an asthma exacerbation during a sars-cov-2 (covid 19) pandemic
TB rarely presents as asthma. Clinical symptoms of COVID-19 and asthma can mask a diagnosis of TB.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2020 Category: Allergy & Immunology Authors: G. Hudes, M. Beronilla Source Type: research
Clinico-radiological and serological features in Allergic bronchopulmonary aspergillosis
Conclusions: There is a high prevalence of ABPA in asthmatic patients presenting at our hospital. The disease entity is still underrecognized in India, the vast majority of patients have bronchiectasis at presentation, and almost half are initially misdiagnosed as having pulmonary tuberculosis. There is a need to redefine the diagnostic criteria of ABPA and to develop a gold standard diagnostic test. This study places emphasis on using IgE levels specific for Aspergillus fumigatus as a screening test for ABPA.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Prasanth, P. Tags: Allergy and immunology Source Type: research
Use of Ultraviolet Blood Irradiation Against Viral Infections
AbstractUltraviolet blood irradiation (UBI) was used with success in the 1930s and 1940s for a variety of diseases. Despite the success, the lack of understanding of the detailed mechanisms of actions, and the achievements of antibiotics, phased off the use of UBI from the 1950s. The emergence of novel viral infections, from HIV/AIDS to Ebola, from SARS and MERS, and SARS-CoV-2, bring back the attention to this therapeutical opportunity. UBI has a complex virucidal activity, mostly acting on the immune system response. It has effects on lymphocytes (T-cells and B-cells), macrophages, monocytes, dendritic cells, low-density...
Source: Clinical Reviews in Allergy and Immunology - October 6, 2020 Category: Allergy & Immunology Source Type: research
Diagnostic accuracy of 3 urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients
CONCLUSION Compared with AlereLAM, FujiLAM detected 5 times more patients with TB in HIV-negative participants, had a high positive predictive value, and has the potential to improve rapid diagnosis of TB at the point-of-care. EclLAM demonstrated that additional sensitivity gains are possible, which highlights LAM’s potential as a biomarker. Additional research is required to assess FujiLAM’s performance in prospective cohorts, its cost-effectiveness, and its impact in real-world clinical settings.FUNDING Global Health Innovative Technology Fund, the UK Department for International Development, the Dutch Ministry of Fo...
Source: Journal of Clinical Investigation - September 29, 2020 Category: Biomedical Science Authors: Tobias Broger, Mark P. Nicol, George B. Sigal, Eduardo Gotuzzo, Alexandra J. Zimmer, Shireen Surtie, Tatiana Caceres-Nakiche, Anna Mantsoki, Elena Ivanova Reipold, Rita Székely, Michael Tsionsky, Judith van Heerden, Tatiana Plisova, Kinuyo Chikamatsu, To Source Type: research
The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems.
Abstract
Infection is the predominant cause of mortality in early life, and immunization is the most promising biomedical intervention to reduce this burden. However, very young infants fail to respond optimally to most vaccines currently in use, especially neonates. In 2005, Stanley Plotkin proposed that new delivery systems would spur a new revolution in pediatric vaccinology, just as attenuation, inactivation, cell culture of viruses, genetic engineering, and adjuvantation had done in preceding decades. Recent advances in the field of immunoengineering, which is evolving alongside vaccinology, have begun to inc...
Source: Pediatric Research - September 13, 2020 Category: Pediatrics Authors: Soni D, Bobbala S, Li S, Scott EA, Dowling DJ Tags: Pediatr Res Source Type: research
Janssen Announces Discontinuation of Phase 3 LOTUS Study Evaluating Ustekinumab in Systemic Lupus Erythematosus
SPRING HOUSE, PENNSYLVANIA, June 26, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today its decision to discontinue the Phase 3 LOTUS study of STELARA® (ustekinumab) in Systemic Lupus Erythematosus (SLE) due to lack of efficacy in SLE.The decision is based on data from a pre-planned interim efficacy analysis. Interim safety findings were consistent with the known safety profile of STELARA, and no new safety signals were identified. Investigators, study participants and health authorities have been informed of the decision. The company intends to thoroughly analyze the totality of the st...
Source: Johnson and Johnson - June 26, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news
What Are Potential Complications of Tattooing?
Discussion
“Tattooing of skin via deposition of pigment particles and ink ingredients in the dermis changes normal skin into abnormal skin. Fortunately, this often causes no harm and no disease, although with important exceptions.” Tattoos can be inadvertent from road dirt, gunpowder, pencil graphite etc., but most are desired. Tattoos are common in many cultures and over time..They have been increasing in popularity in the United States over the past few years particularly with a younger, wider and more diverse population.
Newsweek reported an 18-country study in 2018 which showed 46% of Americans have a tat...
Source: PediatricEducation.org - May 18, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Primary immunodeficiency disorders in children with Non-Cystic Fibrosis Bronchiectasis.
Conclusions.PID accounted for about 40% of NCFB. Early diagnosis/appropriate treatment have impact on clinical course of a PID patient. Thus, follow-up in also immunology clinics should be a routine for patients who experience pneumonia in the first year of their lives and those with NCFB. Most patients with NCFB (84.28%) had their first pulmonary infection within the first year of their lives.
PMID: 32372587 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - May 8, 2020 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
TB, HIV and COVID-19: Urgent Questions as Three Epidemics Collide
This article is republished from The Conversation under a Creative Commons license. Read the original article.
The post TB, HIV and COVID-19: Urgent Questions as Three Epidemics Collide appeared first on Inter Press Service.
Source: IPS Inter Press Service - Health - March 25, 2020 Category: International Medicine & Public Health Authors: External Source Tags: Africa Headlines Health Source Type: news
Recent advances in addressing tuberculosis give hope for future
(NIH/National Institute of Allergy and Infectious Diseases) In September 2018, the National Institute of Allergy and Infectious Diseases issued its Strategic Plan for Tuberculosis Research, which outlined research priorities to reduce and ultimately end the burden of tuberculosis (TB). Now, a new 'Perspective' in The Journal of Infectious Diseases by NIAID Director Anthony S. Fauci, M.D., and other Institute officials summarizes recent progress in improved TB diagnostics, therapeutic regimens and prevention approaches that made 2019 a 'banner year' for TB research.
Source: EurekAlert! - Infectious and Emerging Diseases - February 11, 2020 Category: Infectious Diseases Source Type: news
Interferon-gamma ELISpot assay facilitates safe drug rechallenge in severe cutaneous adverse reactions caused by anti-tuberculosis drugs
This study was to explore the possibility of using Interferon-gamma (IFN- γ) enzyme-linked immunospot (ELISpot) assay to safely guide anti-TB re-administration in SCAR subjects.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Amornrat Prasertcharoensuk, Yuda Chongpison, Pattarawat Thantiworasit, Supranee Buranapraditkun, Pawinee Rerknimitr, Hiroshi Chantaphakul, Jettanong Klaewsongkram Source Type: research
