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Total 482 results found since Jan 2013.

Sex-difference In Associations Between Skin Responses To Purified Protein Derivative And Family Size During Infancy in Japan
Tuberculosis (TB) is a serious infectious disease, especially in males, and a negative associate between delayed hypersensitivity tests to purified protein derivative (PPD) tuberculin in the skin (Mantoux tests; MTs) and atopy was reported. Although MTs for TB diagnosis is not recommended after 2005 in Japan because of influences by TB pandemic, microbiome exposure, and host immunity, thus we investigated associations among MTs, sex, family size, and allergic diseases.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Miwa Shinohara, Kenji Matsumoto Source Type: research

Primary immunodeficiency diseases and Bacillus Calmette-Guérin (BCG)-vaccine-derived complications: a systematic review
ConclusionsSeveral PID entities are susceptible to BCG-VAC. Systemic neonatal PID screening programs may help to prevent a substantial amount of BCG vaccination complications.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 30, 2020 Category: Allergy & Immunology Source Type: research

The Introduction of Hydrazone, Hydrazide or Azepane Moieties to the Triterpenoid Core Enhances an Activity Against M. tuberculosis.
CONCLUSIONS: It was revealed that conjugation of lupanes with INH at C3 is more effective than at C28 and lupane skeleton is preferable among oleanane and ursane types. The replacement of native hexacarbocyclic A ring to seven-member azepane ring is favorably for inhibition of both MTB H37RV and SDR-strains. These data could possibly mean that the antitubercular activity against INH-resistant strains (INH-R) came from both triterpenoid and isoniazid parts of the hybrid molecules. Azepanobetulin showed the highest activity against both INH-R strains in comparison with other triterpenoids and INH. Thus, the introduction of h...
Source: Medicinal Chemistry - January 14, 2020 Category: Chemistry Authors: Kazakova OB, Medvedeva NI, Smirnova IE, Lopatina TV, Veselovsky AV Tags: Med Chem Source Type: research

Intravenous BCG Immunization Prevents Tuberculosis in Macaques Intravenous BCG Immunization Prevents Tuberculosis in Macaques
Intravenous BCG immunization prevents or substantially limits tuberculosis in rhesus macaques, researchers report.Reuters Health Information
Source: Medscape Allergy Headlines - January 14, 2020 Category: Allergy & Immunology Tags: Pulmonary Medicine News Source Type: news

New Injection Method Makes an Old TB Vaccine Far More Powerful
Giving the vaccine intravenously to monkeys provided 90% protection against tuberculosis. More testing is needed before humans can be inoculated that way.
Source: NYT - January 1, 2020 Category: American Health Authors: Donald G. McNeil Jr. Tags: Tuberculosis Vaccination and Immunization Monkeys and Apes Lungs Third World and Developing Countries National Institute of Allergy and Infectious Diseases University of Pittsburgh Nature (Journal) Seder, Robert A Africa your-feed-heal Source Type: news

Changed route of immunization dramatically improves efficacy of TB vaccine
(NIH/National Institute of Allergy and Infectious Diseases) Tuberculosis (TB), an ancient disease, is the leading infectious cause of death globally, yet the world's only licensed TB vaccine, Bacille Calmette-Guerin (BCG), was developed a century ago. Given to infants via a needle placed just under the skin, BCG protects babies from a form of the disease called disseminated TB but is far less effective at preventing pulmonary TB, the major cause of illness and deaths, in teens or adults.
Source: EurekAlert! - Infectious and Emerging Diseases - January 1, 2020 Category: Infectious Diseases Source Type: news

Bronchial inflammation, respiratory symptoms and lung function in patients who finished treatment for pulmonary tuberculosis: is it the beginning of a new disease?
Conclusion: This study suggests the existence of different celullar patterns once the treatment has finished and supports the basis of a treatment hypothesis.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Palma, I., Castro Zorrilla, L., Resguardo, A., Martinez, D., Troncoso, D., Cruz, V., Vina, J., Alves, L., Natiello, M., Estevan, R., Lazari, N., Medin, M. I., Inwentarz, S., Videla, A., Palmero, D. Tags: Allergy and immunology Source Type: research

Indonesians Human Leukocyte Antigen (HLA) Distributions and Correlations with Global Diseases.
Authors: Pradana KA, Widjaya MA, Wahjudi M Abstract In Human, Major Histocompatibility Complex known as Human Leukocyte Antigen (HLA). The HLA grouped into three subclasses regions: the class I region, the class II region, and the class III region. There are thousands of polymorphic HLAs, many of them are proven to have correlations with diseases. Indonesia consists of diverse ethnicity people and populations. It carries a unique genetic diversity between one and another geographical positions. This paper aims to extract Indonesians HLA allele data, mapping the data, and correlating them with global diseases. From ...
Source: Immunological Investigations - October 30, 2019 Category: Allergy & Immunology Tags: Immunol Invest Source Type: research

A near-fatal Valley Fever case opens doors to new treatment method
Of the 8,000 Californians who will contract Valley Fever this year, most will recover without treatment, and those with more serious cases will require an antifungal medication that clears the infection. But a few will experience a life-threatening form of the disease that ravages the body for reasons unknown.Now, an experimental treatment used by physicians atUCLA Mattel Children ’s Hospital that cured a 4-year-old boy may provide an explanation — and a method for manipulating the immune system to combat not just Valley Fever, but a host of infections.In February 2018, the Gonzalez-Martinez family traveled 200 miles f...
Source: UCLA Newsroom: Health Sciences - July 10, 2019 Category: Universities & Medical Training Source Type: news

Evaluation of IL-17 Serum Level, Brain Inflammation and Demyelination in Experimental Autoimmune Encephalomyelitis C57BL/6 Mice Model with Different Doses of Myelin Oligodendrocyte Glycoprotein.
Abstract Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system.MS creates a wide range of symptoms with lifelong debilitating consequences. The hallmark of the disease is the inflammation of the nervous system, which can lead to damage to the nerve tissue and loss of function of the neurons. IL-17 has a prominent role in the beginning of inflammatory reactions. Here, we analyzed a mouse model developed using anti-myelin antibodies. This mouse model mimics many symptoms of MS in humans. C57BL/6 mice were randomly divided into five groups. Mice were immunized subcutaneously with 50...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 7, 2019 Category: Allergy & Immunology Authors: Ghorbani MM, Farazmandfar T, Nasirikenari M, Abediankenari S, Meamarian A, Shahbazi M Tags: Iran J Allergy Asthma Immunol Source Type: research

TB Screening, Testing, and Treatment of Healthcare Personnel TB Screening, Testing, and Treatment of Healthcare Personnel
What are the latest recommendations for the screening and treatment of tuberculosis among health care personnel?Morbidity & Mortality Weekly Report
Source: Medscape Allergy Headlines - June 5, 2019 Category: Allergy & Immunology Tags: Public Health & Prevention Journal Article Source Type: news

Immune cells play unexpected role in early tuberculosis infection
(NIH/National Institute of Allergy and Infectious Diseases) A class of immune cells called innate lymphoid cells (ILCs) mediates the body's initial defense against TB, according to a report published online today in Nature. Boosting this response may provide a new approach to developing treatments and vaccines against TB, which causes more deaths worldwide than any other single infectious disease. The research was supported in part by NIAID, a component of the National Institutes of Health.
Source: EurekAlert! - Infectious and Emerging Diseases - June 5, 2019 Category: Infectious Diseases Source Type: news

Guidelines Nix Annual TB Testing for Most Healthcare Workers Guidelines Nix Annual TB Testing for Most Healthcare Workers
Healthcare workers should be tested for tuberculosis when they are hired and should be retested only after an occupational exposure, according to new CDC guidelines.Medscape Medical News
Source: Medscape Allergy Headlines - May 17, 2019 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Combined immunodeficiency in a patient with deficiency of c-Rel
This study reports a homozygous mutation in REL abrogating c-Rel protein expression in a patient with combined immunodeficiency characterized by susceptibility to Mycobacterium tuberculosis, Salmonella, Cryptosporidium, and cytomegalovirus.
Source: Journal of Allergy and Clinical Immunology - May 15, 2019 Category: Allergy & Immunology Authors: Sarah Beaussant-Cohen, Faris Jaber, Michel J. Massaad, Sabrina Weeks, Jennifer Jones, Mohammed F. Alosaimi, Jacqueline Wallace, Waleed Al-Herz, Raif S. Geha, Janet Chou Source Type: research

TB Alliance and partners form multidisciplinary center for translational TB drug research
(Burness) The National Institute of Allergy and Infectious Diseases (NIAID) has awarded TB Alliance a Center of Excellence in Translational Research (CETR) grant (U19AI142735) for tuberculosis (TB) drug development. New translational research to develop novel anti-TB medicines is being carried out with partners at the University of Illinois at Chicago, Harvard University, Johns Hopkins University, and Research Triangle Institute.
Source: EurekAlert! - Medicine and Health - May 9, 2019 Category: International Medicine & Public Health Source Type: news