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Real-World Safety and Efficacy of Biosimilar CT-P13 in Patients with Immune-Mediated Inflammatory Diseases: Integrated Analysis of Three Japanese Prospective Observational Studies
ConclusionsThe integrated analysis of a large number of patients detected no new safety signals with long-term CT-P13 treatment. Efficacy in rheumatoid arthritis, psoriasis, Crohn ’s disease, and ulcerative colitis cases was confirmed in biologic-naïve patients and switched patients from the originator infliximab or other biologics.
Source: Drug Safety - September 12, 2023 Category: Drugs & Pharmacology Source Type: research
Treating Anemia in Patients With HIV Reduces TB Risk Treating Anemia in Patients With HIV Reduces TB Risk
Markers of anemia and systemic inflammation could help identify patients with HIV who are at risk for active tuberculosis and death.Medscape Medical News
Source: Medscape Allergy Headlines - August 16, 2023 Category: Allergy & Immunology Tags: HIV/AIDS News Source Type: news
News at a glance: Muscular dystrophy therapy, lab-grown chicken, and humans ’ toll on wildlife
BIOMEDICINE
Muscular dystrophy therapy approved
The U.S. Food and Drug Administration has approved the first gene therapy for Duchenne muscular dystrophy (DMD), a genetic disease that cripples boys and usually results in death by age 30. The treatment from Sarepta Therapeutics introduces a short version of the gene for dystrophin, a crucial muscle protein, which is mutated in patients with DMD. A one-time intravenous infusion of a virus delivers the functioning “microdystrophin” gene into patients’ muscle cells. The 22 June approval is only for boys 4 to 5 years old, a group that appeared likely to ben...
Source: Science of Aging Knowledge Environment - June 29, 2023 Category: Geriatrics Source Type: research
No impact of helminth coinfection in patients with smear positive tuberculosis on immunoglobulin levels using a novel method measuring Mycobacterium tuberculosis-specific antibodies
Helminth/tuberculosis (TB)-coinfection can reduce cell-mediated immunity against Mycobacterium tuberculosis (Mtb) and increase disease severity, although the effects are highly helminth species dependent. Mtb hav...
Source: Allergy, Asthma and Clinical Immunology - June 29, 2023 Category: Allergy & Immunology Authors: Giggil Pushpamithran, Camilla Skoglund, Fanny Olsson, Melissa M éndez-Aranda, Thomas Schön, Mårten Segelmark, Olle Stendahl, Robert H. Gilman and Robert Blomgran Tags: Research Source Type: research
Woman Jailed for Refusing TB Treatment or Isolation Woman Jailed for Refusing TB Treatment or Isolation
A woman with tuberculosis refused to receive treatment and would not enter quarantine or isolation. The court sent her to jail before she relented.Medscape Medical News
Source: Medscape Allergy Headlines - June 27, 2023 Category: Allergy & Immunology Tags: Family Medicine/Primary Care News Source Type: news
Neurosarcoidosis: Diagnostic Challenges and Mimics A Review
AbstractPurpose of ReviewNeurosarcoidosis is a rare manifestation of sarcoidosis that is challenging to diagnose. Biopsy confirmation of granulomas is not sufficient, as other granulomatous diseases can present similarly. This review is intended to guide the clinician in identifying key conditions to exclude prior to concluding a diagnosis of neurosarcoidosis.Recent FindingsAlthough new biomarkers are being studied, there are no reliable tests for neurosarcoidosis. Advances in serum testing and imaging have improved the diagnosis for key mimics of neurosarcoidosis in certain clinical scenarios, but biopsy remains an import...
Source: Current Allergy and Asthma Reports - May 31, 2023 Category: Allergy & Immunology Source Type: research
Interstitial Lung Disease: 150 Years of Progress
In 1873, von Buhl published one of the earliest histologic descriptions of interstitial lung disease (ILD) in Tuberkulose und Schwindsucht.1 He described a disorder pathologically characterized by “degeneration and desquamation of alveolar and bronchiolar epithelium” likely caused by tuberculosis or syphilis and coined the term “chronic interstitial pneumonia.” The first histologic description of what today we call idiopathic pulmonary fibrosis (IPF) was published in 1897 by Rindfleis ch, calling the new entity “Cirrhosis Cystica Pulmonum.
Source: Immunology and Allergy Clinics of North America - April 12, 2023 Category: Allergy & Immunology Authors: Joshua J. Solomon, Kevin K. Brown Tags: Preface Source Type: research
AI Cough-Monitoring Can Change the Way We Diagnose Disease
How many times do you cough a day? Do you cough more when you’re indoors or outside? Or more often after you eat? Or at night?
Chances are, your cough memory might not be that accurate. But all of that information about your coughing patterns could be an untapped resource to better understand your health. Coughs may be benign ways to clear a little extra phlegm, or they could be early signs of more serious conditions such as asthma, GERD (gastroesophageal reflux disease), or even lung cancer.
“In the era of precision health, it’s ironic that such a problematic symptom is simply unmeasured,” says Pet...
Source: TIME: Health - April 3, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized healthscienceclimate Technology Source Type: news
Dysregulation of Immunity in Pulmonary Fibrosis is Associated with Increased Myeloid-specific Triggering Receptor-1 and Transforming Growth Factor-beta1 Expression
In this study, the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) as a stimulator for the production of TGF-β1 and also CD4+CD25+Foxp3+ regulatory cells were investigted in FP patients. Sixteen UIP, 14 NSIP and 4 pulmonary fibrosis following Mycobacterium tuberculosis (TB) infection patients, were compared with 12 healthy controls. The frequency of blood CD14+TGF-β1+ and CD14+TREM1+-gated monocytes and CD4+CD25+Foxp3+ regulatory T cells (Treg), as well as the plasma levels of TGF-β1 and IL‑10 were measured. Fibrosis patients compared to healthy controls had a greater frequency of CD14+TGF-β1+...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Shima Rasouli Jalal Heshmatnia Nariman Mosaffa Majid Marjani Esmaeil Mortaz Source Type: research
