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Drug: Dexamethasone

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Total 367 results found since Jan 2013.

Elderly-Onset Neuromyelitis Optica Spectrum Disorder with Pre-Existing Prednisone Allergy
We present a case of an 82-year-old man with new-onset neuromyelitis optica (NMO) spectrum disorder, the treatment of which was complicated by a severe pre-existing prednisone allergy. His age caused much initial doubt about his diagnosis, and his corticosteroid allergy altered our management as we attempted to minimize risk to the patient. Our patient was a healthy 82-year-old, right-handed man who presented with sensory loss of the bilateral lower extremities and progressive, painless vision loss. MRI showed bilateral pre-chiasmatic optic nerve and optic chiasm enhancement, along with enhancement within the thoracic spin...
Source: Case Reports in Neurology - January 23, 2018 Category: Neurology Source Type: research

Glucocorticoids Modulate Th1 and Th2 Responses in Asthmatic Mouse Models by Inhibition of Notch1 Signaling
Conclusions: Through the inhibition of Notch1 signaling, both GSI and GCs could regulate Th1/Th2 balance involved in allergic airway inflammation in OVA-induced asthma.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 17, 2018 Category: Allergy & Immunology Source Type: research

Skin inflammation exacerbates food allergy symptoms in epicutaneously sensitized mice
ConclusionEven after eliminating exposure to the antigen, inflammation from skin barrier disruption can exacerbate the severity of food allergy symptoms. Serum baseline mmcp1 levels might be an effective marker for predicting the severity of antigen‐induced allergic symptoms.This article is protected by copyright. All rights reserved.
Source: Allergy - January 10, 2018 Category: Allergy & Immunology Authors: Akiko Kawasaki, Naohiro Ito, Hiroki Murai, Motoko Yasutomi, Hironobu Naiki, Yusei Ohshima Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Basophil testing with CD63 in pollen-sensitized patients is independent of the circadian clock
Allergy is a public health issue that affects more than 25% of western populations. Diurnal variation in allergic symptoms is well documented; exacerbations frequently occur at night and in the early morning, and may be associated with a diurnal lowering of the threshold for histamine sensitivity in the bronchial tree.1 The pathomechanism underlying these observations is not understood, but is thought to involve mast cell mediators. Diurnal variation of clock genes and release of histamine and synthesis of cysteinyl leukotrienes were measured from human intestinal mast cells synchronized with dexamethasone.
Source: Journal of Allergy and Clinical Immunology - January 9, 2018 Category: Allergy & Immunology Authors: Cecilie Lind, S øren Helbo Skaarup, Axel Lorentz, Hans Jürgen Hoffmann Tags: Letter to the Editor Source Type: research

Effect of roflumilast on neutrophilic asthma model
Conclusions: These results suggest that the administration of roflumilast attenuates airway inflammation and AHR in neutrophilic asthma model. Adding roflumilast to dexamethasone resulted further beneficial effect. The beneficial effect of roflumilast may be related to IL-22 and HDAC pathways.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Rhee, C. K., Kim, J. H., Kim, S. Y., Park, C. K., Yoon, H. K. Tags: Allergy and immunology Source Type: research

CTLA4-Ig enhanced glucocorticoid effect on murine asthma
Conclusions: CD28 signal is involved in steroid responsivenes both in vitro and in vivo, and a good therapeutic target.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Mori, A., Kouyama, S., Yamaguchi, M., Kumitani, C., Ohtomo-Abe, A., Nakamura, Y., Tomita, Y., Hamada, Y., Kamide, Y., Hayashi, H., Watai, K., Mitsui, C., Sekiya, K., Tsuburai, T., Fukutomi, Y., Taniguchi, M., Ohtomo, T., Kaminuma, O. Tags: Allergy and immunology Source Type: research

T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation in Mice.
Abstract Eosinophilic inflammation in combination with immunoglobulin E (IgE) production is a characteristic feature of atopic dermatitis. Although activated T-helper type (Th) 2 cells play critical roles in the local accumulation and activation of eosinophils, whether they induce eosinophilic skin inflammation, independent of the IgE-mediated pathway has been unclear. To address the functional role of T cells in allergic skin diseases, we herein transferred Th1/Th2-differentiated or naive DO11.10 T cells into unprimed BALB/c mice. Ovalbumin-specific Th2 cells, as well as eosinophils, accumulated in the skin upon ...
Source: Cell Research - November 29, 2017 Category: Cytology Authors: Kaminuma O, Nishimura T, Kitamura N, Saeki M, Hiroi T, Mori A Tags: Allergy Asthma Immunol Res Source Type: research

Dexamethasone for inpatient childhood asthma exacerbations is as effective as short-acting corticosteroid treatment
Acute asthma exacerbations result in over 130,000 childhood hospitalizations in the United States annually.1 Systemic corticosteroids (SCS) are a fundamental component of exacerbation management and reduce relapse rates after hospital discharge.2 Use of prednisolone or other short-acting SCS during hospitalization may require continuation of this medication after hospital discharge, yet a recent study demonstrated that only about half of these prescriptions are filled within 3 –7 days of discharge.
Source: Annals of Allergy, Asthma and Immunology - November 20, 2017 Category: Allergy & Immunology Authors: Sara Seghezzo, Donald H. Arnold, James C. Gay, Paul E. Moore, David P. Johnson Tags: Letter Source Type: research

Dexamethasone for inpatient childhood asthma exacerbations is as effective as short-acting corticosteroid treatment.
PMID: 29162317 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - November 18, 2017 Category: Allergy & Immunology Authors: Seghezzo S, Arnold DH, Gay JC, Moore PE, Johnson DP Tags: Ann Allergy Asthma Immunol Source Type: research

Comparison of the Effect of Cold Drink and Dexamethasone, and their Combined Effect on Children with Croup
Conclusion The cold drink has less treating effect than DM and combined simultaneous treatment method. Also, DM had more influence than simultaneous treatment method. In addition, other variables including age, sex, birth weight, BMI, respiratory allergy and previous croup history did not influenced improvement time-scale and only type of intervention influenced improvement time-scale of croup clinical symptoms. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Drug Research - November 3, 2017 Category: Drugs & Pharmacology Authors: Faraji-Goodarzi, Mojgan Taee, Nadereh Mohammadi-Kamalvand, Mehrnoosh Tags: Original Article Source Type: research

Effect of matrix metalloproteinase inhibitor on disrupted E ‐cadherin after acid exposure in the human nasal epithelium
ConclusionOur results suggest that altered expression of E‐cadherin in the nasal epithelium by acid exposure may be a possible mechanism for nasal tissue injury in chronic nasal inflammation with LPRD, and that MMP inhibition is a potential treatment. Level of EvidenceNA. Laryngoscope, 2017
Source: The Laryngoscope - October 17, 2017 Category: ENT & OMF Authors: Byoungjae Kim, Hyun ‐Ji Lee, Nu‐Ri Im, Doh Young Lee, Cha Young Kang, Il‐Ho Park, Seung Hoon Lee, Sang Hag Lee, Seung‐Kuk Baek, Tae Hoon Kim Tags: Allergy/Rhinology Source Type: research

Dexamethasone attenuates methacholine ‐mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF‐κB activation
ConclusionNF‐κB activation is important for inhibition of p‐CREB/AQP5 expression after methacholine intervention, and dexamethasone adjusts it to the opposite side. This observation could provide additional insight into the anti‐inflammatory effects of glucocorticoids that contribute to maintaining airway surface liquid and mucosal defense.
Source: International Forum of Allergy and Rhinology - October 1, 2017 Category: Allergy & Immunology Authors: Yung ‐Lung Chang, Kai Ren Jian, Chun‐Shu Lin, Hsing‐Won Wang, Shao‐Cheng Liu Tags: ORIGINAL ARTICLE Source Type: research

Randomized, Controlled Trial of Dexamethasone Versus Dexamethasone Plus Hydrocortisone as Prophylaxis for Hypersensitivity Reactions Due to Paclitaxel Treatment for Gynecologic Cancer
Conclusions: Adding HCT to routine DXM prophylaxis significantly decreased paclitaxel HSR frequency.
Source: International Journal of Gynecological Cancer - September 26, 2017 Category: Cancer & Oncology Tags: Quality of Life Source Type: research

Ferulic acid supresses Th2 immune response and prevents remodeling in ovalbumin-induced pulmonary allergy associated with inhibition of epithelial-derived cytokines
Conclusions In this study it was demonstrated for the first time that ferulic acid treatment is able to suppress one of the main features of the airway remodeling, indicated by reduction of mucus production, besides the Th2 pathogenic response on ovalbumin-induced pulmonary allergy. Taken together, results shows that the immunopathological mechanism underlying these effects is linked to a reduction of the epithelial-derived chemokines and cytokines, suggesting that ferulic acid may be useful as a potential therapeutic agent for asthma.
Source: Pulmonary Pharmacology and Therapeutics - July 6, 2017 Category: Respiratory Medicine Source Type: research