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Drug: Dexamethasone

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Total 367 results found since Jan 2013.

Tolerogenic Dendritic Cells Reduce Airway Inflammation in a Model of Dust Mite Triggered Allergic Inflammation.
CONCLUSIONS: Preventive treatment with TolDCs protects against dust mite-induced allergy in a mouse model, reinforcing the use of tolerogenic dendritic cells for the management of allergic conditions. PMID: 29949837 [PubMed]
Source: Allergy, Asthma and Immunology Research - June 28, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

The Effects of Allium Cepa Extract on Tracheal Responsiveness, Lung Inflammatory Cells and Phospholipase A2 Level in Asthmatic Rats.
In this study, the effects of A. cepa aqueous-alcoholic extract on tracheal responsiveness, lung inflammatory cells and phospholipase A2 (PLA2) level in bronchoalveolar fluid (BALF) of asthmatic rats were examined. Wistar rats were randomly divided into control group (C), asthmatic group (A), asthmatic group (A) treated with A. cepa extract (AC, 0.175, 0.35, and 0.7 mg/mL) and dexamethasone (D, 1.25 μg/mL). The extract of A. cepa and dexamethasone were added to animal's drinking water during sensitization period. Tracheal responsiveness to methacholine and ovalbumin, lung inflammatory cells and PLA2 level in BALF were ass...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2018 Category: Allergy & Immunology Authors: Ghorani V, Marefati N, Shakeri F, Rezaee R, Boskabady M, Boskabady MH Tags: Iran J Allergy Asthma Immunol Source Type: research

Incidence of infusion hypersensitivity reaction after withholding dexamethasone premedication in early breast cancer patients not experiencing two previous cycles of infusion hypersensitivity reaction for weekly paclitaxel chemotherapy
ConclusionWithholding dexamethasone premedication in non-experiencing HSR patients after two previous cycles of weekly paclitaxel administration was safe and did not impact the higher incidence of HSR. A discontinuing dexamethasone protocol should be recommended generally in these patients, especially those with a high risk for steroid-induced side effects.
Source: Supportive Care in Cancer - May 31, 2018 Category: Cancer & Oncology Source Type: research

Dexamethasone induces ω3-derived immunoresolvents driving resolution of allergic airway inflammation
Dexamethasone induces the production of DHA-derived specialized proresolving lipids and the resolution of allergic airway inflammation. This adds glucocorticosteroids to the short list of drugs that are known to possess direct pro-resolving functions.
Source: Journal of Allergy and Clinical Immunology - April 24, 2018 Category: Allergy & Immunology Authors: Katerina Pyrillou, Aikaterini-Dimitra Chairakaki, Constantin Tamvakopoulos, Evangelos Andreakos Source Type: research

Do we need to keep playing this tune?
Seghezzo and colleagues1 add to the many other studies that report that 2 doses of dexamethasone and 5 to 7 days of prednisone or prednisolone therapy are associated with no detected difference in relapse or readmission. The implication of that study is that 2 doses of 0.6  mg/kg of dexamethasone (equivalent to 3 mg/kg of prednisolone from standard corticosteroid equivalency tables) matches the efficacy of 5 to 7 days of 1 or 2 mg/kg of prednisone or prednisolone. However, the absence of a placebo in this and other studies cannot distinguish equal efficacy from equal inefficacy.
Source: Annals of Allergy, Asthma and Immunology - April 1, 2018 Category: Allergy & Immunology Authors: Miles Weinberger Source Type: research

The kinase LRRK2 is differently expressed in chronic rhinosinusitis with and without nasal polyps
ConclusionLRRK2 and NRON may play different role in CRSsNP and CRSwNP. The molecular mechanisms identified here may aid in the design of novel therapeutic strategies to improve clinical outcomes.
Source: Clinical and Translational Allergy - March 12, 2018 Category: Allergy & Immunology Source Type: research

Galectin-3: role in ocular allergy and potential as a predictive biomarker.
CONCLUSION: Gal-3 contributes to the pathogenesis of ocular allergy and represents a relevant therapeutic target. PMID: 29502069 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - March 3, 2018 Category: Opthalmology Authors: Andrade FEC, Corrêa MP, Gimenes AD, Dos Santos MS, Campos M, Chammas R, Gomes JÁP, Gil CD Tags: Br J Ophthalmol Source Type: research

Allergy to Carbidopa
Conclusions To the best of our knowledge, this is the first case report of an allergic reaction specific to carbidopa. Our case highlights the importance of identifying the source of a hypersensitivity drug response, whether it is caused by the active component or by the excipients.
Source: Clinical Neuropharmacology - March 1, 2018 Category: Neurology Tags: Case Reports Source Type: research

Author response to “do we need to keep playing this tune?”
We thank Dr. Weinberger for the interest in our publication “Dexamethasone for inpatient childhood asthma exacerbations is as effective as short-acting corticosteroid treatment.”1 The growing number of studies in this area reflects the importance of refining our approach to treating children with acute asthma exacerbations, the most common reason for chi ldhood hospitalizations in the U.S.2 We believe our report fills an important knowledge gap by answering the question whether a two-dose dexamethasone regimen is as effective as short-acting systemic corticosteroid for hospitalized children.
Source: Annals of Allergy, Asthma and Immunology - February 19, 2018 Category: Allergy & Immunology Authors: Sara Seghezzo, Donald H. Arnold, James C. Gay, Paul E. Moore, David P. Johnson Tags: Commentary Source Type: research

Authors' response
We thank Dr Weinberger for the interest in our publication “Dexamethasone for inpatient childhood asthma exacerbations is as effective as short-acting corticosteroid treatment.”1 The increasing number of studies in this area reflects the importance of refining our approach to treating children with acute asthma exacerbations, the most common reason for childhood hospitalizations in the United States.2 We believe our report fills an important knowledge gap by answering the question of whether a 2-dose dexamethasone regimen is as effective as short-acting systemic corticosteroid (SCS) for hospitalized children.
Source: Annals of Allergy, Asthma and Immunology - February 19, 2018 Category: Allergy & Immunology Authors: Sara Seghezzo, Donald H. Arnold, James C. Gay, Paul E. Moore, David P. Johnson Source Type: research

Regulatory Effect of Xiaoqinglong Decoction on Thymic Stromal Lymphopoietin (TSLP) Inflammation Promoter in Mice with Cold Asthma.
In this study, the role of the TSLP pathway in the onset of asthma and the protective mechanism of XQL were investigated. A total of 50 female mice were randomly divided into the following groups: the blank group (A), the model group (B), the XQL group (C), the dexamethasone group (D), and the XQL + dexamethasone group (E). Asthma was induced with ovalbumin, and corresponding drug intervention was carried out for 7 days, after which serum and lung tissue end points were analyzed. Serum interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α), nuclear factor κB (NF-κB), and TSLP levels were higher in group B than in g...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Song G, Zhang Y, Zhao K, Sun M, Cheng P, Wang J Tags: Iran J Allergy Asthma Immunol Source Type: research

Role of IL ‐13Rα2 in modulating IL‐13 induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa
ConclusionsIL‐13Rα2 has a potential role in IL‐13 induced MUC5AC and ciliary changes through ERK1/2 signal pathway in the nasal epithelium. IL‐13Rα2 may contribute to airway inflammation and aberrant remodeling which are the main pathological features of CRSwNP.This article is protected by copyright. All rights reserved.
Source: Allergy - February 1, 2018 Category: Allergy & Immunology Authors: Jing Liu, YingYing Li, Anand Kumar Andiappan, Yan Yan, Tan Kai Sen, Hsiao Hui Ong, Kim Thye Thong, Yew Kwang Ong, Feng Gang Yu, Heng Boon Low, Yong Liang Zhang, Li Shi, De Yun Wang Tags: Original Article: Experimental Allergy and Immunology Source Type: research