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Drug: Dexamethasone

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Total 367 results found since Jan 2013.

Meta-analysis of risk factors associated with oxaliplatin hypersensitivity reactions in cancer patients
This study aimed to investigate risk factors associated with oxaliplatin hypersensitivity reactions in cancer patients through a meta-analysis. A comprehensive retrieve of Chinese databases China National Knowledge Infrastructure, Wanfang Data, VIP Database and English databases PubMed, ScienceDirect, Embase and Cochrane library was conducted. The studies that meet the requirements for meta-analysis according to inclusion and exclusion criteria were screened and assessed for eligibility. Odds ratio (OR) / Weighted mean difference (WMD) and 95% confidence intervals (95% CIs) or calculable dichotomous and continuous raw data...
Source: International Journal of Clinical Oncology - October 9, 2021 Category: Cancer & Oncology Source Type: research

Hypothalamic ‐pituitary‐adrenal axis suppression and intranasal corticosteroid use: A systematic review and meta‐analysis
ConclusionOverall, the use of INCS carries a low risk for AI. Although modest, this risk may differ depending on the length of duration and type of INCS used. Informing patients of these risks is of importance for the treatment of chronic sinonasal conditions.
Source: International Forum of Allergy and Rhinology - July 14, 2021 Category: Allergy & Immunology Authors: Gianluca Sampieri, Amirpouyan Namavarian, John J. W. Lee, Amr F. Hamour, John M. Lee Tags: ORIGINAL ARTICLE Source Type: research

Dexamethasone Versus Prednisone for Pediatric Acute Asthma Exacerbations: Specialists' Practice Patterns
Conclusions Although most pediatric emergency medicine academic physicians have transitioned to using dexamethasone to treat acute pediatric asthma exacerbations, other specialties continue to favor prednisone.
Source: Pediatric Emergency Care - July 1, 2021 Category: Emergency Medicine Tags: Original Articles Source Type: research

How our treatment of asthma has changed in the last half century
At the close of the 1960s, asthma treatment was quite simple. For chronic maintenance treatment, there were tablets containing the sympathomimetic ephedrine, the methylxanthine theophylline, a barbiturate or hydroxyzine to offset the stimulatory adverse effects of ephedrine, and in some preparations an expectorant. Other chronic medications included the expectorants iodine and glyceryl guaiacolate administered singly, the oral corticosteroids prednisone and methyl prednisolone, and the long-acting inhaled steroid dexamethasone, which was fully active systemically.
Source: Annals of Allergy, Asthma and Immunology - May 19, 2021 Category: Allergy & Immunology Authors: Harold S. Nelson Tags: Perspective Source Type: research

How our treatment of asthma has changed over the last half century
At the close of the 1960s asthma treatment was quite simple. For chronic maintenance treatment there were tablets containing the sympathomimetic ephedrine, the methylxanthine theophylline, a barbiturate or hydroxyzine to offset the stimulatory side effects of ephedrine and in some preparations an expectorant. Other chronic medications included the expectorants iodine and glyceryl guaiacolate administered singly, the oral corticosteroids prednisone and methyl prednisolone, and the long acting inhaled steroid dexamethasone, which was fully active systemically.
Source: Annals of Allergy, Asthma and Immunology - May 19, 2021 Category: Allergy & Immunology Authors: Harold S Nelson Source Type: research

Efficacy of oral Dexamethasone versus oral Prednisone in school-aged asthmatics treated in the Emergency Department at an Academic Medical Center
Recent studies suggest oral prednisone (PRED) and dexamethasone (DEX) are equally efficacious in treatment of asthma exacerbation in the emergency department (ED). Furthermore, DEX is suggested as potentially superior given improved palatability and fewer doses required. Subsequently, our institution transitioned from PRED to DEX. We hypothesize that both treatments will be equally efficacious in a much larger, predominantly African American (AA) population.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Joseph Howard, Jay Lieberman, Daniel Dibaba, Qi Zhao, Annette Carlisle Source Type: research

Effects of Dexamethasone on airway epithelial cells exposed to oxidative stress
Glucocorticoid insensitivity may be elicited by oxidative stress such as the one caused by exposure to the air pollutant, ozone (O3). We previously showed that O3-induced airway hyperreactivity in mice was associated with the expression of both pro-inflammatory and antioxidant genes. But the relationship of oxidative stress to the anti-inflammatory effects of glucocorticoids is unclear.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Chioma Enweasor, Duane Kim, Cameron Flayer, Angela Linderholm, Lisa Franzi, Angela Haczku Source Type: research

Emergency Considerations in COVID-19 Vaccine Administration
Conclusion The joint response of science and medicine to develop safe and effective COVID-19 vaccines has been brisk and productive. Distribution efforts will now be the next step in limiting the breadth of this pandemic. EMS agencies will play a key role in some areas in the administration of vaccinations for their communities. The authors suggest that to better clarify the side effects of the COVID-19 vaccines, EMS systems must maintain a log of the type and incidence of adverse events following vaccine administration, EMS responses to the adverse events, as well as those patients’ outcomes from this management. ...
Source: JEMS Patient Care - December 16, 2020 Category: Emergency Medicine Authors: JEMS Staff Tags: Coronavirus Exclusives EMS EMT Paramedic Source Type: news

Dexamethasone and lidocaine suppress eosinophilopoiesis from umbilical cord blood cells
Eosinophils play an important role in allergic inflammation. Glucocorticosteroids have been used as an anti-inflammatory medication for inflammatory diseases involving eosinophil infiltration. Some effect of n...
Source: Clinical and Molecular Allergy - December 2, 2020 Category: Allergy & Immunology Authors: Masato Muraki, Hirohito Kita and Gerald J. Gleich Tags: Research Source Type: research

Effect of an Antagonistic Peptide of CCR5 on the Expression of Autophagy-related Genes and β-Arrestin 2 in Lung Tissues of Asthmatic Mice.
CONCLUSIONS: HY peptide inhibits airway inflammation, autophagic dysfunction exists in asthmatic mice, and targeting HY peptide increases the expression of autophagy-related genes. Thus, β-arrestin 2 may participate in the mechanisms underlying these processes. PMID: 33191680 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 18, 2020 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research