Establishment of Patient-Derived Tumor Xenograft Models of High-Risk Endometrial Cancer
Conclusions The combination of 2 engrafting methods increases the tumor engraftment rate. The high tumor engraftment rate ensures the establishment of a high-risk EC biobank, which is a powerful resource for performing preclinical drug-sensitivity tests and identifying biomarkers for response or resistance. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Basic Science Source Type: research

Pilot of an International Collaboration to Build Capacity to Provide Gynecologic Oncology Surgery in Botswana
Conclusions Periodic gynecologic oncology campaigns in settings otherwise lacking local capacity to perform advanced surgery are a feasible model to create access and build local capacity. Strong local collaboration is essential. Future strategies to increase impact include recruitment of more gynecologic oncologists to increase service and training availability. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Surgeons Corner Source Type: research

Laparoscopic Pelvic Exenteration With Radical Vaginectomy Using 3-Dimensional Vision and Multifunction Instrument
Conclusions Laparoscopic anterior pelvic exenteration with radical colpectomy using 3D vision and multifunction instrument is a fast and safe procedure. However, we notice that further prospective trials are needed to compare this technique with other open surgery and minimally invasive approach (ie, robotically). (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Surgeons Corner Source Type: research

Palliative Total Pelvic Exenteration for Gynecologic Cancers: A Cross-sectional Study of Society of Gynecologic Oncology Members
Conclusion Half of gynecologic oncologists seem to be willing to offer a palliative TPE, although more-experienced gynecologic oncologists are more likely to reserve the procedure for curative intent. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Surgeons Corner Source Type: research

Clinical Outcome of Patients With High-Risk Endometrial Carcinoma After Treatment With Chemotherapy Only
Conclusions Patients with high-risk EC have acceptable vaginal/pelvic control rates after adjuvant chemotherapy. However, prognosis remains poor for patients with stage IIIc disease, also after chemotherapy. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Adjuvant Pelvic Radiation “Sandwiched” Between Paclitaxel/Carboplatin Chemotherapy in Women With Completely Resected Uterine Serous Carcinoma: Long-term Follow-up of a Prospective Phase 2 Trial
Conclusions The long-term follow-up in this study demonstrates that “sandwich” therapy is an efficacious, well-tolerated treatment approach with acceptable toxicities. Lymphovascular invasion (LVSI) is a significantly poor prognostic factor in stage I USC. Multimodal “sandwich” therapy should be considered in all USC patients who have undergone complete surgical resection and staging. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Gestational Trophoblastic Neoplasia From Genetically Confirmed Hydatidiform Moles: Prospective Observational Cohort Study
Conclusions Under the cohort cytogenetic diagnosis setting, the traditional risk factors for GTN after molar pregnancy, hCG value before evacuation and age, were confirmed in androgenetic CHMs. The risk of GTN was lower for PHMs than for CHMs. However, 1 patient with cytogenetic PHMs developed into GTN. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Gestational Throphoblastic Neoplasia Source Type: research

Outcome of First-Line Hysterectomy for Gestational Trophoblastic Neoplasia in Patients No Longer Wishing to Conceive and Considered With Isolated Lung Metastases: A Series of 30 Patients
Conclusions For GTN patients no longer wishing to conceive with lung metastases discovered postoperatively, treated by hysterectomy, and whose hCG is decreasing, it is reasonable to expect and to inform patients that approximately 27% will require salvage chemotherapy. However, in patients with lung metastases discovered preoperatively, evidence to recommend first-line hysterectomy is insufficient and these patients should receive first-line chemotherapy. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Gestational Throphoblastic Neoplasia Source Type: research

Assessment of Parametrial Involvement in Early Stages Cervical Cancer With Preoperative Magnetic Resonance Imaging
The objective of this study was to develop a predictive model for parametrial involvement (PMI) and to identify low-risk group of PMI in early stages of cervical cancer based on preoperative magnetic resonance imaging (MRI) parameters. Methods We retrospectively analyzed patients with stages IB1 to IIA2 cervical cancer (N = 1347) who underwent type C radical hysterectomy between 2005 and 2012. Clinical records, preoperative MRI, and its association with pathological data were reviewed. A predictive model for PMI was developed using preoperative MRI parameters for the estimation of its performance. Results Of 1347 pat...
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Small Cell Carcinomas of the Uterine Cervix and Lung: Proteomics Reveals Similar Protein Expression Profiles
Conclusions We demonstrate a significant overlapping similarity of protein expression profiles of lung and cervical small cell carcinomas despite the significant differences in their organs of origin. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Abdominal Radical Trachelectomy for Early-Stage Cervical Cancer During Pregnancy: A Provocative Surgical Approach. Overview of the Literature and a Single-Institute Experience
Conclusions Radical trachelectomy can widen the therapeutic approach of early-stage cervical cancer in pregnant women who wish to preserve their pregnancy, providing a possibility of receiving the proper treatment with no delay. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Sexual Health as Part of Gynecologic Cancer Care: What Do Patients Want?
Conclusions Demographic predictors of importance of sexuality to the patient are age, relationship status, and sexual activity. Providers primarily use age as a proxy for importance of sexuality; however, relationship status and sexual activity may represent additional ways to screen for patients interested in discussing sexual health. Patient discomfort with discussing sexuality is the primary barrier to sexual health discussions, and awareness of this is key to developing effective approaches to providing sexual health care. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research

Quality of Life and Sexual Functioning After Vulvar Reconstruction With the Lotus Petal Flap
Conclusions Patients who underwent vulvar reconstructive surgery with lotus petal flaps seem to have a lower QoL compared with healthy women. Patients report more pain during sexual activity but are satisfied about their sexual functioning. These results should be included in preoperative counseling and follow-up of future patients eligible for vulvar reconstruction with a lotus petal flap. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research

Caregiving Is a Marathon, Not a Road Race: Reenvisioning Caregiver Support Services in Gynecologic Oncology
Conclusions Experts, patients, and caregivers effectively engaged in social media to identify a wide range of needs of caregivers of women with gynecologic cancers. Further research is needed to identify specific support services that could meet the priority needs of a broader network of caregivers. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research

The Impact of Sociodemographic Factors and Emergency Admissions on the Place of Death of Gynecological Cancer Patients in England: An Analysis of a National Mortality–Hospital Episode Statistics–Linked Data Set
Objective The aim of this study was to develop a predictive model for risk of death in hospital for gynecological cancer patients specifically examining the impact of sociodemographic factors and emergency admissions to inform patient choice in place of death. Methods The model was based on data from 71,269 women with gynecological cancer as underlying cause of death in England, January 1, 2000, to July 1, 2012, in a national Hospital Episode Statistics–Office for National Statistics database. Two thousand eight hundred eight deaths were used for validation of the model. Logistic regression identified independen...
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research

Surgical Efforts Might Mitigate Difference in Response to Neoadjuvant Chemotherapy in Stage IIIC–IV Unresectable Ovarian Cancer: A Case-Control Multi-institutional Study
Conclusions Complete cytoreduction might mitigate the difference in response to neoadjuvant chemotherapy. The presence of RD at IDS is associated with worse survival outcomes. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Rectosigmoidectomy and Douglas Peritonectomy in the Management of Serosal Implants in Advanced-Stage Ovarian Cancer Surgery: Survival and Surgical Outcomes
Conclusions Douglas peritonectomy showed similar survival and surgical outcomes to RR and provided shorter hospital stay and earlier admission to chemotherapy in the management of serosal implants during advanced-stage ovarian cancer surgery. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Uterine and Tubal Lavage for Earlier Cancer Detection Using an Innovative Catheter: A Feasibility and Safety Study
Conclusions Our studies demonstrate that the UtL, using the new catheter, is a safe, reliable, and well-tolerated procedure, which does not require elaborate training. Therefore, UtL fulfils all prerequisites to be used in a potential screening setting. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Borderline Ovarian Tumors: Fifteen Years’ Experience at a Scottish Tertiary Cancer Center
Conclusions To our knowledge, this study is the largest BOT cohort in the United Kingdom. Recurrent disease is rare in optimally staged, completely resected, early-stage BOT, without high-risk features. Caution is needed in women electing not to undergo completion staging after diagnosis and in those opting for a fertility-preserving approach. Thorough informed consent and clear plans for surveillance and follow-up are needed with consideration of delayed completion surgery as appropriate. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Prognostic Value of Pathologic Chemotherapy Response Score in Patients With Ovarian Cancer After Neoadjuvant Chemotherapy
Conclusions Patients with CRS 3 have longest progression-free survival and highest CA125 drop after NACT. These parameters have important prognostic value and can be used for clinical decision-making. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Intraoperative Ultrasound-Guided Excision of Cardiophrenic Lymph Nodes in an Advanced Ovarian Cancer Patient
Conclusions Intraoperative transdiaphragmatic ultrasound represents a possible approach to localize suspicious CPLNs and to guide their surgical eradication. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Predictive and Prognostic Implication of Bowel Resections During Primary Cytoreductive Surgery in Advanced Epithelial Ovarian Cancer
Conclusions Anastomotic leakage rate after rectosigmoid resection in advanced EOC is acceptably low and outweighs increased perioperative risks when performed in a high-volume institution. Nonetheless, the occurrence of AL is a severe adverse event, which even seems to negatively affect patients’ overall prognosis. As no factor could be identified to clearly predict AL, extensive procedures comprising multiple bowel resections, should be avoided particularly when complete resection cannot be achieved. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Comparison of Laparoscopic and Open Surgery for Patients With Borderline Ovarian Tumors
This study included patients with BOTs who underwent open (n = 433) or laparoscopic (n = 210) surgery between 1990 and 2015. Surgical outcomes, perioperative morbidity, and disease-free survival and overall survival were compared. Results There was no significant difference in age, histologic type of tumor, and laterality of tumor. However, body mass index was slightly higher for the open surgery group (P = 0.046). The open surgery group had a higher serum cancer antigen 125 level (P (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Malignant Transformation of Mature Cystic Teratoma: Is Squamous Cell Carcinoma Different From the Other Types of Neoplasm?
Conclusions Clinical characteristics and outcomes did not differ significantly between SCC and non-SCC. However, chemotherapy regimens differed to some extent, and the possibility of difference in overall survival among pathological types of non-SCC was suggested. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Clinicopathologic Features and Risk Factors for Recurrence of Mucinous Borderline Ovarian Tumors: A Retrospective Study With Follow-up of More Than 10 Years
This study aimed to evaluate the clinicopathologic features of mucinous borderline ovarian tumors (MBOTs), with an emphasis on the risk factors for recurrence. Methods Data of 76 patients with MBOT diagnosed and treated between 2000 and 2007 at a single institution were analyzed in this retrospective study. The clinicopathologic features of different tumor subgroups were analyzed, including pathology, surgical methodology, recurrence, and overall survival. Results The median patient age was 40 years (13–85 years). Forty-six patients with gastrointestinal mucinous borderline tumors (intestinal MBOTs) (73.7%) and...
Source: International Journal of Gynecological Cancer - November 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Acute Myeloid Leukemia Following Gynecologic Cancer in the Era of Platinum-Based Chemotherapy
Conclusions Therapy-related AML following chemotherapy treatment for a gynecologic malignancy is a very rare late treatment-related event associated with a poor prognosis. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Quality of Life Source Type: research

Treatment Results and Prognostic Factors of Brain Metastases From Ovarian Cancer: A Single Institutional Experience of 56 Patients
The objective of this study was to describe clinical results of treatment and prognostic factors of patients with brain metastases from ovarian cancer treated at a single institution. Materials and Methods We retrieved information from the electronic medical records of 56 consecutive patients (2.8%) with brain metastases, from a total of 2008 patients with ovarian cancer. Endpoints were the pattern of treatment failure, progression-free survival, and overall survival (OS). Results Radiation was the most common initial treatment for brain metastases (59%), followed by surgery (23%). The median progression-free surviva...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Endometrial Cancer Presentation and Outcomes Based on Mismatch Repair Protein Expression From a Population-Based Study
The objective was to evaluate clinical characteristics and outcomes of endometrial cancers based on MMR status within a population-based study. Methods This was a retrospective population-based cohort study of all endometrial cancer cases from the Vancouver Coastal Health Authority region, evaluated for 4 MMR proteins using immunohistochemistry from 2012 to 2015. Patients were classified as MMR deficient (dMMR, any MMR protein absent) or MMR proficient (pMMR), Demographics, tumor characteristics, recurrences, and survival rates were compared according to MMR status. Results There were 892 patients, with 650 pMMR (72....
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

The Clinical Features of Recurrent Endometrial Cancer in Japan: Chemotherapy Instead of Radiotherapy as Postoperative Adjuvant Treatment
Conclusions Adjuvant chemotherapy was insufficient to reduce the incidence of distant recurrence. The prognosis of patients recurred within regional LN and/or vagina was significantly better than that of patients with recurrence in other lesions because of treatment with surgery and/or radiotherapy. The disease-free interval was a significant prognostic factor for REC patients. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Uterine Cancer Source Type: research

Trends and Complications of Vulvar Reconstruction After Vulvectomy: A Study of a Nationwide Cohort
The objective of this study was to determine complications associated with primary closure compared with reconstruction after vulvar excision and predisposing factors to these complications. Methods Patients undergoing vulvar excision with or without reconstruction from 2011 to 2015 were abstracted from the National Surgical Quality Improvement Program database. Common Procedural Terminology codes were used to characterize surgical procedures as vulvar excision alone or vulvar excision with reconstruction. Patient characteristics and 30-day outcomes were used to compare the 2 procedures. Descriptive and univariate stati...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Vulvar Cancer Source Type: research

Number of Nodes Removed With Inguinofemoral Lymphadenectomy and Risk of Isolated Groin Recurrence in Women With FIGO Stage IB–II Squamous Cell Vulvar Cancer
Conclusions Women treated for vulvar cancer in which less than 6 nodes are removed from each groin are at higher risk of groin recurrence. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Vulvar Cancer Source Type: research

Bevacizumab in Metastatic, Recurrent, or Persistent Cervical Cancer: The BC Cancer Experience
Conclusions In this population-based analysis, the combination of bevacizumab and platinum–based chemotherapy as first-line therapy for metastatic, recurrent, or persistent cervical carcinoma was safely delivered and had outcomes comparable to results from the GOG 240 phase III trial. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Prophylactic Extended-Field Irradiation for Patients With Cervical Cancer Treated With Concurrent Chemoradiotherapy: A Propensity-Score Matching Analysis
Conclusions Prophylactic extended-field RT was associated with decreased distant failure and PALNF and showed a trend in improving DFS in patients with cervical cancer treated with CCRT. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Propensity Score Analysis of Radical Hysterectomy Versus Definitive Chemoradiation for FIGO Stage IIB Cervical Cancer
Conclusions The results of this study suggest that RH with adjuvant radiotherapy and definitive CRT are equivalent treatment options for patients with FIGO stage IIB cancer. However, prospective larger studies are needed to confirm this. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Radical Surgery in Advanced Cervical Cancer Patients Receiving Bevacizumab-Containing Chemotherapy: A “Real Life Experience”
Conclusions Radical surgery can be performed in women with CC previously treated with a bevacizumab-containing regimen. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Rising Rates of Upfront Surgery in Early Locally Advanced Cervical Cancer: What Factors Predict for This Treatment Paradigm?
In this study, we analyzed patterns of care for patients with locally advanced cervical cancer to identify predictors for upfront surgery compared with definitive chemoradiation (CRT). Methods The National Cancer Database was queried for patients aged 18 years or older with Federation of Gynecology and Obstetrics IB2–IIB cervical cancer. All patients underwent either upfront hysterectomy with or without postoperative radiation therapy versus definitive CRT. Logistic regression was used to assess variables associated with modality of treatment (surgery vs CRT). Results Of the 9494 patients included, 2151 (22.7%)...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

The Utility of Pretreatment and Posttreatment Lymphopenia in Cervical Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy
Objective The aim of this study was to investigate the prognostic significance of pretreatment and posttreatment lymphopenia in locally advanced squamous cell carcinoma (SCC) cervical cancer patients treated with definitive chemoradiotherapy (ChRT). Methods Data from 95 patients with SCC were retrospectively analyzed. Relationships between pretreatment or posttreatment lymphopenia and patient or tumor characteristics, and overall survival (OS) and disease-free survival (DFS) were evaluated. Results Median follow-ups for the entire cohort and survivors were 68 months (range, 3–133 months) and 88 months (range,...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Tumor Size at Magnetic Resonance Imaging Association With Lymph Node Metastasis and Lymphovascular Space Invasion in Resectable Cervical Cancer: A Multicenter Evaluation of Surgical Specimens
Objective To determine whether gross tumor volume (GTV) and the maximum diameter of resectable cervical cancer at magnetic resonance imaging (MRI) could predict lymph node metastasis (LNM) and lymphovascular space invasion (LVSI). Materials and Methods A total of 315 consecutive patients with cervical cancer were retrospectively identified. Gross tumor volume and the maximum diameter of tumor were evaluated on MRI. Univariate and multivariate logistic regression analyses were performed to determine whether tumor size could predict LNM and LVSI. Cutoffs of GTV, maximum diameter, and the International Federation of Gyne...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research

Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma
Objectives The aim of this study was to investigate the distribution of primary cilia on secretory cells in normal fallopian tube (FT) and serous tubal intraepithelial carcinoma (STIC). Methods Fallopian tube tissue samples were obtained from 4 females undergoing prophylactic hysterectomies and 6 patients diagnosed with STIC. A mogp-TAg transgenic mouse STIC sample was also compared with a wild-type mouse FT sample. Serous tubal intraepithelial carcinoma was identified by hematoxylin and eosin staining and confirmed by positive Ki-67 and p53 immunohistochemical staining of tissue sections. We assessed the relative dis...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Basic Science Source Type: research

Other Primary Malignancies Among Women With Adult-Type Ovarian Granulosa Cell Tumors
Conclusions There is an increased risk for thyroid and soft tissue cancer as well as leukemia after AGCT, which may be associated with late effects of carcinogenic treatments and possibly shared risk factors. After breast cancer, the risk for AGCT was higher, which may indicate a shared hormonal etiology. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Predictive Factors for Surgical Morbidities and Adjuvant Chemotherapy Delay for Advanced Ovarian Cancer Patients Treated by Primary Debulking Surgery or Interval Debulking Surgery
Conclusions Comorbidities and intraoperative bleeding are the most relevant findings related to surgical complications. Surgical approach (PDS or IDS) was not related with complications. Surgical complications were significantly related to ACD. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

The BRCA1 Methylation and PD-L1 Expression in Sporadic Ovarian Cancer
Conclusions This is the first study linking BRCA1 hypermethylation variability to PD-L1 protein expression and the clinicopathologic features of OC. The data demonstrated that an epigenetic alteration of BRCA1 was closely associated with serous OC. The expression of PD-L1 was unrelated to the clinicopathologic features or BRCA1 hypermethylation in sporadic OC. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Stereotactic Body Radiation Therapy in Oligometastatic Ovarian Cancer: A Promising Therapeutic Approach
Conclusions In conclusion, SBRT is a feasible and safe approach for selected cases of oligometastatic ovarian cancer, with satisfactory results in terms of LC and disease free survival. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Efficacy of Neoadjuvant Therapy With Cisplatin Plus Mitomycin C in BRCA1-Mutated Ovarian Cancer
Conclusions The combination of cisplatin plus mitomycin C showed promising results in BRCA1-driven OC and therefore deserves further clinical evaluation. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Clinical Outcome After Completion Surgery in Patients With Ovarian Cancer: The Charite Experience
Conclusions Recent research has shown that the most profound impact on survivorship occurs when women get proper care from surgeons trained in the latest techniques for treating ovarian cancer. Completion surgery maintained that even after initial incomplete cytoreduction outside of the high specialized units, after applying appropriate surgery techniques macroscopically, disease-free situation is achievable and outcomes are comparable with the results of primary debulking surgery. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

When Ovarian Cancer Is Not: Characterizing Nonovarian Cancer Pathology in a Laparoscopy-Based Triage System
This study sought to investigate and describe nonovarian cancer pathologies discovered during the systematic laparoscopic workup of presumed advanced ovarian cancer. Methods A retrospective cohort of patients with presumed advanced ovarian cancer (based on elevated CA125 and/or imaging) presenting to our center without confirmed pathologic diagnosis were identified and characterized. Patients without ovarian cancer on final pathology were described and compared with those with confirmed epithelial ovarian cancer using standard statistical methods. Results Nonovarian cancer was found in 26 (7.1%) of 365 cases over 3.5...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Trends and Outcomes of Venous Thromboembolism in Hospitalized Patients With Ovarian Cancer: Results From Nationwide Inpatient Sample Database 2003 to 2011
Objective Venous thromboembolism (VTE) is a major cause of mortality and morbidity in hospitalized patients with malignancy. Nationwide Inpatient Sample database was analyzed to determine the trends in the rate of hospitalization and mortality from VTE in hospitalized ovarian cancer patients and assess its economic impact and resource utilization. Method We queried the 2003 to 2011 Nationwide Inpatient Sample database from Healthcare Cost and Utilization project (Agency of Healthcare Research and Quality) to identify all adults (age ≥18 years) ovarian cancer. Patients hospitalized with VTE as one of the top 3 disch...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

The Diagnostic Accuracy of Human Epididymis Factor 4 for the Prediction of Optimal Debulking in Patients With Ovarian Cancer: A Meta-Analysis of Observational Studies
Conclusions Human epididymis factor-4 seems to be promising as a minimally invasive method to predict optimal cytoreduction among patients with ovarian cancer. However, interpretation of our findings should be approached with caution because of the significant heterogeneity of included studies. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Changes in the Management and Prognosis of Ovarian Cancer Due to the New FIGO and WHO Classifications: A Case Series Observational Descriptive Study. Seven Years of Follow-up
Conclusions The newly created WHO and FIGO classifications have improved the ability to predict the prognosis and consequently to change the therapeutic managements of patients with ovarian cancer. (Source: International Journal of Gynecological Cancer)
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Ovarian Cancer Source Type: research

Complete Resection Is Essential in the Surgical Treatment of Gestational Trophoblastic Neoplasia
Objective The aim of this study was to determine the utility of surgery in patients with gestational trophoblastic neoplasia (GTN). Materials and Methods We performed a retrospective institutional review board–approved analysis of all patients with GTN at a single institution from 1985 to 2015 and compared all patients who underwent surgery as definitive management for their disease to a matched cohort of those who did not. Kaplan-Meier curves were used to estimate progression-free survival (PFS) and overall survival (OS). Results Sixty-nine patients underwent a total of 94 surgeries as definitive treatment f...
Source: International Journal of Gynecological Cancer - October 1, 2018 Category: Cancer & Oncology Tags: Gestational Throphoblastic Neoplasia Source Type: research