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Total 92 results found since Jan 2013.
Drug prevents cognitive impairment in mice after radiation treatment for brain tumors
FINDINGSA study by researchers at theUCLA Jonsson Comprehensive Cancer Center has identified a possible new drug that could help prevent cognitive decline in people who undergo radiation therapy for brain tumors. The researchers found when the drug was given to mice 24 hours after the animals were exposed to a dose of radiation, it completely prevented cognitive decline from occurring, and that it did not reduce the efficacy of the radiation treatment.This experiment represents one of a very few instances in which a drug reduced cognitive decline in animals after radiation treatment.The drug, NSPP, wasidentified in 2019 by...
Source: UCLA Newsroom: Health Sciences - April 15, 2020 Category: Universities & Medical Training Source Type: news
Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3
1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy
3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy
It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research
Recovering vision in corneal epithelial stem cell deficient eyes
A healthy corneal epithelium is essential for vision. Patients often present with conditions that impact negatively on the integrity of the ocular surface and these can include minor abrasions, allergies, keratitis, dry eye, ocular herpes, and pterygium to name just a few. Treatment regimens for these conditions often involve a pharmacological approach. However, when the epithelium is defective owing to limbal stem cell deficiency, treatment is notoriously difficult. Corneal epithelial stem cells are widely believed to reside in the basal epithelium at the limbus [1,2].
Source: Contact Lens and Anterior Eye - April 28, 2019 Category: Opthalmology Authors: Kiranjit K. Bains, Hideki Fukuoka, Chie Sotozono, Andrew J. Quantock Source Type: research
Repeated Changes to the Gravitational Field Negatively Affect the Serum Concentration of Select Growth Factors and Cytokines
This study was carried out in accordance with the recommendations of the ethical committee of the Ruhr-Universität Bochum with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the ethical committee of the Ruhr-Universität Bochum (Register-Number 5158–14).
Author Contributions
US, FS, LG, and AK performed the experiments. US and TR analyzed the data, created the figures, and drafted the manuscript. TW, FS, and NB designed the study. All authors revised the manuscript and approved its fina...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research
The Study of Dried Ginger and Linggan Wuwei Jiangxin Decoction Treatment of Cold Asthma Rats Using GC –MS Based Metabolomics
Conclusion
In this study, serum and urine metabolites identified by GC–MS and general pharmacodynamic evaluation (morphological observation, histopathology, inflammatory factors, and visceral indices) were used to compare the effects of GJ and LGWWJX decoctions on cold asthma. Significant metabolic abnormalities were observed for 37 metabolites (15 in serum, 22 in urine) in rats with cold asthma. These altered metabolites might be potential biomarkers or therapeutic targets during development of cold asthma. Furthermore, pathway analysis demonstrated that pathways associated with energy metabolism and oxidative str...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research
Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice
Conclusion
Altogether, our results indicate that dietary VitD deficiency is able to decrease lesion growth and provide an increase in Th1 response in C57BL/6 and BALB/c mice upon L. (L.) amazonensis infection, although it does not decrease parasite burden in either of the murine models used. Thus, VitD may contribute to host susceptibility to murine tegumentary leishmaniasis. Further studies on the influence of immunonutrition in the leishmaniases are needed to better understand the immunobiology of these diseases.
Author Contributions
HdMG conceived and designed the experiments. GO-S, DB, MM, JEP, JCP, TR, AdF-M, and L...
Source: Frontiers in cellular and infection microbiology - April 9, 2019 Category: Microbiology Source Type: research
Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis
Conclusion
Via a HPLC system and a BATMAN-TCM platform, for the first time we performed detailed HPLC fingerprint analysis and network pharmacology studies of QP ointment. By in-depth animal and molecular analysis, we identified a number of chronic dermatitis-associated Th1/2 cytokines, itch mediators, and cellular signaling pathways in the skin, DRG and serum for QP to treat the inflammation and chronic itch associated with ACD. Our data clearly suggested, upon stimulation, cytokines and itch-related mediators are released from the skin and neuronal tissues, and QP could effectively work on both the skin and sensory neur...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research
Food allergies linked to increased disease activity in MS
Allergic patients had more relapses and more likely to show further nerve damage on scans Related items fromOnMedica NICE reverses NHS ban on three MS drugs after price cut Multiple sclerosis disease insight report Multiple sclerosis Stem cell treatment hopes for MS One in two women and one in three men will develop neurological disease
Source: OnMedica Latest News - December 19, 2018 Category: UK Health Source Type: news
Hematopoietic stem cell transplantation as treatment for patients with DOCK8 deficiency
ConclusionHSCT is curative in most DOCK8 deficient patients, confirming this approach as the treatment of choice. HSCT using a reduced toxicity regimen may offer the best chance for survival.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research
Resolution of milk-protein allergy after hematopoietic stem cell transplant in a patient with ipex syndrome
We present a patient with IPEX syndrome whose milk protein allergy resolved after receiving a stem cell transplant for his primary immunodeficiency.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: J. Brooks, A. Helgeson, F. Lobo Tags: M310 Source Type: research
Treatment of MCPT8DTR mice with high- or low-dose diphtheria toxin leads to differential depletion of basophils and granulocyte-macrophage progenitors.
This article is protected by copyright. All rights reserved.
PMID: 29315532 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - January 8, 2018 Category: Allergy & Immunology Authors: Hachem CE, Hener P, Kirstetter P, Li J, Chan S, Li M Tags: Eur J Immunol Source Type: research
Ocular Complaint Leads to an Unusual Diagnosis
BY GURDEEP SINGH NAGI, MD; BHAVINI TAILOR, MD; & AHMED RAZIUDDIN, MDA 40-year-old man with no significant past medical history presented to the emergency department with visual problems. He said he had noticed about four days earlier a dark red circle over any object on which he tried to focus. The condition had been constant and had not improved or worsened over the past few days. He also said it did not matter whether he was focusing on an object that was near or far.The patient had seen an optometrist who recommended he have blood work done, but did not specify what exactly to ...
Source: The Case Files - December 28, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Re-educating immunity in respiratory allergies: the potential for hematopoietic stem cell-mediated gene therapy
AbstractRespiratory allergies represent a significant disease burden worldwide affecting up to 300 million people globally. Medication and avoidance of known triggers do not address the underlying pathology. Traditional immunotherapies for allergy aim to reinstate immune homeostasis but require years of treatment and have poor long-term efficacy. Novel approaches, such as gene-engineered hematopoietic stem cell transplantation, induce profound antigen-specific tolerance in autoimmunity. Recent evidence shows this approach may also have therapeutic utility for allergy. Here, we review the mechanisms of antigen-specific tole...
Source: Journal of Molecular Medicine - November 17, 2017 Category: Molecular Biology Source Type: research
The transcription factor C/EBP γ regulates mast cell development and function
Mast cells represent an important part of the immune system. They play a key role in multiple pathologies including allergies and autoimmune disorders, and consequently, it is critical to fully understand the molecular mechanisms that control their generation and activity. Development of hematopoietic stem cell through progenitor stages towards functionally mature mast cell is orchestrated by networks of interacting transcription factors. Expression of several transcription factors, such as GATA1, GATA2, STAT5, and MITF, and downregulation of C/EBP α are already known to be important determinants of mast cell identity.
Source: Experimental Hematology - August 22, 2017 Category: Hematology Authors: Miroslava Kardosova, Lucie Potuckova, Ivana Halova, Polina Zjablovskaja, Lubica Draberova, Petr Draber, Daniel Tenen, Meritxell Alberich-Jorda Source Type: research
Hematopoietic stem cell transplantation from unrelated donors in children with DOCK8 deficiency
Abstract
DIDS is a unique form of combined immune deficiency characterized by an unusual susceptibility to cutaneous viral infections, severe allergies with eosinophilia and elevated immunoglobulin E titers, autoimmunity, and cancer. HSCT is considered the standard of care for this deadly disease. We have retrospectively analyzed the outcome of allogeneic HSCT from unrelated donors in patients with DIDS. Data from four patients, with five transplants, are presented. All patients received transplants from unrelated donors' BM, except for one patient who received a cord blood transplant. The conditioning regimens were based ...
Source: Pediatric Transplantation - June 1, 2017 Category: Transplant Surgery Authors: Dilara Fatma K. Uygun, Vedat Uygun, İsmail Reisli, Sevgi Keleş, Ahmet Özen, Mustafa Yılmaz, Esra H. Sayar, Hayriye Daloğlu, Seda I. Öztürkmen, Suar Çakı, Gülsün T. Karasu, Akif Yeşilipek Tags: ORIGINAL ARTICLE Source Type: research
