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Therapy: Stem Cell Therapy
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Total 92 results found since Jan 2013.
Doctors have long considered the thymus expendable. But could removing it be fatal?
The thymus, a butterfly-shaped organ that sits between our collarbones, has never seemed like a particularly useful appendage—at least in adults. During early childhood, it provides a place for T cells (the T stands for thymus) to mature into immune cells that attack invaders. But during adolescence the organ begins to shrink and mostly stops producing these cells. By adulthood, it’s assumed to be so useless that cardiac surgeons will occasionally remove it just to get easier access to the heart.
But researchers have recently started to question that assumption, and a study published today in
The New England Jo...
Source: ScienceNOW - August 2, 2023 Category: Science Source Type: news
Genetic predisposition to ocular surface disorders and opportunities for gene-based therapies
Ocul Surf. 2023 May 14:S1542-0124(23)00045-9. doi: 10.1016/j.jtos.2023.05.003. Online ahead of print.ABSTRACTThe ocular surface, comprised of the corneal and conjunctival epithelium, innervation system, immune components, and tear-film apparatus, plays a key role in ocular integrity as well as comfort and vision. Gene defects may result in congenital ocular or systemic disorders with prominent ocular surface involvement. Examples include epithelial corneal dystrophies, aniridia, ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome, xeroderma pigmentosum (XP), and hereditary sensory and autonomic neuropathy. In additio...
Source: The Ocular Surface - May 16, 2023 Category: Opthalmology Authors: Danial Roshandel Farbod Semnani Amirmasoud Rayati Damavandi Ali Masoudi Alireza Baradaran-Rafii Stephanie L Watson William H Morgan Samuel McLenachan Source Type: research
Deciphering the role of DOCK8 in tumorigenesis by regulating immunity and the application of nanotechnology in DOCK8 deficiency therapy
The dedicator of cytokinesis 8 (DOCK8) immunodeficiency syndrome is a severe immune disorder and characterized by serum IgE levels elevation, fungal and viral infections, dermatitis and food allergies. It was well known that DOCK8 is crucial for the survival and function of multiple immune related cells. However, the critical role of DOCK8 on tumorigenesis through regulating immunity is poorly investigated. Accumulating evidences indicated that DOCK8 could affect tumorigenesis by regulating the immunity through immune cells, including NK cells, T cells, B cells and dendritic cells. Here, we summarized and discussed the cri...
Source: Frontiers in Pharmacology - November 1, 2022 Category: Drugs & Pharmacology Source Type: research
Eczema herpeticum < em > vs < /em > dermatitis herpetiformis as a clue of dedicator of cytokinesis 8 deficiency diagnosis: A case report
CONCLUSION: Targeted gene testing with CNV analysis might detect deletions that can be missed by WES for diagnosing patients with PID.PMID:36312485 | PMC:PMC9602220 | DOI:10.12998/wjcc.v10.i29.10735
Source: Herpes - October 31, 2022 Category: Infectious Diseases Authors: Amer Alshengeti Source Type: research
Hematopoietic Stem Cell Transplantation in ARPC1B Deficiency
We report the first case series of 7 children with a homozygous mutation in ARPC1B gene who underwent allogeneic-HSCT (allo-HSCT). All patients presented an early clinical onset, characterized by recurrent infections, failure to thrive and gastrointestinal bleeding episodes complicated with neonatal hemorrhagic enteritis in 3 cases, and macrophage activating syndrome in 2. Allo-HSCT was performed at the median age of 1.83 years after a myeloablative conditioning regimen in all cases. Engraftment occurred in all patients with full donor chimerism in 6 out of 7. The clinical course after engraftment was uneventful in 3 out...
Source: Journal of Clinical Immunology - June 29, 2022 Category: Allergy & Immunology Source Type: research
A Pilot Study on Clinical Scores, Immune Cell Modulation, and Microbiota Composition in Allergic Patients with Rhinitis and Asthma Treated with a Probiotic Preparation
Conclusion: Present study suggests that iPROB ® preparation has clinical/biological properties to be a valid add-on supplementation in allergic patients with asthma and rhinitis.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - October 21, 2021 Category: Allergy & Immunology Source Type: research
Hyper-IgE Syndrome due to an Elusive Novel Intronic Homozygous Variant in DOCK8
AbstractRare, biallelic loss-of-function mutations inDOCK8 result in a combined immune deficiency characterized by severe and recurrent cutaneous infections, eczema, allergies, and susceptibility to malignancy, as well as impaired humoral and cellular immunity and hyper-IgE. The advent of next-generation sequencing technologies has enabled the rapid molecular diagnosis of rare monogenic diseases, including inborn errors of immunity. These advances have resulted in the implementation of gene-guided treatments, such as hematopoietic stem cell transplant for DOCK8 deficiency. However, putative disease-causing variants reveale...
Source: Journal of Clinical Immunology - October 17, 2021 Category: Allergy & Immunology Source Type: research
Mesenchymal stem/stromal cell therapy in atopic dermatitis and chronic urticaria: immunological and clinical viewpoints
Stem Cell Res Ther. 2021 Oct 11;12(1):539. doi: 10.1186/s13287-021-02583-4.ABSTRACTAllergic diseases are immune-mediated diseases. Allergies share a common immunopathogenesis, with specific differences according to the specific disease. Mesenchymal stem/stromal cells (MSCs) have been applied to people suffering from allergic and many other diseases. In this review, the immunologic roles of MSCs are systemically reviewed according to disease immunopathogenesis from a clinical viewpoint. MSCs seem to be a promising therapeutic modality not only as symptomatic treatments but also as causative and even preventive treatments fo...
Source: Cell Research - October 12, 2021 Category: Cytology Authors: Eun-Young Kim Hyuk Soon Kim Ki-Sung Hong Hyung-Min Chung Se-Pill Park Geunwoong Noh Source Type: research
Lineage-Specific Chimerism and Outcome After Hematopoietic Stem Cell Transplantation for DOCK8 Deficiency
We report on nine patients, four of whom with mixed chimerism, with a median follow-up of 78 months after transplantation. Overall, we report successful transplantation with improvement of susceptibility to infections and allergies, and resolution of eczema in all patients. Immunological outcome in patients with mixed chimerism suggests a selective advantage for wild-type donor T-cells bu t lower donor B-cell chimerism possibly results in a tendency to hypogammaglobulinemia. No increased infectious and allergic complications were associated with mixed chimerism. Aware of the relatively small cohort size, we could not dem...
Source: Journal of Clinical Immunology - June 2, 2021 Category: Allergy & Immunology Source Type: research
Penicillin Allergy Testing: An Outpatient Nurse-Driven Program for Patients With Cancer
This article describes the development and implementation of an oncology outpatient nurse-driven PAT program.METHODS: A nurse-driven program, initiated with allergy screening at the first encounter, was designed to identify patients with oncologic diagnoses eligible for PAT. Once verified eligible, patients undergo a three-step testing process (scratch test, intradermal injection, and IV challenge dose) administered by the infusion nurse.FINDINGS: From November 2018 to December 2019, 82 outpatients with reported penicillin allergies were screened; 90% were eligible for PAT, and 97% of patients tested were negative for peni...
Source: Clinical Journal of Oncology Nursing - March 19, 2021 Category: Nursing Authors: Sejal Morjaria Faye Inumerables Dhruvkumar Patel Nina Cohen Susan Seo Susan Posthumus Steven C Martin Anna Kaltsas Shawna Lee Nicole Boucher Erica Fischer-Cartlidge Source Type: research
