Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis

In this study we used HPLC and LC/MS analysis, combined with a BATMAN-TCM platform, for detailed HPLC fingerprint analysis and network pharmacology of QP, and investigated the anti-inflammatory and antipruritic activities of QP on ACD induced by squaric acid dibutylester (SADBE) in mice. The BATMAN-TCM analysis provided information of effector molecules of the main ingredients of QP, and possible chronic dermatitis-associated molecules and cell signaling pathways by QP. In ACD mice, QP treatment suppressed the scratching behavior induced by SADBE in a dose-dependent manner and inhibited the production of Th1/2 cytokines in serum and spleen. Also, QP treatment reversed the upregulation of mRNAs levels of itch-related genes in the skin (TRPV4, TSLP, GRP, and MrgprA3) and DRGs (TRPV1, TRPA1, GRP, and MrgprA3). Furthermore, QP suppressed the phosphorylation of Erk and p38 in the skin. In all, our work indicated that QP can significantly attenuate the pathological alterations of Th1/2 cytokines and itch-related mediators, and inhibit the phosphorylation of MAPKs to treat the chronic itch. Introduction Chronic itch has been long known not only as a concomitant manifestation of various skin diseases, such as contact dermatitis, eczema, atopic dermatitis, psoriasis, etc., but also occurs in systemic, neurological, or psychiatric diseases. So far, medications for chronic itch still can be simply categorized into topical (emollients and moisturizers, anesthetics, coolants, gluc...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 24 August 2019Source: Seminars in Cancer BiologyAuthor(s): Crescenzo D’Alterio, Stefania Scala, Gabriella Sozzi, Luca Roz, Giulia BertoliniAbstractSeveral lines of compelling pre-clinical evidence identify chemotherapy as a potentially double-edged sword: therapeutic efficacy on the primary tumor may in fact be counterbalanced by the induction of tumor/host reactive responses supportive for survival and dissemination of cancer cell subpopulations. This paradoxical effect of chemotherapy can affect different districts such as the primary tumor, the circulation and distant organs by s...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
In conclusion, although human studies are needed, NPs obtained from food-derived flavonoids have promising anticancer effects in vivo.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: October 2019Source: Molecular Immunology, Volume 114Author(s): Jun Chen, Shengjun Lu, Xiufang Weng, Zhihui Liang, Xiongwen WuAbstractHLA-A2 is the most common serological HLA type among all ethnic groups. Through advances in DNA typing, more than 800 subtypes of HLA-A2 have been identified, and the existence of heterogeneity of antigen specificity among the HLA-A2 subtypes has been suggested by retrospective analyses of allogeneic transplantation patients and by studies of antigen amino acid structure. However, prior to this study, the antigenicity of a given subtype or the mismatch extent between two giv...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Authors: Druschky K, Bleich S, Grohmann R, Engel RR, Toto S, Neyazi A, Däubl B, Stübner S Abstract The aim of the study was to assess rates of severe parkinsonism related to different antipsychotic drugs (APDs) using data from an observational pharmacovigilance programme in German-speaking countries-Arzneimittelsicherheit in der Psychiatrie (AMSP). Data on APD utilization and reports of severe APD-induced parkinsonism were collected in 99 psychiatric hospitals in Austria, Germany and Switzerland during the period 2001-2016. Of 340,099 patients under surveillance, 245,958 patients were treated with APDs fo...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Publication date: Available online 24 August 2019Source: Materials Today: ProceedingsAuthor(s): S. Venugopal Rao, M. Venkata Ramana, A.C.S. KumarAbstractCompact Graphite Iron (CGI) is used at various applications at elevated temperatures. This material is recently using in automobile braking system and engine cylinders. In the present study, sliding wear test on Pin-on disc tribometer was conducted on CGI. The wear behavior was studied at room temperature (32 °C) and 200 °C test against rotating hardened steel metal disc as counter face. The influence of the temperatures on abrasive wear behavior of CGI was rep...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
The objective of this study is to improve the corrosion resistance of nickel bipolar plate by means of conductive polymer coating. Typically, polypyrrole film has been electrodeposited using chronopotentiometric technique at different current densities in aqueous sodium saccharin medium. The electrochemical behaviour of nickel in the presence of sodium saccharinate solution in the absence and the presence of the pyrrole monomer were investigated using cyclic voltammetry. Characterization of the polypyrrole coating was carried out using x-ray photoelectrons (XPS) and scanning electron microscopy (SEM). Corrosion behavior of...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
In this study, indium concentration dependence on Volatile Organic Compounds (VOCs) interaction were examined in InGaN-GaN multi quantum well structures (MQWs) grown on sapphire substrate at different quantum well (InGaN) growth temperatures. The periodicity, structural properties and indium dependent dislocation density was deduced from high resolution X-ray diffraction pattern. The variation of energy bandgap of InGaN quantum well clearly depicts that the bandgap decreases with increase in indium concentration in InGaN well layer. The interaction properties of the device with various VOCs such as ethanol, benzene, n-hexa...
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Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
This study obtained alloys with higher tungsten composition, up to 69.59%, in comparison to papers with similar results of faradaic efficiency (10–15%). Using 0.1 mo/L iron sulfate concentration, the decrease of the temperature and the current density increases the tungsten composition, making the FeW alloys more anticorrosive.
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
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