Unravelling pituitary tumours in medically treated patients with acromegaly: the impact of systematic MRI reassessment
CONCLUSION: In most patients with pharmacologically treated acromegaly, we identified a certain or suspected pituitary tumor. These findings were more frequent compared to the routine MRI reports. Based on our results, patients will be considered for a change in long-term treatment modality.PMID:38659302 | DOI:10.1177/02841851241246107 (Source: Acta Radiologica)
Source: Acta Radiologica - April 25, 2024 Category: Radiology Authors: Shahriar Atai Martin Knudtzon Andersen Markus Wiedmann Daniel Dahlberg Kristin Astrid B Øystese Jens Bollerslev Geir Ringstad Ansgar Heck Source Type: research
Quality of life in Prolactinoma: A systematic review
ConclusionPoor quality of life in prolactinoma is multifactorial, related to biochemical control, side effects of therapy, and sellar mass effect. Targeting persistent symptoms, reducing healthcare costs, and reducing side-effects of therapy are avenues to improving QOL in patients with prolactinoma. (Source: Pituitary)
Source: Pituitary - April 24, 2024 Category: Endocrinology Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Cancer Control)
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Investigational drugs for the Treatment of Acromegaly: new agents to transform therapy
Expert Opin Investig Drugs. 2024 Apr 23. doi: 10.1080/13543784.2024.2343056. Online ahead of print.ABSTRACTINTRODUCTION: Disease control is essential to decrease morbidity burden and mortality in acromegaly patients. In the last decades, the availability of new drugs increased the rate of disease control. However, up to 55% of patients remain uncontrolled despite available treatment strategies in real-world data. The reasons for this finding may include poor adherence, inadequate tolerability, therapeutic inertia, and high costs. Since acromegaly is a chronic disease and medical therapy is usually life-long, patient's adhe...
Source: Expert Opinion on Investigational Drugs - April 23, 2024 Category: Drugs & Pharmacology Authors: Rosa Pirchio Renata S Auriemma Alice Vergura Rosario Pivonello Annamaria Colao Source Type: research
Increased mortality in acromegaly is due to vascular and respiratory disease and is normalised by control of GH levels-A retrospective analysis from the UK Acromegaly Register 1970-2016
CONCLUSION: Acromegaly is associated with increased incidence of all cancers but not thyroid or colon cancer and no increase in cancer mortality. Excess mortality is due to vascular and respiratory disease. The risk is highest in the first 5 years following diagnosis and is mitigated by normalising GH levels.PMID:38652736 | DOI:10.1111/cen.15060 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Steve Orme Richard McNally Peter W James Jessica Davis John Ayuk Claire Higham John Wass UK Acromegaly Register Study Group Source Type: research
Pregnancy and acromegaly: clinical outcomes of retrospectively analysed data from the German acromegaly registry
CONCLUSION: Pregnancies in women with acromegaly are possible and the course of pregnancy is in general safe for mother and child both with and without specific treatment for acromegaly. The prevalence of concomitant metabolic diseases such as gestational diabetes is comparable to the prevalence in healthy pregnant women. Nevertheless, larger studies with more data in pregnant patients with acromegaly are needed to provide safe and effective care for pregnant women with this condition.PMID:38650041 | PMC:PMC11034139 | DOI:10.1186/s12958-024-01207-9 (Source: Reproductive Biology)
Source: Reproductive Biology - April 22, 2024 Category: Reproduction Medicine Authors: Anke T önjes Marleen W ürfel Marcus Quinkler Ulrich J Knappe J ürgen Honegger Nina Krause-Joppig Konrad Bacher Timo Deutschbein Sylv ère Störmann Jochen Schopohl Sebastian M Meyh öfer participants of the German Acromegaly Registry Source Type: research
Clinicopathological Correlates of PIT1 and SF1-Multilineage Pituitary Neuroendocrine Tumors and the Diagnostic Utility of NKX2.2 Immunohistochemistry in Pituitary Pathology
CONCLUSIONS.—: In conclusion, NKX2.2 is a transcription factor that can be used as an additional tool in pituitary pathology, and PIT1 and SF1-multilineage PitNETs are specific tumors that usually present with acromegaly, show signs of a nonaggressive clinical course, have a pseudopapillary histomorphology, and express NKX2.2.PMID:38649148 | DOI:10.5858/arpa.2023-0543-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 22, 2024 Category: Laboratory Medicine Authors: Fatih Mert Do ğukan H üseyin Karatay Sabahattin Y üzkan Şebnem Burhan Buru ç Erkan Banu Y ılmaz-Özgüven Source Type: research
Pregnancy and acromegaly: clinical outcomes of retrospectively analysed data from the German acromegaly registry
Acromegaly is a rare disease caused by excessive growth hormone (GH) secretion, mostly induced by pituitary adenomas. The care of pregnant women with acromegaly is challenging, in part due to existing clinical... (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - April 22, 2024 Category: Endocrinology Authors: Anke T önjes, Marleen Würfel, Marcus Quinkler, Ulrich J. Knappe, Jürgen Honegger, Nina Krause-Joppig, Konrad Bacher, Timo Deutschbein, Sylvère Störmann, Jochen Schopohl and Sebastian M. Meyhöfer Tags: Research Source Type: research
Evaluation of the relation between subclinical systolic dysfunction defined by four-dimensional speckle-tracking echocardiography and growth differentiation factor-15 levels in patients with acromegaly
CONCLUSION: Our study demonstrates that while LVEF was within normal limits, global strain parameters (GLS, GCS, GAS, and GRS) measured by using a novel imaging technique, 4DSTE, were lower in patients with acromegaly, suggesting the presence of subclinical systolic dysfunction in patients with acromegaly. GDF-15 can be a potential predictor of cardiovascular risk in patients with acromegaly.PMID:38632216 | DOI:10.1007/s42000-024-00558-7 (Source: Hormones)
Source: Hormones - April 17, 2024 Category: Endocrinology Authors: Busra Firlatan Ugur Nadir Karakulak Vedat Hekimsoy Burcin Gonul Iremli Incilay Lay Deniz Yuce Selcuk Dagdelen Giray Kabakci Tomris Erbas Source Type: research
The spectrum of growth hormone excess in Carney complex and genotype-phenotype correlations
CONCLUSION: Dysregulation of GH secretion is a common finding in CNC. The clinical spectrum of this disorder and its association with genetic and imaging characteristics of the patient make prompt diagnosis and management more successful.PMID:38626285 | DOI:10.1210/clinem/dgae253 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Christina Tatsi Georgia Pitsava Fabio R Faucz Meg Keil Constantine A Stratakis Source Type: research
The spectrum of growth hormone excess in Carney complex and genotype-phenotype correlations
CONCLUSION: Dysregulation of GH secretion is a common finding in CNC. The clinical spectrum of this disorder and its association with genetic and imaging characteristics of the patient make prompt diagnosis and management more successful.PMID:38626285 | DOI:10.1210/clinem/dgae253 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Christina Tatsi Georgia Pitsava Fabio R Faucz Meg Keil Constantine A Stratakis Source Type: research
The effect of coping strategies on health –related quality of life in acromegaly patients
ConclusionOur results show that maladaptive coping styles have a substantial negative impact on psychological HRQoL in patients with acromegaly, whereas physical HRQoL is influenced to a lesser extent. Specialized training programs aimed at improving coping strategies could reduce long-term disease burden and increase HRQoL in the affected patients. (Source: Endocrine)
Source: Endocrine - April 13, 2024 Category: Endocrinology Source Type: research
