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Clinical Importance of Somatostatin Receptor 2 (SSTR2) and Somatostatin Receptor 5 (SSTR5) Expression in Thyrotropin-Producing Pituitary Adenoma (TSHoma).
CONCLUSIONS The present data confirm that somatostatin analogs should be considered as a medical alternative to surgical treatment, especially in patients with TSHoma, and short-term response to OCT therapy may be related to the expression of SSTR5. PMID: 28434012 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - April 25, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Suffocation due to Thoracic Deformity Caused by Acromegaly.
Authors: Yoshizawa T, Iwazaki M, Jitsuiki K, Ishikawa K, Ohsaka H, Yanagawa Y Abstract A 61-year-old man with gigantism and acromegaly choked and fell into a coma. Immediate tracheal intubation resulted in a return of his consciousness. Enhanced computed tomography indicated that the trachea and left main bronchus were compressed by the thoracic spine and sternum. He required tracheotomy and positive end-expiratory pressure to maintain his pulmonary function. This is the first case of suffocation due to a thoracic deformity associated with acromegaly. Physicians should focus on clearing the tracheal airway using co...
Source: Internal Medicine - April 22, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Efficacy and optimal timing of tongue reduction surgery in three patients with Beckwith –Wiedemann syndrome
We report three cases with BWS who were considered efficacy and optimal timing of tongue reduction surgery and had positive outcome. It is concluded that the capable timing for tongue surgery to mitigate macroglossia should be between 2 to 3 years of age. (Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology)
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - April 21, 2017 Category: ENT & OMF Source Type: research

Role of Phosphodiesterases on the Function of Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Pituitary Gland and on the Evaluation of AIP Gene Variants
Horm Metab Res 2017; 49: 286-295 DOI: 10.1055/s-0043-104700Familial isolated pituitary adenoma (FIPA) is caused in about 20% of cases by loss-of-function germline mutations in the AIP gene. Patients harboring AIP mutations usually present with somatotropinomas resulting either in gigantism or young-onset acromegaly. AIP encodes for a co-chaperone protein endowed with tumor suppressor properties in somatotroph cells. Among other mechanisms proposed to explain this function, a regulatory effect over the 3′,5′-cyclic adenosine monophosphate (cAMP) signaling pathway seems to play a prominent role. In this setting, the well...
Source: Hormone and Metabolic Research - April 20, 2017 Category: Endocrinology Authors: Hern ández-Ramírez, Laura C. Trivellin, Giampaolo Stratakis, Constantine A. Tags: Review Source Type: research

Endocrine Comorbidities in Patients with Psoriatic Arthritis: A Population-based Case-controlled Study.
CONCLUSION: PsA is associated with a high frequency of hypothyroidism, osteoporosis, DM, and Cushing disease. Awareness of these comorbidities may help physicians provide the optimal medical care to patients with PsA. PMID: 28412706 [PubMed - as supplied by publisher] (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 17, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

High-dose and high-frequency lanreotide autogel in acromegaly: a randomized, multicenter study.
Conclusion: HF- and HD- LAN-ATG regimens are effective in normalizing IGF-I values in about one-third of patients with active acromegaly inadequately controlled by long-term conventional SRL therapy. PMID: 28419317 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 17, 2017 Category: Endocrinology Authors: Giustina A, Mazziotti G, Cannavò S, Castello R, Arnaldi G, Bugari G, Cozzi R, Ferone D, Formenti AM, Gatti E, Grottoli S, Maffei P, Maffezzoni F, Montini M, Terzolo M, Ghigo E Tags: J Clin Endocrinol Metab Source Type: research

A case of neuronal gigantism and cortical thickening: A rare complication of therapeutic radiation (P6.187)
Conclusions:Our case presented only 2 years after radiotherapy suggesting this toxicity can be an earlier complication that clinicians should be aware of.Disclosure: Dr. Shaikh has nothing to disclose. Dr. kumthekar has nothing to disclose. Dr. Raizer has received personal compensation for activities with Genentech/Roche, Abbvie, Stemline, Foundation Medicine, Novocure, Proximagene, Bristol-Meyers Squibb, and Aurasense as a speaker and advisory board member. Dr. Raizer has received research support from Genentech, Plexxikon, Novartis, Ziopharm, and Celldex. Dr. dixit has nothing to disclose. (Source: Neurology)
Source: Neurology - April 17, 2017 Category: Neurology Authors: Shaikh, N., Kumthekar, P., Raizer, J., Dixit, K. S. Tags: Neurologic Complications of Cancer Source Type: research

Mixed Gangliocytoma-Pituitary Adenoma: Insights on the Pathogenesis of a Rare Sellar Tumor
Gangliocytomas originating in the sellar region are rare; most are tumors composed of gangliocytic and pituitary adenomatous elements, forming the so-called mixed gangliocytoma-pituitary adenoma. The majority of mixed gangliocytoma adenomas are associated with endocrinopathies, mainly acromegaly and less often Cushing disease and hyperprolactinemia. In the present study, 10 cases of mixed gangliocytoma and somatotroph adenomas were evaluated for patterns of cellular differentiation and expression of lineage-specific transcription factors. The tumors were characterized by immunohistochemistry for pituitary hormones, cytoker...
Source: The American Journal of Surgical Pathology - April 15, 2017 Category: Pathology Tags: Original Articles Source Type: research

Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues.
In conclusion, the protein expression of SSTR2, but not of SSTR5, is a valuable indicator in predicting biochemical and tumor size response to short-term SSA treatment in acromegalic patients. PMID: 28396686 [PubMed - in process] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - April 12, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Calcium and bone turnover markers in acromegaly: a prospective controlled study.
Conclusion: Acromegaly patients exhibited PTH-independent calcium-phosphate alterations and enhanced coupled bone formation and resorption. Within 6 months of treatment, bone resorption decreased, while RANK-L/osteoprotegerin changes were inconsistent. PMID: 28407138 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 12, 2017 Category: Endocrinology Authors: Constantin T, Tangpricha V, Shah R, Oyesiku NM, Ioachimescu OC, Ritchie J, Ioachimescu AG Tags: J Clin Endocrinol Metab Source Type: research

The acylated/unacylated ghrelin ratio is similar in acromegaly patients during different treatment regimens.
Conclusions: Although plasma AG and UAG are suppressed during combination treatment of LA-SSA and PEGV, the AG/UAG ratio remained similar. This shows that somatostatin analogues decrease both AG and UAG, which suggest that they do not alter metabolism significantly in acromegaly patients. PMID: 28402548 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 11, 2017 Category: Endocrinology Authors: Muhammad A, Delhanty PJ, Huisman M, Visser JA, van der Lelij AJ, Neggers SJ Tags: J Clin Endocrinol Metab Source Type: research

Marked alteration of glycemic profile surrounding lanreotide administration in acromegaly: a case report
This article is protected by copyright. All rights reserved. (Source: Journal of Diabetes Investigation)
Source: Journal of Diabetes Investigation - April 8, 2017 Category: Endocrinology Authors: Sho Tanaka, Akira Haketa, Shun Yamamuro, Toshiko Suzuki, Hiroki Kobayashi, Yoshinari Hatanaka, Takahiro Ueno, Noboru Fukuda, Masanori Abe, Atsuo Yoshino, Masayoshi Soma Tags: Case Report Source Type: research

Treatment adherence and persistence with long-acting somatostatin analog therapy for the treatment of acromegaly: a retrospective analysis.
CONCLUSIONS: Treatment adherence was similarly good for both injectable SSA treatments studied, at 87% or greater. Persistence was greater with lanreotide than octreotide and the risk of discontinuing therapy was lower with lanreotide than octreotide. Further studies to determine factors leading to these differences in persistence or to predict discontinuation of therapy may aid in clinical management of these patients. PMID: 28372573 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - April 6, 2017 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Treatment adherence and persistence with long-acting somatostatin analog therapy for the treatment of acromegaly: a retrospective analysis
Many patients with acromegaly require medical treatment that includes somatostatin analogs (SSAs). Long-acting SSA formulations are widely used, due in part to increased patient convenience and increased treat... (Source: BMC Clinical Pharmacology)
Source: BMC Clinical Pharmacology - April 4, 2017 Category: Drugs & Pharmacology Authors: Michelle H. Gurel, Yi Han, Andrea L. Stevens, Aaron Furtado and David Cox Source Type: research

Clinical Images: Widening of joint spaces in acromegaly
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - April 4, 2017 Category: Rheumatology Authors: Masei Suda, Yasuhiro Suyama, Masato Okada Tags: Clinical Image Source Type: research

Vitamin D across growth hormone (GH) disorders: From GH deficiency to GH excess.
Abstract The interplay between vitamin D and the growth hormone (GH)/insulin-like growth factor (IGF)-I system is very complex and to date it is not fully understood. GH directly regulates renal 1 alpha-hydroxylase activity, although the action of GH in modulating vitamin D metabolism may also be IGF-I mediated. On the other hand, vitamin D increases circulating IGF-I and the vitamin D deficiency should be normalized before measurement of IGF-I concentrations to obtain reliable and unbiased IGF-I values. Indeed, linear growth after treatment of nutritional vitamin D deficiency seems to be mediated through activati...
Source: Growth Hormone and IGF Research - April 1, 2017 Category: Endocrinology Authors: Ciresi A, Giordano C Tags: Growth Horm IGF Res Source Type: research

Utility of baseline serum phosphorus levels for predicting remission in acromegaly patients
ConclusionHigh serum P levels may be an indicator for a low likelihood of onset of remission in acromegaly patients. Further studies with wider spectrum are needed to make specific suggestions. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - March 29, 2017 Category: Endocrinology Source Type: research

Growth hormone deficiency in treated acromegaly and active Cushing's syndrome
Publication date: Available online 9 March 2017 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Anna Maria Formenti, Filippo Maffezzoni, Mauro Doga, Gherardo Mazziotti, Andrea Giustina Growth hormone deficiency (GHD) in adults is characterized by reduced quality of life and physical fitness, skeletal fragility, increased weight and cardiovascular risk. It may be found in (over-) treated acromegaly as well as in active Cushing's syndrome. Hypopituitarism may develop in patients after definitive treatment of acromegaly, although the exact prevalence of GHD in this population is...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - March 27, 2017 Category: Endocrinology Source Type: research

Body mass index and insulin-like growth factor 1 as risk factors for discordant growth hormone and insulin-like growth factor 1  levels following pituitary surgery in acromegaly
Conclusion Body mass index and percentage of upper limit of normal range IGF-1 before TSA might constitute prognostic risk factors for discordance in IGF-1 and GH levels in acromegaly. Additional attention should be devoted to potential risk factors for this phenomenon, and methods for modifying the cure and control criteria for acromegaly should be developed. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - March 22, 2017 Category: Journals (General) Source Type: research

Matrix metalloproteinase 2 (MMP-2) levels are increased in active acromegaly patients
ConclusionsIn this study, serum matrix metalloproteinase-2 level is increased in the active acromegaly patients and a threshold value in determining active disease was defined for serum matrix metalloproteinase-2 level. This study is the first to compare acromegaly patients having active or controlled disease in terms of matrix metalloproteinase-2 and matrix metalloproteinase-9 levels. The results need to be confirmed by a study that will be conducted in a larger patient group also including a healthy control group to demonstrate the value of this novel marker in disease activity. (Source: Endocrine)
Source: Endocrine - March 22, 2017 Category: Endocrinology Source Type: research

Body mass index and insulin-like growth factor 1 as risk factors for discordant growth hormone and insulin-like growth factor 1  levels following pituitary surgery in acromegaly.
CONCLUSION: Body mass index and percentage of upper limit of normal range IGF-1 before TSA might constitute prognostic risk factors for discordance in IGF-1 and GH levels in acromegaly. Additional attention should be devoted to potential risk factors for this phenomenon, and methods for modifying the cure and control criteria for acromegaly should be developed. PMID: 28341329 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - March 21, 2017 Category: Journals (General) Authors: Zhang S, Li Y, Guo X, Gao L, Lian W, Yao Y, Feng M, Bao X, Wang R, Xing B Tags: J Formos Med Assoc Source Type: research

Efficacy of transsphenoidal surgery in achieving biochemical cure of growth hormone-secreting pituitary adenomas among patients with cavernous sinus invasion: a systematic review and meta-analysis.
DISCUSSION: The prevalence of biochemical remission in patients with cavernous sinus invasion was lower than in patients without cavernous sinus invasion after TSS for acromegaly. PMID: 28301972 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - March 20, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Impaired quality of life in patients with treated acromegaly despite long ‐term biochemically stable disease: results from a 5‐year prospective study
ConclusionsPatients with biochemically controlled acromegaly demonstrate impaired QoL, which persists despite long‐term disease control. This primarily consists of impaired physical function and secondly of impaired psycho‐social well‐being. Duration of biochemical disease control and current use of GH lowering therapy were the predominant factors determining patients’ QoL.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - March 19, 2017 Category: Endocrinology Authors: Nikolaos Kyriakakis, Julie Lynch, Stephen G Gilbey, Susan M Webb, Robert D Murray Tags: Original Article Source Type: research

Persistent reduction of circulating myeloid calcifying cells in acromegaly. Relevance to the bone-vascular axis.
Conclusions: In patients with acromegaly, the levels of MCCs are reduced and remain low even years after complete cure. This finding may be related to low atherosclerotic calcification and persistence of bone pathology after acromegaly remission or cure. PMID: 28323966 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 17, 2017 Category: Endocrinology Authors: Fadini GP, Dassie F, Cappellari R, Persano M, Vigili de Kreutzenberg S, Martini C, Parolin M, Avogaro A, Vettor R, Maffei P Tags: J Clin Endocrinol Metab Source Type: research

Focal gigantism in tuberous sclerosis
Publication date: Available online 17 March 2017 Source:International Journal of Epilepsy Author(s): Sanat R. Bhatkar, Aastha Takkar A 38 year lady had recurrent generalized and myoclonic seizures since 6 years of age. On examination she had facial adenoma sebaceum and periungal fibromas, cutaneous angiofibromas on the back. Contrast enhanced magnetic Resonance Imaging of brain was suggestive of multiple cortical tubers with sub ependymal nodules consistent with the diagnosis of Tuberous sclerosis. Focal hypertrophy of the skin of the dorsal aspect of the left hand with focal gigantism was noted. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - March 16, 2017 Category: Neurology Source Type: research

Airway and sleep disorders in patients with acromegaly
ConclusionSDB seems to be common and clinically important in patients with acromegaly, particularly in men. The most frequent type of apnea in acromegalics is obstructive. Hormonal activity of acromegaly does not seem to have an effect on the development of SAS. Despite its high prevalence, SAS is frequently under‐assessed in patients with acromegaly. Systemic complications and SDB should be researched in acromegalics. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 13, 2017 Category: Respiratory Medicine Authors: Onur Turan, Bar ış Akinci, Ahmet Omer Ikiz, Oya Itil, Ibrahim Oztura, Emel Ada, Bahri Akdeniz, Serkan Yener, Murat Kaya, Arzu Gedik, Abdurrahman Comlekci Tags: ORIGINAL ARTICLE Source Type: research

In vitro head-to-head comparison between octreotide and pasireotide in GH-secreting pituitary adenomas.
Conclusions: Overall, OCT and PAS equally reduced GH secretion in vitro. Adenomas with lower sst2 mRNA expression and a lower sst2/sst5 mRNA ratio showed a better response to PAS compared to OCT (6/33, 18%). SSTR evaluation in GH-omas may become a tool for tailored SSA treatment in acromegaly patients. PMID: 28323931 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 13, 2017 Category: Endocrinology Authors: Gatto F, Feelders RA, Franck SE, van Koetsveld PM, Dogan F, Kros JM, Neggers SJ, van der Lely AJ, Lamberts SW, Ferone D, Hofland LJ Tags: J Clin Endocrinol Metab Source Type: research

The association between biochemical control and cardiovascular risk factors in acromegaly
The study aim was to estimate the proportion of acromegaly patients with various comorbidities and to determine if biochemical control was associated with reduced proportion of cardiovascular risk factors. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - March 9, 2017 Category: Endocrinology Authors: John D. Carmichael, Michael S. Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P. Neary and Vivien Bonert Source Type: research

Growth hormone deficiency in treated acromegaly and active cushing ’s syndrome
Publication date: Available online 9 March 2017 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Anna Maria Formenti, Filippo Maffezzoni, Mauro Doga, Gherardo Mazziotti, Andrea Giustin Growth hormone deficiency (GHD) in adults is characterized by reduced quality of life and physical fitness, skeletal fragility, increased weight and cardiovascular risk. It may be found in (over-) treated acromegaly as well as in active Cushing’s syndrome. Hypopituitarism may develop in patients after definitive treatment of acromegaly, although the exact prevalence of GHD in this population i...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - March 8, 2017 Category: Endocrinology Source Type: research

A case of coexistence of TSH/GH-secreting pituitary tumor and papillary thyroid carcinoma: Challenges in pathogenesis and management
We report a case of pituitary macroadenoma, with clinical syndromes of acromegaly and hyperthyroidism, and a thyroid nodule, with cytologically confirmed to be a papillary thyroid carcinoma. Clinical implications, focusing on the strategy for proper management, and possible pathogenesis were discussed. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - March 7, 2017 Category: Neuroscience Source Type: research

Growth hormone deficiency in treated acromegaly and active cushing ’s syndrome
Growth hormone deficiency (GHD) in adults is characterized by reduced quality of life and physical fitness, skeletal fragility, increased weight and cardiovascular risk. It may be found in (over-) treated acromegaly as well as in active Cushing ’s syndrome. Hypopituitarism may develop in patients after definitive treatment of acromegaly, although the exact prevalence of GHD in this population is still uncertain because of limited awareness, and scarce and conflicting data so far available. Because GHD associated with acromegaly and Cushi ng’s syndrome may yield adverse consequences on similar target systems, the final ...
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - March 7, 2017 Category: Endocrinology Authors: Anna Maria Formenti, Filippo Maffezzoni, Mauro Doga, Gherardo Mazziotti, Andrea Giustin Source Type: research

Growth hormone deficiency in treated acromegaly and active Cushing's syndrome
Growth hormone deficiency (GHD) in adults is characterized by reduced quality of life and physical fitness, skeletal fragility, increased weight and cardiovascular risk. It may be found in (over-) treated acromegaly as well as in active Cushing's syndrome. Hypopituitarism may develop in patients after definitive treatment of acromegaly, although the exact prevalence of GHD in this population is still uncertain because of limited awareness, and scarce and conflicting data so far available. Because GHD associated with acromegaly and Cushing's syndrome may yield adverse consequences on similar target systems, the final outcom...
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - March 7, 2017 Category: Endocrinology Authors: Anna Maria Formenti, Filippo Maffezzoni, Mauro Doga, Gherardo Mazziotti, Andrea Giustina Tags: 8 Source Type: research

Thyroid lesions in patients with acromegaly - case-control study and update to the meta-analysis.
CONCLUSIONS: According to our results thyroid lesions were significantly more common in patients with acromegaly; in case of TC the difference was not significant. The updated meta-analysis showed significantly increased prevalence of both disorders. In conclusion, systematic thyroid examination should be an important part of follow-up in case of acromegalic patients. (Endokrynol Pol 2017; 68 (1): 2-6). PMID: 28255974 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 5, 2017 Category: Endocrinology Authors: Woliński K, Stangierski A, Gurgul E, Bromińska B, Czarnywojtek A, Lodyga M, Ruchała M Tags: Endokrynol Pol Source Type: research

Biochemical assessment of disease control in acromegaly: reappraisal of the glucose suppression test in somatostatin analogue (SA) treated patients
Conclusions(1) Patients controlled by somatostatin analog fail to suppress growth hormone in response to both mixed meals and oral glucose tolerance test (2) This phenomenon is likely to result in elevated serum growth hormone levels during everyday life in somatostatin analog-treated patients, (3) We postulate that measuring growth hormone levels during oral glucose tolerance test is useful to unmask potential somatostatin analog under-treatment in the presence of ‘safe’ insulin-like growth factor-I levels. (Source: Endocrine)
Source: Endocrine - March 3, 2017 Category: Endocrinology Source Type: research

Frequency of Achilles Tendon Xanthoma in Patients with Acute Coronary Syndrome.
CONCLUSION: This is the first report in which the frequency of ACS patients with ATX was 11.4%. The serum lipid profiles of ACS patients with ATX were similar to those without ATX. In the future, ACS patients with ATX will be diagnosed as having FH. PMID: 28250352 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - March 3, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Predictors of Quality of Life in Acromegaly: No Consensus on Biochemical Parameters
Victor J. Geraedts, Cornelie D. Andela, G ünter K. Stalla, Alberto M. Pereira, Wouter R. van Furth, Caroline Sievers, Nienke R. Biermasz (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 2, 2017 Category: Endocrinology Source Type: research

Risk of malignant neoplasms in acromegaly: a case –control study
ConclusionsMalignant neoplasms are significantly more common in patients with acromegaly. Particularly, risk of thyroid cancer was increased over fivefold. Systematic screening for neoplastic diseases should be important part of follow-up in these patients. Further case –control studies are strongly indicated to evaluate which neoplasms are more common in acromegalic patients and what is the exact risk of malignancy. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Daily life reflections of acromegaly guidelines
ConclusionsAlthough there were subtle differences, clinical practice guidelines were usually followed among Turkish endocrinologists. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Pituitary acromegaly: not one disease
Acromegaly has traditionally been regarded as a monomorphous disorder resulting from a benign pituitary adenoma. Increasing evidence, however, is highlighting that this disorder is associated with a spectrum of morphologically distinct pituitary tumors with variable clinical, biochemical and radiologic features and differing therapeutic outcomes that are attributed to different genetic and epigenetic changes. These data underscore the need for developing a more refined clinicopathological risk stratification system and implementing personalized targeted therapeutic approaches. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - February 23, 2017 Category: Endocrinology Authors: Asa, S. L., Kucharczyk, W., Ezzat, S. Tags: Commentary Source Type: research

The depiction of acromegaly in ancient Greek and Hellenistic art.
Authors: Laios K, Zozolou M, Markatos K, Karamanou M, Androutsos G PMID: 28222410 [PubMed - in process] (Source: Hormones)
Source: Hormones - February 23, 2017 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Clinical characteristics of acromegalic patients with empty sella and their outcomes following transsphenoidal surgery
ConclusionsCo-existence of acromegaly with ES is not rare, and is associated with occult adenoma, intra/postoperative CSF leakage, and a worse endocrinological outcome after transsphenoidal surgery; although, the underlying mechanism remains unclear. (Source: Pituitary)
Source: Pituitary - February 22, 2017 Category: Endocrinology Source Type: research

Therapeutic use of hormones on tendinopathies: a narrative review.
CONCLUSION: Because tendons injuries are frequent, often with long lasting sequels, it is important to improve our understanding concerning the therapeutic potential of hormones on healing. LEVEL OF EVIDENCE: IV. PMID: 28217565 [PubMed - in process] (Source: Muscles, Ligaments and Tendons Journal)
Source: Muscles, Ligaments and Tendons Journal - February 22, 2017 Category: Sports Medicine Tags: Muscles Ligaments Tendons J Source Type: research

A ırway and sleep dısorders ın patıents wıth acromegaly
CONCLUSION: SDB seems to be common and clinically important in patients with acromegaly,particularly in men. The most frequent type of apnea in acromegalics is obstructive.Hormonal activity of acromegaly does not seem to have an effect on the development of SAS. Despite its high prevalence,SAS is frequently under‐assessed in patients with acromegaly.Systemic complications and SDB should be researched in acromegalics. This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 21, 2017 Category: Respiratory Medicine Authors: Onur Turan, Bar ış Akıncı, Ahmet Omer Ikız, Oya Itıl, Ibrahim Oztura, Emel Ada, Bahri Akdenız, Serkan Yener, Murat Kaya, Arzu Gedık, Abdurrahman Comlekcı Tags: Original Article Source Type: research

Controversies in the risk of neoplasia in GH deficiency
Publication date: Available online 22 February 2017 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): S. Pekic, M. Stojanovic, V. Popovic Growth hormone (GH) replacement in GH deficient (GHD) children secures normal linear growth, while in GHD adults it improves metabolic status, body composition and quality of life. Safety of GH treatment is an important issue in particular concerning the controversy of potential cancer risk. Unlike in congenital IGF-1 deficiency, there is no complete protection against cancer in GHD patients. Important modifiable risk factors in GHD patients ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - February 21, 2017 Category: Endocrinology Source Type: research

The prevalence of colonic polyps in patients with acromegaly: a case control, nested in a cohort colonoscopic study
Endocrine Practice, Ahead of Print. (Source: Endocrine Practice)
Source: Endocrine Practice - February 21, 2017 Category: Endocrinology Authors: Baldomero Gonzalez Guadalupe Vargas Victoria Mendoza Mariana Nava Mois és Rojas Mois és Mercado Source Type: research

Rapid onset of diabetic ketoacidosis following SGLT2 inhibition in a patient with unrecognized acromegaly.
Conclusion: We hypothesize that SGLT2i, through their intrinsic effects on ketone body metabolism may possibly precipitate ketoacidosis in patients with active acromegaly and diabetes mellitus. PMID: 28323955 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 21, 2017 Category: Endocrinology Authors: Quarella M, Walser D, Brändle M, Fournier JY, Bilz S Tags: J Clin Endocrinol Metab Source Type: research

Acromegalic Cardiomyopathy with Malignant Arrhythmogenic Pattern Successfully Treated with Mechanical Circulatory Support and Heart Transplantation
We reported a case of a 48 years old man with acromegalic cardiomyopathy caused by pituitary adenoma. Despite the successful transsphenoidal resection of the tumour, the patient was re-hospitalized for ventricular arrhythmic storms that led to cardiogenic shock which required mechanical hemodynamic support with intra aortic balloon pump, venoarterial extracorporeal membrane oxygenation and urgent heart transplantation. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - February 20, 2017 Category: Cardiology Source Type: research

Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities
AbstractAcromegaly is associated with an enhanced mortality, with cardiovascular and respiratory complications representing not only the most frequent comorbidities but also two of the main causes of deaths, whereas a minor role is played by metabolic complications, and particularly diabetes mellitus. The most prevalent cardiovascular complications of acromegaly include a cardiomyopathy, characterized by  cardiac hypertrophy and diastolic and systolic dysfunction together with arterial hypertension, cardiac rhythm disorders and valve diseases, as well as vascular endothelial dysfunction. Biochemical control of acromeg...
Source: Pituitary - February 20, 2017 Category: Endocrinology Source Type: research

Two-dimensional speckle tracking echocardiography demonstrates no effect of active acromegaly on left ventricular strain
ConclusionsAcromegaly patients, despite presenting with a higher LVMi when analyzed by 2D echocardiography, did not present with impairment in the strain when compared to a control group; this finding indicates a low chance of evolution to systolic dysfunction and agrees with recent studies that show a lower frequency of cardiac disease in these patients. (Source: Pituitary)
Source: Pituitary - February 19, 2017 Category: Endocrinology Source Type: research