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Body mass index and insulin-like growth factor 1 as risk factors for discordant growth hormone and insulin-like growth factor 1  levels following pituitary surgery in acromegaly
Conclusion Body mass index and percentage of upper limit of normal range IGF-1 before TSA might constitute prognostic risk factors for discordance in IGF-1 and GH levels in acromegaly. Additional attention should be devoted to potential risk factors for this phenomenon, and methods for modifying the cure and control criteria for acromegaly should be developed. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - March 22, 2017 Category: Journals (General) Source Type: research

Matrix metalloproteinase 2 (MMP-2) levels are increased in active acromegaly patients
ConclusionsIn this study, serum matrix metalloproteinase-2 level is increased in the active acromegaly patients and a threshold value in determining active disease was defined for serum matrix metalloproteinase-2 level. This study is the first to compare acromegaly patients having active or controlled disease in terms of matrix metalloproteinase-2 and matrix metalloproteinase-9 levels. The results need to be confirmed by a study that will be conducted in a larger patient group also including a healthy control group to demonstrate the value of this novel marker in disease activity. (Source: Endocrine)
Source: Endocrine - March 22, 2017 Category: Endocrinology Source Type: research

Efficacy of transsphenoidal surgery in achieving biochemical cure of growth hormone-secreting pituitary adenomas among patients with cavernous sinus invasion: a systematic review and meta-analysis.
DISCUSSION: The prevalence of biochemical remission in patients with cavernous sinus invasion was lower than in patients without cavernous sinus invasion after TSS for acromegaly. PMID: 28301972 [PubMed - as supplied by publisher] (Source: Neurological Research)
Source: Neurological Research - March 20, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Impaired quality of life in patients with treated acromegaly despite long ‐term biochemically stable disease: results from a 5‐year prospective study
ConclusionsPatients with biochemically controlled acromegaly demonstrate impaired QoL, which persists despite long‐term disease control. This primarily consists of impaired physical function and secondly of impaired psycho‐social well‐being. Duration of biochemical disease control and current use of GH lowering therapy were the predominant factors determining patients’ QoL.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - March 19, 2017 Category: Endocrinology Authors: Nikolaos Kyriakakis, Julie Lynch, Stephen G Gilbey, Susan M Webb, Robert D Murray Tags: Original Article Source Type: research

Persistent reduction of circulating myeloid calcifying cells in acromegaly. Relevance to the bone-vascular axis.
Conclusions: In patients with acromegaly, the levels of MCCs are reduced and remain low even years after complete cure. This finding may be related to low atherosclerotic calcification and persistence of bone pathology after acromegaly remission or cure. PMID: 28323966 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 17, 2017 Category: Endocrinology Authors: Fadini GP, Dassie F, Cappellari R, Persano M, Vigili de Kreutzenberg S, Martini C, Parolin M, Avogaro A, Vettor R, Maffei P Tags: J Clin Endocrinol Metab Source Type: research

Focal gigantism in tuberous sclerosis
Publication date: Available online 17 March 2017 Source:International Journal of Epilepsy Author(s): Sanat R. Bhatkar, Aastha Takkar A 38 year lady had recurrent generalized and myoclonic seizures since 6 years of age. On examination she had facial adenoma sebaceum and periungal fibromas, cutaneous angiofibromas on the back. Contrast enhanced magnetic Resonance Imaging of brain was suggestive of multiple cortical tubers with sub ependymal nodules consistent with the diagnosis of Tuberous sclerosis. Focal hypertrophy of the skin of the dorsal aspect of the left hand with focal gigantism was noted. (Source: International Journal of Epilepsy)
Source: International Journal of Epilepsy - March 16, 2017 Category: Neurology Source Type: research

Airway and sleep disorders in patients with acromegaly
ConclusionSDB seems to be common and clinically important in patients with acromegaly, particularly in men. The most frequent type of apnea in acromegalics is obstructive. Hormonal activity of acromegaly does not seem to have an effect on the development of SAS. Despite its high prevalence, SAS is frequently under‐assessed in patients with acromegaly. Systemic complications and SDB should be researched in acromegalics. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 13, 2017 Category: Respiratory Medicine Authors: Onur Turan, Bar ış Akinci, Ahmet Omer Ikiz, Oya Itil, Ibrahim Oztura, Emel Ada, Bahri Akdeniz, Serkan Yener, Murat Kaya, Arzu Gedik, Abdurrahman Comlekci Tags: ORIGINAL ARTICLE Source Type: research

In vitro head-to-head comparison between octreotide and pasireotide in GH-secreting pituitary adenomas.
Conclusions: Overall, OCT and PAS equally reduced GH secretion in vitro. Adenomas with lower sst2 mRNA expression and a lower sst2/sst5 mRNA ratio showed a better response to PAS compared to OCT (6/33, 18%). SSTR evaluation in GH-omas may become a tool for tailored SSA treatment in acromegaly patients. PMID: 28323931 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 13, 2017 Category: Endocrinology Authors: Gatto F, Feelders RA, Franck SE, van Koetsveld PM, Dogan F, Kros JM, Neggers SJ, van der Lely AJ, Lamberts SW, Ferone D, Hofland LJ Tags: J Clin Endocrinol Metab Source Type: research

The association between biochemical control and cardiovascular risk factors in acromegaly
The study aim was to estimate the proportion of acromegaly patients with various comorbidities and to determine if biochemical control was associated with reduced proportion of cardiovascular risk factors. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - March 9, 2017 Category: Endocrinology Authors: John D. Carmichael, Michael S. Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P. Neary and Vivien Bonert Source Type: research

Growth hormone deficiency in treated acromegaly and active cushing ’s syndrome
Publication date: Available online 9 March 2017 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Anna Maria Formenti, Filippo Maffezzoni, Mauro Doga, Gherardo Mazziotti, Andrea Giustin Growth hormone deficiency (GHD) in adults is characterized by reduced quality of life and physical fitness, skeletal fragility, increased weight and cardiovascular risk. It may be found in (over-) treated acromegaly as well as in active Cushing’s syndrome. Hypopituitarism may develop in patients after definitive treatment of acromegaly, although the exact prevalence of GHD in this population i...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - March 8, 2017 Category: Endocrinology Source Type: research

A case of coexistence of TSH/GH-secreting pituitary tumor and papillary thyroid carcinoma: Challenges in pathogenesis and management
We report a case of pituitary macroadenoma, with clinical syndromes of acromegaly and hyperthyroidism, and a thyroid nodule, with cytologically confirmed to be a papillary thyroid carcinoma. Clinical implications, focusing on the strategy for proper management, and possible pathogenesis were discussed. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - March 7, 2017 Category: Neuroscience Source Type: research

Growth hormone deficiency in treated acromegaly and active cushing ’s syndrome
Growth hormone deficiency (GHD) in adults is characterized by reduced quality of life and physical fitness, skeletal fragility, increased weight and cardiovascular risk. It may be found in (over-) treated acromegaly as well as in active Cushing ’s syndrome. Hypopituitarism may develop in patients after definitive treatment of acromegaly, although the exact prevalence of GHD in this population is still uncertain because of limited awareness, and scarce and conflicting data so far available. Because GHD associated with acromegaly and Cushi ng’s syndrome may yield adverse consequences on similar target systems, the final ...
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - March 7, 2017 Category: Endocrinology Authors: Anna Maria Formenti, Filippo Maffezzoni, Mauro Doga, Gherardo Mazziotti, Andrea Giustin Source Type: research

Growth hormone deficiency in treated acromegaly and active Cushing's syndrome
Growth hormone deficiency (GHD) in adults is characterized by reduced quality of life and physical fitness, skeletal fragility, increased weight and cardiovascular risk. It may be found in (over-) treated acromegaly as well as in active Cushing's syndrome. Hypopituitarism may develop in patients after definitive treatment of acromegaly, although the exact prevalence of GHD in this population is still uncertain because of limited awareness, and scarce and conflicting data so far available. Because GHD associated with acromegaly and Cushing's syndrome may yield adverse consequences on similar target systems, the final outcom...
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - March 7, 2017 Category: Endocrinology Authors: Anna Maria Formenti, Filippo Maffezzoni, Mauro Doga, Gherardo Mazziotti, Andrea Giustina Tags: 8 Source Type: research

Thyroid lesions in patients with acromegaly - case-control study and update to the meta-analysis.
CONCLUSIONS: According to our results thyroid lesions were significantly more common in patients with acromegaly; in case of TC the difference was not significant. The updated meta-analysis showed significantly increased prevalence of both disorders. In conclusion, systematic thyroid examination should be an important part of follow-up in case of acromegalic patients. (Endokrynol Pol 2017; 68 (1): 2-6). PMID: 28255974 [PubMed - in process] (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - March 5, 2017 Category: Endocrinology Authors: Woliński K, Stangierski A, Gurgul E, Bromińska B, Czarnywojtek A, Lodyga M, Ruchała M Tags: Endokrynol Pol Source Type: research

Biochemical assessment of disease control in acromegaly: reappraisal of the glucose suppression test in somatostatin analogue (SA) treated patients
Conclusions(1) Patients controlled by somatostatin analog fail to suppress growth hormone in response to both mixed meals and oral glucose tolerance test (2) This phenomenon is likely to result in elevated serum growth hormone levels during everyday life in somatostatin analog-treated patients, (3) We postulate that measuring growth hormone levels during oral glucose tolerance test is useful to unmask potential somatostatin analog under-treatment in the presence of ‘safe’ insulin-like growth factor-I levels. (Source: Endocrine)
Source: Endocrine - March 3, 2017 Category: Endocrinology Source Type: research

Frequency of Achilles Tendon Xanthoma in Patients with Acute Coronary Syndrome.
CONCLUSION: This is the first report in which the frequency of ACS patients with ATX was 11.4%. The serum lipid profiles of ACS patients with ATX were similar to those without ATX. In the future, ACS patients with ATX will be diagnosed as having FH. PMID: 28250352 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - March 3, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Predictors of Quality of Life in Acromegaly: No Consensus on Biochemical Parameters
Victor J. Geraedts, Cornelie D. Andela, G ünter K. Stalla, Alberto M. Pereira, Wouter R. van Furth, Caroline Sievers, Nienke R. Biermasz (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 2, 2017 Category: Endocrinology Source Type: research

Risk of malignant neoplasms in acromegaly: a case –control study
ConclusionsMalignant neoplasms are significantly more common in patients with acromegaly. Particularly, risk of thyroid cancer was increased over fivefold. Systematic screening for neoplastic diseases should be important part of follow-up in these patients. Further case –control studies are strongly indicated to evaluate which neoplasms are more common in acromegalic patients and what is the exact risk of malignancy. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Daily life reflections of acromegaly guidelines
ConclusionsAlthough there were subtle differences, clinical practice guidelines were usually followed among Turkish endocrinologists. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 28, 2017 Category: Endocrinology Source Type: research

Pituitary acromegaly: not one disease
Acromegaly has traditionally been regarded as a monomorphous disorder resulting from a benign pituitary adenoma. Increasing evidence, however, is highlighting that this disorder is associated with a spectrum of morphologically distinct pituitary tumors with variable clinical, biochemical and radiologic features and differing therapeutic outcomes that are attributed to different genetic and epigenetic changes. These data underscore the need for developing a more refined clinicopathological risk stratification system and implementing personalized targeted therapeutic approaches. (Source: Endocrine-Related Cancer)
Source: Endocrine-Related Cancer - February 23, 2017 Category: Endocrinology Authors: Asa, S. L., Kucharczyk, W., Ezzat, S. Tags: Commentary Source Type: research

The depiction of acromegaly in ancient Greek and Hellenistic art.
Authors: Laios K, Zozolou M, Markatos K, Karamanou M, Androutsos G PMID: 28222410 [PubMed - in process] (Source: Hormones)
Source: Hormones - February 23, 2017 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Clinical characteristics of acromegalic patients with empty sella and their outcomes following transsphenoidal surgery
ConclusionsCo-existence of acromegaly with ES is not rare, and is associated with occult adenoma, intra/postoperative CSF leakage, and a worse endocrinological outcome after transsphenoidal surgery; although, the underlying mechanism remains unclear. (Source: Pituitary)
Source: Pituitary - February 22, 2017 Category: Endocrinology Source Type: research

Therapeutic use of hormones on tendinopathies: a narrative review.
CONCLUSION: Because tendons injuries are frequent, often with long lasting sequels, it is important to improve our understanding concerning the therapeutic potential of hormones on healing. LEVEL OF EVIDENCE: IV. PMID: 28217565 [PubMed - in process] (Source: Muscles, Ligaments and Tendons Journal)
Source: Muscles, Ligaments and Tendons Journal - February 22, 2017 Category: Sports Medicine Tags: Muscles Ligaments Tendons J Source Type: research

A ırway and sleep dısorders ın patıents wıth acromegaly
CONCLUSION: SDB seems to be common and clinically important in patients with acromegaly,particularly in men. The most frequent type of apnea in acromegalics is obstructive.Hormonal activity of acromegaly does not seem to have an effect on the development of SAS. Despite its high prevalence,SAS is frequently under‐assessed in patients with acromegaly.Systemic complications and SDB should be researched in acromegalics. This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 21, 2017 Category: Respiratory Medicine Authors: Onur Turan, Bar ış Akıncı, Ahmet Omer Ikız, Oya Itıl, Ibrahim Oztura, Emel Ada, Bahri Akdenız, Serkan Yener, Murat Kaya, Arzu Gedık, Abdurrahman Comlekcı Tags: Original Article Source Type: research

Controversies in the risk of neoplasia in GH deficiency
Publication date: Available online 22 February 2017 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): S. Pekic, M. Stojanovic, V. Popovic Growth hormone (GH) replacement in GH deficient (GHD) children secures normal linear growth, while in GHD adults it improves metabolic status, body composition and quality of life. Safety of GH treatment is an important issue in particular concerning the controversy of potential cancer risk. Unlike in congenital IGF-1 deficiency, there is no complete protection against cancer in GHD patients. Important modifiable risk factors in GHD patients ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - February 21, 2017 Category: Endocrinology Source Type: research

The prevalence of colonic polyps in patients with acromegaly: a case control, nested in a cohort colonoscopic study
Endocrine Practice, Ahead of Print. (Source: Endocrine Practice)
Source: Endocrine Practice - February 21, 2017 Category: Endocrinology Authors: Baldomero Gonzalez Guadalupe Vargas Victoria Mendoza Mariana Nava Mois és Rojas Mois és Mercado Source Type: research

Rapid onset of diabetic ketoacidosis following SGLT2 inhibition in a patient with unrecognized acromegaly.
Conclusion: We hypothesize that SGLT2i, through their intrinsic effects on ketone body metabolism may possibly precipitate ketoacidosis in patients with active acromegaly and diabetes mellitus. PMID: 28323955 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - February 21, 2017 Category: Endocrinology Authors: Quarella M, Walser D, Brändle M, Fournier JY, Bilz S Tags: J Clin Endocrinol Metab Source Type: research

Acromegalic Cardiomyopathy with Malignant Arrhythmogenic Pattern Successfully Treated with Mechanical Circulatory Support and Heart Transplantation
We reported a case of a 48 years old man with acromegalic cardiomyopathy caused by pituitary adenoma. Despite the successful transsphenoidal resection of the tumour, the patient was re-hospitalized for ventricular arrhythmic storms that led to cardiogenic shock which required mechanical hemodynamic support with intra aortic balloon pump, venoarterial extracorporeal membrane oxygenation and urgent heart transplantation. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - February 20, 2017 Category: Cardiology Source Type: research

Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities
AbstractAcromegaly is associated with an enhanced mortality, with cardiovascular and respiratory complications representing not only the most frequent comorbidities but also two of the main causes of deaths, whereas a minor role is played by metabolic complications, and particularly diabetes mellitus. The most prevalent cardiovascular complications of acromegaly include a cardiomyopathy, characterized by  cardiac hypertrophy and diastolic and systolic dysfunction together with arterial hypertension, cardiac rhythm disorders and valve diseases, as well as vascular endothelial dysfunction. Biochemical control of acromeg...
Source: Pituitary - February 20, 2017 Category: Endocrinology Source Type: research

Two-dimensional speckle tracking echocardiography demonstrates no effect of active acromegaly on left ventricular strain
ConclusionsAcromegaly patients, despite presenting with a higher LVMi when analyzed by 2D echocardiography, did not present with impairment in the strain when compared to a control group; this finding indicates a low chance of evolution to systolic dysfunction and agrees with recent studies that show a lower frequency of cardiac disease in these patients. (Source: Pituitary)
Source: Pituitary - February 19, 2017 Category: Endocrinology Source Type: research

Widening of Joint Spaces in Acromegaly
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 18, 2017 Category: Rheumatology Authors: Masei Suda, Yasuhiro Suyama, Masato Okada Tags: Clinical Image Source Type: research

Associations between Body Composition, Circulating Interleukin-1 Receptor Antagonist, Osteocalcin, and Insulin Metabolism in Active Acromegaly.
Authors: Ueland T, Fougner SL, Godang K, Lekva T, Schurgers LJ, Scholz H, Halvorsen B, Schreiner T, Aukrust PL, Bollerslev J PMID: 28199500 [PubMed] (Source: Endocrine Reviews)
Source: Endocrine Reviews - February 17, 2017 Category: Endocrinology Tags: Endocr Rev Source Type: research

Updates in outcomes of stereotactic radiation therapy in acromegaly
Conclusion Although the use of radiotherapy in patients with acromegaly has decreased with advances in medical treatments, it remains an effective treatment option after unsuccessful surgery and/or resistance or unavailability of medical therapy. Long-term studies evaluating secondary morbidity and mortality rate after the new stereotactic techniques are needed, in order to evaluate their potential brain-sparing effect. (Source: Pituitary)
Source: Pituitary - February 15, 2017 Category: Endocrinology Source Type: research

T2-weighted MRI signal intensity as a predictor of hormonal and tumoral responses to somatostatin receptor ligands in acromegaly: a perspective
AbstractT2-weighted MRI signal intensity of GH-secreting pituitary adenomas is gaining recognition as a marker of disease characteristics and may be a predictor of response to treatment of acromegaly. Adenomas that are T2-hypointense are more common, are smaller and are less likely to invade the cavernous sinus compared to the T2-iso and hyperintense tumors. T2-hypointense tumors are also accompanied by higher IGF1 values at baseline. When presurgical somatostatin receptor ligand (SRL) therapy is administered, T2-hypointense adenomas have better hormonal responses and have greater tumor shrinkage. Adjuvant SRL therapy of p...
Source: Pituitary - February 13, 2017 Category: Endocrinology Source Type: research

Somatostatin receptor ligands in the treatment of acromegaly
AbstractFirst-generation somatostatin receptors ligands (SRL) are the mainstay in the medical treatment of acromegaly, however the percentage of patients controlled with these drugs significantly varies in the different studies. Many factors are involved in the resistance to SRL. In this review, we update the physiology of somatostatin and its receptors (sst), the use of SRL in the treatment of acromegaly and the factors involved in the response to these drugs. The SRL act through interaction with the sst, which up to now have been characterized as five subtypes. The first-generation SRL, octreotide and lanreotide, are con...
Source: Pituitary - February 6, 2017 Category: Endocrinology Source Type: research

Pegvisomant in acromegaly: an update
ConclusionsPEG increasingly appears to be an effective and safe medical option for many patients not controlled by SRL but its use still needs to be optimized. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 6, 2017 Category: Endocrinology Source Type: research

Biochemical investigations in diagnosis and follow up of acromegaly
AbstractMeasurements of human growth hormone (GH) and insulin-like growth-factor I (IGF-I) are cornerstones in the diagnosis of acromegaly. Both hormones are also used as biochemical markers in the evaluation of disease activity during treatment. Management of acromegaly is particularly challenging in cases where discordant information is obtained from measurement of GH concentrations following oral glucose load and from measurement of IGF-I. While in some patients biological factors can explain the discrepancy, in many cases issues with the analytical methods seem to be responsible. Assays used by endocrine laboratories t...
Source: Pituitary - February 5, 2017 Category: Endocrinology Source Type: research

Renin-Angiotensin System Blockade Improves Cardiac Indices in Acromegaly Patients
Exp Clin Endocrinol Diabetes DOI: 10.1055/s-0042-123710Blockade of the angiotensin-renin system, with angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs), has been shown to improve cardiac outcomes following myocardial infarction and delay progression of heart failure. Acromegaly is associated with a disease-specific cardiomyopathy, the pathogenesis of which is poorly understood.The cardiac indices of patients with active acromegaly with no hypertension (Group A, n=4), established hypertension not taking ACEi/ARBs (Group B, n=4) and established hypertension taking ACEi/ARBs (Group C, n=...
Source: Experimental and Clinical Endocrinology and Diabetes - February 5, 2017 Category: Endocrinology Authors: Thomas, Julia D. J. Dattani, Abhishek Zemrak, Filip Burchell, Thomas Akker, Scott A. Kaplan, Felicity J. L. Khoo, Bernard Aylwin, Simon Grossman, Ashley B. Davies, L. Ceri Korbonits, M árta Tags: Article Source Type: research

The genetic background of acromegaly
AbstractAcromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in sporadic somatotropinomas. This short review concentrates on the current knowledge of the genetic basis of both familial and sporadic acromegaly. (Source: Pituitary)
Source: Pituitary - February 3, 2017 Category: Endocrinology Source Type: research

Impact of acromegaly treatment on cardiovascular complications
(Source: Endocrine)
Source: Endocrine - February 2, 2017 Category: Endocrinology Source Type: research

Assessment of diastolic dysfunction, arterial stiffness and carotid intima-media thickness in patients with acromegaly
Endocrine Practice, Ahead of Print. (Source: Endocrine Practice)
Source: Endocrine Practice - February 2, 2017 Category: Endocrinology Authors: G üven Barış Cansu Nusret Y ılmaz Atakan Yan ıkoğlu Sebahat Özdem Ayt ül Belgi Yıldırım G ültekin Süleymanlar Hasan Ali Altunba ş Source Type: research

Understanding and predicting fracture risk in acromegaly
(Source: Endocrine)
Source: Endocrine - February 1, 2017 Category: Endocrinology Source Type: research

Diabetes in Patients With Acromegaly
AbstractPurpose of ReviewAcromegaly is a clinical syndrome which results from growth hormone excess. Uncontrolled acromegaly is associated with cardiovascular mortality, due to an excess of risk factors including diabetes mellitus, hypertension and cardiomegaly. Diabetes mellitus is a frequent complication of acromegaly with a prevalence of 12 –37%. This review will provide an overview of a number of aspects of diabetes mellitus and glucose intolerance in acromegaly including the following:Epidemiology and pathophysiology of abnormalities of glucose homeostasisThe impact of different management options for acromegaly on ...
Source: Current Diabetes Reports - January 31, 2017 Category: Endocrinology Source Type: research

Computed tomography airway lumen volumetry in patients with acromegaly: Association with growth hormone levels and lung function
ConclusionPatients with acromegaly exhibit tracheobronchomegaly and tracheal sinuosity/stenosis. Moreover, there are associations between the results of CT airway lumen volumetry, hormone levels and functional parameters of large airway obstruction. (Source: Australasian Radiology)
Source: Australasian Radiology - January 31, 2017 Category: Radiology Authors: Gustavo Bittencourt Camilo, Alysson Roncally Silva Carvalho, Alan Ranieri Medeiros Guimar ães, Leandro Kasuki, Mônica Roberto Gadelha, Roberto Mogami, Pedro Lopes Melo, Agnaldo José Lopes Tags: Medical Imaging —Original Article Source Type: research

Acromegaly, a pituitary special issue
(Source: Pituitary)
Source: Pituitary - January 31, 2017 Category: Endocrinology Source Type: research

Decrease of Serum IGF-I following Transsphenoidal Pituitary Surgery for Acromegaly [Endocrinology and Metabolism]
CONCLUSIONS: Rapid decline of serum IGF-I during the immediate postoperative period warrants further study as an analytically independent adjunct to GH measurement for early prediction of biochemical remission of acromegaly. (Source: Clinical Chemistry)
Source: Clinical Chemistry - January 26, 2017 Category: Chemistry Authors: Yu, M., Bruns, D. E., Jane, J. A., Nass, R. M., Oldfield, E. H., Vance, M. L., Thorner, M. O. Tags: Endocrinology and Metabolism Source Type: research

The evaluation of central corneal thickness and intraocular pressure in conjunction with tear IGF-1 levels in patients with acromegaly.
CONCLUSIONS: There was no significant difference in tear IGF-1 levels between patients with acromegaly and controls. Additionally, there was no correlation between disease duration and tear IGF-1 levels with CCT or IOP levels. This lack of association may suggest that tear IGF-1 levels might not have an effect on CCT or IOP findings in patients with acromegaly. PMID: 28127733 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - January 26, 2017 Category: Opthalmology Authors: Kan E, Kan EK, Okuyucu A Tags: Eur J Ophthalmol Source Type: research

An approach to using data mining to support early identification of acromegaly
Endocrine Practice, Ahead of Print. (Source: Endocrine Practice)
Source: Endocrine Practice - January 16, 2017 Category: Endocrinology Authors: Michael S. Broder Eunice Chang Sheila R. Reddy Maureen P. Neary Source Type: research