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Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research
Functionalization of bacterial microcompartment shell interior with cysteine containing peptides enhances the iron and cobalt loading capacity
In this study, we present a method for functionalizing recombinant GRM2-type BMC shell lumens with short cysteine-containing sequences and demonstrate that the iron and cobalt loading capacity of such modified shells is markedly increased. These results also imply that a passive flow of cobalt and iron atoms across the BMC shell could be possible.PMID:37728832 | DOI:10.1007/s10534-023-00538-1
Source: Biometals - September 20, 2023 Category: Biochemistry Authors: Gints Kalnins Maris Bertins Arturs Viksna Kaspars Tars Source Type: research
Peroxiredoxins in erythrocytes: far beyond the antioxidant role
J Mol Med (Berl). 2023 Sep 20. doi: 10.1007/s00109-023-02368-7. Online ahead of print.ABSTRACTThe red blood cells (RBCs) are essential to transport oxygen (O2) and nutrients throughout the human body. Changes in the structure or functioning of the erythrocytes can lead to several deficiencies, such as hemolytic anemias, in which an increase in reactive oxidative species generation is involved in the pathophysiological process, playing a significant role in the severity of several clinical manifestations. There are important lines of defense against the damage caused by oxidizing molecules. Among the antioxidant molecules, ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Carla Peres de Paula Jo ão Pedro Maia de Oliveira da Silva Karen Simone Romanello Victoria Sim ões Bernardo Flaviene Felix Torres Danilo Gr ünig Humberto da Silva Anderson Ferreira da Cunha Source Type: research
Impact of ferroptosis on preeclampsia: A review
Biomed Pharmacother. 2023 Sep 18;167:115466. doi: 10.1016/j.biopha.2023.115466. Online ahead of print.ABSTRACTPreeclampsia (PE) is usually associated with the accumulation of reactive oxygen species (ROS) resulting from heightened oxidative stress (OS). Ferroptosis is a unique type of lipid peroxidation-induced iron-dependent cell death distinct from traditional apoptosis, necroptosis, and pyroptosis and most likely contributes considerable to PE pathogenesis. At approximately 10-12 weeks of gestation, trophoblasts create an environment rich in oxygen and iron. In patients with PE, ferroptosis-related genes such as HIF1 an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Yuping Shan Chengcheng Guan Jingli Wang Weihong Qi Aiping Chen Shiguo Liu Source Type: research
Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model
Biosci Rep. 2023 Sep 20:BSR20230128. doi: 10.1042/BSR20230128. Online ahead of print.ABSTRACTFerroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an Hallmark of Non Alcoholic Fatty Liver Disease (NAFLD). Melatonin (MLT) is an important pineal hormone with tremendous antioxidant and anti-inflammatory properties. Various studies targeted ferroptosis in different diseases using melatonin. However, none of them focused the intrinsic mechanism of MLT's action to counteract ferroptosis in NAFLD. Hence, the ...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Moumita Saha Sanjib Das Krishnendu Manna Krishna Das Saha Source Type: research
Functionalized activated carbon as support for trypsin immobilization and its application in casein hydrolysis
This study aimed to immobilize trypsin on activated carbon submitted to different surface modifications and its application in casein hydrolysis. With the aim of determining which support can promote better maintenance of the immobilized enzyme. Results showed that pH 5.0 was obtained as optimal for immobilization and pH 9.0 for the casein hydrolysis reaction for activated carbon and glutaraldehyde functionalized carbon. Among the supports used, activated carbon modified with iron ions in the presence of a chelating agent was the one that showed best results, under the conditions evaluated in this study. Presenting an immo...
Source: Bioprocess and Biosystems Engineering - September 20, 2023 Category: Biomedical Engineering Authors: Mateus P F Santos Matheus A Ferreira Evaldo C S Junior Renata C F Bonomo Cristiane M Veloso Source Type: research
The role of B-cell ferroptosis in the pathogenesis of systemic lupus erythematosus
Clin Immunol. 2023 Sep 18:109778. doi: 10.1016/j.clim.2023.109778. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the dysregulation of B cell subpopulation and function. Recent studies have suggested a potential role of ferroptosis, an iron-dependent form of regulated cell death, in the pathogenesis of SLE. Here, we demonstrate that B-cell ferroptosis occurs both in lupus patients and MRL/lpr mice. Treatment with liproxstatin-1, a potent ferroptosis inhibitor, could reduce autoantibody production, improve renal damage, and alleviate lupus symptoms in vivo. ...
Source: Clinical Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Qian Chen Mengmeng Xiang Zhanyan Gao Fan Lvu Zhan Sun Yilun Wang Xiangguang Shi Jinhua Xu Jie Wang Jun Liang Source Type: research
Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research
The role of B-cell ferroptosis in the pathogenesis of systemic lupus erythematosus
Clin Immunol. 2023 Sep 18:109778. doi: 10.1016/j.clim.2023.109778. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the dysregulation of B cell subpopulation and function. Recent studies have suggested a potential role of ferroptosis, an iron-dependent form of regulated cell death, in the pathogenesis of SLE. Here, we demonstrate that B-cell ferroptosis occurs both in lupus patients and MRL/lpr mice. Treatment with liproxstatin-1, a potent ferroptosis inhibitor, could reduce autoantibody production, improve renal damage, and alleviate lupus symptoms in vivo. ...
Source: Clinical Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Qian Chen Mengmeng Xiang Zhanyan Gao Fan Lvu Zhan Sun Yilun Wang Xiangguang Shi Jinhua Xu Jie Wang Jun Liang Source Type: research
Bacterial respiratory inhibition triggers dispersal of < em > Pseudomonas aeruginosa < /em > biofilms
Appl Environ Microbiol. 2023 Sep 20:e0110123. doi: 10.1128/aem.01101-23. Online ahead of print.ABSTRACTPseudomonas aeruginosa grows as a biofilm under many environmental conditions, and the bacterium can disperse from biofilms via highly regulated, dynamic processes. However, physiologic triggers of biofilm dispersal remain poorly understood. Based on prior literature describing dispersal triggered by forms of starvation, we tested bacterial respiratory inhibitors for biofilm dispersal in two models resembling chronic airway infections. Our underlying hypothesis was that respiratory inhibitors could serve as a model for th...
Source: Applied and Environmental Microbiology - September 20, 2023 Category: Microbiology Authors: Anna C Zemke Emily J D'Amico Angela M Torres Grace P Carreno-Florez Patrick Keeley Matt DuPont Naomi Kasturiarachi Jennifer M Bomberger Source Type: research
Impact of ferroptosis on preeclampsia: A review
Biomed Pharmacother. 2023 Sep 18;167:115466. doi: 10.1016/j.biopha.2023.115466. Online ahead of print.ABSTRACTPreeclampsia (PE) is usually associated with the accumulation of reactive oxygen species (ROS) resulting from heightened oxidative stress (OS). Ferroptosis is a unique type of lipid peroxidation-induced iron-dependent cell death distinct from traditional apoptosis, necroptosis, and pyroptosis and most likely contributes considerable to PE pathogenesis. At approximately 10-12 weeks of gestation, trophoblasts create an environment rich in oxygen and iron. In patients with PE, ferroptosis-related genes such as HIF1 an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Yuping Shan Chengcheng Guan Jingli Wang Weihong Qi Aiping Chen Shiguo Liu Source Type: research
Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens
J Inorg Biochem. 2023 Sep 12;249:112368. doi: 10.1016/j.jinorgbio.2023.112368. Online ahead of print.ABSTRACTHeme is the most abundant source of iron in the human body and is actively scavenged by bacterial pathogens during infections. Corynebacterium diphtheriae and other species of actinobacteria scavenge heme using cell wall associated and secreted proteins that contain Conserved Region (CR) domains. Here we report the development of a fluorescent sensor to measure heme transfer from the C-terminal CR domain within the HtaA protein (CR2) to other hemoproteins within the heme-uptake system. The sensor contains the CR2 do...
Source: Journal of Inorganic Biochemistry - September 20, 2023 Category: Biochemistry Authors: Brendan J Mahoney Andrew K Goring Yueying Wang Poojita Dasika Anqi Zhou Emmitt Grossbard Duilio Cascio Joseph A Loo Robert T Clubb Source Type: research
Ruthenium and Iron Co-doped Molybdenum Carbide as a Stable Hydrogen Evolution Electrocatalyst in Harsh Electrolyte
Chemistry. 2023 Sep 20:e202302398. doi: 10.1002/chem.202302398. Online ahead of print.ABSTRACTElectrocatalytic water splitting is one of the most commercially valuable pathways of hydrogen production especially combined with renewable electricity; however, efficient and durable electrocatalysts are urgently needed to reduce electric energy consumption. Here, we reported a Ru and Fe co-doped Mo2C on nitrogen doped carbon via a controllable two-step method, which can be used for efficient and enduring hydrogen evolution reaction. At 10, 100 and 200 mA cm-2 in acidic electrolyte, the resultant Ru-Fe/Mo2C@NC delivered low over...
Source: Chemistry - September 20, 2023 Category: Chemistry Authors: Xiao Peng Fu Kai Zhi Sun Xiaoxia Li Hao Guan Xu Fangxin Mao Huagui Yang Peng Fei Liu Source Type: research
The Emerging Roles of Ferroptosis in Pathophysiology and Treatment of Acute Lung Injury
J Inflamm Res. 2023 Sep 14;16:4073-4085. doi: 10.2147/JIR.S420676. eCollection 2023.ABSTRACTFerroptosis, a programmed cell death discovered in recent years, is an iron-dependent lipid peroxidation accumulation. Unlike other modes of cell death (autophagy, necroptosis, pyroptosis, cuproptosis, etc.), ferroptosis has unique morphological characteristics and plays an important role in a variety of diseases. In recent years, there has been great progress in the study of ferroptosis. Studies have found that ferroptosis is associated with acute lung injury (ALI), a condition with a high mortality rate and limited treatment optio...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Yufei Wang Zijun Zhao Zhaoyang Xiao Source Type: research
Evaluation of genetic variants in ferroptosis-related genes and house dust mite-induced allergic rhinitis risk
CONCLUSIONS: These findings suggest that the genetic variants in ferroptosis-related genes ENPP2 and EPAS1 may increase HDM-induced AR risk and serve as potential predictors of HDM-induced AR susceptibility.PMID:37724950 | DOI:10.1016/j.intimp.2023.109707
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Yi-Fan Yang Rui Zheng Xiang Gu Fang Gao Min Chen Mu-Long Du Zheng-Dong Zhang Mei-Ping Lu Lei Cheng Source Type: research
