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Nutrition: Iron
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TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner
In this study, TFEB overexpression promoted the clearance of misfolded α-synuclein and prevented ferroptosis and iron overload. TFEB overexpression up-regulated transferrin receptor 1 (TfR1) synthesis and increased the localization of TfR1 in the lysosome, facilitating lysosomal iron import and transient lysosomal iron storage. TFEB overexpression increased the levels of cellular iron-safe storage proteins (both ferritin light and heavy chains). These functions in iron metabolism maintain the cellular labile iron at a low level and electrical activity, even under iron overload conditions. Notably, lower levels of cellular...
Source: Free Radical Biology and Medicine - September 8, 2023 Category: Biology Authors: Leilei Chen Yue Ma Xizhen Ma Lin Liu Xianhui Jv Ang Li Qingqing Shen Wenting Jia Le Qu Limin Shi Junxia Xie Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
Accelerated Atherosclerosis in Beta Thalassemia
Am J Physiol Heart Circ Physiol. 2023 Sep 8. doi: 10.1152/ajpheart.00306.2023. Online ahead of print.ABSTRACTChildren with Beta Thalassemia (BT) present with an increase in carotid intima-medial thickness, an early sign suggestive of premature atherosclerosis. However, it is unknown if there is a direct relationship between BT and atherosclerotic disease. To evaluate this, WT (littermates) and BT (Hbbth3/+) mice, both male and female, were placed on a 3-month high fat diet with low-density lipoprotein receptor suppression via overexpression of proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 8, 2023 Category: Physiology Authors: Julian Hurtado Hassan Sellak Giji Joseph Caitlin V Lewis Crystal R Naudin Sergio Garcia James Robert Wodicka David R Archer W Robert Taylor Source Type: research
Synergistic Activation of Inert Iron Oxide Basal Planes through Heterostructure Formation and Doping for Efficient Hydrogen Evolution
In this study, we employed heterostructure engineering and doped nickel to cooperatively activate the basal planes of iron oxide (Ni-Fe2O3/CeO2 HSs) to achieve high hydrogen evolution reaction (HER) activity. The Ni-Fe2O3/CeO2 HSs electrocatalyst demonstrates excellent basic HER activity and stability, such as an extremely low overpotential of 43 mV at 10 mA cm-2 current density and corresponding Tafel slope of 58.6 mV dec-1. The increase in electrocatalyst activity and acceleration of hydrogen precipitation kinetics arises from the dual modulation of Ni doping and heterostructure, which not only modulates the electrocatal...
Source: Chemistry - September 8, 2023 Category: Chemistry Authors: Hong Su Shanshan Wang Wanyi Liao Rong Gan Yiling Ran Qin Zhao Ling Fang Yan Zhang Source Type: research
Blue-Light Driven Iron-Catalyzed Oxy-phosphinylation of Activated Alkenes for β-Ketophosphine Oxide Synthesis
Chemistry. 2023 Sep 8:e202302358. doi: 10.1002/chem.202302358. Online ahead of print.ABSTRACTWe have developed an original blue-light mediated ironcatalyzed oxy-phosphinylation of activated alkenes by secondary phosphine oxides under air at room temperature. Various βketophosphine oxides were then obtained in 43-97% isolated yields. Control experiments revealed that radical process is involved in the mechanism.PMID:37681747 | DOI:10.1002/chem.202302358
Source: Chemistry - September 8, 2023 Category: Chemistry Authors: Yumeng Yuan Qiufeng Huang Christophe Darcel Source Type: research
Arsenic fractionation and speciation in different textured soils supplied with farmyard manure and accumulation by sunflower under alkaline calcareous conditions
Environ Sci Pollut Res Int. 2023 Sep 8. doi: 10.1007/s11356-023-29659-3. Online ahead of print.ABSTRACTArsenic (As) is a naturally occurring element that is found in soil, water, and rocks. However, it can also be released into the environment through human activities. Arsenic is considered an environmental hazard because it is toxic to humans and animals and can cause serious health problems. Additionally, As-contaminated soil can limit plant growth and reduce crop yields, leading to economic losses for farmers. So, decreasing metal/metalloid solubility in soil by synthetic and organic amendments leads to better crop prod...
Source: Environmental Science and Pollution Research International - September 8, 2023 Category: Environmental Health Authors: Muhammad Awais Piracha Muhammad Ashraf Sher Muhammad Shahzad Sajid Masood Naeem Akhtar Rizwana Kausar Awais Shakoor Source Type: research
One Ligand to Bind them All: S~C~S < sup > 2- < /sup > Carbon- and Sulfur-Based Gem-Dianion as Structuring Ligand for Iron Polymetallic Assemblies
Chemistry. 2023 Sep 8:e202302130. doi: 10.1002/chem.202302130. Online ahead of print.ABSTRACTNumerous synthetic models of the FeMo-co cluster of nitrogenases have been proposed to find the simplest structure with relevant reactivity. Indeed, such structures are able to perform multi-electrons reduction processes, such as the conversion of N2 to ammonia, and of CO2 into methane and alkenes. The most challenging parameter to imitate is indeed the central carbide ligand, which is believed to maintain the integrity of iron sulfide assembly during the course of catalytic cycles. The study proposes the use of bis(diphenylthiopho...
Source: Chemistry - September 8, 2023 Category: Chemistry Authors: Rapha ël Ravel-Massol Sandip Munshi Anthony Pujol Ricardo Garcia-Serres Nathalie Saffon-Merceron Nicolas M ézailles Marie Fustier-Boutignon Source Type: research
The bidirectional extracellular electron transfer process aids iron cycling by < em > Geoalkalibacter halelectricus < /em > in a highly saline-alkaline condition
This study advances the understanding of extremophilic microbial taxa capable of bidirectional EET and its role in barely investigated Fe cycling in highly saline-alkaline environments. It also offers research opportunities for understanding the membrane components involved in the bidirectional EET of G. halelectricus. The high rate of Fe3+ oxide reduction activity by G. halelectricus suggests its possible use as a biocatalyst in the anaerobic iron bioleaching process under neutral-alkaline pH conditions.PMID:37681980 | DOI:10.1128/aem.00609-23
Source: Applied and Environmental Microbiology - September 8, 2023 Category: Microbiology Authors: Sukrampal Yadav Chetan Sadhotra Sunil A Patil Source Type: research
New iron export pathways acting via holo-ferritin secretion
Arch Biochem Biophys. 2023 Sep 6:109737. doi: 10.1016/j.abb.2023.109737. Online ahead of print.ABSTRACTFerritin is a spherical nanocage protein for iron storage, composed of 24 light- or heavy-polypeptide chain subunits. A single ferritin molecule can carry up to 4500 iron atoms in its core, which plays an important role in suppressing intracellular iron toxicity. Serum ferritin levels are used as a marker for the total amount of iron stored in the body. Most serum ferritin is iron-free (apo-ferritin) and it is unclear how ferritin is released from cells. Ferritin is secreted into serum via extracellular vesicles (EVs) or ...
Source: Archives of Biochemistry and Biophysics - September 8, 2023 Category: Biochemistry Authors: Izumi Yanatori Fumio Kishi Shinya Toyokuni Source Type: research
Water-promoted carbon-carbon bond cleavage employing a reusable Fe single-atom catalyst
Angew Chem Int Ed Engl. 2023 Sep 8:e202311913. doi: 10.1002/anie.202311913. Online ahead of print.ABSTRACTThe development of methods for selective cleavage reactions of thermodynamically stable C-C/C=C bonds in a green manner is a challenging research field which is largely unexplored. Herein, we present a heterogeneous Fe-N-C catalyst with highly dispersed iron centers that allows for the oxidative C-C/C=C bond cleavage of amines, secondary alcohols, ketones, and olefins in the presence of air (O2) and water (H2O). Mechanistic studies reveal the presence of water to be essential for the performance of the Fe-N-C system, b...
Source: Angewandte Chemie - September 8, 2023 Category: Chemistry Authors: Haifeng Qi Shuxin Mao Jabor Rabeah Ruiyang Qu Na Yang Zupeng Chen Florian Bourriquen Ji Yang Jianfeng Li Kathrin Junge Matthias Beller Source Type: research
New iron export pathways acting via holo-ferritin secretion
Arch Biochem Biophys. 2023 Sep 6:109737. doi: 10.1016/j.abb.2023.109737. Online ahead of print.ABSTRACTFerritin is a spherical nanocage protein for iron storage, composed of 24 light- or heavy-polypeptide chain subunits. A single ferritin molecule can carry up to 4500 iron atoms in its core, which plays an important role in suppressing intracellular iron toxicity. Serum ferritin levels are used as a marker for the total amount of iron stored in the body. Most serum ferritin is iron-free (apo-ferritin) and it is unclear how ferritin is released from cells. Ferritin is secreted into serum via extracellular vesicles (EVs) or ...
Source: Archives of Biochemistry and Biophysics - September 8, 2023 Category: Biochemistry Authors: Izumi Yanatori Fumio Kishi Shinya Toyokuni Source Type: research
Glutathione and Glutathione-dependent Enzymes: From Biochemistry to Gerontology and Successful Aging
Ageing Res Rev. 2023 Sep 6:102066. doi: 10.1016/j.arr.2023.102066. Online ahead of print.ABSTRACTThe tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous low-molecular weight thiol nucleophile and reductant of utmost importance, representing the central redox agent of most aerobic organisms. GSH has vital functions involving also antioxidant protection, detoxification, redox homeostasis, cell signaling, iron metabolism/homeostasis, DNA synthesis, gene expression, cysteine/protein metabolism, and cell proliferation/differentiation or death including apoptosis and ferroptosis. Various func...
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Domenico Lapenna Source Type: research
Treatment of salt from hides curing stage by electrocoagulation for use in the pickling stage of the tanning industry
Environ Res. 2023 Sep 6:117095. doi: 10.1016/j.envres.2023.117095. Online ahead of print.ABSTRACTThe raw materials for the tanning industry, namely hides and skins, are preserved (curing stage) and carried with common salt, i.e., sodium chloride (NaCl). Proceeding to conversion into leather, pickling is a key stage of the tannery process, which entails high demand of water and salt. In this work, the salt-derived brine (SdB) generated from the curing of hides was treated by iron-driven electrocoagulation (EC), aiming at its later application in the pickling stage of the tanning industry, promoting a transition to zero wast...
Source: Environmental Research - September 8, 2023 Category: Environmental Health Authors: Luana Sarinho Pedro Carvalho Diana Patoilo Jo ão Peres Ribeiro Jos é Baião da Cruz Joaquim Gai ão Catarina Marques Maria Isabel Nunes Source Type: research
Accelerated Atherosclerosis in Beta Thalassemia
Am J Physiol Heart Circ Physiol. 2023 Sep 8. doi: 10.1152/ajpheart.00306.2023. Online ahead of print.ABSTRACTChildren with Beta Thalassemia (BT) present with an increase in carotid intima-medial thickness, an early sign suggestive of premature atherosclerosis. However, it is unknown if there is a direct relationship between BT and atherosclerotic disease. To evaluate this, WT (littermates) and BT (Hbbth3/+) mice, both male and female, were placed on a 3-month high fat diet with low-density lipoprotein receptor suppression via overexpression of proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation ...
Source: Atherosclerosis - September 8, 2023 Category: Cardiology Authors: Julian Hurtado Hassan Sellak Giji Joseph Caitlin V Lewis Crystal R Naudin Sergio Garcia James Robert Wodicka David R Archer W Robert Taylor Source Type: research
Glutathione and Glutathione-dependent Enzymes: From Biochemistry to Gerontology and Successful Aging
Ageing Res Rev. 2023 Sep 6:102066. doi: 10.1016/j.arr.2023.102066. Online ahead of print.ABSTRACTThe tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous low-molecular weight thiol nucleophile and reductant of utmost importance, representing the central redox agent of most aerobic organisms. GSH has vital functions involving also antioxidant protection, detoxification, redox homeostasis, cell signaling, iron metabolism/homeostasis, DNA synthesis, gene expression, cysteine/protein metabolism, and cell proliferation/differentiation or death including apoptosis and ferroptosis. Various func...
Source: Ageing Research Reviews - September 8, 2023 Category: Genetics & Stem Cells Authors: Domenico Lapenna Source Type: research
