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Nutrition: Iron
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Initial characterization of an iron superoxide dismutase from Thermobifida fusca
In this study, a superoxide dismutase from the thermophilic bacteria Thermobifida fusca (TfSOD) was cloned and expressed before the recombinant enzyme was characterized. The enzyme was found to be active for superoxide dismutation measured by inhibition of cytochrome c oxidation and the inhibition of the autoxidation of pyrogallol. Its pH-optimum was determined to be 7.5, while it has a broad temperature optimum ranging from 20 to 90 °C. Combined with the Tm that was found to be 78.5 ± 0.5 °C at pH 8.0, TfSOD can be defined as a thermostable enzyme. Moreover, the crystal structure of TfSOD was determined and refined to ...
Source: Journal of Biological Inorganic Chemistry : JBIC - September 19, 2023 Category: Chemistry Authors: Anne Grethe Hamre Rim Al-Sadawi Kirsti Merete Johannesen Bastien Bisarro Åsmund Røhr Kjendseth Hanna-Kirsti S Leiros Morten S ørlie Source Type: research
Evaluation of genetic variants in ferroptosis-related genes and house dust mite-induced allergic rhinitis risk
CONCLUSIONS: These findings suggest that the genetic variants in ferroptosis-related genes ENPP2 and EPAS1 may increase HDM-induced AR risk and serve as potential predictors of HDM-induced AR susceptibility.PMID:37724950 | DOI:10.1016/j.intimp.2023.109707
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Yi-Fan Yang Rui Zheng Xiang Gu Fang Gao Min Chen Mu-Long Du Zheng-Dong Zhang Mei-Ping Lu Lei Cheng Source Type: research
Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model
Nanoscale. 2023 Sep 19. doi: 10.1039/d3nr02816j. Online ahead of print.ABSTRACTLocalized heat generation from manganese iron oxide nanoparticles (MIONPs) conjugated with chemotherapeutics under the exposure of an alternating magnetic field (magneto-chemotherapy) can revolutionize targeted breast cancer therapy. On the other hand, the lack of precise control of local temperature and adequate MIONP distribution in laboratory settings using the conventional two-dimensional (2D) cellular models has limited its further translation in tumor sites. Our current study explored advanced 3D in vitro tumor models as a promising altern...
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Satish S Phalake Sandeep B Somvanshi Syed A M Tofail Nanasaheb D Thorat Vishwajeet M Khot Source Type: research
A novel slow-release selenium approach for cadmium reduction and selenium enrichment in rice (Oryza sativa L.)
In this study, a novel slightly-soluble selenium (Se) fertilizer (SSF) was successfully applied to address the problems of Cd pollution in paddy soil and rice, and Se deficiency in human beings. The pot and field experiments showed that Cd content in the rice grains was reduced by 48.4%-82.89% and Se content was increased nearly by 30-fold comparing the control group. The application of SSF increased the soil pH and significantly reduced the DGT-extracted Cd in the soil. Moreover, DCB-extractable Fe content on the surface of roots was prompt by SSF, which formed a physical barrier, namely iron plaque (IP), to inhibit Cd tr...
Source: Chemosphere - September 19, 2023 Category: Chemistry Authors: Peicheng Huang Weichun Yang Qingzu Li Qi Liao Mengying Si Meiqing Shi Zhihui Yang Source Type: research
Comprehensive Analysis of Iron Deficiency Anemia and Its Related Disorders in Premenopausal Women Based on a Propensity Score Matching Case Control Study Using National Health Insurance Service Database in Korea
CONCLUSION: In this study, we found that the gynecologic disease is the main cause of IDA in premenopausal women. Gynecological evaluations should be performed more actively in the clinic to prevent and control IDA and IRDs.PMID:37724497 | DOI:10.3346/jkms.2023.38.e299
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Hyun Jung Lee Haeyong Pak Jae Joon Han Myung Hee Chang Source Type: research
Initial characterization of an iron superoxide dismutase from Thermobifida fusca
In this study, a superoxide dismutase from the thermophilic bacteria Thermobifida fusca (TfSOD) was cloned and expressed before the recombinant enzyme was characterized. The enzyme was found to be active for superoxide dismutation measured by inhibition of cytochrome c oxidation and the inhibition of the autoxidation of pyrogallol. Its pH-optimum was determined to be 7.5, while it has a broad temperature optimum ranging from 20 to 90 °C. Combined with the Tm that was found to be 78.5 ± 0.5 °C at pH 8.0, TfSOD can be defined as a thermostable enzyme. Moreover, the crystal structure of TfSOD was determined and refined to ...
Source: Journal of Biological Inorganic Chemistry : JBIC - September 19, 2023 Category: Chemistry Authors: Anne Grethe Hamre Rim Al-Sadawi Kirsti Merete Johannesen Bastien Bisarro Åsmund Røhr Kjendseth Hanna-Kirsti S Leiros Morten S ørlie Source Type: research
Comprehensive Analysis of Iron Deficiency Anemia and Its Related Disorders in Premenopausal Women Based on a Propensity Score Matching Case Control Study Using National Health Insurance Service Database in Korea
CONCLUSION: In this study, we found that the gynecologic disease is the main cause of IDA in premenopausal women. Gynecological evaluations should be performed more actively in the clinic to prevent and control IDA and IRDs.PMID:37724497 | PMC:PMC10506900 | DOI:10.3346/jkms.2023.38.e299
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Hyun Jung Lee Haeyong Pak Jae Joon Han Myung Hee Chang Source Type: research
Evaluation of genetic variants in ferroptosis-related genes and house dust mite-induced allergic rhinitis risk
CONCLUSIONS: These findings suggest that the genetic variants in ferroptosis-related genes ENPP2 and EPAS1 may increase HDM-induced AR risk and serve as potential predictors of HDM-induced AR susceptibility.PMID:37724950 | DOI:10.1016/j.intimp.2023.109707
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Yi-Fan Yang Rui Zheng Xiang Gu Fang Gao Min Chen Mu-Long Du Zheng-Dong Zhang Mei-Ping Lu Lei Cheng Source Type: research
An Investigation of Allyl-Substituted Bis(Diphosphine) Iron Complexes: Towards Precursors for Cooperative CO2 Activation
Chemistry. 2023 Sep 19:e202302721. doi: 10.1002/chem.202302721. Online ahead of print.ABSTRACTIn developing homogenous catalysts capable of CO2 activation, interaction with a metal center is often imperative. This work provides our primary efforts towards the cooperative activation of CO2 using a Lewis acidic secondary coordination sphere (SCS) and iron via a paired theoretical/experimental approach. Specifically, we report efforts towards [Fe(diphosphine)2(N2)] as a CO2-coordinated synthon where diphosphine = 1,2-bis(di(3-cyclohexylboraneyl)propylphosphino)ethane) (P2BCy4) or its precursor, tetrakisallyldiphosphinoethane ...
Source: Chemistry - September 19, 2023 Category: Chemistry Authors: Connor Durfy Joseph Zurakowski Gabriel Jobin Marcus W Drover Source Type: research
Impacts of Some Trace Metals in Cyprinus carpio (Linnaeus, 1758) and Tor soro (Valenciennes, 1842) on Human Health
Biol Trace Elem Res. 2023 Sep 19. doi: 10.1007/s12011-023-03852-4. Online ahead of print.ABSTRACTAlthough fish are rich sources of various trace metals in their bodies, when these metals exceed health safety limits, it becomes a global concern. Fish exposed to trace metal pollution in their aquatic ecosystems can lead to bioaccumulation and transfer to consumers. Monitoring trace metal contamination of fish food is crucial because they can reach humans through the aquatic food chain, resulting in health problems. Therefore, a first attempt was made for the analysis of trace metals in two cyprinid fish species, namely Cypri...
Source: Biological Trace Element Research - September 19, 2023 Category: Biology Authors: Nima Nazeer Zubia Masood Mourad Ben Said Tawseef Khan Asim Ullah Wajid Ali Ayman A Swelum Source Type: research
Exceptional peroxidase-like activity of an iron and copper based organic framework nanosheet for consecutive colorimetric biosensing of glucose and kanamycin in real food samples
Analyst, 2023, Advance Article DOI: 10.1039/D3AN01242E, PaperRajakumari Jesuraj, Arunjegan Amalraj, Vinoth Kumar Vaidyanathan, Panneerselvam Perumal Two-dimensional metal –organic framework nanosheets are attractive as peroxidase mimicking nanocatalysts due to their rich chemical functional groups, large surface area, high porosity, and accessible active sites. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - September 18, 2023 Category: Chemistry Authors: Rajakumari Jesuraj Source Type: research
Tert-Butyl Hydroperoxide induces Ferroptosis of Bone Mesenchymal Stem cells by repressing the Prominin2/BACH1/ROS axis
CONCLUSION: Our findings revealed a mechanism that the prominin2/BACH1/ROS axis participates in BMSCs ferroptosis and the strengthening of this axis is promising to subsist BMSCs after explantation.PMID:37721001 | DOI:10.1152/ajpcell.00224.2023
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Yuzhu Xu Pan Fan Xuanfei Xu Lei Liu Lele Zhang Xi Li Jiadong Wang Yuao Tao Xiaolong Li Dandan Xu Xiaohui Wang Yan Zhou Yuntao Wang Source Type: research
