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Exposure to normobaric hypoxia shapes the acute inflammatory response in human whole blood cells in vivo
Pflugers Arch. 2024 May 7. doi: 10.1007/s00424-024-02969-2. Online ahead of print.ABSTRACTCells of the immune defence, especially leukocytes, often have to perform their function in tissue areas that are characterized by oxygen deficiency, so-called hypoxia. Physiological hypoxia significantly affects leukocyte function and controls the innate and adaptive immune response mainly through transcriptional gene regulation via the hypoxia-inducible factors (HIFs). Multiple pathogens including components of bacteria, such as lipopolysaccharides (LPS) trigger the activation of leukocytes. HIF pathway activation enables immune cel...
Source: Pflugers Archiv : European Journal of Physiology - May 7, 2024 Category: Physiology Authors: Tina Sch önberger Marie Jakobs Anna-Lena Friedel Tina H örbelt-Grünheidt Bastian Tebbe Oliver Witzke Manfred Schedlowski Joachim Fandrey Source Type: research

Correction to: pH ‑regulated single cell migration
Pflugers Arch. 2024 May 8. doi: 10.1007/s00424-024-02970-9. Online ahead of print.NO ABSTRACTPMID:38714573 | DOI:10.1007/s00424-024-02970-9 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - May 7, 2024 Category: Physiology Authors: Christian Stock Source Type: research

Long-term continuous monitoring of arrhythmias in pigs with insertable cardiac monitors
Pflugers Arch. 2024 May 4. doi: 10.1007/s00424-024-02962-9. Online ahead of print.ABSTRACTArrhythmia detection is essential when assessing the safety of novel drugs and therapies in preclinical studies. Many short-term arrhythmia monitoring methods exist, including non-invasive ECG and Holter. However, there are no reliable, long-term, non-invasive, or minimally invasive methods for cardiac arrhythmia follow-up in large animals that allows free movement with littermates. A long follow-up time is needed when estimating the impact of long-lasting drugs or therapies, such as gene therapy. We evaluated the feasibility and perf...
Source: Pflugers Archiv : European Journal of Physiology - May 4, 2024 Category: Physiology Authors: Jonna Airaksinen Satu Siimes Juha Hartikainen Seppo Yl ä-Herttuala Source Type: research

SGLT2 inhibitor as a potential therapeutic approach in hyperthyroidism-induced cardiopulmonary injury in rats
This study intended to investigate the potential therapeutic effect of SGLT2-I on hyperthyroidism-related cardiopulmonary injury, targeting the possible underlying mechanisms. The impact of the SGLT2-I, dapagliflozin (DAPA), (1 mg/kg/day, p.o) on LT4 (0.3 mg/kg/day, i.p)-induced cardiopulmonary injury was investigated in rats. The body weight, ECG, and serum hormones were evaluated. Also, redox balance, DNA fragmentation, inflammatory cytokines, and PCR quantification in heart and lung tissues were employed to investigate the effect of DAPA in experimentally induced hyperthyroid rats along with histological and immunohisto...
Source: Pflugers Archiv : European Journal of Physiology - May 3, 2024 Category: Physiology Authors: Nermeen Bastawy Aliaa E M K El-Mosallamy Samira H Aljuaydi Huda O AbuBakr Rabab Ahmed Rasheed A S Sadek R T Khattab Wael Botros Abualyamin Shereen E Abdelaal Amy F Boushra Source Type: research

Cardiac hypertrophy that affects hyperthyroidism occurs independently of the NLRP3 inflammasome
Pflugers Arch. 2024 Apr 29. doi: 10.1007/s00424-024-02965-6. Online ahead of print.ABSTRACTCardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation. Hypert...
Source: Pflugers Archiv : European Journal of Physiology - April 28, 2024 Category: Physiology Authors: Aline Cristina Parletta Gabriela Cavazza Cerri Claudia Ribeiro Borba Gasparini Karine Panico Denival Nascimento Vieira-Junior Larissa Maria Zacarias-Rodrigues Nathalia Senger Amanda de Almeida Silva Marina Fevereiro Gabriela Placon á Diniz Maria Cl áudi Source Type: research

Angiotensin receptors and α < sub > 1B < /sub > -adrenergic receptors regulate native IK < sub > (ACh) < /sub > and phosphorylation-deficient GIRK4 (S418A) channels through different PKC isoforms
Pflugers Arch. 2024 Apr 24. doi: 10.1007/s00424-024-02966-5. Online ahead of print.ABSTRACTSignaling of G protein-activated inwardly rectifying K+ (GIRK) channels is an important mechanism of the parasympathetic regulation of the heart rate and cardiac excitability. GIRK channels are inhibited during stimulation of Gq-coupled receptors (GqPCRs) by depletion of phosphatidyl-4,5-bisphosphate (PIP2) and/or channel phosphorylation by protein kinase C (PKC). The GqPCR-dependent modulation of GIRK currents in terms of specific PKC isoform activation was analyzed in voltage-clamp experiments in rat atrial myocytes and in CHO or H...
Source: Pflugers Archiv : European Journal of Physiology - April 24, 2024 Category: Physiology Authors: Leonie Inderwiedenstra ße Marie-C écile Kienitz Source Type: research