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The mighty proton
Pflugers Arch. 2024 Mar 9. doi: 10.1007/s00424-024-02942-z. Online ahead of print.NO ABSTRACTPMID:38460007 | DOI:10.1007/s00424-024-02942-z (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - March 9, 2024 Category: Physiology Authors: Carsten A Wagner Pedro H Imenez Silva Source Type: research

Locally applied heat stress during exercise training may promote adaptations to mitochondrial enzyme activities in skeletal muscle
Pflugers Arch. 2024 Mar 6. doi: 10.1007/s00424-024-02939-8. Online ahead of print.ABSTRACTThere is some evidence for temperature-dependent stimulation of mitochondrial biogenesis; however, the role of elevated muscle temperature during exercise in mitochondrial adaptation to training has not been studied in humans in vivo. The purpose of this study was to determine the role of elevating muscle temperature during exercise in temperate conditions through the application of mild, local heat stress on mitochondrial adaptations to endurance training. Eight endurance-trained males undertook 3 weeks of supervised cycling training...
Source: Pflugers Archiv : European Journal of Physiology - March 6, 2024 Category: Physiology Authors: Ed Maunder Andrew King Jeffrey A Rothschild Matthew J Brick Warren B Leigh Christopher P Hedges Troy L Merry Andrew E Kilding Source Type: research

New functions and roles of the Na < sup > + < /sup > -H < sup > + < /sup > -exchanger NHE3
Pflugers Arch. 2024 Mar 7. doi: 10.1007/s00424-024-02938-9. Online ahead of print.ABSTRACTThe sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney, where it contributes to hydrogen secretion and sodium (re)absorption. The roles of this transporter have been studied by the use of the respective knockout mice and by using pharmacological inhibitors. Whole-body NHE3 knockout mice suffer from a high mortality rate (with only ∼30% of mice surviving into adulthood), and based on the expression of NHE3 in both intestine and kidney, some conclusions that were originally derived were based on this...
Source: Pflugers Archiv : European Journal of Physiology - March 6, 2024 Category: Physiology Authors: Jessica A Dominguez Rieg Timo Rieg Source Type: research

State of knowledge on ammonia handling by the kidney
Pflugers Arch. 2024 Mar 7. doi: 10.1007/s00424-024-02940-1. Online ahead of print.ABSTRACTThe disposal of ammonia, the main proton buffer in the urine, is important for acid-base homeostasis. Renal ammonia excretion is the predominant contributor to renal net acid excretion, both under basal condition and in response to acidosis. New insights into the mechanisms of renal ammonia production and transport have been gained in the past decades. Ammonia is the only urinary solute known to be produced in the kidney and selectively transported through the different parts of the nephron. Both molecular forms of total ammonia, NH3 ...
Source: Pflugers Archiv : European Journal of Physiology - March 6, 2024 Category: Physiology Authors: Soline Bourgeois Pascal Houillier Source Type: research