Pflugers Archiv : European Journal of Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Optogenetics meets physiology
Pflugers Arch. 2023 Dec 4. doi: 10.1007/s00424-023-02887-9. Online ahead of print.NO ABSTRACTPMID:38047968 | DOI:10.1007/s00424-023-02887-9 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - December 4, 2023 Category: Physiology Authors: Sophia Ohnemus Johannes Vierock Franziska Schneider-Warme Source Type: research

Potential regulatory role of PGC-1 α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models
Pflugers Arch. 2023 Dec 4. doi: 10.1007/s00424-023-02890-0. Online ahead of print.ABSTRACTHigh-fat diet (HFD) feeding in rodents has become an essential tool to critically analyze and study the pathological effects of obesity, including mitochondrial dysfunction and insulin resistance. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) regulates cellular energy metabolism to influence insulin sensitivity, beyond its active role in stimulating mitochondrial biogenesis to facilitate skeletal muscle adaptations in response to HFD feeding. Here, some of the major electronic databases like PubMed, Embase, a...
Source: Pflugers Archiv : European Journal of Physiology - December 3, 2023 Category: Physiology Authors: Sinenhlanhla X H Mthembu Sithandiwe E Mazibuko-Mbeje Khanyisani Ziqubu Ndivhuwo Muvhulawa Fabio Marcheggiani Ilenia Cirilli Bongani B Nkambule Christo J F Muller Albertus K Basson Luca Tiano Phiwayinkosi V Dludla Source Type: research

Modulating signalling lifetime to optimise a prototypical animal opsin for optogenetic applications
Pflugers Arch. 2023 Dec 1. doi: 10.1007/s00424-023-02879-9. Online ahead of print.ABSTRACTAnimal opsins are light activated G-protein-coupled receptors, capable of optogenetic control of G-protein signalling for research or therapeutic applications. Animal opsins offer excellent photosensitivity, but their temporal resolution can be limited by long photoresponse duration when expressed outside their native cellular environment. Here, we explore methods for addressing this limitation for a prototypical animal opsin (human rod opsin) in HEK293T cells. We find that the application of the canonical rhodopsin kinase (GRK1)/visu...
Source: Pflugers Archiv : European Journal of Physiology - November 30, 2023 Category: Physiology Authors: Jessica Rodgers Phillip Wright Edward R Ballister Rebecca B Hughes Riccardo Storchi Jonathan Wynne Franck P Martial Robert J Lucas Source Type: research

GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome
In conclusion, SCN5A-G1661R produces dysfunctional channels and associates with BrS. SCN5A mediated currents are modulated by co-expression of GDP1L and this interaction is altered by mutations in both proteins. Thus, additive genetic burden may aggravate disease severity, explaining higher arrhythmogenicity in double mutation carriers.PMID:38036776 | DOI:10.1007/s00424-023-02882-0 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - November 30, 2023 Category: Physiology Authors: Francesca Semino Fabrice F Darche Claus Bruehl Michael Koenen Heyko Skladny Hugo A Katus Norbert Frey Andreas Draguhn Patrick A Schweizer Source Type: research

The T-type calcium channelosome
Pflugers Arch. 2023 Dec 1. doi: 10.1007/s00424-023-02891-z. Online ahead of print.ABSTRACTT-type calcium channels perform crucial physiological roles across a wide spectrum of tissues, spanning both neuronal and non-neuronal system. For instance, they serve as pivotal regulators of neuronal excitability, contribute to cardiac pacemaking, and mediate the secretion of hormones. These functions significantly hinge upon the intricate interplay of T-type channels with interacting proteins that modulate their expression and function at the plasma membrane. In this review, we offer a panoramic exploration of the current knowledge...
Source: Pflugers Archiv : European Journal of Physiology - November 30, 2023 Category: Physiology Authors: Norbert Weiss Gerald W Zamponi Source Type: research

Reinhardt R üdel : Muscle physiologist, mentor, role model
Pflugers Arch. 2023 Nov 28. doi: 10.1007/s00424-023-02886-w. Online ahead of print.NO ABSTRACTPMID:38015255 | DOI:10.1007/s00424-023-02886-w (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - November 28, 2023 Category: Physiology Authors: Christoph Fahlke Source Type: research