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Correction to: Liraglutide versus pramlintide in protecting against cognitive function impairment through affecting PI3K/AKT/GSK ‑3β/TTBK1 pathway and decreasing Tau hyperphosphorylation in high‑fat dietstreptozocin rat model
Pflugers Arch. 2024 Apr 5. doi: 10.1007/s00424-024-02959-4. Online ahead of print.NO ABSTRACTPMID:38575720 | DOI:10.1007/s00424-024-02959-4 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - April 4, 2024 Category: Physiology Authors: Hoda M Moghazy Nesreen G Abdelhaliem Sherine Ahmed Mohammed Asmaa Hassan Amany Abdelrahman Source Type: research

Phosphatidylserine externalization as immune checkpoint in cancer
Pflugers Arch. 2024 Apr 4. doi: 10.1007/s00424-024-02948-7. Online ahead of print.ABSTRACTCancer is the second leading cause of mortality worldwide. Despite recent advances in cancer treatment including immunotherapy with immune checkpoint inhibitors, new unconventional biomarkers and targets for the detection, prognosis, and treatment of cancer are still in high demand. Tumor cells are characterized by mutations that allow their unlimited growth, program their local microenvironment to support tumor growth, and spread towards distant sites. While a major focus has been on altered tumor genomes and proteomes, crucial signa...
Source: Pflugers Archiv : European Journal of Physiology - April 4, 2024 Category: Physiology Authors: Ivan-Maximiliano Kur Andreas Weigert Source Type: research

Hypoxia-inducible factor-driven glycolytic adaptations in host-microbe interactions
Pflugers Arch. 2024 Apr 4. doi: 10.1007/s00424-024-02953-w. Online ahead of print.ABSTRACTMammalian cells utilize glucose as a primary carbon source to produce energy for most cellular functions. However, the bioenergetic homeostasis of cells can be perturbed by environmental alterations, such as changes in oxygen levels which can be associated with bacterial infection. Reduction in oxygen availability leads to a state of hypoxia, inducing numerous cellular responses that aim to combat this stress. Importantly, hypoxia strongly augments cellular glycolysis in most cell types to compensate for the loss of aerobic respiratio...
Source: Pflugers Archiv : European Journal of Physiology - April 3, 2024 Category: Physiology Authors: Emily DeMichele Andre G Buret Cormac T Taylor Source Type: research

The extracellular matrix protein fibronectin promotes metanephric kidney development
In conclusion, the ECM protein fibronectin acts as a regulator of kidney development and is a determinant of the final nephron number.PMID:38563997 | DOI:10.1007/s00424-024-02954-9 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - April 2, 2024 Category: Physiology Authors: Kathrin Skoczynski Andre Kraus Christoph Daniel Maike B üttner-Herold Kerstin Amann Mario Schiffer Kristina Hermann Leonie Herrnberger-Eimer Ernst R Tamm Bjoern Buchholz Source Type: research

Oscillatory work and the step that generates force in single myofibrils from rabbit psoas
Pflugers Arch. 2024 Apr 1. doi: 10.1007/s00424-024-02935-y. Online ahead of print.ABSTRACTThe elementary molecular step that generates force by cross-bridges (CBs) in active muscles has been under intense investigation in the field of muscle biophysics. It is known that an increase in the phosphate (Pi) concentration diminishes isometric force in active fibers, indicating a tight coupling between the force generation step and the Pi release step. The question asked here is whether the force generation occurs before Pi release or after release. We investigated the effect of Pi on oscillatory work production in single myofib...
Source: Pflugers Archiv : European Journal of Physiology - April 1, 2024 Category: Physiology Authors: Masataka Kawai Bogdan Iorga Source Type: research

The pain target Na < sub > V < /sub > 1.7 is expressed late during human iPS cell differentiation into sensory neurons as determined in high-resolution imaging
Pflugers Arch. 2024 Mar 27. doi: 10.1007/s00424-024-02945-w. Online ahead of print.ABSTRACTHuman-induced pluripotent stem cells (iPS cells) are efficiently differentiated into sensory neurons. These cells express the voltage-gated sodium channel NaV1.7, which is a validated pain target. NaV1.7 deficiency leads to pain insensitivity, whereas NaV1.7 gain-of-function mutants are associated with chronic pain. During differentiation, the sensory neurons start spontaneous action potential firing around day 22, with increasing firing rate until day 40. Here, we used CRISPR/Cas9 genome editing to generate a HA-tag NaV1.7 to follow...
Source: Pflugers Archiv : European Journal of Physiology - March 28, 2024 Category: Physiology Authors: Yi Liu Rachna Balaji Marcelo A Szymanski de Toledo Sabrina Ernst Petra Hautvast Aylin B Kesdo ğan Jannis K örner Martin Zenke Anika Neureiter Angelika Lampert Source Type: research

The ex vivo perfused mouse adrenal gland-a new model to study aldosterone secretion
Pflugers Arch. 2024 Mar 28. doi: 10.1007/s00424-024-02950-z. Online ahead of print.ABSTRACTAldosterone is a steroid hormone that is important for maintaining the volume and ionic composition of extracellular fluids and is produced in the zona glomerulosa of the adrenal cortex. The basic mechanisms controlling aldosterone secretion are known. However, more detailed studies on the regulation of aldosterone secretion often fail due to the lack of suitable models: although secretion can be studied in cultured adrenocortical cells under defined conditions, the differentiation status of the cells is difficult to control and the ...
Source: Pflugers Archiv : European Journal of Physiology - March 28, 2024 Category: Physiology Authors: Allein Plain Laura Kn ödl Ines Tegtmeier Sascha Bandulik Richard Warth Source Type: research