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Role of cytosolic and endoplasmic reticulum Ca 2+ in pancreatic beta-cells: pros and cons
Pflugers Arch. 2023 Nov 9. doi: 10.1007/s00424-023-02872-2. Online ahead of print.ABSTRACTPancreatic beta cells utilize Ca2+ to secrete insulin in response to glucose. The glucose-dependent increase in cytosolic Ca2+ concentration ([Ca2+]C) activates a series of insulin secretory machinery in pancreatic beta cells. Therefore, the amount of insulin secreted in response to glucose is determined in a [Ca2+]C-dependent manner, at least within a moderate range. However, the demand for insulin secretion may surpass the capability of beta cells. Abnormal elevation of [Ca2+]C levels beyond the beta-cell endurance capacity can dama...
Source: Pflugers Archiv : European Journal of Physiology - November 8, 2023 Category: Physiology Authors: Seung-Eun Song Su-Kyung Shin Hyeon Yeong Ju Seung-Soon Im Dae-Kyu Song Source Type: research

Zebrafish cardiac repolarization does not functionally depend on the expression of the hERG1b-like transcript
Pflugers Arch. 2023 Nov 7. doi: 10.1007/s00424-023-02875-z. Online ahead of print.ABSTRACTZebrafish provide a translational model of human cardiac function. Their similar cardiac electrophysiology enables screening of human cardiac repolarization disorders, drug arrhythmogenicity, and novel antiarrhythmic therapeutics. However, while zebrafish cardiac repolarization is driven by delayed rectifier potassium channel current (IKr), the relative role of alternate channel transcripts is uncertain. While human ether-a-go-go-related-gene-1a (hERG1a) is the dominant transcript in humans, expression of the functionally distinct alt...
Source: Pflugers Archiv : European Journal of Physiology - November 7, 2023 Category: Physiology Authors: Christine E Genge Padmapriya Muralidharan Jake Kemp Christina M Hull Mandy Yip Kyle Simpson Diana V Hunter Thomas W Claydon Source Type: research

Effect of salivary gland removal on taste preference in mice
Pflugers Arch. 2023 Nov 3. doi: 10.1007/s00424-023-02873-1. Online ahead of print.ABSTRACTTo evaluate the effect of decreased salivary secretion on taste preference, we investigated taste preference for five basic tastes by a 48 h two-bottle preference test using a mouse model (desalivated mice) that underwent surgical removal of three major salivary glands: the parotid, submandibular, and sublingual glands. In the desalivated mice, the avoidance behaviors for bitter and salty tastes and the attractive behaviors for sweet and umami tastes were significantly decreased. We confirmed that saliva is necessary to maintain norma...
Source: Pflugers Archiv : European Journal of Physiology - November 3, 2023 Category: Physiology Authors: Masataka Narukawa Rina Matsuda Ippei Watari Takashi Ono Takumi Misaka Source Type: research

Correction to: The context ‑dependent role of the Na + /Ca 2+ ‑exchanger (NCX) in pancreatic stellate cell migration
Pflugers Arch. 2023 Nov 3. doi: 10.1007/s00424-023-02874-0. Online ahead of print.NO ABSTRACTPMID:37922097 | DOI:10.1007/s00424-023-02874-0 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - November 3, 2023 Category: Physiology Authors: Thorsten Loeck Micol Rugi Luca Matteo Todesca Paulina Kalinowska Benjamin Soret Ilka Neumann Sandra Schimmelpfennig Karolina Najder Zolt án Pethő Valerio Farfariello Natalia Prevarskaya Albrecht Schwab Source Type: research

Cigarette smoke extract induces foam cell formation by impairing machinery involved in lipid droplet degradation
Pflugers Arch. 2023 Nov 1. doi: 10.1007/s00424-023-02870-4. Online ahead of print.ABSTRACTThe formation of foam cells, lipid-loaded macrophages, is the hallmark event of atherosclerosis. Since cigarette smoking is a risk factor for developing atherosclerosis, the current study investigated the effects of cigarette smoke extract (CSE) on different events like expressions of genes involved in lipid influx and efflux, lipophagy, etc., that play vital roles in foam cell formation. The accumulation of lipids after CSE treatment U937 macrophage cells was examined by staining lipids with specific dyes: Oil red O and BODIPY493/503...
Source: Pflugers Archiv : European Journal of Physiology - November 1, 2023 Category: Physiology Authors: Soudipta Pramanik Alok Kumar Sil Source Type: research