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Evaluation of skeletal muscle function in male rats with doxorubicin-induced myopathy following various exercise techniques: the significant role of glucose transporter 4
Pflugers Arch. 2024 Feb 17. doi: 10.1007/s00424-024-02922-3. Online ahead of print.ABSTRACTA common anthracycline antibiotic used to treat cancer patients is doxorubicin (DOX). One of the effects of DOX therapy is skeletal muscle fatigue. Our goal in this research was to study the beneficial effect of exercise on DOX-induced damaged muscle fibers and compare the effect of different exercise strategies (prophylactic, post- toxicity and combined) on DOX toxicity. Five groups were created from 40 male rats: group I, control group; group II, DOX was administered intraperitoneally for 2 weeks over 6 equal injections (each 2.5 m...
Source: Pflugers Archiv : European Journal of Physiology - February 17, 2024 Category: Physiology Authors: Eman Osama Effat Khowailed L Rashed A Fawzy Rokia Mohamad Hassan Inas Harb Muhammad Maher Source Type: research

Intertwined regulators: hypoxia pathway proteins, microRNAs, and phosphodiesterases in the control of steroidogenesis
Pflugers Arch. 2024 Feb 15. doi: 10.1007/s00424-024-02921-4. Online ahead of print.ABSTRACTOxygen sensing is of paramount importance for maintaining cellular and systemic homeostasis. In response to diminished oxygen levels, the hypoxia-inducible factors (HIFs) orchestrate various biological processes. These pivotal transcription factors have been identified as key regulators of several biological events. Notably, extensive research from our group and others has demonstrated that HIF1α exerts an inverse regulatory effect on steroidogenesis, leading to the suppression of crucial steroidogenic enzyme expression and a subseq...
Source: Pflugers Archiv : European Journal of Physiology - February 14, 2024 Category: Physiology Authors: Stephen Ariyeloye Susanne K ämmerer Erik Klapproth Ben Wielockx Ali El-Armouche Source Type: research

Recent advances in acid sensing by G protein coupled receptors
Pflugers Arch. 2024 Feb 10. doi: 10.1007/s00424-024-02919-y. Online ahead of print.ABSTRACTChanges in extracellular proton concentrations occur in a variety of tissues over a range of timescales under physiological conditions and also accompany virtually all pathologies, notably cancers, stroke, inflammation and trauma. Proton-activated, G protein coupled receptors are already partially active at physiological extracellular proton concentrations and their activity increases with rising proton concentrations. Their ability to monitor and report changes in extracellular proton concentrations and hence extracellular pH appear...
Source: Pflugers Archiv : European Journal of Physiology - February 10, 2024 Category: Physiology Authors: Maike D Glitsch Source Type: research

Acid-base transporters in the context of tumor heterogeneity
Pflugers Arch. 2024 Feb 9. doi: 10.1007/s00424-024-02918-z. Online ahead of print.ABSTRACTThe copious metabolic acid production and -extrusion by cancer cells render poorly vascularized regions of solid tumors highly acidic. A growing list of proton - and bicarbonate transporters has been suggested to contribute to net acid extrusion from cancer cells, and/or been shown to be dysregulated and favor malignant development in various cancers. The great majority of these roles have been studied at the level of the cancer cells. However, recent advances in understanding of the cellular and physicochemical heterogeneity of solid...
Source: Pflugers Archiv : European Journal of Physiology - February 8, 2024 Category: Physiology Authors: Stine Helene Falsig Pedersen Source Type: research

Renal and cardiac effects of the PDE9 inhibitor BAY 73-6691 in 5/6 nephrectomized rats
Pflugers Arch. 2024 Feb 2. doi: 10.1007/s00424-024-02915-2. Online ahead of print.ABSTRACTIt has been suggested that the novel selective phosphodiesterase 9 (PDE9) inhibitor may improve cardiac and renal function by blocking 3',5'-cyclic guanosine monophosphate (cGMP) degradation. 5/6 nephrectomized (5/6Nx) rats were used to investigate the effects of the PDE9 inhibitor (BAY 73-6691) on the heart and kidney. Two doses of BAY 73-6691 (1 mg/kg/day and 5 mg/kg/day) were given for 95 days. The 5/6Nx rats developed albuminuria, a decrease in serum creatinine clearance (Ccr), and elevated serum troponin T levels. Echocardiograph...
Source: Pflugers Archiv : European Journal of Physiology - February 2, 2024 Category: Physiology Authors: Xin Chen Denis Deli ć Yaochen Cao Zeyu Zhang Hongwei Wu Ahmed A Hasan Mohamed M S Gaballa Lianghong Yin Bernhard K Kr ämer Thomas Klein Xin Shi Ben He Linghong Shen Berthold Hocher Source Type: research

Effects of physical training on hypothalamic neuronal activation and expressions of vasopressin and oxytocin in SHR after running until fatigue
Pflugers Arch. 2024 Mar;476(3):365-377. doi: 10.1007/s00424-024-02916-1. Epub 2024 Feb 3.ABSTRACTTo assess the influence of physical training on neuronal activation and hypothalamic expression of vasopressin and oxytocin in spontaneously hypertensive rats (SHR), untrained and trained normotensive rats and SHR were submitted to running until fatigue while internal body and tail temperatures were recorded. Hypothalamic c-Fos expression was evaluated in thermoregulatory centers such as the median preoptic nucleus (MnPO), medial preoptic nucleus (mPOA), paraventricular nucleus of the hypothalamus (PVN), and supraoptic nucleus ...
Source: Pflugers Archiv : European Journal of Physiology - February 2, 2024 Category: Physiology Authors: Henrique P Santiago Laura H R Leite Paulo M A Lima Daniela R C F óscolo Ant ônio José Natali Thales Nicolau Pr ímola-Gomes Raphael E Szawka C ândido C Coimbra Source Type: research

Cargo-specific effects of hypoxia on clathrin-mediated trafficking
Pflugers Arch. 2024 Jan 31. doi: 10.1007/s00424-024-02911-6. Online ahead of print.ABSTRACTClathrin-associated trafficking is a major mechanism for intracellular communication, as well as for cells to communicate with the extracellular environment. A decreased oxygen availability termed hypoxia has been described to influence this mechanism in the past. Mostly biochemical studies were applied in these analyses, which miss spatiotemporal information. We have applied live cell microscopy and a newly developed analysis script in combination with a GFP-tagged clathrin-expressing cell line to obtain insight into the dynamics of...
Source: Pflugers Archiv : European Journal of Physiology - January 31, 2024 Category: Physiology Authors: Gijsbert J van Belle Anke Zieseniss Doris Heidenreich Maxime Olmos Asia Zhuikova Wiebke M öbius Maarten W Paul D örthe M Katschinski Source Type: research

Dietary acid load in health and disease
Pflugers Arch. 2024 Jan 29. doi: 10.1007/s00424-024-02910-7. Online ahead of print.ABSTRACTMaintaining an appropriate acid-base equilibrium is crucial for human health. A primary influencer of this equilibrium is diet, as foods are metabolized into non-volatile acids or bases. Dietary acid load (DAL) is a measure of the acid load derived from diet, taking into account both the potential renal acid load (PRAL) from food components like protein, potassium, phosphorus, calcium, and magnesium, and the organic acids from foods, which are metabolized to bicarbonate and thus have an alkalinizing effect. Current Western diets are ...
Source: Pflugers Archiv : European Journal of Physiology - January 28, 2024 Category: Physiology Authors: Michiel L A J Wie ërs Beverley Beynon-Cobb Wesley J Visser Ilias Attaye Source Type: research

Metabolic acidosis in chronic kidney disease: mere consequence or also culprit?
Pflugers Arch. 2024 Jan 27. doi: 10.1007/s00424-024-02912-5. Online ahead of print.ABSTRACTMetabolic acidosis is a frequent complication in non-transplant chronic kidney disease (CKD) and after kidney transplantation. It occurs when net endogenous acid production exceeds net acid excretion. While nephron loss with reduced ammoniagenesis is the main cause of acid retention in non-transplant CKD patients, additional pathophysiological mechanisms are likely inflicted in kidney transplant recipients. Functional tubular damage by calcineurin inhibitors seems to play a key role causing renal tubular acidosis. Notably, experiment...
Source: Pflugers Archiv : European Journal of Physiology - January 27, 2024 Category: Physiology Authors: Christian Kuhn Nilufar Mohebbi Alexander Ritter Source Type: research

Histamine H < sub > 2 < /sub > -receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II-hypertensive mice
Pflugers Arch. 2024 Mar;476(3):307-321. doi: 10.1007/s00424-024-02909-0. Epub 2024 Jan 27.ABSTRACTAldosterone through the mineralocorticoid receptor MR has detrimental effects on cardiovascular disease. It reduces the bioavailability of nitric oxide and impairs endothelium-dependent vasodilatation. In resistance arteries, aldosterone impairs the sensitivity of vascular smooth muscle cells to nitric oxide by promoting the local secretion of histamine which activates H2 receptors. The present experiments tested in vivo and ex vivo the hypothesis that systemic H2-receptor antagonism reduces arterial blood pressure and improve...
Source: Pflugers Archiv : European Journal of Physiology - January 27, 2024 Category: Physiology Authors: Kasper B Assersen Boye L Jensen Camilla Enggaard Paul M Vanhoutte Pernille B L Hansen Source Type: research

The mechanism of 25-hydroxycholesterol-mediated suppression of atrial β1-adrenergic responses
Pflugers Arch. 2024 Mar;476(3):407-421. doi: 10.1007/s00424-024-02913-4. Epub 2024 Jan 22.ABSTRACT25-Hydroxycholesterol (25HC) is a biologically active oxysterol, whose production greatly increases during inflammation by macrophages and dendritic cells. The inflammatory reactions are frequently accompanied by changes in heart regulation, such as blunting of the cardiac β-adrenergic receptor (AR) signaling. Here, the mechanism of 25HC-dependent modulation of responses to β-AR activation was studied in the atria of mice. 25HC at the submicromolar levels decreased the β-AR-mediated positive inotropic effect and enhancement...
Source: Pflugers Archiv : European Journal of Physiology - January 22, 2024 Category: Physiology Authors: Julia G Odnoshivkina Alexey S Averin Ildar R Khakimov Nazar A Trusov Diliara A Trusova Alexey M Petrov Source Type: research

The renin angiotensin aldosterone system
Pflugers Arch. 2024 Jan 17. doi: 10.1007/s00424-024-02908-1. Online ahead of print.ABSTRACTIn this review, we will cover (i) the proteolytic cascade of the RAAS, (ii) its regulation by multiple feedback-controlled parameters, and (iii) the major effects of the RAAS. For the effects of the RAAS, we focus on the role of the RAAS in the regulation of volume homeostasis and vascular tone, as major determinants of arterial blood pressure.PMID:38233636 | DOI:10.1007/s00424-024-02908-1 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - January 17, 2024 Category: Physiology Authors: Hannah Triebel Hayo Castrop Source Type: research