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Modulating cardiac physiology in engineered heart tissue with the bidirectional optogenetic tool BiPOLES
Pflugers Arch. 2023 Oct 21. doi: 10.1007/s00424-023-02869-x. Online ahead of print.ABSTRACTOptogenetic actuators are rapidly advancing tools used to control physiology in excitable cells, such as neurons and cardiomyocytes. In neuroscience, these tools have been used to either excite or inhibit neuronal activity. Cell type-targeted actuators have allowed to study the function of distinct cell populations. Whereas the first described cation channelrhodopsins allowed to excite specific neuronal cell populations, anion channelrhodopsins were used to inhibit neuronal activity. To allow for simultaneous excitation and inhibitio...
Source: Pflugers Archiv : European Journal of Physiology - October 20, 2023 Category: Physiology Authors: Barbora Schwarzov á Tim St üdemann Muhammed S önmez Judith R össinger Bangfen Pan Thomas Eschenhagen Justus Stenzig J Simon Wiegert Torsten Christ Florian Weinberger Source Type: research

Direct investigation of cell contraction signal networks by light-based perturbation methods
Pflugers Arch. 2023 Oct 18. doi: 10.1007/s00424-023-02864-2. Online ahead of print.ABSTRACTCell contraction plays an important role in many physiological and pathophysiological processes. This includes functions in skeletal, heart, and smooth muscle cells, which lead to highly coordinated contractions of multicellular assemblies, and functions in non-muscle cells, which are often highly localized in subcellular regions and transient in time. While the regulatory processes that control cell contraction in muscle cells are well understood, much less is known about cell contraction in non-muscle cells. In this review, we focu...
Source: Pflugers Archiv : European Journal of Physiology - October 18, 2023 Category: Physiology Authors: Perihan Nalbant Jessica Wagner Leif Dehmelt Source Type: research

Excitation-secretion coupling in chromaffin cells of the adrenal gland: Where does calcium come from?
Pflugers Arch. 2023 Oct 16. doi: 10.1007/s00424-023-02867-z. Online ahead of print.NO ABSTRACTPMID:37843577 | DOI:10.1007/s00424-023-02867-z (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - October 16, 2023 Category: Physiology Authors: Petronel Tuluc Emilio Carbone Source Type: research

Effect of a resistance exercise at acute moderate altitude on muscle health biomarkers
We examined the effect of acute moderate terrestrial hypoxia on metabolic, inflammation, antioxidant capacity and muscle atrophy biomarkers after a single RT session in a young male population. Twenty healthy volunteers allocated to the normoxia (N < 700 m asl) or moderate altitude (HH = 2320 m asl) group participated in this study. Before and throughout the 30 min following the RT session (3 × 10 reps, 90 s rest, 70% 1RM), venous blood samples were taken and analysed for circulating calcium, inorganic phosphate, cytokines (IL-6, IL-10 and TNF-α), total antioxidant capacity (TAC) and myostatin. Main results displayed ...
Source: Pflugers Archiv : European Journal of Physiology - October 10, 2023 Category: Physiology Authors: Sergio P érez-Regalado Josefa Le ón Paulino Padial Cristina Benavente Jose D Puentes-Pardo Filipa Almeida Bel én Feriche Source Type: research

Spatial and temporal aspects of neuronal calcium and sodium signals measured with low-affinity fluorescent indicators
Pflugers Arch. 2023 Oct 6. doi: 10.1007/s00424-023-02865-1. Online ahead of print.ABSTRACTLow-affinity fluorescent indicators for Ca2+ or Na+ allow measuring the dynamics of intracellular concentration of these ions with little perturbation from physiological conditions because they are weak buffers. When using synthetic indicators, which are small molecules with fast kinetics, it is also possible to extract spatial and temporal information on the sources of ion transients, their localization, and their disposition. This review examines these important aspects from the biophysical point of view, and how they have been rece...
Source: Pflugers Archiv : European Journal of Physiology - October 5, 2023 Category: Physiology Authors: Marco Canepari William N Ross Source Type: research