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Normobaric hypoxia shows enhanced FOXO1 signaling in obese mouse gastrocnemius muscle linked to metabolism and muscle structure and neuromuscular innervation
Pflugers Arch. 2023 Sep 1. doi: 10.1007/s00424-023-02854-4. Online ahead of print.ABSTRACTSkeletal muscle relies on mitochondria for sustainable ATP production, which may be impacted by reduced oxygen availability (hypoxia). Compared with long-term hypoxia, the mechanistic in vivo response to acute hypoxia remains elusive. Therefore, we aimed to provide an integrated description of the Musculus gastrocnemius response to acute hypoxia. Fasted male C57BL/6JOlaHsd mice, fed a 40en% fat diet for six weeks, were exposed to 12% O2 normobaric hypoxia or normoxia (20.9% O2) for six hours (n = 12 per group). Whole-body energy metab...
Source: Pflugers Archiv : European Journal of Physiology - September 1, 2023 Category: Physiology Authors: Jingyi Song Loes P M Duivenvoorde Sander Grefte Ondrej Kuda Felipe Mart ínez-Ramírez Inge van der Stelt Dimitra Mastorakou Evert M van Schothorst Jaap Keijer Source Type: research

Intra- and inter-session reliability of electrical detection and pain thresholds of cutaneous and muscle primary afferents in the lower back of healthy individuals
In conclusion, cutaneous and intramuscular electrical stimulation will potentially close an important diagnostic gap regarding the selective examination of deep tissue afferents and provide location-specific information for the excitability of non-nociceptive and nociceptive afferents.PMID:37624386 | DOI:10.1007/s00424-023-02851-7 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - August 25, 2023 Category: Physiology Authors: Daniel Streuli Luana Nyir ö Jan Rosner Andreas Schilder Miklos Csato Petra Schweinhardt Source Type: research

Impact of stretch on sarcomere length variability in isolated fully relaxed rat cardiac myocytes
Pflugers Arch. 2023 Aug 21. doi: 10.1007/s00424-023-02848-2. Online ahead of print.ABSTRACTThe contractility of cardiac muscle is greatly affected by preload via the Frank-Starling mechanism (FSM). It is based on preload-dependent activation of sarcomeres-the elementary contractile units in muscle cells. Recent findings show a natural variability in sarcomere length (SL) in resting cardiomyocytes that, moreover, is altered in an actively contracting myocyte. SL variability may contribute to the FSM, but it remains unresolved whether the change in the SL variability is regulated by activation process per se or simply by cha...
Source: Pflugers Archiv : European Journal of Physiology - August 21, 2023 Category: Physiology Authors: Oleg Lookin Najlae Boulali Olivier Cazorla Pieter de Tombe Source Type: research

Neural targets of the enteric dopaminergic system in regulating motility of rat proximal colon
Pflugers Arch. 2023 Aug 17. doi: 10.1007/s00424-023-02849-1. Online ahead of print.ABSTRACTIn isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes a dilatation, while the D1-like receptor antagonist SCH 23390 (SCH) induces a tonic constriction, suggesting that neurally released dopamine tonically stimulates enteric inhibitory efferent neurons. Here, the targets of the enteric dopaminergic neurons were investigated. Cannulated segments of rat proximal colon were bathed in physiological salt solution and luminally perfused with 0.9% saline, while all drugs were applied to the ba...
Source: Pflugers Archiv : European Journal of Physiology - August 17, 2023 Category: Physiology Authors: Hiroyuki Nakamori Hikaru Hashitani Source Type: research