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Heat production during exercise in pregnancy: discerning the contribution of total body weight
This study aimed to determine if total body weight will influence thermoregulation (heat production (Hprod)), heart rate, and perceptual measurements in response to weight-bearing exercise during early to late pregnancy. A cross-sectional design of healthy pregnant women at different pregnancy time points (early, T1; middle, T2; late, T3) performed a 7-stage weight-bearing incremental exercise protocol. Measurements of Hprod, HR, and RPE were examined. Two experimental groups were studied: (1) weight matched and (2) non-weight matched, in T1, T2, and T3. During exercise, equivalent Hprod at T1 (326 ± 88 kJ), T2 (330 ± 43...
Source: Pflugers Archiv : European Journal of Physiology - March 3, 2024 Category: Physiology Authors: Nicholas O'Rourke Sheila Dervis Danilo F da Silva Carla Geurts Fran çois Haman Kristi Bree Adamo Source Type: research

Application of near infra-red laser light increases current threshold in optic nerve consistent with increased Na < sup > + < /sup > -dependent transport
Pflugers Arch. 2024 Feb 29. doi: 10.1007/s00424-024-02932-1. Online ahead of print.ABSTRACTIncreases in the current threshold occur in optic nerve axons with the application of infra-red laser light, whose mechanism is only partly understood. In isolated rat optic nerve, laser light was applied near the site of electrical stimulation, via a flexible fibre optic. Paired applications of light produced increases in threshold that were reduced on the second application, the response recovering with increasing delays, with a time constant of 24 s. 3-min duration single applications of laser light gave rise to a rapid increase i...
Source: Pflugers Archiv : European Journal of Physiology - February 29, 2024 Category: Physiology Authors: Hin Heng Lo Tawan Munkongcharoen Rosa M Muijen Ritika Gurung Anjali G Umredkar Mark D Baker Source Type: research

PTHrP attenuates spontaneous contractions in detrusor smooth muscle of the rat bladder by activating spontaneous transient outward potassium currents
In conclusion, PTHrP accelerates STOCs discharge presumably by facilitating SR Ca2+ release which prematurely terminates Ca2+ transient bursts resulting in the attenuation of SPCs.PMID:38421408 | DOI:10.1007/s00424-024-02931-2 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - February 29, 2024 Category: Physiology Authors: Wataru Kudo Hikaru Hashitani Source Type: research

Biophysical mechanisms of myocardium sodium channelopathies
Pflugers Arch. 2024 Mar 1. doi: 10.1007/s00424-024-02930-3. Online ahead of print.ABSTRACTGenetic variants of gene SCN5A encoding the alpha-subunit of cardiac voltage-gated sodium channel Nav1.5 are associated with various diseases, including long QT syndrome (LQT3), Brugada syndrome (BrS1), and progressive cardiac conduction disease (PCCD). In the last decades, the great progress in understanding molecular and biophysical mechanisms of these diseases has been achieved. The LQT3 syndrome is associated with gain-of-function of sodium channels Nav1.5 due to impaired inactivation, enhanced activation, accelerated recovery fro...
Source: Pflugers Archiv : European Journal of Physiology - February 29, 2024 Category: Physiology Authors: Anastasia K Zaytseva Olga E Kulichik Anna A Kostareva Boris S Zhorov Source Type: research

Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats
In conclusion, the enhancement of Glu-NMDA receptor transmission in the hippocampal DG contributes to the impairment of spatial learning and memory in DIO rats, maybe via the modulation of CaMKII-CREB-BDNF signaling pathway.PMID:38416255 | DOI:10.1007/s00424-024-02924-1 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - February 28, 2024 Category: Physiology Authors: Dingding Lv Bin Xiao Huaying Liu Linping Wang Yingshun Li Yin Hua Zhang Qinghua Jin Source Type: research

The origin of myocardial passive stiffness: more than the sum of its parts?
Pflugers Arch. 2024 Feb 29. doi: 10.1007/s00424-024-02936-x. Online ahead of print.NO ABSTRACTPMID:38418696 | DOI:10.1007/s00424-024-02936-x (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - February 28, 2024 Category: Physiology Authors: Martina Kr üger Source Type: research

Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice
Pflugers Arch. 2024 Feb 24. doi: 10.1007/s00424-024-02920-5. Online ahead of print.ABSTRACTTransmembrane prolyl 4-hydroxylase (P4H-TM) is an enigmatic enzyme whose cellular function and primary substrate remain to be identified. Its loss-of-function mutations cause a severe neurological HIDEA syndrome with hypotonia, intellectual disability, dysautonomia and hypoventilation. Previously, P4H-TM deficiency in mice was associated with reduced atherogenesis and lower serum triglyceride levels. Here, we characterized the glucose and lipid metabolism of P4h-tm-/- mice in physiological and tissue analyses. P4h-tm-/- mice showed v...
Source: Pflugers Archiv : European Journal of Physiology - February 24, 2024 Category: Physiology Authors: Tuulia Ala-Nisula Riikka Halmetoja Henri Leinonen Margareta Kurkela Henna-Riikka Lipponen Samuli Sakko Mikko Karpale Antti M Salo Niina Sissala Tapio R öning Ghulam S Raza Kari A M äkelä J érôme Thevenot Karl-Heinz Herzig Raisa Serpi Johanna Myllyhar Source Type: research