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The pain target Na < sub > V < /sub > 1.7 is expressed late during human iPS cell differentiation into sensory neurons as determined in high-resolution imaging
Pflugers Arch. 2024 Mar 27. doi: 10.1007/s00424-024-02945-w. Online ahead of print.ABSTRACTHuman-induced pluripotent stem cells (iPS cells) are efficiently differentiated into sensory neurons. These cells express the voltage-gated sodium channel NaV1.7, which is a validated pain target. NaV1.7 deficiency leads to pain insensitivity, whereas NaV1.7 gain-of-function mutants are associated with chronic pain. During differentiation, the sensory neurons start spontaneous action potential firing around day 22, with increasing firing rate until day 40. Here, we used CRISPR/Cas9 genome editing to generate a HA-tag NaV1.7 to follow...
Source: Pflugers Archiv : European Journal of Physiology - March 28, 2024 Category: Physiology Authors: Yi Liu Rachna Balaji Marcelo A Szymanski de Toledo Sabrina Ernst Petra Hautvast Aylin B Kesdo ğan Jannis K örner Martin Zenke Anika Neureiter Angelika Lampert Source Type: research

The ex vivo perfused mouse adrenal gland-a new model to study aldosterone secretion
Pflugers Arch. 2024 Mar 28. doi: 10.1007/s00424-024-02950-z. Online ahead of print.ABSTRACTAldosterone is a steroid hormone that is important for maintaining the volume and ionic composition of extracellular fluids and is produced in the zona glomerulosa of the adrenal cortex. The basic mechanisms controlling aldosterone secretion are known. However, more detailed studies on the regulation of aldosterone secretion often fail due to the lack of suitable models: although secretion can be studied in cultured adrenocortical cells under defined conditions, the differentiation status of the cells is difficult to control and the ...
Source: Pflugers Archiv : European Journal of Physiology - March 28, 2024 Category: Physiology Authors: Allein Plain Laura Kn ödl Ines Tegtmeier Sascha Bandulik Richard Warth Source Type: research

Acute sodium bicarbonate administration improves ventilatory efficiency in experimental respiratory acidosis: clinical implications
Pflugers Arch. 2024 Mar 26. doi: 10.1007/s00424-024-02949-6. Online ahead of print.ABSTRACTAdministering sodium bicarbonate (NaHCO3) to patients with respiratory acidosis breathing spontaneously is contraindicated because it increases carbon dioxide load and depresses pulmonary ventilation. Nonetheless, several studies have reported salutary effects of NaHCO3 in patients with respiratory acidosis but the underlying mechanism remains uncertain. Considering that such reports have been ignored, we examined the ventilatory response of unanesthetized dogs with respiratory acidosis to hypertonic NaHCO3 infusion (1 N, 5 mmol/kg) ...
Source: Pflugers Archiv : European Journal of Physiology - March 27, 2024 Category: Physiology Authors: Horacio J Adrogu é Nicolaos E Madias Source Type: research

Liraglutide versus pramlintide in protecting against cognitive function impairment through affecting PI3K/AKT/GSK-3 β/TTBK pathway and decreasing Tau hyperphosphorylation in high-fat diet- streptozocin rat model
This study confirmed that pramlintide and liraglutide are promising antidiabetic medications that could prevent associated cognitive disorders in different mechanisms.PMID:38536493 | DOI:10.1007/s00424-024-02933-0 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - March 27, 2024 Category: Physiology Authors: Hoda M Moghazy Nesreen G Abdelhaliem Sherine Ahmed Mohammed Asmaa Hassan Amany Abdelrahman Source Type: research

The role of Na < sup > + < /sup > -coupled bicarbonate transporters (NCBT) in health and disease
Pflugers Arch. 2024 Mar 27. doi: 10.1007/s00424-024-02937-w. Online ahead of print.ABSTRACTCellular and organism survival depends upon the regulation of pH, which is regulated by highly specialized cell membrane transporters, the solute carriers (SLC) (For a comprehensive list of the solute carrier family members, see: https://www.bioparadigms.org/slc/ ). The SLC4 family of bicarbonate (HCO3-) transporters consists of ten members, sorted by their coupling to either sodium (NBCe1, NBCe2, NBCn1, NBCn2, NDCBE), chloride (AE1, AE2, AE3), or borate (BTR1). The ionic coupling of SLC4A9 (AE4) remains controversial. These SLC4 bic...
Source: Pflugers Archiv : European Journal of Physiology - March 27, 2024 Category: Physiology Authors: Shannon R Holmberg Yohei Sakamoto Akira Kato Michael F Romero Source Type: research

Correction to: Histamine H2 ‑receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II-hypertensive mice
Pflugers Arch. 2024 Mar 27. doi: 10.1007/s00424-024-02955-8. Online ahead of print.NO ABSTRACTPMID:38536495 | DOI:10.1007/s00424-024-02955-8 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - March 27, 2024 Category: Physiology Authors: Kasper B Assersen Boye L Jensen Camilla Enggaard Paul M Vanhoutte Pernille B L Hansen Source Type: research

Role of pH-sensing receptors in colitis
Pflugers Arch. 2024 Mar 22. doi: 10.1007/s00424-024-02943-y. Online ahead of print.ABSTRACTLow pH in the gut is associated with severe inflammation, fibrosis, and colorectal cancer (CRC) and is a hallmark of active inflammatory bowel disease (IBD). Subsequently, pH-sensing mechanisms are of interest for the understanding of IBD pathophysiology. Tissue hypoxia and acidosis-two contributing factors to disease pathophysiology-are linked to IBD, and understanding their interplay is highly relevant for the development of new therapeutic options. One member of the proton-sensing G protein-coupled receptor (GPCR) family, GPR65 (T...
Source: Pflugers Archiv : European Journal of Physiology - March 22, 2024 Category: Physiology Authors: Martin Hausmann Klaus Seuwen Cheryl de Valli ère Moana Busch Pedro A Ruiz Gerhard Rogler Source Type: research

PHD1-3 oxygen sensors in vivo-lessons learned from gene deletions
Pflugers Arch. 2024 Mar 21. doi: 10.1007/s00424-024-02944-x. Online ahead of print.ABSTRACTOxygen sensors enable cells to adapt to limited oxygen availability (hypoxia), affecting various cellular and tissue responses. Prolyl-4-hydroxylase domain 1-3 (PHD1-3; also called Egln1-3, HIF-P4H 1-3, HIF-PH 1-3) proteins belong to the Fe2+- and 2-oxoglutarate-dependent dioxygenase superfamily and utilise molecular oxygen (O2) alongside 2-oxoglutarate as co-substrate to hydroxylate two proline residues of α subunits of the dimeric hypoxia inducible factor (HIF) transcription factor. PHD1-3-mediated hydroxylation of HIF-α leads to...
Source: Pflugers Archiv : European Journal of Physiology - March 21, 2024 Category: Physiology Authors: Agnieszka E Jucht Carsten C Scholz Source Type: research

Is XPR1 mediating phosphate efflux?
Pflugers Arch. 2024 Mar 21. doi: 10.1007/s00424-024-02946-9. Online ahead of print.NO ABSTRACTPMID:38512477 | DOI:10.1007/s00424-024-02946-9 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - March 21, 2024 Category: Physiology Authors: Nati Hernando Source Type: research

XPR1: a regulator of cellular phosphate homeostasis rather than a Pi exporter
Pflugers Arch. 2024 Mar 20. doi: 10.1007/s00424-024-02941-0. Online ahead of print.ABSTRACTPhosphate (Pi) is an essential nutrient, and its plasma levels are under tight hormonal control. Uphill transport of Pi into cells is mediated by the two Na-dependent Pi transporter families SLC34 and SLC20. The molecular identity of a potential Pi export pathway is controversial, though XPR1 has recently been suggested by Giovannini and coworkers to mediate Pi export. We expressed XPR1 in Xenopus oocytes to determine its functional characteristics. Xenopus isoforms of proteins were used to avoid species incompatibility. Protein tagg...
Source: Pflugers Archiv : European Journal of Physiology - March 20, 2024 Category: Physiology Authors: David Burns Rolando Berlinguer-Palmini Andreas Werner Source Type: research