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Pain quality patterns in delayed onset muscle soreness of the lower back suggest sensitization of fascia rather than muscle afferents: a secondary analysis study
Pflugers Arch. 2023 Dec 16. doi: 10.1007/s00424-023-02896-8. Online ahead of print.ABSTRACTDelayed onset muscle soreness (DOMS) of the lower back is considered a surrogate for acute low back pain (aLBP) in experimental studies. Of note, it is often unquestioningly assumed to be muscle pain. To date, there has not been a study analyzing lumbar DOMS in terms of its pain origin, which was the aim of this study. Sixteen healthy individuals (L-DOMS) were enrolled for the present study and matched to participants from a previous study (n = 16, L-PAIN) who had undergone selective electrical stimulation of the thoracolumbar fascia...
Source: Pflugers Archiv : European Journal of Physiology - December 15, 2023 Category: Physiology Authors: Andreas Brandl Jan Wilke Christoph Egner Tobias Schmidt Andreas Schilder Robert Schleip Source Type: research

In silico optical modulation of spiral wave trajectories in cardiac tissue
Pflugers Arch. 2023 Dec 14. doi: 10.1007/s00424-023-02889-7. Online ahead of print.ABSTRACTLife-threatening cardiac arrhythmias such as ventricular tachycardia and fibrillation are common precursors to sudden cardiac death. They are associated with the occurrence of abnormal electrical spiral waves in the heart that rotate at a high frequency. In severe cases, arrhythmias are combated with a clinical method called defibrillation, which involves administering a single global high-voltage shock to the heart to reset all its activity and restore sinus rhythm. Despite its high efficiency in controlling arrhythmias, defibrillat...
Source: Pflugers Archiv : European Journal of Physiology - December 14, 2023 Category: Physiology Authors: Sayedeh Hussaini Rupamanjari Majumder Valentin Krinski Stefan Luther Source Type: research

Cardiac optogenetics: shining light on signaling pathways
Pflugers Arch. 2023 Dec 14. doi: 10.1007/s00424-023-02892-y. Online ahead of print.ABSTRACTIn the early 2000s, the field of neuroscience experienced a groundbreaking transformation with the advent of optogenetics. This innovative technique harnesses the properties of naturally occurring and genetically engineered rhodopsins to confer light sensitivity upon target cells. The remarkable spatiotemporal precision offered by optogenetics has provided researchers with unprecedented opportunities to dissect cellular physiology, leading to an entirely new level of investigation. Initially revolutionizing neuroscience, optogenetics...
Source: Pflugers Archiv : European Journal of Physiology - December 14, 2023 Category: Physiology Authors: Siri Leemann Franziska Schneider-Warme Sonja Kleinlogel Source Type: research

Lectin-mediated, time-efficient, and high-yield sorting of different morphologically intact nephron segments
Pflugers Arch. 2023 Dec 13. doi: 10.1007/s00424-023-02894-w. Online ahead of print.ABSTRACTThe kidney is a highly complex organ equipped with a multitude of miniscule filter-tubule units called nephrons. Each nephron can be subdivided into multiple segments, each with its own morphology and physiological function. To date, conventional manual approaches to isolate specific nephron segments are very laborious, time-consuming, often limited to only a specific segment, and typically have low yield. Here, we describe a novel, unconventional method that is superior in many aspects to previous protocols by combining low-cost flu...
Source: Pflugers Archiv : European Journal of Physiology - December 13, 2023 Category: Physiology Authors: Jessica Roskosch Uyen Huynh-Do Stefan Rudloff Source Type: research

Nobel Prize for physiology or medicine in 2023: how to dupe the cellular innate immune system using modified RNA for therapeutic treatment
Pflugers Arch. 2023 Dec 13. doi: 10.1007/s00424-023-02895-9. Online ahead of print.NO ABSTRACTPMID:38087083 | DOI:10.1007/s00424-023-02895-9 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - December 12, 2023 Category: Physiology Authors: Jan Medenbach Herbert Tschochner Source Type: research

State-independent inhibition of the oncogenic Kv10.1 channel by desethylamiodarone, a comparison with amiodarone
Pflugers Arch. 2023 Dec 8. doi: 10.1007/s00424-023-02893-x. Online ahead of print.ABSTRACTKv10.1 is a voltage-dependent K channel whose ectopic expression is associated with several human cancers. Additionally, Kv10.1 has structure-function properties which are not yet well understood. We are using drugs of clinical importance in an attempt to gain insight on the relationship between pharmacology and characteristic functional properties of this channel. Herein, we report the interaction of desethylamiodarone (desAd), the active metabolic product of the antiarrhythmic amiodarone with Kv10.1: desAd binds to both closed and o...
Source: Pflugers Archiv : European Journal of Physiology - December 8, 2023 Category: Physiology Authors: F Gomez-Lagunas C Barriga-Montoya J P Pardo Source Type: research

Optogenetics meets physiology
Pflugers Arch. 2023 Dec 4. doi: 10.1007/s00424-023-02887-9. Online ahead of print.NO ABSTRACTPMID:38047968 | DOI:10.1007/s00424-023-02887-9 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - December 4, 2023 Category: Physiology Authors: Sophia Ohnemus Johannes Vierock Franziska Schneider-Warme Source Type: research