Neural targets of the enteric dopaminergic system in regulating motility of rat proximal colon
Pflugers Arch. 2023 Aug 17. doi: 10.1007/s00424-023-02849-1. Online ahead of print.ABSTRACTIn isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes a dilatation, while the D1-like receptor antagonist SCH 23390 (SCH) induces a tonic constriction, suggesting that neurally released dopamine tonically stimulates enteric inhibitory efferent neurons. Here, the targets of the enteric dopaminergic neurons were investigated. Cannulated segments of rat proximal colon were bathed in physiological salt solution and luminally perfused with 0.9% saline, while all drugs were applied to the ba...
Source: Pflugers Archiv : European Journal of Physiology - August 17, 2023 Category: Physiology Authors: Hiroyuki Nakamori Hikaru Hashitani Source Type: research

Neural targets of the enteric dopaminergic system in regulating motility of rat proximal colon
Pflugers Arch. 2023 Aug 17. doi: 10.1007/s00424-023-02849-1. Online ahead of print.ABSTRACTIn isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes a dilatation, while the D1-like receptor antagonist SCH 23390 (SCH) induces a tonic constriction, suggesting that neurally released dopamine tonically stimulates enteric inhibitory efferent neurons. Here, the targets of the enteric dopaminergic neurons were investigated. Cannulated segments of rat proximal colon were bathed in physiological salt solution and luminally perfused with 0.9% saline, while all drugs were applied to the ba...
Source: Pflugers Archiv : European Journal of Physiology - August 17, 2023 Category: Physiology Authors: Hiroyuki Nakamori Hikaru Hashitani Source Type: research

Neural targets of the enteric dopaminergic system in regulating motility of rat proximal colon
Pflugers Arch. 2023 Aug 17. doi: 10.1007/s00424-023-02849-1. Online ahead of print.ABSTRACTIn isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes a dilatation, while the D1-like receptor antagonist SCH 23390 (SCH) induces a tonic constriction, suggesting that neurally released dopamine tonically stimulates enteric inhibitory efferent neurons. Here, the targets of the enteric dopaminergic neurons were investigated. Cannulated segments of rat proximal colon were bathed in physiological salt solution and luminally perfused with 0.9% saline, while all drugs were applied to the ba...
Source: Pflugers Archiv : European Journal of Physiology - August 17, 2023 Category: Physiology Authors: Hiroyuki Nakamori Hikaru Hashitani Source Type: research

Effects of aurantiamide on a rat model of renovascular arterial hypertension
In conclusion, ASP lowered blood pressure, improved endothelium-mediated relaxation, decreased renovascular ROS/RNS production in hypertensive rats. ASP also increased eNOS protein expression in aorta and HUVEC at nontoxic doses. ASP may have future potential as an anti-hypertensive agent.PMID:37582694 | DOI:10.1007/s00424-023-02850-8 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - August 15, 2023 Category: Physiology Authors: Mutay Aslan Filiz Basral ı P ınar Ülker Zerrin Barut Çağatay Yılmaz Tu ğçe Çeker Nur Özen Aleyna Öztüzün Özlem Elpek Source Type: research

Effects of aurantiamide on a rat model of renovascular arterial hypertension
In conclusion, ASP lowered blood pressure, improved endothelium-mediated relaxation, decreased renovascular ROS/RNS production in hypertensive rats. ASP also increased eNOS protein expression in aorta and HUVEC at nontoxic doses. ASP may have future potential as an anti-hypertensive agent.PMID:37582694 | DOI:10.1007/s00424-023-02850-8 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - August 15, 2023 Category: Physiology Authors: Mutay Aslan Filiz Basral ı P ınar Ülker Zerrin Barut Çağatay Yılmaz Tu ğçe Çeker Nur Özen Aleyna Öztüzün Özlem Elpek Source Type: research