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Cargo-specific effects of hypoxia on clathrin-mediated trafficking
Pflugers Arch. 2024 Jan 31. doi: 10.1007/s00424-024-02911-6. Online ahead of print.ABSTRACTClathrin-associated trafficking is a major mechanism for intracellular communication, as well as for cells to communicate with the extracellular environment. A decreased oxygen availability termed hypoxia has been described to influence this mechanism in the past. Mostly biochemical studies were applied in these analyses, which miss spatiotemporal information. We have applied live cell microscopy and a newly developed analysis script in combination with a GFP-tagged clathrin-expressing cell line to obtain insight into the dynamics of...
Source: Pflugers Archiv : European Journal of Physiology - January 31, 2024 Category: Physiology Authors: Gijsbert J van Belle Anke Zieseniss Doris Heidenreich Maxime Olmos Asia Zhuikova Wiebke M öbius Maarten W Paul D örthe M Katschinski Source Type: research

Dietary acid load in health and disease
Pflugers Arch. 2024 Jan 29. doi: 10.1007/s00424-024-02910-7. Online ahead of print.ABSTRACTMaintaining an appropriate acid-base equilibrium is crucial for human health. A primary influencer of this equilibrium is diet, as foods are metabolized into non-volatile acids or bases. Dietary acid load (DAL) is a measure of the acid load derived from diet, taking into account both the potential renal acid load (PRAL) from food components like protein, potassium, phosphorus, calcium, and magnesium, and the organic acids from foods, which are metabolized to bicarbonate and thus have an alkalinizing effect. Current Western diets are ...
Source: Pflugers Archiv : European Journal of Physiology - January 28, 2024 Category: Physiology Authors: Michiel L A J Wie ërs Beverley Beynon-Cobb Wesley J Visser Ilias Attaye Source Type: research

Metabolic acidosis in chronic kidney disease: mere consequence or also culprit?
Pflugers Arch. 2024 Jan 27. doi: 10.1007/s00424-024-02912-5. Online ahead of print.ABSTRACTMetabolic acidosis is a frequent complication in non-transplant chronic kidney disease (CKD) and after kidney transplantation. It occurs when net endogenous acid production exceeds net acid excretion. While nephron loss with reduced ammoniagenesis is the main cause of acid retention in non-transplant CKD patients, additional pathophysiological mechanisms are likely inflicted in kidney transplant recipients. Functional tubular damage by calcineurin inhibitors seems to play a key role causing renal tubular acidosis. Notably, experiment...
Source: Pflugers Archiv : European Journal of Physiology - January 27, 2024 Category: Physiology Authors: Christian Kuhn Nilufar Mohebbi Alexander Ritter Source Type: research

Histamine H 2 -receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II-hypertensive mice
Pflugers Arch. 2024 Mar;476(3):307-321. doi: 10.1007/s00424-024-02909-0. Epub 2024 Jan 27.ABSTRACTAldosterone through the mineralocorticoid receptor MR has detrimental effects on cardiovascular disease. It reduces the bioavailability of nitric oxide and impairs endothelium-dependent vasodilatation. In resistance arteries, aldosterone impairs the sensitivity of vascular smooth muscle cells to nitric oxide by promoting the local secretion of histamine which activates H2 receptors. The present experiments tested in vivo and ex vivo the hypothesis that systemic H2-receptor antagonism reduces arterial blood pressure and improve...
Source: Pflugers Archiv : European Journal of Physiology - January 27, 2024 Category: Physiology Authors: Kasper B Assersen Boye L Jensen Camilla Enggaard Paul M Vanhoutte Pernille B L Hansen Source Type: research

The mechanism of 25-hydroxycholesterol-mediated suppression of atrial β1-adrenergic responses
Pflugers Arch. 2024 Mar;476(3):407-421. doi: 10.1007/s00424-024-02913-4. Epub 2024 Jan 22.ABSTRACT25-Hydroxycholesterol (25HC) is a biologically active oxysterol, whose production greatly increases during inflammation by macrophages and dendritic cells. The inflammatory reactions are frequently accompanied by changes in heart regulation, such as blunting of the cardiac β-adrenergic receptor (AR) signaling. Here, the mechanism of 25HC-dependent modulation of responses to β-AR activation was studied in the atria of mice. 25HC at the submicromolar levels decreased the β-AR-mediated positive inotropic effect and enhancement...
Source: Pflugers Archiv : European Journal of Physiology - January 22, 2024 Category: Physiology Authors: Julia G Odnoshivkina Alexey S Averin Ildar R Khakimov Nazar A Trusov Diliara A Trusova Alexey M Petrov Source Type: research

The renin angiotensin aldosterone system
Pflugers Arch. 2024 Jan 17. doi: 10.1007/s00424-024-02908-1. Online ahead of print.ABSTRACTIn this review, we will cover (i) the proteolytic cascade of the RAAS, (ii) its regulation by multiple feedback-controlled parameters, and (iii) the major effects of the RAAS. For the effects of the RAAS, we focus on the role of the RAAS in the regulation of volume homeostasis and vascular tone, as major determinants of arterial blood pressure.PMID:38233636 | DOI:10.1007/s00424-024-02908-1 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - January 17, 2024 Category: Physiology Authors: Hannah Triebel Hayo Castrop Source Type: research

Intercalated cell function, kidney innate immunity, and urinary tract infections
Pflugers Arch. 2024 Jan 16. doi: 10.1007/s00424-024-02905-4. Online ahead of print.ABSTRACTIntercalated cells (ICs) in the kidney collecting duct have a versatile role in acid-base and electrolyte regulation along with the host immune defense. Located in the terminal kidney tubule segment, ICs are among the first kidney cells to encounter bacteria when bacteria ascend from the bladder into the kidney. ICs have developed several mechanisms to combat bacterial infections of the kidneys. For example, ICs produce antimicrobial peptides (AMPs), which have direct bactericidal activity, and in many cases are upregulated in respon...
Source: Pflugers Archiv : European Journal of Physiology - January 16, 2024 Category: Physiology Authors: Andrew L Schwaderer Evan Rajadhyaksha Jorge Canas Vijay Saxena David S Hains Source Type: research

Role of corticotropin-releasing factor neurotransmission in the lateral hypothalamus on baroreflex impairment evoked by chronic variable stress in rats
Pflugers Arch. 2024 Mar;476(3):351-364. doi: 10.1007/s00424-024-02904-5. Epub 2024 Jan 17.ABSTRACTDespite the importance of physiological responses to stress in a short-term, chronically these adjustments may be harmful and lead to diseases, including cardiovascular diseases. The lateral hypothalamus (LH) has been reported to be involved in expression of physiological and behavioral responses to stress, but the local neurochemical mechanisms involved are not completely described. The corticotropin-releasing factor (CRF) neurotransmission is a prominent brain neurochemical system implicated in the physiological and behavior...
Source: Pflugers Archiv : European Journal of Physiology - January 16, 2024 Category: Physiology Authors: Lucas Barretto-de-Souza Ricardo Benini Lilian L Reis-Silva Cristiane Busnardo Carlos C Crestani Source Type: research

Secretin: a hormone for HCO 3 - homeostasis
We describe its new function as a hormone for HCO3- homeostasis.PMID:38221598 | DOI:10.1007/s00424-024-02906-3 (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - January 14, 2024 Category: Physiology Authors: Peder Berg Samuel L Svendsen Niklas Ayasse Mads Vaarby Sorensen Jens Leipziger Source Type: research

pH-regulated single cell migration
Pflugers Arch. 2024 Jan 12. doi: 10.1007/s00424-024-02907-2. Online ahead of print.ABSTRACTOver the last two decades, extra- and intracellular pH have emerged as fundamental regulators of cell motility. Fundamental physiological and pathological processes relying on appropriate cell migration, such as embryonic development, wound healing, and a proper immune defense on the one hand, and autoimmune diseases, metastatic cancer, and the progression of certain parasitic diseases on the other, depend on surrounding pH. In addition, migrating single cells create their own localized pH nanodomains at their surface and in the cyto...
Source: Pflugers Archiv : European Journal of Physiology - January 12, 2024 Category: Physiology Authors: Christian Stock Source Type: research

Novel functions of the anion exchanger AE4 (SLC4A9)
Pflugers Arch. 2024 Jan 9. doi: 10.1007/s00424-023-02899-5. Online ahead of print.ABSTRACTThe kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells accomplish urinary base (HCO3-) secretion. β-intercalated cells regulate the acid base status through modulation of the apical Cl-/HCO3- exchanger pendrin (SLC26A4) activity. In this review, we summarize and discuss our current knowledge of the physiological role of the renal transporter AE4 (SLC4A9). The AE4, as cation-dependent Cl-/HCO3- exchanger, is exclusively ...
Source: Pflugers Archiv : European Journal of Physiology - January 10, 2024 Category: Physiology Authors: Helga Vitzthum Catherine Meyer-Schwesinger Heimo Ehmke Source Type: research

The good company of T-type calcium channels : Commentary on: "T-type calcium channelosome," a review by N. Weiss and G. W. Zamponi
Pflugers Arch. 2024 Jan 9. doi: 10.1007/s00424-023-02903-y. Online ahead of print.NO ABSTRACTPMID:38191755 | DOI:10.1007/s00424-023-02903-y (Source: Pflugers Archiv : European Journal of Physiology)
Source: Pflugers Archiv : European Journal of Physiology - January 8, 2024 Category: Physiology Authors: Philippe Lory Source Type: research

Acid-sensing ion channels and downstream signalling in cancer cells: is there a mechanistic link?
Pflugers Arch. 2024 Jan 4. doi: 10.1007/s00424-023-02902-z. Online ahead of print.ABSTRACTIt is increasingly appreciated that the acidic microenvironment of a tumour contributes to its evolution and clinical outcomes. However, our understanding of the mechanisms by which tumour cells detect acidosis and the signalling cascades that it induces is still limited. Acid-sensing ion channels (ASICs) are sensitive receptors for protons; therefore, they are also candidates for proton sensors in tumour cells. Although in non-transformed tissue, their expression is mainly restricted to neurons, an increasing number of studies have r...
Source: Pflugers Archiv : European Journal of Physiology - January 4, 2024 Category: Physiology Authors: Stefan Gr ünder Jakob Vanek Karolos-Philippos Pissas Source Type: research

Artificial light at night suppresses the day-night cardiovascular variability: evidence from humans and rats
Pflugers Arch. 2024 Jan 4. doi: 10.1007/s00424-023-02901-0. Online ahead of print.ABSTRACTArtificial light at night (ALAN) affects most of the population. Through the retinohypothalamic tract, ALAN modulates the activity of the central circadian oscillator and, consequently, various physiological systems, including the cardiovascular one. We summarised the current knowledge about the effects of ALAN on the cardiovascular system in diurnal and nocturnal animals. Based on published data, ALAN reduces the day-night variability of the blood pressure and heart rate in diurnal and nocturnal animals by increasing the nocturnal va...
Source: Pflugers Archiv : European Journal of Physiology - January 4, 2024 Category: Physiology Authors: Lubos Molcan Katarina Babarikova Diana Cvikova Natalia Kincelova Lenka Kubincova Hana Mauer Sutovska Source Type: research