Systemic inflammation score as a predictor of death within one year after esophagectomy
ConclusionSIS assessment undertaken before beginning esophageal cancer treatment is a useful predictor of death within 1 year of surgery. (Source: Esophagus)
Source: Esophagus - April 16, 2024 Category: Gastroenterology Source Type: research
Risk stratification for synchronous/metachronous recurrence after endoscopic submucosal dissection for Barrett ’s esophageal adenocarcinoma using the length of Barrett’s esophagus
ConclusionsRisk stratification of multifocal cancer using length of Barrett ’s esophagus was effective. Further multicenter prospective studies are needed to substantiate our findings. (Source: Esophagus)
Source: Esophagus - April 12, 2024 Category: Gastroenterology Source Type: research
First-line pembrolizumab plus chemotherapy for advanced/metastatic esophageal cancer: 1-year extended follow-up in the Japanese subgroup of the phase 3 KEYNOTE-590 study
ConclusionsWith longer-term follow-up of Japanese patients with advanced/metastatic esophageal cancer, efficacy continued to favor pembrolizumab –chemotherapy compared with placebo–chemotherapy, with no new safety signals observed.Clinical trial registration: ClinicalTrials.gov, NCT03189719. (Source: Esophagus)
Source: Esophagus - April 12, 2024 Category: Gastroenterology Source Type: research
Japanese Classification of Esophageal Cancer, 12th Edition: Part I
AbstractThis is the first half of English edition of Japanese Classification of Esophageal Cancer, 12th Edition that was published by the Japan Esophageal Society in 2022. (Source: Esophagus)
Source: Esophagus - April 3, 2024 Category: Gastroenterology Source Type: research
In females, salivary secretion was significantly lower in patients with severe reflux esophagitis than in healthy controls
ConclusionAmong females, the salivary secretion was significantly lower in severe RE patients than in HCs. This reduction in salivary secretion may contribute to the pathophysiology of severe RE in females. (Source: Esophagus)
Source: Esophagus - March 27, 2024 Category: Gastroenterology Source Type: research
Japanese Classification of Esophageal Cancer, 12th Edition: Part II
AbstractThis is the second half of English edition of Japanese Classification of Esophageal Cancer, 12th Edition that was published by the Japan Esophageal Society in 2022. (Source: Esophagus)
Source: Esophagus - March 21, 2024 Category: Gastroenterology Source Type: research
Transparency-enhancing technology allows the three-dimensional assessment of esophageal carcinoma obtained by endoscopic submucosal dissection
ConclusionsThe results suggested that transparency-enhancing technology and virtual HE images may be feasible for clinical application and represent a novel histopathological method for evaluating endoscopically resected specimens. (Source: Esophagus)
Source: Esophagus - March 18, 2024 Category: Gastroenterology Source Type: research
Preoperative docetaxel, cisplatin, and 5-fluorouracil for resectable locally advanced esophageal and esophagogastric junctional adenocarcinoma
ConclusionsPreoperative DCF for resectable EGJ-AC was well tolerated and has promising efficacy. (Source: Esophagus)
Source: Esophagus - March 12, 2024 Category: Gastroenterology Source Type: research
Reply to: The use of drugs to prevent postoperative delirium in elderly patients with radical esophagectomy
(Source: Esophagus)
Source: Esophagus - March 8, 2024 Category: Gastroenterology Source Type: research
Role of modified Glasgow Prognostic Score in patients with achalasia who underwent laparoscopic Heller-myotomy with Dor-fundoplication
ConclusionsAlthough severe reflux esophagitis was more common in patients with achalasia with a high mGPS, good clinical success was obtained regardless of the preoperative mGPS. (Source: Esophagus)
Source: Esophagus - March 2, 2024 Category: Gastroenterology Source Type: research
Effectiveness of prehabilitation during neoadjuvant therapy for patients with esophageal or gastroesophageal junction cancer: a systematic review
This study analyzed data from three randomized controlled trials (RCTs) and nine non-RCTs involving 664 patients. The meta-analysis of two RCTs demonstrated that prehabilitation during NAT may be more effective than usual c are in enhancing tolerance to NAT and grip strength; moreover, one RCT and three non-RCTs revealed that prehabilitation may reduce the risk of postoperative complications. The adherence rates for exercise programs in two RCTs and seven non-RCTs were 55–76%. Additionally, two studies reported a 76% adherence rate for multimodal prehabilitation programs, including exercise, dietary, and psychological ca...
Source: Esophagus - February 27, 2024 Category: Gastroenterology Source Type: research
Pretreatment periodontitis is predictive of a poorer prognosis after esophagectomy for esophageal cancer
ConclusionEsophageal cancer patients had a high prevalence of periodontitis. Moreover, the presence of periodontitis and severity of periodontitis are independent risk factors contributing to a poorer prognosis after esophagectomy. (Source: Esophagus)
Source: Esophagus - February 20, 2024 Category: Gastroenterology Source Type: research
Remarkable response as a new indicator for endoscopic evaluation of local efficacy of non-surgical treatments for esophageal cancer
AbstractIn Japan, standard of care of the patients with resectable esophageal cancer is neoadjuvant chemotherapy (NAC) followed by esophagectomy. Patients unfitted for surgery or with unresectable locally advanced esophageal cancer are generally indicated with definitive chemoradiotherapy (CRT). Local disease control is undoubtful important for the management of patients with esophageal cancer, therefore endoscopic evaluation of local efficacy after non-surgical treatments must be essential. The significant shrink of primary site after NAC has been reported as a good indicator of pathological good response as well as favor...
Source: Esophagus - February 14, 2024 Category: Gastroenterology Source Type: research
The tumor cell-intrinsic cGAS –STING pathway is associated with the high density of CD8+ T cells after chemotherapy in esophageal squamous cell carcinoma
ConclusionOur findings suggest that the tumor cell-intrinsic cGAS –STING pathway might contribute to chemotherapy-induced immune cell activation in the ESCC TME. (Source: Esophagus)
Source: Esophagus - February 7, 2024 Category: Gastroenterology Source Type: research
Efficacy of thoracic endovascular aortic repair for aorto-esophageal fistula due to esophageal cancer: a systematic review and meta-analysis
AbstractAorto-esophageal fistula (AEF) due to esophageal cancer (EC) is a life-threatening condition characterized by sudden hemorrhage, which often causes sudden death. To evaluate the efficacy and safety of thoracic endovascular aortic repair (TEVAR) for AEF due to EC, we performed a systematic review and meta-analysis. We searched the MEDLINE (PubMed) databases, the Cochrane Library databases, Ichushi-Web (the databases of the Japan Medical Abstract Society), and CiNii (Academic information search service of the National Institute of Information from Japan) from January 2000 to November 2023 for articles about TEVAR for...
Source: Esophagus - February 1, 2024 Category: Gastroenterology Source Type: research
