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Vaccination: Veterinary Vaccinations
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Total 6987 results found since Jan 2013.
Human intestinal organoids as models to study enteric bacteria and viruses
Curr Opin Microbiol. 2023 Aug 1;75:102362. doi: 10.1016/j.mib.2023.102362. Online ahead of print.ABSTRACTLaboratory studies of host-microbe interactions have historically been carried out using transformed cell lines and animal models. Although much has been learned from these models, recent advances in the development of multicellular, physiologically active, human intestinal organoid (HIO) cultures are allowing unprecedented discoveries of host-microbe interactions. Here, we review recent literature using HIOs as models to investigate the pathogenesis of clinically important enteric bacteria and viruses and study commens...
Source: Current Opinion in Microbiology - August 3, 2023 Category: Microbiology Authors: Grace Adeniyi-Ipadeola Hephzibah Nwanosike Sasirekha Ramani Source Type: research
The role of zinc sulfate in enhancing cellular and humoral immune responses to foot-and-mouth disease vaccine
Virus Res. 2023 Aug 1:199189. doi: 10.1016/j.virusres.2023.199189. Online ahead of print.ABSTRACTFoot-and-mouth disease (FMD) is a rapidly propagating infectious disease of cloven-hoofed animals, especially cattle and pigs, affecting the productivity and profitability of the livestock industry. Presently, FMD is controlled and prevented using vaccines; however, conventional FMD vaccines have several disadvantages, including short vaccine efficacy, low antibody titers, and safety issues in pigs, indicating the need for further studies. Here, we evaluated the efficacy of a novel bivalent vaccine containing zinc sulfate as an...
Source: Virus Research - August 3, 2023 Category: Virology Authors: Mi-Kyeong Ko Hyeong Won Kim So Hui Park Jong-Hyeon Park Su-Mi Kim Min Ja Lee Source Type: research
A novel therapeutic vaccine targeting the soluble TNF α receptor II to limit the progression of cardiovascular disease: AtheroVax™
We describe a peptide vaccine targeting sTNFR2 in limiting the progression of atherosclerosis. A therapeutic vaccine limiting the progression of atherosclerosis will greatly contribute to the reduction in morbidity and mortality from cardiovascular disease. It is likely the vaccine will be used in combination with the current standards of care and lifestyle modifications.PMID:37534280 | PMC:PMC10392828 | DOI:10.3389/fcvm.2023.1206541
Source: Atherosclerosis - August 3, 2023 Category: Cardiology Authors: Patrick L Iversen Nicholas Kipshidze Nodar Kipshidze George Dangas Eduardo Ramacciotti Zurab Kakabadze Jawed Fareed Source Type: research
Production of a chimeric porcine reproductive and respiratory syndrome virus (PRRSV)-2 vaccine using a lab-scale packed-bed bioreactor CelCradle
CONCLUSIONS: Overall, this study demonstrates that the CelCradle system is an economical platform for PRRS vaccine production.PMID:37528389 | DOI:10.1186/s12917-023-03659-4
Source: Cell Research - August 1, 2023 Category: Cytology Authors: Hwi-Yeon Choi Jong-Chul Choi Yeong-Lim Kang So-Hyeun Ahn Sang-Won Lee Seung-Yong Park Chang-Seon Song In-Soo Choi Joong-Bok Lee Source Type: research
Variability of in vivo potency assays of whole-cell pertussis, inactivated polio, and meningococcal B vaccines
Vaccine. 2023 Jul 30:S0264-410X(23)00885-X. doi: 10.1016/j.vaccine.2023.07.054. Online ahead of print.ABSTRACTFor the batch release of vaccines, potency release assays are required. Non-animal in vitro tests have numerous advantages and are preferred; however, several vaccines are still released using in vivo assays. Their major drawback is the inherent variability with its practical implications. We quantified the variability of in vivo potency release assays for whole-cell pertussis, inactivated polio and meningococcal B (MenB) vaccines which showed large CV (Coefficient of Variation) ranging from 34% to 125%. As inheren...
Source: Vaccine - August 1, 2023 Category: Allergy & Immunology Authors: Cerissa van Walstijn Stefan Verweij Rory Care Peter Rigsby Eli-Boaz Clapper Kevin Markey Rob J Vandebriel Paul Stickings Marcel H N Hoefnagel Source Type: research
Novel phenanthrene imidazoles as telomeric G-quadruplex ligands trigger potent immunogenic cell death in triple-negative breast cancer
In this study, we rationally designed and synthesized a series of novel phenanthrene imidazoles targeting telomeric G4. Among them, PI-2 was identified as the most promising ligand with high cytotoxicity, cellular uptake efficiency and G4-interacting ability. Cellular studies indicated that PI-2 inhibited the proliferation and migration of both human and mouse triple-negative breast cancer (TNBC) cells. PI-2 triggered the occurrence of DDR and ICD, where the related pathways were further decided. In vivo experiments displayed that PI-2-treated dying cells could be an effective vaccination to reduce tumor burden and promote...
Source: International Journal of Biological Macromolecules - July 31, 2023 Category: Biochemistry Authors: Xiao-Dong Wang Jia-Xin Wang Ming-Hao Hu Source Type: research
"EvoVax" - A rationally designed inactivated Salmonella Typhimurium vaccine induces strong and long-lasting immune responses in pigs
In this study we tested safety and immunogenicity of an oral inactivated S.Tm vaccine, which has been recently shown to generate an "evolutionary trap" and to massively reduce S.Tm colonization and transmission in mice. We show that this vaccine is highly immunogenic and safe in post-weaning pigs and that administration of a single oral dose results in a strong and long-lasting serum IgG response. This has several advantages over existing - mainly live - vaccines against S.Tm, both in improved seroconversion and reduced risk of vaccine-strain persistence and reversion to virulence.PMID:37517910 | DOI:10.1016/j.vaccine.2023.07.059
Source: Vaccine - July 30, 2023 Category: Allergy & Immunology Authors: Verena Lentsch Selma Aslani Thomas Echtermann Swapan Preet Elisa Cappio Barazzone Daniel Hoces Claudia Moresi Dolf K ümmerlen Emma Slack Source Type: research
ICP8-vhs- HSV-2 Vaccine Expressing B7 Costimulation Molecules Optimizes Safety and Efficacy against HSV-2 Infection in Mice
Viruses. 2023 Jul 18;15(7):1570. doi: 10.3390/v15071570.ABSTRACTHerpes simplex virus 2 (HSV-2) causes most sexually transmitted genital ulcerative disease. No effective prophylactic vaccine is currently available. Replication-defective (ICP8-) HSV stimulates immune responses in animals without producing progeny virus, making it potentially useful as a safe form of a live vaccine against HSV. We previously demonstrated that mice generate a stronger response to ICP8- virus encoding B7-2 costimulation molecules than to the parental replication-defective virus. We have also demonstrated enhanced immunogenicity of an ICP8-, vir...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Maria Korom Hong Wang Kaelin M Bernier Brian J Geiss Lynda A Morrison Source Type: research
Recent advances in genome editing of bloodstream forms of Trypanosoma congolense using CRISPR-Cas9 ribonucleoproteins: Proof of concept
We present an efficient, reproducible and stable CRISPR-Cas9 genome editing system for use in Tc bloodstream forms (Tc-BSF). This plasmid-free system is based on transient expression of Cas9 protein and the use of a ribonucleoprotein formed by the Cas9 and sgRNA complex. This is the first proof of concept of genome editing using CRISPR-Cas9 ribonucleoproteins on Tc-BSF. This adapted protocol enriches the "toolbox" for the functional study of genes of interest in blood forms of the Trypanosoma congolense. This proof of concept is an important step for the scientific community working on the study of trypanosomes and opens u...
Source: Experimental Parasitology - July 29, 2023 Category: Parasitology Authors: C écile Minet Isabelle Chantal David Berthier Source Type: research
ICP8-vhs- HSV-2 Vaccine Expressing B7 Costimulation Molecules Optimizes Safety and Efficacy against HSV-2 Infection in Mice
Viruses. 2023 Jul 18;15(7):1570. doi: 10.3390/v15071570.ABSTRACTHerpes simplex virus 2 (HSV-2) causes most sexually transmitted genital ulcerative disease. No effective prophylactic vaccine is currently available. Replication-defective (ICP8-) HSV stimulates immune responses in animals without producing progeny virus, making it potentially useful as a safe form of a live vaccine against HSV. We previously demonstrated that mice generate a stronger response to ICP8- virus encoding B7-2 costimulation molecules than to the parental replication-defective virus. We have also demonstrated enhanced immunogenicity of an ICP8-, vir...
Source: Herpes - July 29, 2023 Category: Infectious Diseases Authors: Maria Korom Hong Wang Kaelin M Bernier Brian J Geiss Lynda A Morrison Source Type: research
Recent advances in genome editing of bloodstream forms of Trypanosoma congolense using CRISPR-Cas9 ribonucleoproteins: Proof of concept
We present an efficient, reproducible and stable CRISPR-Cas9 genome editing system for use in Tc bloodstream forms (Tc-BSF). This plasmid-free system is based on transient expression of Cas9 protein and the use of a ribonucleoprotein formed by the Cas9 and sgRNA complex. This is the first proof of concept of genome editing using CRISPR-Cas9 ribonucleoproteins on Tc-BSF. This adapted protocol enriches the "toolbox" for the functional study of genes of interest in blood forms of the Trypanosoma congolense. This proof of concept is an important step for the scientific community working on the study of trypanosomes and opens u...
Source: Experimental Parasitology - July 29, 2023 Category: Parasitology Authors: C écile Minet Isabelle Chantal David Berthier Source Type: research
3Rs implementation in veterinary vaccine batch-release testing: Current state-of-the-art and future opportunities. A webinar and workshop report
Biologicals. 2023 Jul 27;83:101695. doi: 10.1016/j.biologicals.2023.101695. Online ahead of print.ABSTRACTRegulatory authorities require veterinary batch-release testing to confirm vaccine potency and safety, but these tests have traditionally relied on large numbers of laboratory animals. Advances in vaccine research and development offer increasing opportunities to replace in vivo testing, and some stakeholders have made significant progress in incorporating 3Rs elements in quality control strategies. A three-part event series entitled "3Rs Implementation in Veterinary Vaccine Batch-Release Testing: Current state-of-the-...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 29, 2023 Category: Biotechnology Authors: Laura Viviani Elisabeth Balks Sonja Beken Anna-Maria Brady Rick Clayton Florence Cliquet Liys Desmayanti Silvia Fragoeiro Terrie Jo Hamtak David John Carmen Jungba ëck M Kalaivani Imke Kross Catherine Lang Ni Made Ria Isriyanthi Laurent Mallet Catherine Source Type: research
