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Vaccination: Veterinary Vaccinations
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Molecular and genetic characterization of bovine parainfluenza type 3 European field and vaccine strains
In this study, we sequenced the full-genome and genetically characterized BPIV-3 strains isolated from animals displaying respiratory illness in France and Sweden, as well as the vaccine strains contained in three different commercialized vaccines. Our results show that the sequences from France and Sweden belong to genotype C. However, a third sequence from Sweden from 2017 clustered within genotype A. The sequencing of vaccine strains revealed that two of the vaccine strains clustered within genotype C, whereas the third vaccine strain belonged to genotype A. Altogether, our findings suggest that both genotypes A and C c...
Source: Infection, Genetics and Evolution - July 23, 2023 Category: Genetics & Stem Cells Authors: Maria Gaudino Jean-Fran çois Valarcher Sara H ägglund Katarina N äslund Siamak Zohari Mariette F Ducatez Gilles Meyer Source Type: research
Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2
Antiviral Res. 2023 Jul 19:105677. doi: 10.1016/j.antiviral.2023.105677. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a respiratory virus that causes COVID-19 disease, with an estimated global mortality of approximately 2%. While global response strategies, which are predominantly reliant on regular vaccinations, have shifted from zero COVID to living with COVID, there is a distinct lack of broad-spectrum direct acting antiviral therapies that maintain efficacy across evolving SARS-CoV-2 variants of concern. This is of most concern for immunocompromised and immunosuppressed ...
Source: Antiviral Research - July 21, 2023 Category: Virology Authors: Ellen Bowden-Reid Scott Ledger Yuan Zhang Francesca Di Giallonardo Anupriya Aggarwal Alberto Ospina Stella Anouschka Akerman Vanessa Milogiannakis Gregory Walker William Rawlinson Stuart Turville Anthony D Kelleher Chantelle Ahlenstiel Source Type: research
Report of the third conference on next-generation sequencing for adventitious virus detection in biologics for humans and animals
Biologicals. 2023 Jul 19;83:101696. doi: 10.1016/j.biologicals.2023.101696. Online ahead of print.ABSTRACTNext-generation sequencing (NGS) has been proven to address some of the limitations of the current testing methods for adventitious virus detection in biologics. The International Alliance for Biological Standardization (IABS), the U.S. Food and Drug Administration (FDA), and the European Directorate for the Quality of Medicines and Healthcare (EDQM) co-organized the "3rd Conference on Next-generation Sequencing for Adventitious Virus Detection in Biologics for Humans and Animals", which was held on September 27-28, 20...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 21, 2023 Category: Biotechnology Authors: Arifa S Khan Laurent Mallet Johannes Bl ümel Jean-Pol Cassart Ivana Knezevic Siemon H S Ng Michael Wall Miia Jakava-Viljanen Carine Logvinoff Ana Goios Pieter Neels Source Type: research
Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2
Antiviral Res. 2023 Jul 19:105677. doi: 10.1016/j.antiviral.2023.105677. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a respiratory virus that causes COVID-19 disease, with an estimated global mortality of approximately 2%. While global response strategies, which are predominantly reliant on regular vaccinations, have shifted from zero COVID to living with COVID, there is a distinct lack of broad-spectrum direct acting antiviral therapies that maintain efficacy across evolving SARS-CoV-2 variants of concern. This is of most concern for immunocompromised and immunosuppressed ...
Source: Cell Research - July 21, 2023 Category: Cytology Authors: Ellen Bowden-Reid Scott Ledger Yuan Zhang Francesca Di Giallonardo Anupriya Aggarwal Alberto Ospina Stella Anouschka Akerman Vanessa Milogiannakis Gregory Walker William Rawlinson Stuart Turville Anthony D Kelleher Chantelle Ahlenstiel Source Type: research
Report of the third conference on next-generation sequencing for adventitious virus detection in biologics for humans and animals
Biologicals. 2023 Jul 19;83:101696. doi: 10.1016/j.biologicals.2023.101696. Online ahead of print.ABSTRACTNext-generation sequencing (NGS) has been proven to address some of the limitations of the current testing methods for adventitious virus detection in biologics. The International Alliance for Biological Standardization (IABS), the U.S. Food and Drug Administration (FDA), and the European Directorate for the Quality of Medicines and Healthcare (EDQM) co-organized the "3rd Conference on Next-generation Sequencing for Adventitious Virus Detection in Biologics for Humans and Animals", which was held on September 27-28, 20...
Source: Biologicals : Journal of the International Association of Biological Standardization - July 21, 2023 Category: Biotechnology Authors: Arifa S Khan Laurent Mallet Johannes Bl ümel Jean-Pol Cassart Ivana Knezevic Siemon H S Ng Michael Wall Miia Jakava-Viljanen Carine Logvinoff Ana Goios Pieter Neels Source Type: research
Examination of the cross-reactivity between vaccinia virus Tiantan strain and monkeypox virus
CONCLUSIONS: Sera of vaccinia virus-vaccinated rabbits exhibited cross-reactivity with viral antigens of monkeypox virus. Potential in improving the accuracy of antigen discovery while reducing the lengthy work needed for the screening as BLI method possesses, it contributes greatly to the rapid preliminary evaluation of immune response generated by vaccines.PMID:37473582 | DOI:10.1016/j.jviromet.2023.114772
Source: Journal of Virological Methods - July 20, 2023 Category: Virology Authors: Qiufang Huang Yuwei Wang Tingting Zhao Yinan Wang Xiaojie Wang Shishi Li Wenhao Su Xiuxiu Ren Xiaohuan Zhang Jingjing Liu Jiangbo Wei Source Type: research
