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Vaccination: Veterinary Vaccinations
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Total 6987 results found since Jan 2013.
rWTC-MBTA: autologous vaccine prevents metastases via antitumor immune responses
CONCLUSION: The rWTC-MBTA vaccine demonstrated efficacy in multiple animal models through T-cell mediated cytotoxicity and has potential as a therapeutic option for preventing and treating tumor metastasis with minimal systemic toxicity.PMID:37434263 | DOI:10.1186/s13046-023-02744-8
Source: Cell Research - July 11, 2023 Category: Cytology Authors: Juan Ye Herui Wang Rogelio Medina Samik Chakraborty Mitchell Sun Alex Valenzuela Xueyu Sang Yaping Zhang Ondrej Uher Jan Zenka Karel Pacak Zhengping Zhuang Source Type: research
Repurposing Polyether Ionophores as a New-Class of Anti-SARS-Cov-2 Agents as Adjunct Therapy
Curr Microbiol. 2023 Jul 6;80(8):273. doi: 10.1007/s00284-023-03366-1.ABSTRACTThe emergence of SARS-CoV-2 and its variants have posed a significant threat to humankind in tackling the viral spread. Furthermore, currently repurposed drugs and frontline antiviral agents have failed to cure severe ongoing infections effectively. This insufficiency has fuelled research for potent and safe therapeutic agents to treat COVID-19. Nonetheless, various vaccine candidates have displayed a differential efficacy and need for repetitive dosing. The FDA-approved polyether ionophore veterinary antibiotic for treating coccidiosis has been ...
Source: Current Microbiology - July 6, 2023 Category: Microbiology Authors: Keerthana Gurukkalot Vinoth Rajendran Source Type: research
Specific mRNA lipid nanoparticles and acquired resistance to ticks
This study demonstrates that more than one I. scapularis target within 19ISP is required for resistance to ticks, and that additional targets may also play a role in this process.PMID:37407406 | DOI:10.1016/j.vaccine.2023.06.081
Source: Vaccine - July 5, 2023 Category: Allergy & Immunology Authors: Jaqueline Matias Yingjun Cui Xiaotian Tang Andaleeb Sajid Gunjan Arora Ming-Jie Wu Kathleen DePonte Hiromi Muramatsu Ying K Tam Sukanya Narasimhan Norbert Pardi Drew Weissman Erol Fikrig Source Type: research
Prevalence of equine parvovirus-hepatitis in healthy broodmares in Ontario, Canada
This study investigated the prevalence of EqPV-H DNA in 170 healthy broodmares of various breeds located on 37 farms in southern Ontario, Canada. The occurrence of EqPV-H infection was determined by quantitative PCR for EqPV-H DNA in serum samples. The effects of age, breed, season, pregnancy status, and equine herpesvirus-1 (EHV-1) vaccination history on EqPV-H status were also investigated. There was a prevalence of 15.9% (27/170) with viral loads of EqPV-H ranging from detectable to 2900 copies/mL. Statistical analysis showed that increasing age was a significant factor in the detection of EqPV-H DNA. Neither breed, sea...
Source: Canadian Journal of Veterinary Research - July 3, 2023 Category: Veterinary Research Authors: Maria A Papapetrou Luis G Arroyo Toni L Meister John D Baird Eike Steinmann Brandon N Lillie Source Type: research
Effect of supplementation with < em > Saccharomyces boulardii < /em > CNCM I-1079 on vaccine response to an inactivated bacterial vaccine in young Japanese Black calves: A field trial
In conclusion, S. boulardii may have positively affected immune responses to the inactivated multi-bacterial vaccine in young calves in the field.PMID:37397640 | PMC:PMC10291731
Source: Canadian Journal of Veterinary Research - July 3, 2023 Category: Veterinary Research Authors: Kazusa Mori Asato Uchiumi Kai Yamamoto Yuki Shimizu Risa Ueda Keigo Kosenda Tomochika Fukuhara Syunsuke Kure Hiroyuki Fukazawa Hiromichi Ohtsuka Source Type: research
Prevalence of equine parvovirus-hepatitis in healthy broodmares in Ontario, Canada
This study investigated the prevalence of EqPV-H DNA in 170 healthy broodmares of various breeds located on 37 farms in southern Ontario, Canada. The occurrence of EqPV-H infection was determined by quantitative PCR for EqPV-H DNA in serum samples. The effects of age, breed, season, pregnancy status, and equine herpesvirus-1 (EHV-1) vaccination history on EqPV-H status were also investigated. There was a prevalence of 15.9% (27/170) with viral loads of EqPV-H ranging from detectable to 2900 copies/mL. Statistical analysis showed that increasing age was a significant factor in the detection of EqPV-H DNA. Neither breed, sea...
Source: Canadian Journal of Veterinary Research - July 3, 2023 Category: Veterinary Research Authors: Maria A Papapetrou Luis G Arroyo Toni L Meister John D Baird Eike Steinmann Brandon N Lillie Source Type: research
Effect of supplementation with < em > Saccharomyces boulardii < /em > CNCM I-1079 on vaccine response to an inactivated bacterial vaccine in young Japanese Black calves: A field trial
In conclusion, S. boulardii may have positively affected immune responses to the inactivated multi-bacterial vaccine in young calves in the field.PMID:37397640 | PMC:PMC10291731
Source: Canadian Journal of Veterinary Research - July 3, 2023 Category: Veterinary Research Authors: Kazusa Mori Asato Uchiumi Kai Yamamoto Yuki Shimizu Risa Ueda Keigo Kosenda Tomochika Fukuhara Syunsuke Kure Hiroyuki Fukazawa Hiromichi Ohtsuka Source Type: research
Development of toxin-antitoxin self-destructive bacteria, aimed for salmonella vaccination
This study aimed to develop a novel vaccination strategy, which combines the effectiveness of live-attenuated and safety of inactivated vaccines by construction of inducible self-destructing bacteria utilizing toxin-antitoxin (TA) systems. Hok-Sok and CeaB-CeiB toxin-antitoxin systems were coupled with three induction systems aimed for activating cell killing upon lack of arabinose, anaerobic conditions or low concentration of metallic di-cations. The constructs were transformed into a pathogenic Salmonella enterica serovar Enteritidis strain and bacteria elimination was evaluated in vitro under specific activating conditi...
Source: Vaccine - July 3, 2023 Category: Allergy & Immunology Authors: Nady Gruzdev Jacob Pitcovski Chen Katz Nili Ruimi Dalia Eliahu Caroline Noach Ella Rosenzweig Avner Finger Ehud Shahar Source Type: research
Development of Shigella conjugate vaccines targeting Shigella flexneri 2a and S. flexneri 3a using a simple platform-approach conjugation by squaric acid chemistry
Vaccine. 2023 Jul 1:S0264-410X(23)00738-7. doi: 10.1016/j.vaccine.2023.06.052. Online ahead of print.ABSTRACTThere is a need for vaccines effective against shigella infection in young children in resource-limited areas. Protective immunity against shigella infection targets the O-specific polysaccharide (OSP) component of lipopolysaccharide. Inducing immune responses to polysaccharides in young children can be problematic, but high level and durable responses can be induced by presenting polysaccharides conjugated to carrier proteins. An effective shigella vaccine will need to be multivalent, targeting the most common glob...
Source: Vaccine - July 3, 2023 Category: Allergy & Immunology Authors: Meagan Kelly Anjali Mandlik Richelle C Charles Smriti Verma Stephen B Calderwood Daniel T Leung Rajib Biswas Kamrul Islam Mohammad Kamruzzaman Fahima Chowdhury Farhana Khanam Willie F Vann Ashraful Islam Khan Taufiqur Rahman Bhuiyan Firdausi Qadri Anthony Source Type: research
