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Vaccination: Influenza Vaccine
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Comparative effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in immunocompromised individuals: a systematic review and meta-analysis using the GRADE framework
ConclusionThis GRADE meta-analysis based on a large number of consistent observational studies showed that the mRNA-1273 COVID-19 vaccine is associated with improved clinical effectiveness in IC populations compared with BNT162b2.
Source: Frontiers in Immunology - September 12, 2023 Category: Allergy & Immunology Source Type: research
Antiviral Compounds to Address Influenza Pandemics: An Update from 2016-2022
Curr Med Chem. 2023 Sep 7. doi: 10.2174/0929867331666230907093501. Online ahead of print.ABSTRACTIn recent decades, the world has gained experience of the dangerous effects of pandemic events caused by emerging respiratory viruses. In particular, annual epidemics of influenza are responsible for severe illness and deaths. Even if conventional influenza vaccines represent the most effective tool for preventing virus infections, they are not completely effective in patients with severe chronic disease and immunocompromised and new small molecules have emerged to prevent and control the influenza viruses. Thus, the attention ...
Source: Current Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Roberto Romeo Laura Legnani Maria Assunta Chiacchio Salvatore V Giofr è Daniela Iannazzo Source Type: research
Vaccine Effectiveness of non-adjuvanted and adjuvanted trivalent inactivated influenza vaccines in the prevention of influenza-related hospitalization in older adults: A pooled analysis from the Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN)
CONCLUSIONS: Adjusting for frailty, aTIV showed statistically significantly better protection than naTIV against influenza-associated hospitalizations in older adults. In future studies, it is important to consider frailty as a significant confounder of VE.PMID:37696717 | DOI:10.1016/j.vaccine.2023.08.070
Source: Vaccine - September 11, 2023 Category: Allergy & Immunology Authors: Henrique Pott Melissa K Andrew Zachary Shaffelburg Michaela K Nichols Lingyun Ye May ElSherif Todd F Hatchette Jason LeBlanc Ardith Ambrose Guy Boivin William Bowie Jennie Johnstone Kevin Katz Phillipe Lagac é-Wiens Mark Loeb Anne McCarthy Allison McGeer Source Type: research
Antiviral Compounds to Address Influenza Pandemics: An Update from 2016-2022
Curr Med Chem. 2023 Sep 7. doi: 10.2174/0929867331666230907093501. Online ahead of print.ABSTRACTIn recent decades, the world has gained experience of the dangerous effects of pandemic events caused by emerging respiratory viruses. In particular, annual epidemics of influenza are responsible for severe illness and deaths. Even if conventional influenza vaccines represent the most effective tool for preventing virus infections, they are not completely effective in patients with severe chronic disease and immunocompromised and new small molecules have emerged to prevent and control the influenza viruses. Thus, the attention ...
Source: Current Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Roberto Romeo Laura Legnani Maria Assunta Chiacchio Salvatore V Giofr è Daniela Iannazzo Source Type: research
Healthcare personnel in 2016-2019 prospective cohort infrequently got vaccinated, worked while ill, and frequently used antibiotics rather than antivirals against viral influenza illnesses
Influenza Other Respir Viruses. 2023 Sep 7;17(9):e13189. doi: 10.1111/irv.13189. eCollection 2023 Sep.ABSTRACTBACKGROUND: Uncertainty about risk of illness and the value of influenza vaccines negatively affects vaccine uptake among persons targeted for influenza vaccination.METHODS: During 2016-2019, we followed a cohort of healthcare personnel (HCP) targeted for free-of-charge influenza vaccination in five Lima hospitals to quantify risk of influenza, workplace presenteeism (coming to work despite illness), and absenteeism (taking time off from work because of illness). The HCP who developed acute respiratory illnesses (A...
Source: Respiratory Care - September 11, 2023 Category: Respiratory Medicine Authors: Eduardo Azziz-Baumgartner Joan Neyra Tat S Yau Giselle Soto Daniel Owusu Chao Zhang Candice Romero Young M Yoo Miriam Gonzales Yeny Tinoco Mar ía Silva Eduar Bravo Nancy Rojas Serrano Eduardo Matos Victor Chavez-Perez Juan Carlos Castro Maria Esther Cast Source Type: research
Vaccine Effectiveness of non-adjuvanted and adjuvanted trivalent inactivated influenza vaccines in the prevention of influenza-related hospitalization in older adults: A pooled analysis from the Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN)
CONCLUSIONS: Adjusting for frailty, aTIV showed statistically significantly better protection than naTIV against influenza-associated hospitalizations in older adults. In future studies, it is important to consider frailty as a significant confounder of VE.PMID:37696717 | DOI:10.1016/j.vaccine.2023.08.070
Source: Vaccine - September 11, 2023 Category: Allergy & Immunology Authors: Henrique Pott Melissa K Andrew Zachary Shaffelburg Michaela K Nichols Lingyun Ye May ElSherif Todd F Hatchette Jason LeBlanc Ardith Ambrose Guy Boivin William Bowie Jennie Johnstone Kevin Katz Phillipe Lagac é-Wiens Mark Loeb Anne McCarthy Allison McGeer Source Type: research
A recombinant chimeric influenza virus vaccine expressing the consensus H3 hemagglutinin elicits broad hemagglutination inhibition antibodies against divergent swine H3N2 influenza viruses
This study focuses on the hemagglutinin (HA) consensus-based approach towards developing a more broadly protective swine influenza vaccine against various H3 strains circulating in domestic pig populations. By computationally analyzing >1000 swine H3 full-length HA sequences, we generated a consensus H3 and expressed it in the context of influenza A WSN/33 reverse genetics system. The derived recombinant chimeric swine influenza virus with the consensus H3 was inactivated and further evaluated as a potential universal vaccine in pigs. The consensus H3 vaccine elicited broadly active hemagglutination inhibition (HI) anti...
Source: Vaccine - September 9, 2023 Category: Allergy & Immunology Authors: Jieshi Yu Chithra Sreenivasan Zhizhang Sheng Shao-Lun Zhai Jared W Wollman Sisi Luo Chen Huang Rongyuan Gao Zhao Wang Radhey S Kaushik Jane Christopher-Hennings Eric Nelson Ben M Hause Feng Li Dan Wang Source Type: research
TWiV 1042: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization, temporal changes in fecal microbiota of patients infected with C...
Source: This Week in Virology - MP3 Edition - September 9, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Optimisation of SARS-CoV-2 peptide stimulation and measurement of cytokine output by intracellular flow cytometry and bio-Plex analysis
J Immunol Methods. 2023 Sep 6:113556. doi: 10.1016/j.jim.2023.113556. Online ahead of print.ABSTRACTOur study was conducted to optimise a peptide stimulation and an intracellular cytokine staining protocol, alongside Bio-Plex supernatant analysis, for use in patients who had previously contracted SARS-CoV-2 or received vaccination against this virus in a clinical laboratory setting. Peripheral Blood Mononuclear Cell extraction and cryopreservation allowed for cells to be stored long term and enhanced logistical processing of samples. Viability and functionality of cells were analysed by flow cytometric methodology using vi...
Source: Journal of Immunological Methods - September 8, 2023 Category: Allergy & Immunology Authors: Jemma Victoria Taylor Emma Louise Callery Anthony Rowbottom Source Type: research
HVT-vectored H7 vaccine protects chickens from lethal infection with the highly pathogenic H7N9 Avian in fluenza virus
Vet Microbiol. 2023 Aug 20;285:109852. doi: 10.1016/j.vetmic.2023.109852. Online ahead of print.ABSTRACTSince mid-2016, the highly pathogenic H7N9 subtype avian influenza virus (AIV) has threatened both public health and the poultry industry. Although a vaccination strategy has been deemed imperative to manage the virus, the most commonly used inactivated vaccines today are susceptible to interference from maternal antibodies and associated with an over-reliance on humoral immunity. In response, we developed a recombination vaccine with the herpesvirus of turkeys (HVT) as the vector to squeeze HPAI H7N9 and assessed its pr...
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Yi-Qun Chen Guan-Ming Su Jia-Hao Zhang Bo Li Kai-Xiong Ma Xu Zhang Li-Hong Huang Ming Liao Wen-Bao Qi Source Type: research
Global burden of influenza lower respiratory tract infections in older people from 1990 to 2019
CONCLUSION: Efforts to improve vaccination for influenza are needed for preparedness of another influenza pandemic, especially in low-SDI regions.PMID:37682492 | DOI:10.1007/s40520-023-02553-1
Source: Aging Clinical and Experimental Research - September 8, 2023 Category: Geriatrics Authors: Jing-Nan Feng Hou-Yu Zhao Si-Yan Zhan Source Type: research
Assessment of Disease Burden and Immunization Rates for Vaccine-Preventable Diseases in People Living with HIV: The Korea HIV/AIDS Cohort Study
CONCLUSION: The burden of vaccine-preventable diseases was quite high in HIV-infected patients. Nadir CD4 T-cell counts, peak HIV viral loads, and the number of ART regimen change are significant factors related to vaccination. Considering the low vaccination rates for VPDs, there was a discordance between experts' opinions and real clinical practice in the medical field.PMID:37674339 | DOI:10.3947/ic.2023.0045
Source: Herpes - September 7, 2023 Category: Infectious Diseases Authors: Hye Seong Yunsu Choi Kyoung Hwan Ahn Jun Yong Choi Shin-Woo Kim Sang Il Kim Mee-Kyung Kee Bo Youl Choi Boyoung Park Hak Jun Hyun Jin Gu Yoon Ji Yun Noh Hee Jin Cheong Woo Joo Kim Joon Young Song Source Type: research
