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Vaccination: Influenza Vaccine
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Total 6499 results found since Jan 2013.
The role of pneumococcal vaccination in reducing the cardiovascular risk of cardiac patients: opinion of experts of the Prevention Committee of the Polish Cardiac Society supported by the Polish Vaccinology Society
Kardiol Pol. 2023 Sep 3. doi: 10.33963/v.kp.96718. Online ahead of print.ABSTRACTRespiratory diseases have been the fourth most common cause of death in Poland in recent years. Respiratory infection, especially pneumonia, can lead to exacerbation of chronic cardiovascular disease. Streptococcus pneumoniae is the most common bacterial pathogen causing community-acquired pneumonia. Pneumococci are also the most common pathogen complicating the course of influenza virus infection. Pneumonia, especially invasive pneumococcal disease, is associated with the risk of death in the course of respiratory failure or sepsis and also w...
Source: Kardiologia Polska - September 3, 2023 Category: Cardiology Authors: Artur Mamcarz Marcin We łnicki Jaros ław Drożdż Marcin Grabowski Piotr Jankowski Ernest Kuchar Przemys ław Leszek Przemys ław Mitkowski Jacek Wysocki Source Type: research
Developmental and reproductive safety of Advax-CpG55.2 ™ adjuvanted COVID-19 and influenza vaccines in mice
Vaccine. 2023 Aug 31:S0264-410X(23)01007-1. doi: 10.1016/j.vaccine.2023.08.053. Online ahead of print.ABSTRACTSpikoGen® is a recombinant spike protein vaccine against COVID-19 that obtained marketing authorization in the Middle East on October 6th, 2021, becoming the first adjuvanted protein-based COVID-19 vaccine of its type to achieve approval. SpikoGen® vaccine utilizes a unique adjuvant Advax-CpG55.2, which comprises delta inulin and CpG55.2 oligonucleotide, a synthetic human toll-like receptor (TLR)-9 agonist. As part of a safety assessment, developmental and reproductive toxicity (DART) studies were undertaken in m...
Source: Vaccine - September 2, 2023 Category: Allergy & Immunology Authors: Isaac G Sakala Yoshikazu Honda-Okubo Nikolai Petrovsky Source Type: research
Immunogenicity and protective efficacy of human metapneumovirus virus-like particles produced by a recombinant baculovirus in mice
CONCLUSIONS: This is the first study to demonstrate that HMPV VLP was successfully prepared in the baculovirus expression system. HMPV VLP could induce specific humoral and cellular immune responses as well as protective efficacy, and aluminum hydroxide may be an effective adjuvant in mice.PMID:37657510 | DOI:10.1016/j.virusres.2023.199215
Source: Virus Research - September 1, 2023 Category: Virology Authors: Fenlian Ma Aijun Chen Lihong Yao Hanchun Gao Qian Zhang Wenzhe Hou Lishu Zheng Source Type: research
The Adenylyl Cyclase Activator Forskolin Increases Influenza Virus Propagation in MDCK Cells by Regulating ERK1/2 Activity
In this study, we investigated whether treatment with forskolin (FSK), an adenylyl cyclase activator, affected the output of a cell-based influenza vaccine. We found that FSK increased the propagation of three influenza virus subtypes (A/H1N1/California/4/09, A/H3N2/Mississippi/1/85, and B/Shandong/7/97) in Madin-Darby canine kidney (MDCK) cells. Interestingly, FSK suppressed the growth of MDCK cells. This effect could be a result of protein kinase A (PKA)-Src axis activation, which downregulates extracellular signal-regulated kinase (ERK)1/2 activity and delays cell cycle progression from G1 to S. This delay in cell growt...
Source: Journal of Microbiology and Biotechnology - August 30, 2023 Category: Biotechnology Authors: Sang-Yeon Lee Jisun Lee Hye-Lim Park Yong-Wook Park Hun Kim Jae-Hwan Nam Source Type: research
