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Vaccination: Influenza Vaccine
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Total 6499 results found since Jan 2013.
Neutralizing Antibody Responses against Five SARS-CoV-2 Variants and T Lymphocyte Change after Vaccine Breakthrough Infections from the SARS-CoV-2 Omicron BA.1 Variant in Tianjin, China: A Prospective Study
CONCLUSION: Omicron BA.1 breakthrough infection mainly evoked humoral immune memory in the original strain after vaccination and hardly produced neutralizing antibodies specific to Omicron BA.1. Neutralizing antibodies against the different strains declined rapidly and showed features similar to those of influenza. Thus, T-lymphocytes may play an important role in recovery.PMID:37533385 | DOI:10.3967/bes2023.047
Source: Biomedical and Environmental Sciences : BES - August 3, 2023 Category: Biomedical Science Authors: Ying Zhang Jiang Wen Qu Min Na Zheng Ya Xing Ding Wei Chen Shao Dong Ye Xiao Yan Li Yan Kun Li Ying Liu Di Zhu Can Rui Jin Lin Wang Jin Ye Yang Yu Zhai Er Qiang Wang Xing Meng Source Type: research
Rational design and optimization of acylthioureas as novel potent influenza virus non-nucleoside polymerase inhibitors
Eur J Med Chem. 2023 Jul 26;259:115678. doi: 10.1016/j.ejmech.2023.115678. Online ahead of print.ABSTRACTEvidence suggests that rapidly evolving virus subvariants risk rendering current vaccines and anti-influenza drugs ineffective. Hence, exploring novel scaffolds or new targets of anti-influenza drugs is of great urgency. Herein, we report the discovery of a series of acylthiourea derivatives produced via a scaffold-hopping strategy as potent antiviral agents against influenza A and B subtypes. The most effective compound 10m displayed subnanomolar activity against H1N1 proliferation (EC50 = 0.8 nM) and exhibited inhibit...
Source: European Journal of Medicinal Chemistry - August 2, 2023 Category: Chemistry Authors: Xinjin Liu Zhichao Xu Jinsen Liang Ting Xu Wenting Zou Lijun Zhu Yihe Wu Chune Dong Ke Lan Shuwen Wu Hai-Bing Zhou Source Type: research
An Advax-CpG55.2 adjuvanted recombinant hemagglutinin vaccine provides immunity against H7N9 influenza in adult and neonatal mice
Vaccine. 2023 Jul 31:S0264-410X(23)00892-7. doi: 10.1016/j.vaccine.2023.07.061. Online ahead of print.ABSTRACTThere is a major unmet need for strategies to improve the immunogenicity and effectiveness of pandemic influenza vaccines, particularly in poor responder populations such as neonates. Recombinant protein approaches to pandemic influenza offer advantages over more traditional inactivated virus approaches, as they are free of problems such as egg adaptation or need for high level biosecurity containment for manufacture. However, a weakness of recombinant proteins is their low immunogenicity. We asked whether the use ...
Source: Vaccine - August 2, 2023 Category: Allergy & Immunology Authors: Yoshikazu Honda-Okubo Isaac G Sakala Greiciely Andr é E Bart Tarbet Brett L Hurst Nikolai Petrovsky Source Type: research
Psychological and Personality Characteristics Associated With COVID-19 Vaccination Behavior in Korean General Population
CONCLUSIONS: People weighed the benefits of COVID-19 vaccination against the risk of side effects when deciding to receive the COVID-19 vaccine. Our findings also indicate that this vaccination behavior may be affected by coping mechanisms and psychological factors.PMID:37527911 | PMC:PMC10396430 | DOI:10.3346/jkms.2023.38.e234
Source: J Korean Med Sci - August 1, 2023 Category: General Medicine Authors: Seunghyong Ryu Ju-Wan Kim Ju-Yeon Lee Young-Shin Kang Hee-Young Shin Sook-In Jung Jae-Min Kim Sung-Wan Kim Source Type: research
Treatment and prevention of influenza in geriatric patients
Expert Rev Clin Pharmacol. 2023 Aug 1. doi: 10.1080/17512433.2023.2243221. Online ahead of print.ABSTRACTINTRODUCTION: Older adults are the most vulnerable population to the effects of influenza. These patients have age-related characteristics that make response to both infection and therapeutics different than younger patients.AREAS COVERED: Influenza vaccination and antiviral therapy are the foundational approach to preventing and treating influenza in geriatric patients. Older adults should receive one of three enhanced vaccines before influenza season beings. There are five antivirals used in influenza. Geriatric patie...
Source: Pharmacological Reviews - August 1, 2023 Category: Drugs & Pharmacology Authors: Marilyn N Bulloch Source Type: research
Psychological and Personality Characteristics Associated With COVID-19 Vaccination Behavior in Korean General Population
CONCLUSIONS: People weighed the benefits of COVID-19 vaccination against the risk of side effects when deciding to receive the COVID-19 vaccine. Our findings also indicate that this vaccination behavior may be affected by coping mechanisms and psychological factors.PMID:37527911 | PMC:PMC10396430 | DOI:10.3346/jkms.2023.38.e234
Source: J Korean Med Sci - August 1, 2023 Category: General Medicine Authors: Seunghyong Ryu Ju-Wan Kim Ju-Yeon Lee Young-Shin Kang Hee-Young Shin Sook-In Jung Jae-Min Kim Sung-Wan Kim Source Type: research
Treatment and prevention of influenza in geriatric patients
Expert Rev Clin Pharmacol. 2023 Aug 1. doi: 10.1080/17512433.2023.2243221. Online ahead of print.ABSTRACTINTRODUCTION: Older adults are the most vulnerable population to the effects of influenza. These patients have age-related characteristics that make response to both infection and therapeutics different than younger patients.AREAS COVERED: Influenza vaccination and antiviral therapy are the foundational approach to preventing and treating influenza in geriatric patients. Older adults should receive one of three enhanced vaccines before influenza season beings. There are five antivirals used in influenza. Geriatric patie...
Source: Pharmacological Reviews - August 1, 2023 Category: Drugs & Pharmacology Authors: Marilyn N Bulloch Source Type: research
Psychological and Personality Characteristics Associated With COVID-19 Vaccination Behavior in Korean General Population
CONCLUSIONS: People weighed the benefits of COVID-19 vaccination against the risk of side effects when deciding to receive the COVID-19 vaccine. Our findings also indicate that this vaccination behavior may be affected by coping mechanisms and psychological factors.PMID:37527911 | PMC:PMC10396430 | DOI:10.3346/jkms.2023.38.e234
Source: J Korean Med Sci - August 1, 2023 Category: General Medicine Authors: Seunghyong Ryu Ju-Wan Kim Ju-Yeon Lee Young-Shin Kang Hee-Young Shin Sook-In Jung Jae-Min Kim Sung-Wan Kim Source Type: research
Interventions for increasing the uptake of immunisations in healthcare workers: A systematic review
CONCLUSION: Few robust studies that evaluate interventions to increase vaccination in HCWs are available. A limitation of this systematic review is that interventions are diverse, poorly reported and few were sufficiently alike to combine in an evaluation. More research on the effects of interventions to increase vaccination in HCWs is required, this should address a variety of vaccines and not just influenza vaccination.PMID:37527954 | DOI:10.1016/j.vaccine.2023.07.064
Source: Vaccine - August 1, 2023 Category: Allergy & Immunology Authors: Jane Tuckerman Kathryn Riley Sebastian Straube Hassen Mohammed Margie Danchin Helen S Marshall Source Type: research
Psychological and Personality Characteristics Associated With COVID-19 Vaccination Behavior in Korean General Population
CONCLUSIONS: People weighed the benefits of COVID-19 vaccination against the risk of side effects when deciding to receive the COVID-19 vaccine. Our findings also indicate that this vaccination behavior may be affected by coping mechanisms and psychological factors.PMID:37527911 | PMC:PMC10396430 | DOI:10.3346/jkms.2023.38.e234
Source: J Korean Med Sci - August 1, 2023 Category: General Medicine Authors: Seunghyong Ryu Ju-Wan Kim Ju-Yeon Lee Young-Shin Kang Hee-Young Shin Sook-In Jung Jae-Min Kim Sung-Wan Kim Source Type: research
Interventions for increasing the uptake of immunisations in healthcare workers: A systematic review
CONCLUSION: Few robust studies that evaluate interventions to increase vaccination in HCWs are available. A limitation of this systematic review is that interventions are diverse, poorly reported and few were sufficiently alike to combine in an evaluation. More research on the effects of interventions to increase vaccination in HCWs is required, this should address a variety of vaccines and not just influenza vaccination.PMID:37527954 | DOI:10.1016/j.vaccine.2023.07.064
Source: Vaccine - August 1, 2023 Category: Allergy & Immunology Authors: Jane Tuckerman Kathryn Riley Sebastian Straube Hassen Mohammed Margie Danchin Helen S Marshall Source Type: research
