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Vaccination: Influenza Vaccine
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Total 6499 results found since Jan 2013.
Attitudes of parents towards influenza vaccine in the Eastern Mediterranean Region: A multilevel analysis
CONCLUSION: A high seasonal influenza VH rate was found in the EMR. Health authorities should implement different interventions targeting the identified modifiable risk factor to increase vaccine uptake among children, especially those at risk of complication from seasonal influenza infection.PMID:37481405 | DOI:10.1016/j.vaccine.2023.07.005
Source: Vaccine - July 22, 2023 Category: Allergy & Immunology Authors: Ramy Mohamed Ghazy Sarah Assem Ibrahim Sarah Hamed N Taha Abdelhamid Elshabrawy Sally Waheed Elkhadry Suzan Abdel-Rahman Mahmoud A Hassaan Noha Fadl Source Type: research
Understanding structure activity relationships of Good HEPES lipids for lipid nanoparticle mRNA vaccine applications
Biomaterials. 2023 Jul 8;301:122243. doi: 10.1016/j.biomaterials.2023.122243. Online ahead of print.ABSTRACTLipid nanoparticles (LNPs) have shown great promise as delivery vehicles to transport messenger ribonucleic acid (mRNA) into cells and act as vaccines for infectious diseases including COVID-19 and influenza. The ionizable lipid incorporated within the LNP is known to be one of the main driving factors for potency and tolerability. Herein, we describe a novel family of ionizable lipids synthesized with a piperazine core derived from the HEPES Good buffer. These ionizable lipids have unique asymmetric tails and two di...
Source: Biomaterials - July 22, 2023 Category: Materials Science Authors: Rebecca L Goldman Namratha Turuvekere Vittala Murthy Trent P Northen Anuranjani Balakrishnan Sudha Chivukula Hillary Danz Timothy Tibbitts Anusha Dias Jorel Vargas Dustin Cooper Hardip Gopani Angela Beaulieu Kirill V Kalnin Timothy Plitnik Saswata Karmaka Source Type: research
Exploring the value of in-practice point-of-care testing (POCT) for high-risk groups
CONCLUSION: This work highlights the value of POCT for vulnerable patients.PMID:37479283 | DOI:10.3399/bjgp23X734361
Source: The British Journal of General Practice - July 21, 2023 Category: Primary Care Authors: Meredith Leston Uy Hoang Simon de Lusignan Source Type: research
Safety signal identification for COVID-19 bivalent booster vaccination using tree-based scan statistics in the Vaccine Safety Datalink
CONCLUSIONS: For Pfizer-BioNTech only, we detected clusters of: (1) unspecified adverse effects, as have been observed in other vaccine studies using this method, and (2) respiratory disease toward the end of follow-up. The respiratory clusters were likely due to overlap of follow-up with the spread of respiratory syncytial virus, influenza, and COVID-19, i.e., confounding by seasonality. The untargeted nature of the method and its inherent adjustment for the many diagnoses and risk intervals evaluated are unique advantages. Limitations include susceptibility to time-varying confounding, lower statistical power for assessi...
Source: Vaccine - July 21, 2023 Category: Allergy & Immunology Authors: W Katherine Yih Matthew F Daley Jonathan Duffy Bruce Fireman David L McClure Jennifer C Nelson Lei Qian Ning Smith Gabriela Vazquez-Benitez Eric Weintraub Joshua T B Williams Stanley Xu Judith C Maro Source Type: research
Exploring the value of in-practice point-of-care testing (POCT) for high-risk groups
CONCLUSION: This work highlights the value of POCT for vulnerable patients.PMID:37479283 | DOI:10.3399/bjgp23X734361
Source: The British Journal of General Practice - July 21, 2023 Category: Primary Care Authors: Meredith Leston Uy Hoang Simon de Lusignan Source Type: research
Vaccine effectiveness of recombinant and standard dose influenza vaccines against influenza related hospitalization using a retrospective test-negative design
CONCLUSIONS: Over all adults, both RIV4 and SD-IIV4 were effective against influenza hospitalization, with RIV4 providing better protection compared with SD-IIV4 overall, for females, younger adults, and those with no high-risk conditions.PMID:37474406 | DOI:10.1016/j.vaccine.2023.06.056
Source: Vaccine - July 20, 2023 Category: Allergy & Immunology Authors: Richard K Zimmerman Mary Patricia Nowalk Klancie Dauer Lloyd Clarke Jonathan M Raviotta G K Balasubramani Source Type: research
Understanding the Global Burden of Influenza in Adults Aged 18-64 years: A Systematic Literature Review from 2012 to 2022
CONCLUSIONS: High levels of hospitalization and outpatient visits demonstrated a clinical influenza-associated burden on patients and healthcare systems, which is exacerbated by comorbidities. Considering the size and breadth of the general population aged 18-64 years, the limited humanistic and economic findings of this SLR likely reflect an underreported burden. Greater investigation into indirect costs and prolonged absenteeism associated with influenza infection is required to fully understand the economic burden in this population.PMID:37470942 | DOI:10.1007/s12325-023-02610-1
Source: Respiratory Care - July 20, 2023 Category: Respiratory Medicine Authors: Farzaneh Maleki Verna Welch Santiago M C Lopez Alejandro Cane Jakob Langer Ashley Enstone Kristen Markus Olivia Wright Nicole Hewitt Isabelle Whittle Source Type: research
Vaccine effectiveness of recombinant and standard dose influenza vaccines against influenza related hospitalization using a retrospective test-negative design
CONCLUSIONS: Over all adults, both RIV4 and SD-IIV4 were effective against influenza hospitalization, with RIV4 providing better protection compared with SD-IIV4 overall, for females, younger adults, and those with no high-risk conditions.PMID:37474406 | DOI:10.1016/j.vaccine.2023.06.056
Source: Vaccine - July 20, 2023 Category: Allergy & Immunology Authors: Richard K Zimmerman Mary Patricia Nowalk Klancie Dauer Lloyd Clarke Jonathan M Raviotta G K Balasubramani Source Type: research
Understanding the Global Burden of Influenza in Adults Aged 18-64 years: A Systematic Literature Review from 2012 to 2022
CONCLUSIONS: High levels of hospitalization and outpatient visits demonstrated a clinical influenza-associated burden on patients and healthcare systems, which is exacerbated by comorbidities. Considering the size and breadth of the general population aged 18-64 years, the limited humanistic and economic findings of this SLR likely reflect an underreported burden. Greater investigation into indirect costs and prolonged absenteeism associated with influenza infection is required to fully understand the economic burden in this population.PMID:37470942 | DOI:10.1007/s12325-023-02610-1
Source: Respiratory Care - July 20, 2023 Category: Respiratory Medicine Authors: Farzaneh Maleki Verna Welch Santiago M C Lopez Alejandro Cane Jakob Langer Ashley Enstone Kristen Markus Olivia Wright Nicole Hewitt Isabelle Whittle Source Type: research
Understanding the Global Burden of Influenza in Adults Aged 18 –64 years: A Systematic Literature Review from 2012 to 2022
ConclusionsHigh levels of hospitalization and outpatient visits demonstrated a clinical influenza-associated burden on patients and healthcare systems, which is exacerbated by comorbidities. Considering the size and breadth of the general population aged 18 –64 years, the limited humanistic and economic findings of this SLR likely reflect an underreported burden. Greater investigation into indirect costs and prolonged absenteeism associated with influenza infection is required to fully understand the economic burden in this population.
Source: Advances in Therapy - July 20, 2023 Category: Drugs & Pharmacology Source Type: research
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Quantitation of strain-specific hemagglutinin trimers in mosaic quadrivalent influenza nanoparticle vaccine by ELISA
Vaccine. 2023 Jul 12:S0264-410X(23)00821-6. doi: 10.1016/j.vaccine.2023.07.009. Online ahead of print.ABSTRACTAn enzyme linked immunosorbent assay (ELISA) method was developed to analyze the assembly of a tetravalent mosaic influenza nanoparticle (NP) vaccine, Flumos-v1, consisting of hemagglutinin trimers (HAT) from H1 (A/Idaho/07/2018), H3 (A/Perth/1008/2019), HBV (Vic-B/Colorado/06/2017) and HBY (Yam-B/Phuket/3073/2013) strains. The sandwich ELISA assay used lectin from Galanthus nivalis as a universal capture reagent for all HAT strains and specific monoclonal antibody (mAb) to detect corresponding hemagglutinin antige...
Source: Vaccine - July 14, 2023 Category: Allergy & Immunology Authors: Casper Alabanza Victor Gavrilov Taylor Scott Rong Sylvie Yang Daniel B Gowetski Jason G Gall Q Paula Lei Source Type: research
A complex intervention on vaccination uptake among older adults ( ≥ 60 years) in Germany - a study protocol with a mixed methods design
In this study, a complex intervention to improve vaccination rates in GP practices for the vaccinations recommended for people aged 60 years and older will be implemented and evaluated. Additionally, improvements in patients' vaccine-related health literacy and knowledge, and patients' intention to get vaccinated are expected. The mixed methods design can deliver results that can be used to improve preventive health care for elderly people and to gain more knowledge on vaccination uptake and the intervention's effectiveness.TRIAL REGISTRATION: Trial registration number: DRKS00027252 (retrospectively registered).PMID:374522...
Source: Primary Care - July 14, 2023 Category: Primary Care Authors: Sarah A K Uthoff Anna Zinkevich Dominika Franiel Maike Below Helene Splieth Julia Iwen Marc Biedermann Dorothee Heinemeier Lena Ansmann Source Type: research
COVID-19 infection following influenza vaccine injection and its complications among nurses working in educational-medical hospitals of Ardabil in 2020
CONCLUSION: Influenza vaccine reduces the incidence of COVID-19 and reduces the need for hospitalization in patients with this disease. However, due to the positive effects of influenza vaccine on COVID-19 and its low cost, it is recommended to inject influenza vaccine more than before.PMID:37448928 | PMC:PMC10336958 | DOI:10.4103/jfmpc.jfmpc_1257_22
Source: Primary Care - July 14, 2023 Category: Primary Care Authors: Ali Bakhtiari Kerigh Rahele Mohammadi Hamidreza Shaker Mehri Seyedjavadi Source Type: research
