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Naphthoquinone derivatives targeting melanoma
Curr Top Med Chem. 2023 Sep 1. doi: 10.2174/1568026623666230901124059. Online ahead of print.ABSTRACTCancer is responsible for high mortality rates worldwide, representing a serious health problem. In this sense, melanoma corresponds to the most aggressive type of skin cancer, being the cause of the highest death rates. Therapeutic strategies for the treatment of melanoma remain limited, with problems associated with toxicity, serious side effects, and mechanisms of resistance. The potential of natural products for the prevention and treatment of melanoma has been reported in different studies. Among these compounds, napht...
Source: Current Topics in Medicinal Chemistry - September 8, 2023 Category: Chemistry Authors: J éssica Alves Nunes Adrielle Firmino da Silva Nunes Dimas Jos é da Paz Lima Edeildo Ferreira da Silva-J únior Source Type: research
Does genetic risk modify the effect of skin screening on melanoma detection rates?
CONCLUSIONS: Genetic risk predicts subsequent melanoma incidence, and is weakly associated with screening behaviour, but does not explain the higher rate of melanoma detection between screened and unscreened people.PMID:37681503 | DOI:10.1093/bjd/ljad333
Source: The British Journal of Dermatology - September 8, 2023 Category: Dermatology Authors: Nirmala Pandeya Jean Claude Dusingize Catherine M Olsen Stuart MacGregor Rachel E Neale Matthew H Law David C Whiteman Source Type: research
Can active sun exposure decrease the risk of giant cell arteritis and polymyalgia rheumatica in women?
CONCLUSION: Active sun exposure did not affect the risk of developing GCA or PMR in women in a cohort with restricted latitudinal variability.PMID:37675201 | PMC:PMC10477307 | DOI:10.1093/rap/rkad071
Source: Adv Data - September 7, 2023 Category: Epidemiology Authors: Karl Gisslander Ra ïssa de Boer Christian Ingvar Carl Turesson Karolin Isaksson David Jayne Aladdin J Mohammad Source Type: research
The level of macrophage migration inhibitory factor is negatively correlated with the efficacy of PD-1 blockade immunotherapy combined with chemotherapy as a neoadjuvant therapy for esophageal squamous cell carcinoma
CONCLUSION: Baseline MIF levels were negatively correlated with neoadjuvant therapy efficacy. Thus, MIF may serve as a predictive biomarker for this therapy. The accuracy of the prediction could be improved if the serum concentration of MIF is measured again after the patient received several weeks of treatment.PMID:37678132 | DOI:10.1016/j.tranon.2023.101775
Source: Translational Oncology - September 7, 2023 Category: Cancer & Oncology Authors: Liangliang Wu Yiming Gao Shengzhi Xie Wan Ye Yasushi Uemura Rong Zhang Yanju Yu Jinfeng Li Man Chen Qiyan Wu Pengfei Cui Hongyu Liu Shuai Mu Yilan Li Lingxiong Wang Chunxi Liu Jiahui Li Lijun Zhang Shunchang Jiao Guoqing Zhang Tianyi Liu Source Type: research
Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross-sectional, case-control study
CONCLUSION: Our study provides valuable insights into the epidemiology and prognosis of PE in lung cancer patients and suggests that a poor ECOG PS, which has not been previously reported, is an independent risk factor for PE.PMID:37675831 | DOI:10.1111/crj.13692
Source: Respiratory Care - September 7, 2023 Category: Respiratory Medicine Authors: Yongkang Huang Shiyuan Gao Ting Li Beilei Zhang Juan Du Yajuan Qian Yufei Xing Tong Zhou Minhua Shi Jian-An Huang Yixin Lian Source Type: research
"Squamous cell carcinoma developed in a trichilemmal cyst, an incidental finding"
Actas Dermosifiliogr. 2023 Sep 5:S0001-7310(23)00690-7. doi: 10.1016/j.ad.2023.05.032. Online ahead of print.NO ABSTRACTPMID:37678632 | DOI:10.1016/j.ad.2023.05.032
Source: Actas Dermo-Sifiliograficas - September 7, 2023 Category: Dermatology Authors: J P érez Wilson G Coulon C Whittle A Castro Source Type: research
Can active sun exposure decrease the risk of giant cell arteritis and polymyalgia rheumatica in women?
CONCLUSION: Active sun exposure did not affect the risk of developing GCA or PMR in women in a cohort with restricted latitudinal variability.PMID:37675201 | PMC:PMC10477307 | DOI:10.1093/rap/rkad071
Source: Adv Data - September 7, 2023 Category: Epidemiology Authors: Karl Gisslander Ra ïssa de Boer Christian Ingvar Carl Turesson Karolin Isaksson David Jayne Aladdin J Mohammad Source Type: research
ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023225. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) commonly has aggressive properties and a poor prognosis. Investigating the molecular mechanisms underlying the progression of ESCC is crucial for developing effective therapeutic strategies. Here, by performing transcriptome sequencing in ESCC and adjacent normal tissues, we find that E74-like transcription factor 4 (ELF4) is the main upregulated transcription factor in ESCC. The results of the immunohistochemistry show that ELF4 is overexpressed in ESCC tissues and is signific...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aiping Xu Mingchuang Sun Zhaoxing Li Yuan Chu Kang Fang Yunwei Zhang Jingjing Lian Li Zhang Tao Chen Meidong Xu Source Type: research
Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross-sectional, case-control study
CONCLUSION: Our study provides valuable insights into the epidemiology and prognosis of PE in lung cancer patients and suggests that a poor ECOG PS, which has not been previously reported, is an independent risk factor for PE.PMID:37675831 | DOI:10.1111/crj.13692
Source: Respiratory Care - September 7, 2023 Category: Respiratory Medicine Authors: Yongkang Huang Shiyuan Gao Ting Li Beilei Zhang Juan Du Yajuan Qian Yufei Xing Tong Zhou Minhua Shi Jian-An Huang Yixin Lian Source Type: research
ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023225. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) commonly has aggressive properties and a poor prognosis. Investigating the molecular mechanisms underlying the progression of ESCC is crucial for developing effective therapeutic strategies. Here, by performing transcriptome sequencing in ESCC and adjacent normal tissues, we find that E74-like transcription factor 4 (ELF4) is the main upregulated transcription factor in ESCC. The results of the immunohistochemistry show that ELF4 is overexpressed in ESCC tissues and is signific...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aiping Xu Mingchuang Sun Zhaoxing Li Yuan Chu Kang Fang Yunwei Zhang Jingjing Lian Li Zhang Tao Chen Meidong Xu Source Type: research
Characteristics and risk factors for advanced lung cancer with pulmonary embolism: A cross-sectional, case-control study
CONCLUSION: Our study provides valuable insights into the epidemiology and prognosis of PE in lung cancer patients and suggests that a poor ECOG PS, which has not been previously reported, is an independent risk factor for PE.PMID:37675831 | DOI:10.1111/crj.13692
Source: Clinical Lung Cancer - September 7, 2023 Category: Cancer & Oncology Authors: Yongkang Huang Shiyuan Gao Ting Li Beilei Zhang Juan Du Yajuan Qian Yufei Xing Tong Zhou Minhua Shi Jian-An Huang Yixin Lian Source Type: research
Crosstalk between PD-L1 and Jak2-Stat3/ MAPK-AP1 signaling promotes oral cancer progression, invasion and therapy resistance
CONCLUSIONS: PD-L1 was regulated mainly by the Jak2-Stat3/ MAPK-AP1 pathway, and besides the routine immunological functions, it supports OSCC survival, invasion, and therapy resistance. PD-L1 can be used as an indicator of severity and can be targeted along with Jak2-Stat3/ MAPK-AP1 for a better outcome OSCC.PMID:37678027 | DOI:10.1016/j.intimp.2023.110894
Source: International Immunopharmacology - September 7, 2023 Category: Allergy & Immunology Authors: Arpita Jha Manzar Alam Tanushree Kashyap Nidhi Nath Anjali Kumari Kamdeo K Pramanik Siddavaram Nagini Rajakishore Mishra Source Type: research
Mutational signatures and their association with survival and gene expression in urological carcinomas
Neoplasia. 2023 Sep 5;44:100933. doi: 10.1016/j.neo.2023.100933. Online ahead of print.ABSTRACTDifferent sources of mutagenesis cause consistently identifiable patterns of mutations and mutational signatures that mirror the various carcinogenetic processes. We used publicly available data from the Cancer Genome Atlas to evaluate the associations between the activity of the mutational signatures and various survival endpoints in six types of urological cancers after adjusting for established prognostic factors. The predictive power of the signatures was evaluated with dynamic area under curve models. In addition, links betw...
Source: Neoplasia - September 7, 2023 Category: Cancer & Oncology Authors: Peeter Karihtala Outi Kilpivaara Katja Porvari Source Type: research
