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A fluorescence biosensor for tyrosinase activity analysis based on silicon-doped carbon quantum dots
Chem Pharm Bull (Tokyo). 2023 Sep 14. doi: 10.1248/cpb.c23-00410. Online ahead of print.ABSTRACTTyrosinase (TYR) plays a pivotal role in the biosynthesis of melanin, and its activity level holds critical implications for vitiligo, melanoma cancer, and food nutritional value. The sensitive determination of TYR activity is of great significance for both fundamental research and clinical investigations. In this work, we successfully synthesized silicon-doped carbon quantum dots (Si-CQDs) through a one-pot hydrothermal method with trans-aconitic acid as carbon source and N-[3-(Trimethoxysilyl)propyl]ethylenediamine as the dopa...
Source: Chemical and Pharmaceutical Bulletin - September 13, 2023 Category: Drugs & Pharmacology Authors: Qiang Chen Lili Zheng Xiaoqin Deng Menghan Zhang Wendi Han Zhengjun Huang Chenfang Miao Shaohuang Weng Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
A fluorescence biosensor for tyrosinase activity analysis based on silicon-doped carbon quantum dots
Chem Pharm Bull (Tokyo). 2023 Sep 14. doi: 10.1248/cpb.c23-00410. Online ahead of print.ABSTRACTTyrosinase (TYR) plays a pivotal role in the biosynthesis of melanin, and its activity level holds critical implications for vitiligo, melanoma cancer, and food nutritional value. The sensitive determination of TYR activity is of great significance for both fundamental research and clinical investigations. In this work, we successfully synthesized silicon-doped carbon quantum dots (Si-CQDs) through a one-pot hydrothermal method with trans-aconitic acid as carbon source and N-[3-(Trimethoxysilyl)propyl]ethylenediamine as the dopa...
Source: Chemical and Pharmaceutical Bulletin - September 13, 2023 Category: Drugs & Pharmacology Authors: Qiang Chen Lili Zheng Xiaoqin Deng Menghan Zhang Wendi Han Zhengjun Huang Chenfang Miao Shaohuang Weng Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
Fibroblast growth factor 5 expression predicts the progression of oral squamous cell carcinoma
CONCLUSION: FGF5 can be induced by cellular stress and risk factors of OSCC, where high expression levels of FGF5 is potentially a useful parameter for predicting OSCC progression and patient survival.PMID:37704482 | DOI:10.1016/j.jfma.2023.08.020
Source: J Formos Med Assoc - September 13, 2023 Category: General Medicine Authors: Wan-Yi Shie Shih-Jung Cheng Kuan-Chi Chen Ching-Chun Tang Hsin-Hui Peng Hui-Hsin Ko Hsin-Han Hou Han-Yi Elizabeth Chou Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
A fluorescence biosensor for tyrosinase activity analysis based on silicon-doped carbon quantum dots
Chem Pharm Bull (Tokyo). 2023 Sep 14. doi: 10.1248/cpb.c23-00410. Online ahead of print.ABSTRACTTyrosinase (TYR) plays a pivotal role in the biosynthesis of melanin, and its activity level holds critical implications for vitiligo, melanoma cancer, and food nutritional value. The sensitive determination of TYR activity is of great significance for both fundamental research and clinical investigations. In this work, we successfully synthesized silicon-doped carbon quantum dots (Si-CQDs) through a one-pot hydrothermal method with trans-aconitic acid as carbon source and N-[3-(Trimethoxysilyl)propyl]ethylenediamine as the dopa...
Source: Chemical and Pharmaceutical Bulletin - September 13, 2023 Category: Drugs & Pharmacology Authors: Qiang Chen Lili Zheng Xiaoqin Deng Menghan Zhang Wendi Han Zhengjun Huang Chenfang Miao Shaohuang Weng Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
Cancers, Vol. 15, Pages 4539: Prognostic Value of Necroptosis-Related Genes Signature in Oral Squamous Cell Carcinoma
In conclusion, the high expression of NRG prognostic signature is associated with poor prognosis in OSCC, and HPRT1 can serve as a novel independent prognostic factor for OSCC.
Source: Cancers - September 13, 2023 Category: Cancer & Oncology Authors: Ke Huang Xiaoting Gu Huimei Xu Hui Li Mingxuan Shi Defang Wei Shiqi Wang Yao Li Bin Liu Yi Li Tags: Article Source Type: research
Enhanced systemic tumor suppression by in situ vaccine combining radiation and OX40 agonist with CpG therapy
CONCLUSION: This triple combining in situ vaccine induced intensive antitumor responses, mediated effective systemic tumor control and survival benefit, and displayed impressive synergistic antitumor effect with checkpoint blockade therapy. These data preliminary confirmed the efficacy, feasibility and safety of the triple combining in situ vaccine, suggesting its great application potential as both monotherapy and a part of combined immunotherapeutic regimens in clinical scenario.PMID:37700338 | DOI:10.1186/s12967-023-04504-w
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Zhichen Sun Yanhong Chu Jie Xiao Yueling Yang Fanyan Meng Xinyue Wang Yanbing Dong Junmeng Zhu Yirong Wu Lanqun Qin Yaohua Ke Baorui Liu Qin Liu Source Type: research
Definitive chemoradiation in vulvar squamous cell carcinoma: outcome and toxicity from an observational multicenter Italian study on vulvar cancer (OLDLADY 1.1)
CONCLUSION: In the context of CRT for LAVC, the present study reports encouraging results even if there is clearly room for further improvements, in terms of both treatment outcomes, toxicity and treatment interruption management.PMID:37700153 | DOI:10.1007/s11547-023-01712-8
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Gabriella Macchia Valentina Lancellotta Martina Ferioli Calogero Cas à Donato Pezzulla Brigida Pappalardi Concetta Laliscia Edy Ippolito Jacopo Di Muzio Alessandra Huscher Francesca Tortoreto Mariangela Boccardi Roberta Lazzari Anna Myriam Perrone France Source Type: research
Personalized Biomarker-Based Umbrella Trial for Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: KCSG HN 15-16 TRIUMPH Trial
CONCLUSION: To our knowledge, this study is the first biomarker-driven umbrella trial for platinum-refractory HNSCC using matched molecular targeted agents. We found that NGS-based genomic phenotyping was methodologically feasible and applicable.PMID:37699162 | DOI:10.1200/JCO.22.02786
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Bhumsuk Keam Min Hee Hong Seong Hoon Shin Seong Gu Heo Ji Eun Kim Hee Kyung Ahn Yun-Gyoo Lee Keon-Uk Park Tak Yun Keun-Wook Lee Sung-Bae Kim Sang-Cheol Lee Min Kyoung Kim Sang Hee Cho So Yeon Oh Sang-Gon Park Shinwon Hwang Byung-Ho Nam Sangwoo Kim Hye Ryu Source Type: research
