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Total 36609 results found since Jan 2013.
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: International Journal of Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
Long term prognosis of anti-melanoma differentiation-associated gene 5-positive dermatomyositis with interstitial lung disease
CONCLUSION: Triple combination therapy in the induction phase can reduce the risk of recurrence and facilitate drug withdrawal in anti-MDA5-positive DM-ILD.PMID:37714541 | DOI:10.3899/jrheum.2023-0371
Source: J Rheumatol - September 15, 2023 Category: Rheumatology Authors: Tsuneo Sasai Ran Nakashima Hideaki Tsuji Toshiki Nakajima Yoshitaka Imura Yusuke Yoshida Shintaro Hirata Mirei Shirakashi Ryosuke Hiwa Koji Kitagori Shuji Akizuki Hajime Yoshifuji Tsuneyo Mimori Akio Morinobu Source Type: research
Necrotizing pneumonia due to Aspergillus and Salmonella after immune checkpoint inhibitor treatment: An unusual case and review of the literature
CONCLUSIONS: Awareness of unusual pathogens in the etiology of pneumonia after ICI treatment may help to avoid underdiagnosis.PMID:37714729 | DOI:10.1016/j.riam.2023.05.001
Source: Revista Iberoamericana de Micologia - September 15, 2023 Category: Biology Authors: Muhammed Cihan I şık O ğuz Karcıoğlu G ülşen Hazırolan Dolunay G ülmez Mehmet Ruhi Onur Mehmet Mahir Kunt Sevtap Arikan-Akdagli G ökhan Metan Source Type: research
Clinical Value Analysis of Serum TK1, SCC-Ag, and MUC-1 in the Diagnosis and Prognosis Evaluation of Cervical Cancer
CONCLUSIONS: Serum levels of TK1, SCC-Ag, and MUC-1 show promise as biomarkers for cervical cancer diagnosis and prognosis. TK1 and SCC-Ag are elevated, while MUC-1 is decreased in cervical cancer patients. Further research is warranted to confirm these findings and explore additional biomarkers.PMID:37708549
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Mei Zhang Lingli Xin Bo Cheng Bin Yan Jie Zhen Chao Yang Li Ma Qingxiang Hou Source Type: research
Construction of a Diagnostic Model for Small Cell Lung Cancer Combining Metabolomics and Integrated Machine Learning
CONCLUSION: This study is the first to analyze the difference between metabolomics and lipidomics and to construct a d-model to detect SCLC using integrated machine learning. This study may be of great significance for the screening and early diagnosis of SCLC patients.PMID:37706531 | DOI:10.1093/oncolo/oyad261
Source: The Oncologist - September 14, 2023 Category: Cancer & Oncology Authors: Xiaoling Shang Chenyue Zhang Ronghua Kong Chenglong Zhao Haiyong Wang Source Type: research
Antibiotics may interfere with nivolumab efficacy in patients with head and neck squamous cell carcinoma
CONCLUSION: Our findings indicate that antibiotic treatment significantly shortens the PFS with nivolumab therapy in patients with head and neck SCC.PMID:37708868 | DOI:10.1159/000533860
Source: Oncology - September 14, 2023 Category: Cancer & Oncology Authors: Reio Ueta Hiroo Imai Ken Saijo Yoshifumi Kawamura Shuto Kodera Keigo Komine Kota Ouchi Yuki Kasahara Sakura Taniguchi Yuya Yoshida Keiju Sasaki Hidekazu Shirota Masanobu Takahashi Chikashi Ishioka Source Type: research
Neoadjuvant triplet chemotherapy with docetaxel, cisplatin plus 5-FU vs docetaxel, cisplatin plus S-1 for advanced esophageal squamous cell carcinoma: Propensity score matched analysis
CONCLUSIONS: Neoadjuvant DCS therapy for resectable advanced ESCC did not result in significantly higher clinical and pathological response than neoadjuvant DCF therapy. However, neoadjuvant DCS therapy for resectable ESCC required comparatively shorter hospital stays and incurred lower costs, making it an attractive therapeutic option.PMID:37708864 | DOI:10.1159/000533790
Source: Oncology - September 14, 2023 Category: Cancer & Oncology Authors: Junya Kitadani Toshiyasu Ojima Keiji Hayata Taro Goda Akihiro Takeuchi Shinta Tominaga Naoki Fukuda Tomoki Nakai Hiroki Yamaue Manabu Kawai Source Type: research
BAP1 mutations inhibit the NF- κB signaling pathway to induce an immunosuppressive microenvironment in uveal melanoma
CONCLUSION: BAP1 mutations may inhibit the NF-κB signaling pathway, repressing the cytokine secretion and antigen presentation by macrophages, which induces the immunosuppressive microenvironment, enhances the malignant phenotypes of UM cells and ultimately promotes the growth and metastasis of UM.PMID:37710185 | DOI:10.1186/s10020-023-00713-7
Source: Molecular Medicine - September 14, 2023 Category: Molecular Biology Authors: Chao Zhang Shuai Wu Source Type: research
Clinical Value Analysis of Serum TK1, SCC-Ag, and MUC-1 in the Diagnosis and Prognosis Evaluation of Cervical Cancer
CONCLUSIONS: Serum levels of TK1, SCC-Ag, and MUC-1 show promise as biomarkers for cervical cancer diagnosis and prognosis. TK1 and SCC-Ag are elevated, while MUC-1 is decreased in cervical cancer patients. Further research is warranted to confirm these findings and explore additional biomarkers.PMID:37708549
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Mei Zhang Lingli Xin Bo Cheng Bin Yan Jie Zhen Chao Yang Li Ma Qingxiang Hou Source Type: research
Antibiotics may interfere with nivolumab efficacy in patients with head and neck squamous cell carcinoma
CONCLUSION: Our findings indicate that antibiotic treatment significantly shortens the PFS with nivolumab therapy in patients with head and neck SCC.PMID:37708868 | DOI:10.1159/000533860
Source: Oncology - September 14, 2023 Category: Cancer & Oncology Authors: Reio Ueta Hiroo Imai Ken Saijo Yoshifumi Kawamura Shuto Kodera Keigo Komine Kota Ouchi Yuki Kasahara Sakura Taniguchi Yuya Yoshida Keiju Sasaki Hidekazu Shirota Masanobu Takahashi Chikashi Ishioka Source Type: research
Neoadjuvant triplet chemotherapy with docetaxel, cisplatin plus 5-FU vs docetaxel, cisplatin plus S-1 for advanced esophageal squamous cell carcinoma: Propensity score matched analysis
CONCLUSIONS: Neoadjuvant DCS therapy for resectable advanced ESCC did not result in significantly higher clinical and pathological response than neoadjuvant DCF therapy. However, neoadjuvant DCS therapy for resectable ESCC required comparatively shorter hospital stays and incurred lower costs, making it an attractive therapeutic option.PMID:37708864 | DOI:10.1159/000533790
Source: Oncology - September 14, 2023 Category: Cancer & Oncology Authors: Junya Kitadani Toshiyasu Ojima Keiji Hayata Taro Goda Akihiro Takeuchi Shinta Tominaga Naoki Fukuda Tomoki Nakai Hiroki Yamaue Manabu Kawai Source Type: research
Construction of a Diagnostic Model for Small Cell Lung Cancer Combining Metabolomics and Integrated Machine Learning
CONCLUSION: This study is the first to analyze the difference between metabolomics and lipidomics and to construct a d-model to detect SCLC using integrated machine learning. This study may be of great significance for the screening and early diagnosis of SCLC patients.PMID:37706531 | DOI:10.1093/oncolo/oyad261
Source: The Oncologist - September 14, 2023 Category: Cancer & Oncology Authors: Xiaoling Shang Chenyue Zhang Ronghua Kong Chenglong Zhao Haiyong Wang Source Type: research
Antibiotics may interfere with nivolumab efficacy in patients with head and neck squamous cell carcinoma
CONCLUSION: Our findings indicate that antibiotic treatment significantly shortens the PFS with nivolumab therapy in patients with head and neck SCC.PMID:37708868 | DOI:10.1159/000533860
Source: Oncology - September 14, 2023 Category: Cancer & Oncology Authors: Reio Ueta Hiroo Imai Ken Saijo Yoshifumi Kawamura Shuto Kodera Keigo Komine Kota Ouchi Yuki Kasahara Sakura Taniguchi Yuya Yoshida Keiju Sasaki Hidekazu Shirota Masanobu Takahashi Chikashi Ishioka Source Type: research
Neoadjuvant triplet chemotherapy with docetaxel, cisplatin plus 5-FU vs docetaxel, cisplatin plus S-1 for advanced esophageal squamous cell carcinoma: Propensity score matched analysis
CONCLUSIONS: Neoadjuvant DCS therapy for resectable advanced ESCC did not result in significantly higher clinical and pathological response than neoadjuvant DCF therapy. However, neoadjuvant DCS therapy for resectable ESCC required comparatively shorter hospital stays and incurred lower costs, making it an attractive therapeutic option.PMID:37708864 | DOI:10.1159/000533790
Source: Oncology - September 14, 2023 Category: Cancer & Oncology Authors: Junya Kitadani Toshiyasu Ojima Keiji Hayata Taro Goda Akihiro Takeuchi Shinta Tominaga Naoki Fukuda Tomoki Nakai Hiroki Yamaue Manabu Kawai Source Type: research
