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Clinical Value Analysis of Serum TK1, SCC-Ag, and MUC-1 in the Diagnosis and Prognosis Evaluation of Cervical Cancer
CONCLUSIONS: Serum levels of TK1, SCC-Ag, and MUC-1 show promise as biomarkers for cervical cancer diagnosis and prognosis. TK1 and SCC-Ag are elevated, while MUC-1 is decreased in cervical cancer patients. Further research is warranted to confirm these findings and explore additional biomarkers.PMID:37708549
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Mei Zhang Lingli Xin Bo Cheng Bin Yan Jie Zhen Chao Yang Li Ma Qingxiang Hou Source Type: research
Antibiotics may interfere with nivolumab efficacy in patients with head and neck squamous cell carcinoma
CONCLUSION: Our findings indicate that antibiotic treatment significantly shortens the PFS with nivolumab therapy in patients with head and neck SCC.PMID:37708868 | DOI:10.1159/000533860
Source: Oncology - September 14, 2023 Category: Cancer & Oncology Authors: Reio Ueta Hiroo Imai Ken Saijo Yoshifumi Kawamura Shuto Kodera Keigo Komine Kota Ouchi Yuki Kasahara Sakura Taniguchi Yuya Yoshida Keiju Sasaki Hidekazu Shirota Masanobu Takahashi Chikashi Ishioka Source Type: research
Clinical Value Analysis of Serum TK1, SCC-Ag, and MUC-1 in the Diagnosis and Prognosis Evaluation of Cervical Cancer
CONCLUSIONS: Serum levels of TK1, SCC-Ag, and MUC-1 show promise as biomarkers for cervical cancer diagnosis and prognosis. TK1 and SCC-Ag are elevated, while MUC-1 is decreased in cervical cancer patients. Further research is warranted to confirm these findings and explore additional biomarkers.PMID:37708549
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Mei Zhang Lingli Xin Bo Cheng Bin Yan Jie Zhen Chao Yang Li Ma Qingxiang Hou Source Type: research
Neoadjuvant triplet chemotherapy with docetaxel, cisplatin plus 5-FU vs docetaxel, cisplatin plus S-1 for advanced esophageal squamous cell carcinoma: Propensity score matched analysis
CONCLUSIONS: Neoadjuvant DCS therapy for resectable advanced ESCC did not result in significantly higher clinical and pathological response than neoadjuvant DCF therapy. However, neoadjuvant DCS therapy for resectable ESCC required comparatively shorter hospital stays and incurred lower costs, making it an attractive therapeutic option.PMID:37708864 | DOI:10.1159/000533790
Source: Oncology - September 14, 2023 Category: Cancer & Oncology Authors: Junya Kitadani Toshiyasu Ojima Keiji Hayata Taro Goda Akihiro Takeuchi Shinta Tominaga Naoki Fukuda Tomoki Nakai Hiroki Yamaue Manabu Kawai Source Type: research
Clinical Value Analysis of Serum TK1, SCC-Ag, and MUC-1 in the Diagnosis and Prognosis Evaluation of Cervical Cancer
CONCLUSIONS: Serum levels of TK1, SCC-Ag, and MUC-1 show promise as biomarkers for cervical cancer diagnosis and prognosis. TK1 and SCC-Ag are elevated, while MUC-1 is decreased in cervical cancer patients. Further research is warranted to confirm these findings and explore additional biomarkers.PMID:37708549
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Mei Zhang Lingli Xin Bo Cheng Bin Yan Jie Zhen Chao Yang Li Ma Qingxiang Hou Source Type: research
Risk factors for metachronous esophageal squamous cell carcinoma after endoscopic or surgical resection of esophageal carcinoma: a systematic review and meta-analysis
Conclusiontimely investigating the age of patients, previous history of cancer and monitoring the number of LVLs in the first 5 years after operation are of great significance to identify high-risk populations of MESCC for timely medical care. Education and behavior correction about smoking are advocated. Tumor markers should be regularly detected in the head and neck, esophagus, and stomach. Endoscopic resection was associated with a higher incidence of MESCC, which provided a reference for doctors to choose the removal method.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022377030.
Source: Frontiers in Oncology - September 14, 2023 Category: Cancer & Oncology Source Type: research
Diagnostic accuracy of sentinel lymph node frozen section analysis in patients with early-stage cervical cancer: A systematic review and meta-analysis
CONCLUSION: SLN frozen section detects 65% of lymph node metastases compared with SLN ultrastaging and may prevent unnecessary radical surgery in some patients with early-stage cervical cancer.PMID:37703622 | DOI:10.1016/j.ygyno.2023.08.019
Source: Gynecologic Oncology - September 13, 2023 Category: Cancer & Oncology Authors: Nuria Agust í David Viveros-Carre ño Nathalia Mora-Soto Pedro T Ram írez Alejandro Rauh-Hain Chi-Fang Wu Juliana Rodr íguez Carlos Fernando Grillo-Ardila Catherin Salazar Kirsten Jorgensen Blanca Segarra-Vidal Enrique Chac ón Alexander Melamed Ren é Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
A fluorescence biosensor for tyrosinase activity analysis based on silicon-doped carbon quantum dots
Chem Pharm Bull (Tokyo). 2023 Sep 14. doi: 10.1248/cpb.c23-00410. Online ahead of print.ABSTRACTTyrosinase (TYR) plays a pivotal role in the biosynthesis of melanin, and its activity level holds critical implications for vitiligo, melanoma cancer, and food nutritional value. The sensitive determination of TYR activity is of great significance for both fundamental research and clinical investigations. In this work, we successfully synthesized silicon-doped carbon quantum dots (Si-CQDs) through a one-pot hydrothermal method with trans-aconitic acid as carbon source and N-[3-(Trimethoxysilyl)propyl]ethylenediamine as the dopa...
Source: Chemical and Pharmaceutical Bulletin - September 13, 2023 Category: Drugs & Pharmacology Authors: Qiang Chen Lili Zheng Xiaoqin Deng Menghan Zhang Wendi Han Zhengjun Huang Chenfang Miao Shaohuang Weng Source Type: research
Diagnostic accuracy of sentinel lymph node frozen section analysis in patients with early-stage cervical cancer: A systematic review and meta-analysis
CONCLUSION: SLN frozen section detects 65% of lymph node metastases compared with SLN ultrastaging and may prevent unnecessary radical surgery in some patients with early-stage cervical cancer.PMID:37703622 | DOI:10.1016/j.ygyno.2023.08.019
Source: Gynecologic Oncology - September 13, 2023 Category: Cancer & Oncology Authors: Nuria Agust í David Viveros-Carre ño Nathalia Mora-Soto Pedro T Ram írez Alejandro Rauh-Hain Chi-Fang Wu Juliana Rodr íguez Carlos Fernando Grillo-Ardila Catherin Salazar Kirsten Jorgensen Blanca Segarra-Vidal Enrique Chac ón Alexander Melamed Ren é Source Type: research
Machine learning analysis of lung squamous cell carcinoma gene expression datasets reveals novel prognostic signatures
CONCLUSION: This study demonstrates that an integrated approach involving machine learning and system biology may effectively identify novel biomarkers for LUSC.PMID:37703712 | DOI:10.1016/j.compbiomed.2023.107430
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Hemant Kumar Joon Anamika Thalor Dinesh Gupta Source Type: research
Targeting IL-4/IL-13 in immune checkpoint inhibitor induced bullous pemphigoid: a cautionary note on the beneficial effect of Th2 in melanoma and immunotherapy
Br J Dermatol. 2023 Sep 13:ljad324. doi: 10.1093/bjd/ljad324. Online ahead of print.NO ABSTRACTPMID:37703325 | DOI:10.1093/bjd/ljad324
Source: The British Journal of Dermatology - September 13, 2023 Category: Dermatology Authors: Christian F Guerrero-Juarez Parul K Goyal Kyle T Amber Source Type: research
Risk factors for the occurrence of infection in patients with oral squamous cell carcinoma after restorative reconstruction and its impact on recurrence and quality of life: a retrospective cohort study
CONCLUSIONS: The incidence of postoperative infection after restorative and reconstructive surgery for OSCC deserves the attention of clinicians. For high-risk infected persons, relevant anti-infection measures should be taken early against the infectious source, and the possibility of nosocomial infection should be attached great importance in clinical work. After discharge, patients should also actively do follow-up, education and other related work to reduce the incidence of postoperative infection.PMID:37701120 | PMC:PMC10493792 | DOI:10.21037/tcr-23-1150
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Miaomiao Shen Weilan Shan Siyi Lv Kuan Cai Xuan Chen Zhengyun Xu Mingjin Gao Guodong Wang Source Type: research
OCT4's role and mechanism underlying oral squamous cell carcinoma
J Zhejiang Univ Sci B. 2023 Sept 15;24(9):796-806. doi: 10.1631/jzus.B2200602.ABSTRACTOral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. Octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem c...
Source: J Zhejiang Univ Sci ... - September 13, 2023 Category: Science Authors: Yuwei Dai Ziqiong Wu Yitong Chen Xinjian Ye Chaowei Wang Huiyong Zhu Source Type: research
Fibroblast growth factor 5 expression predicts the progression of oral squamous cell carcinoma
CONCLUSION: FGF5 can be induced by cellular stress and risk factors of OSCC, where high expression levels of FGF5 is potentially a useful parameter for predicting OSCC progression and patient survival.PMID:37704482 | DOI:10.1016/j.jfma.2023.08.020
Source: J Formos Med Assoc - September 13, 2023 Category: General Medicine Authors: Wan-Yi Shie Shih-Jung Cheng Kuan-Chi Chen Ching-Chun Tang Hsin-Hui Peng Hui-Hsin Ko Hsin-Han Hou Han-Yi Elizabeth Chou Source Type: research
