Filtered By:
Cancer: Skin Cancer
This page shows you your search results in order of date. This is page number 20.
Order by Relevance | Date
Total 36609 results found since Jan 2013.
Genomic and Transcriptomic Landscape of an Oral Squamous Cell Carcinoma Mouse Model for Immunotherapy
Cancer Immunol Res. 2023 Sep 5. doi: 10.1158/2326-6066.CIR-23-0133. Online ahead of print.ABSTRACTThe immune checkpoint inhibitor (ICI), anti-programmed death-1 (anti-PD-1), has shown moderate efficacy in some patients with head and neck squamous cell carcinoma (HNSCC). Because of this, it is imperative to establish a mouse tumor model to explore mechanisms of antitumor immunity and to develop novel therapeutic options. Here, we examined the 4-nitroquinoline-1-oxide (4NQO)-induced oral squamous cell carcinoma (OSCC) model for genetic aberrations, transcriptomic profiles, and immune cell composition at different pathologica...
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Yi-Mei Lee Chia-Lang Hsu Yu-Hsin Chen Da-Liang Ou Chiun Hsu Ching-Ting Tan Source Type: research
Precise pattern of lymphatic spread of esophageal squamous cell carcinoma: results of 1074 patients with N1 disease
CONCLUSION: Bilateral recurrent nerve nodes, paraesophageal lymph nodes, and perigastric nodes were the most common sites of early lymph node metastasis. Esophageal squamous cell carcinoma involves more longitudinal than transverse lymph node metastases.PMID:37668800 | DOI:10.1007/s00432-023-05359-w
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Kailin Lin Bin Li Yihua Sun Hong Hu Yawei Zhang Jiaqing Xiang Haiquan Chen Source Type: research
The unexpected benefit of TCR cross-reactivity in cancer immunotherapy
Cancer Res. 2023 Sep 5. doi: 10.1158/0008-5472.CAN-23-2594. Online ahead of print.ABSTRACTThe ability of T cell receptors (TCR) to recognize tumor associated antigens (TAAs) is a key driver of adoptive transfer of tumor infiltrating lymphocyte T cells (TIL), which can be a highly effective cancer immunotherapy. While it is common knowledge that TCRs are cross-reactive and can bind multiple different peptide antigens, this is typically considered an unattractive feature and limitation for TCR-based therapies. In a recent publication in Cell, Dolton and colleagues discover that certain TCRs, isolated from TILs used for succe...
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Florian Bieberich Sai Reddy Source Type: research
Cancer Modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)
Methods Mol Biol. 2024;2707:83-97. doi: 10.1007/978-1-0716-3401-1_5.ABSTRACTTransgenic expression of genes is a mainstay of cancer modeling in zebrafish. Traditional transgenic techniques rely upon injection into one-cell embryos, but ideally these transgenes would be expressed only in adult somatic tissues. We provide a method to model cancer in adult zebrafish in which transgenes can be expressed via electroporation. Using melanoma as an example, we demonstrate the feasibility of expressing oncogenes such as BRAFV600E as well as CRISPR/Cas9 inactivation of tumor suppressors such as PTEN. These approaches can be performed...
Source: Mol Biol Cell - September 5, 2023 Category: Molecular Biology Authors: Emily Montal Shruthy Suresh Yilun Ma Mohita M Tagore Richard M White Source Type: research
The reliability and validity of lung cancer and melanoma clinical quality survival measures
CONCLUSIONS: Our results suggest that these cancer survival measures demonstrated adequate test-retest reliability and expected findings for the known-group validity analysis. If data limitations and feasibility challenges can be addressed, implementation of these quality measures may provide a survival metric used for oncology quality improvement efforts.PMID:37669902 | DOI:10.1111/1475-6773.14164
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Emma Pendl-Robinson Keri L Calkins Samuel E Simon Kirsten Barrett Dmitriy Poznyak Source Type: research
A case of squamous cell carcinoma in situ of the cornea of the left eye
Asian J Surg. 2023 Sep 1:S1015-9584(23)01351-9. doi: 10.1016/j.asjsur.2023.08.192. Online ahead of print.NO ABSTRACTPMID:37661481 | DOI:10.1016/j.asjsur.2023.08.192
Source: Asian Journal of Surgery - September 4, 2023 Category: Surgery Authors: Shuang Rao Source Type: research
Poly(A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells
CONCLUSION: PARN has antiapoptotic effects on EC cells and promotes their proliferation, invasion and migration, which is associated with the development of EC and poor patient prognosis. PARN may become a potential target for the diagnosis, prognosis prediction and treatment of EC.PMID:37664151 | PMC:PMC10473923 | DOI:10.3748/wjg.v29.i31.4783
Source: World Journal of Gastroenterology - September 4, 2023 Category: Gastroenterology Authors: Fu-Wei Zhang Xiao-Wei Xie Meng-Hua Chen Jian Tong Qun-Qing Chen Jing Feng Feng-Ti Chen Wen-Qi Liu Source Type: research
Mutant HRas Signaling and Rationale for Use of Farnesyltransferase Inhibitors in Head and Neck Squamous Cell Carcinoma
Target Oncol. 2023 Sep 4. doi: 10.1007/s11523-023-00993-3. Online ahead of print.ABSTRACTHead and neck squamous cell carcinomas (HNSCCs) are often associated with poor outcomes, due at least in part to the limited number of treatment options available for those patients who develop recurrent and/or metastatic disease (R/M HNSCC). Even with the recent validation and approval of immunotherapies in the first-line setting for these patients, the need for the development of new and alternative precision medicine strategies with survival benefit is clear. Oncogenic alterations in the HRAS (Harvey rat sarcoma virus) proto-oncogen...
Source: Ann Oncol - September 4, 2023 Category: Cancer & Oncology Authors: Jiayu Wang Dana Al-Majid J Chad Brenner Joshua D Smith Source Type: research
Poly(A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells
CONCLUSION: PARN has antiapoptotic effects on EC cells and promotes their proliferation, invasion and migration, which is associated with the development of EC and poor patient prognosis. PARN may become a potential target for the diagnosis, prognosis prediction and treatment of EC.PMID:37664151 | PMC:PMC10473923 | DOI:10.3748/wjg.v29.i31.4783
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Fu-Wei Zhang Xiao-Wei Xie Meng-Hua Chen Jian Tong Qun-Qing Chen Jing Feng Feng-Ti Chen Wen-Qi Liu Source Type: research
Two new naphthoquinone derivatives from < em > Sinningia conspicua < /em > (Gesneriaceae)
Nat Prod Res. 2023 Sep 4:1-6. doi: 10.1080/14786419.2023.2253971. Online ahead of print.ABSTRACTTwo new naphthoquinones, 7-hydroxy-2-O-methyldunniol (1) and 7-methoxy-2-O-methyldunniol (2) were isolated from the tubers of Sinningia conspicua (Seem.) G. Nicholson (Gesneriaceae). Nine known compounds were also obtained: 7-methoxydunniol (3), dunniol (4), 7-methoxy-α-dunnione (5), 7-hydroxydunnione (6), 2,4,4',6-tetramethoxychalcone (7), loureirin B (8), allo-calceolarioside A (9), β-sitosterol (10) and stigmasterol (11). This is the first report of compounds 3 and 5 in Sinningia. n-Hexane, ethyl acetate and ethanol extract...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Vanessa Winiewski Maria Helena Verdan Cristhian Santos Oliveira Tayn á Eloyane Barreto Rodrigues Marcos Jos é Salvador Maria Élida Alves Stefanello Source Type: research
Cumulative thiopurine dosing and keratinocyte skin cancer in inflammatory bowel disease: a case-control study
CONCLUSION: Cumulative thiopurine dose and duration did not show an association with KSC development. Future KSC risk stratification, based on all available KSC risk factors, may aid in selecting individuals who can benefit most from dermatologic screening programs.PMID:37665613 | DOI:10.1097/MEG.0000000000002617
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Fenna M Jansen Nathan den Broeder Satish F K Lubeek Edo H J Savelkoul Carlijne M Marcus Frank Hoentjen Willemijn A van Dop Source Type: research
Poly(A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells
CONCLUSION: PARN has antiapoptotic effects on EC cells and promotes their proliferation, invasion and migration, which is associated with the development of EC and poor patient prognosis. PARN may become a potential target for the diagnosis, prognosis prediction and treatment of EC.PMID:37664151 | PMC:PMC10473923 | DOI:10.3748/wjg.v29.i31.4783
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Fu-Wei Zhang Xiao-Wei Xie Meng-Hua Chen Jian Tong Qun-Qing Chen Jing Feng Feng-Ti Chen Wen-Qi Liu Source Type: research
Causal association between serum 25-Hydroxyvitamin D levels and cutaneous melanoma: a two-sample Mendelian randomization study
CONCLUSION: The findings indicated a potentially causal positive association between serum 25-Hydroxyvitamin D levels and melanoma risk, challenging traditional beliefs about vitamin D's role in melanoma. This emphasizes the need for a balanced and personalized approach to vitamin D supplementation and sun exposure, particularly in high-risk populations. These results should be interpreted with caution due to potential unrecognized pleiotropy and confounding factors. Future research should focus on validating these findings in diverse populations and exploring underlying biological mechanisms.PMID:37664026 | PMC:PMC1047062...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Beichen Cai Qian Lin Ruonan Ke Xiuying Shan Jiaqi Yu Xuejun Ni Xinjian Lin Biao Wang Source Type: research
Personalised decision making to predict absolute metastatic risk in cutaneous squamous cell carcinoma: development and validation of a clinico-pathological model
EClinicalMedicine. 2023 Aug 19;63:102150. doi: 10.1016/j.eclinm.2023.102150. eCollection 2023 Sep.ABSTRACTBACKGROUND: Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer, affecting more than 2 million people worldwide yearly and metastasising in 2-5% of patients. However, current clinical staging systems do not provide estimates of absolute metastatic risk, hence missing the opportunity for more personalised treatment advice. We aimed to develop a clinico-pathological model that predicts the probability of metastasis in patients with cSCC.METHODS: Nationwide cohorts from (1) all patients with a first primary c...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Barbara Rentroia-Pacheco Selin Tokez Edo M Bramer Zoe C Venables Harmen J G van de Werken Domenico Bellomo David van Klaveren Antien L Mooyaart Loes M Hollestein Marlies Wakkee Source Type: research
Tumour budding in cutaneous squamous cell carcinoma: A novel prognosis risk factor
CONCLUSION: An association was found between tumour budding and most known risk factors in cSCC. We found findings that indicate that the presence of tumour budding is associated with a worse prognosis in terms of LNM, OS and DSS. This supports the results of previous work which has suggested that budding could be related to high-risk cSCC.PMID:37665122 | DOI:10.1111/ajd.14150
Source: The Australasian Journal of Dermatology - September 4, 2023 Category: Dermatology Authors: Loreto Heredia Pablo Vargas-Mora Catalina Jahr Jos é Herranz Pedro Ferrer-Rosende Source Type: research
