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Identification of a TRP channel-related risk model for predicting prognosis and therapeutic effects of patients with hepatocellular carcinoma
CONCLUSIONS: We successfully established a highly accurate prognostic model for predicting overall survival and therapeutic effects using TRP channel-related genes.PMID:37733242 | DOI:10.1007/s00432-023-05394-7
Source: Clinical Breast Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Chong Pang Zhe Xu Jilong Han Fujun Li Hongyan Zhu Jiaqi Zhang Dong Wang Xundi Xu Source Type: research
Traumatic sigmoid colon rupture due to breast cancer metastasis: a case report
Clin J Gastroenterol. 2023 Sep 21. doi: 10.1007/s12328-023-01859-x. Online ahead of print.ABSTRACTThe metastasis of breast cancer to the gastrointestinal tract is rare. Herein, we presented the case of an 85-year-old woman who had a history of invasive lobular carcinoma and experienced complete colon rupture due to relatively low-energy trauma. The patient underwent bilateral total mastectomy and axillary dissection following preoperative chemotherapy 6 years ago. She had a local recurrence 2 years after the surgery and underwent chemotherapy. Subsequently, the cancer metastasized to the thoracolumbar area and retroperiton...
Source: Clinical Breast Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Tomonori Yoshida Munenori Ide Kazuhisa Katayama Mitsuhiro Yanai Ryo Kurosaki Hisashi Shimizu Kazuhisa Arakawa Tatsuya Miyazaki Hiroshi Saeki Ken Shirabe Source Type: research
Left epigastric isolated tumor fed by the inferior phrenic artery diagnosed as ectopic hepatocellular carcinoma: A case report
CONCLUSION: This asymptomatic ectopic HCC case described achieved an excellent result due to early detection, radical resection, and systematic surveillance.PMID:37731571 | PMC:PMC10507550 | DOI:10.12998/wjcc.v11.i26.6231
Source: Clinical Lung Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hong-Bo Liu Li-Hua Zhao Yong-Jian Zhang Zhi-Feng Li Lei Li Qian-Peng Huang Source Type: research
A Novel Scoring Model of Deubiquitination Patterns Predicts Prognosis and Immunotherapeutic Response in Hepatocellular Carcinoma
In conclusion, our study revealed the crucial role of deubiquitination patterns in shaping TME complexity and diversity. A more personalized and effective antitumour immunotherapy strategy can be developed by utilizing the DUBscore model to identify deubiquitination patterns in individual HCC patients. Our findings also highlight that BRCC3 may serve as a potential therapeutic target in HCC and a predictive marker for immunotherapeutic response.PMID:37734237 | DOI:10.1016/j.tranon.2023.101789
Source: Translational Oncology - September 21, 2023 Category: Cancer & Oncology Authors: Jiahao Zhang Gefeng Wu Rui Peng Jun Cao Daoyuan Tu Jie Zhou Bingbing Su Shengjie Jin Guoqing Jiang Chi Zhang Dousheng Bai Source Type: research
Identification of a TRP channel-related risk model for predicting prognosis and therapeutic effects of patients with hepatocellular carcinoma
CONCLUSIONS: We successfully established a highly accurate prognostic model for predicting overall survival and therapeutic effects using TRP channel-related genes.PMID:37733242 | DOI:10.1007/s00432-023-05394-7
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Chong Pang Zhe Xu Jilong Han Fujun Li Hongyan Zhu Jiaqi Zhang Dong Wang Xundi Xu Source Type: research
Traumatic sigmoid colon rupture due to breast cancer metastasis: a case report
Clin J Gastroenterol. 2023 Sep 21. doi: 10.1007/s12328-023-01859-x. Online ahead of print.ABSTRACTThe metastasis of breast cancer to the gastrointestinal tract is rare. Herein, we presented the case of an 85-year-old woman who had a history of invasive lobular carcinoma and experienced complete colon rupture due to relatively low-energy trauma. The patient underwent bilateral total mastectomy and axillary dissection following preoperative chemotherapy 6 years ago. She had a local recurrence 2 years after the surgery and underwent chemotherapy. Subsequently, the cancer metastasized to the thoracolumbar area and retroperiton...
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Tomonori Yoshida Munenori Ide Kazuhisa Katayama Mitsuhiro Yanai Ryo Kurosaki Hisashi Shimizu Kazuhisa Arakawa Tatsuya Miyazaki Hiroshi Saeki Ken Shirabe Source Type: research
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength
CONCLUSIONS: Deuterium MRI at 1.5T proved feasibility to track 2H distribution throughout mouse tissues during D2O administration and revealed a higher 2H accumulation in the tumor xenografts. This research demonstrated a promising successful method for preliminary assessment of radiotherapy and chemotherapy of cancer.PMID:37732903 | DOI:10.1158/1078-0432.CCR-23-1635
Source: Clinical Colorectal Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hirofumi Asano Abdelazim Elsayed Elhelaly Fuminori Hyodo Ryota Iwasaki Yoshifumi Noda Hiroki Kato Koki Ichihashi Hiroyuki Tomita Masaharu Murata Takashi Mori Masayuki Matsuo Source Type: research
Long non-coding RNA as a potential diagnostic biomarker in head and neck squamous cell carcinoma: A systematic review and meta-analysis
ConclusionsLncRNAs could be used as diagnostic biomarkers for HNSCC, but further investigation is needed to validate clinical efficacy and elucidate mechanisms. High-throughput sequencing and bioinformatics should be used to ascertain expression profiles.
Source: PLoS One - September 21, 2023 Category: Biomedical Science Authors: Mahdi Masrour Source Type: research
< sup > 68 < /sup > GaGa ‑LNC1007 PET/CT in the evaluation of renal cell carcinoma: comparison with 2- < sup > 18 < /sup > FFDG/ < sup > 68 < /sup > GaGa-PSMA PET/CT
CONCLUSION: [68Ga]Ga-LNC1007 is a promising tracer for RCC imaging and can effectively identify aggressive pathological characteristics of RCC.PMID:37728667 | DOI:10.1007/s00259-023-06436-5
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Rong Lin Chao Wang Shaohao Chen Tingting Lin Hai Cai Shaoming Chen Yun Yang Jiaying Zhang Fuqi Xu Jingjing Zhang Xiaoyuan Chen Jie Zang Weibing Miao Source Type: research
Upregulation of FAM134B inhibits endoplasmic reticulum stress-related degradation protein expression and promotes hepatocellular carcinogenesis
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17964. Online ahead of print.ABSTRACTEndoplasmic reticulum (ER) stress can stimulate the proliferation and metastasis of hepatocellular carcinoma (HCC) cells while hindering apoptosis and immune system function, but the molecular mechanism of ER stress in HCC has yet to be fully studied. We aim to investigate the molecular mechanism by which FAM134B inhibits autophagy of HCC cells by reducing the expression of ER stress-related degradation proteins. Clinical samples were collected for this study. Normal liver cell lines HL7702 and Hep3B and Huh7 HCC cell lines were cultured. C...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Houhong Wang Lu Liu Huihui Gong Heng Li Source Type: research
Characterization of tumor microenvironment and sensitive chemotherapy drugs based on cuproptosis-related signatures in renal cell carcinoma
Aging (Albany NY). 2023 Sep 19;15. doi: 10.18632/aging.205043. Online ahead of print.ABSTRACTCuproptosis is a novel type of copper-induced cell death and is considered as a new therapeutic target for many cancers. Distant metastases occur in about 40% of patients with advanced renal cell carcinoma (RCC), with a poor 5-year prognosis of about 10%. Through a series of comprehensive analyses, four differentially expressed cuproptosis-related lncRNAs (DECRLs) were identified as candidate biomarkers for RCC. The risk model constructed by using these four DECRLs can better predict the prognosis of patients with RCC, which is det...
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Jiefu Tang Fan Yao Zhiyong Yao Xiao-Liang Xing Source Type: research
Malignancy risk in Bethesda class IV thyroid nodules in an iodine deficient region
CONCLUSIONS: In patients with Bethesda IV thyroid nodules, diagnostic lobectomy should be the preferable surgical approach in absence of factors that suggest total thyroidectomy. In our opinion, total thyroidectomy remains the first choice in large nodules (≥4 cm) as these nodules have a high malignancy rate, greater local/lymphovascular invasion and a consequent frequent indication for post-operative radiometabolic treatment.PMID:37727346 | PMC:PMC10506119 | DOI:10.21037/gs-22-491
Source: Hand Surgery - September 20, 2023 Category: Surgery Authors: Tommaso Loderer Elena Bonati Valentina Donato Lorenzo Viani Federico Cozzani Paolo Del Rio Source Type: research
Upregulation of FAM134B inhibits endoplasmic reticulum stress-related degradation protein expression and promotes hepatocellular carcinogenesis
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17964. Online ahead of print.ABSTRACTEndoplasmic reticulum (ER) stress can stimulate the proliferation and metastasis of hepatocellular carcinoma (HCC) cells while hindering apoptosis and immune system function, but the molecular mechanism of ER stress in HCC has yet to be fully studied. We aim to investigate the molecular mechanism by which FAM134B inhibits autophagy of HCC cells by reducing the expression of ER stress-related degradation proteins. Clinical samples were collected for this study. Normal liver cell lines HL7702 and Hep3B and Huh7 HCC cell lines were cultured. C...
Source: J Cell Mol Med - September 20, 2023 Category: Molecular Biology Authors: Houhong Wang Lu Liu Huihui Gong Heng Li Source Type: research
Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119595. doi: 10.1016/j.bbamcr.2023.119595. Online ahead of print.ABSTRACTThe nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of hepatocellular carcinoma (HCC). Phosphorylation of p65 is considered as an important mechanism for the positive regulation of NF-κB activity. According to our previous data, p65 can be SUMOylated by small ubiquitin-related modifier 1 (SUMO1) protein, and SUMO1 promotes p65 nuclear import and HCC progression. However, the effect of SUMO1-related p65 SUMOylation on NF-κB transcriptional activity and the relations...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Can Jiang Chunyang Zhang Min Dai Fuyan Wang Sa Xu Dan Han Yanyan Wang Yajie Cao Yanyan Liang Ziyu Zhang Lina Yan Yujun Shen Kewu He Yuxian Shen Jun Liu Source Type: research
MEK inhibition induces expression of differentiation marker Keratin 10 in human keratinocytes
Pathol Res Pract. 2023 Sep 2;250:154788. doi: 10.1016/j.prp.2023.154788. Online ahead of print.ABSTRACTBRAF mutant metastatic melanoma was regularly treated in the past with a BRAF inhibitor (BRAFi) alone or in combination with inhibitors of the mitogen-activated protein kinase kinase (MEKi), which is still a common treatment. This combination therapy strongly reduced the occurrence of keratoacanthomas and squamous cell carcinoma, which was frequently seen when BRAFi was used as monotherapy. Here we addressed the question whether MEK inhibition counteracts squamous cell carcinoma development in part by promoting keratinocy...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: F Karras M Bonsack S Seifert L Friedrich M Kunz Source Type: research
