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Cancer: Carcinoma
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Total 97099 results found since Jan 2013.
Epiberberine suppresses the metastasis of head and neck squamous cell carcinoma cells by regulating the MMP-13 and JNK pathway
In conclusion, the present study demonstrates that epiberberine suppresses cell migration and invasion by regulating the JNK pathway and MMP-13. These results suggest that epiberberine could be a potential antimetastatic agent in HNSCC cells.PMID:37710409 | DOI:10.1111/jcmm.17954
Source: J Cell Mol Med - September 15, 2023 Category: Molecular Biology Authors: Hsin-Yu Ho Mu-Kuan Chen Chia-Chieh Lin Yu-Sheng Lo Yi-Ching Chuang Ming-Ju Hsieh Source Type: research
Clinical experiences with online adaptive radiotherapy of vulvar carcinoma
CONCLUSION: CTVs and PTVs dose coverage were significantly improved with adaptation compared to image-guided RT. This gain was robust during the treatment time.PMID:37713179 | DOI:10.1080/0284186X.2023.2257377
Source: Acta Oncologica - September 15, 2023 Category: Cancer & Oncology Authors: Malene E Bak Nikolaj K G Jensen Trine J N øttrup Hanne F Mathiesen Henrik Roed Maria Sj ölin Flemming Kj ær-Kristoffersen Vibeke N Hansen Ivan R Vogelius Source Type: research
Synthesis and Anticancer Activity of Phosphinoylated and Phosphonoylated N-Heterocycles Obtained by the Microwave-Assisted Palladium Acetate-Catalyzed Hirao Reaction
Chemistry. 2023 Sep 15:e202302465. doi: 10.1002/chem.202302465. Online ahead of print.ABSTRACTA literature survey showed that different derivatives with the 9-phenyl-9H-carbazole or the dihydroindoline scaffold may be of biological activity including cytotoxic effect. Driven by this experience, we wished to synthesize P-functionalized derivatives of the above mentioned N-heterocycles. Three N-heterocycles, 9-(4-bromophenyl)-9H-carbazole, 3-bromo-9-phenyl-9H-carbazole and 1-(5-bromoindolin-1-yl)ethan-1-one were coupled with dialkyl phosphites and diarylphosphine oxides using Pd(OAc)2 (10%) as the catalyst precursor and trie...
Source: Chemistry - September 15, 2023 Category: Chemistry Authors: Bianka Husz ár Ren áta Szolga Szilvia B ősze Rita Ol áhné Szabó Andr ás Simon Konstantin Karaghiosoff M átyás Czugler L ászló Drahos Gy örgy Keglevich Source Type: research
Two-dimensional chromatography for enantiomeric analysis of mitotane and its metabolite o,p'-DDA in patients with adrenocortical carcinoma indicates enantioselective metabolism
In this study, we analyzed the enantiomers of mitotane and o,p'-DDA in the plasma of patients by a newly developed chiral-phase method employed in two-dimensional chromatography. Important differences were observed in the ratio of (S)/(R)-mitotane, which varied substantially from 1:1.2 to 1:10 whereas the (S)/(R)-o,p'-DDA ratio was relatively conserved, at approximately 2:1. These findings provide evidence for the enantioselective metabolism and provide a method for further analyses of mitotane and metabolites, which can explain the variation in the therapeutic response.PMID:37713949 | DOI:10.1016/j.bioorg.2023.106835
Source: Bioorganic Chemistry - September 15, 2023 Category: Chemistry Authors: Gabriela Stadler Alan de Almeida Veiga Claudia Rita Corso Camila Bach de Assis Beatriz de Toledo Nogueira Lucia Regina Rocha Martins Beatriz Cruz Bonk Fl ávia Lada Degaut Pontes Bonald Cavalcante de Figueiredo Lauro Mera de Souza Source Type: research
Podophyllotoxin reduces the aggressiveness of human oral squamous cell carcinoma through myeloid cell leukemia ‑1
Int J Mol Med. 2023 Nov;52(5):103. doi: 10.3892/ijmm.2023.5306. Epub 2023 Sep 15.ABSTRACTPodophyllotoxin (PPT), which is derived from the podophyllum plant, exhibits marked cytotoxic effects against cancer cells; however, the precise molecular mechanism underlying its activity against human oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, the mechanism by which PPT induced cytotoxicity in two OSCC cell lines, HSC3 and HSC4, was determined. The effects of PPT on cytotoxicity in HSC3 and HSC4 cells were analyzed using Annexin V/PI double staining, Sub‑G1 analysis, soft agar assays, western...
Source: International Journal of Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Hyun-Ju Yu Ji-Ae Shin Su-Jung Choi Sung-Dae Cho Source Type: research
A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells
Arch Toxicol. 2023 Sep 15. doi: 10.1007/s00204-023-03600-6. Online ahead of print.ABSTRACTOccupational and environmental exposure of various toxins or cigarette smoke causes non-small cell lung carcinoma (NSCLC); a devastating disease with a very low survival rate after metastasis. Increased activity of plasmin is a hallmark in NSCLC metastasis. It is accepted that metastatic cells exhibit higher plasmin activity than cells from primary tumors. Mechanisms behind this elevation, however, are barely understood. We compared plasmin activity and cell migration of A549 cells derived from a primary lung tumor with metastatic H12...
Source: Archives of Toxicology - September 15, 2023 Category: Toxicology Authors: Sarah Zeitlmayr Ditila Cami Belinda Selmani Thomas Gudermann Andreas Breit Source Type: research
Molecular imaging and related therapeutic options for medullary thyroid carcinoma: state of the art and future opportunities
Rev Endocr Metab Disord. 2023 Sep 16. doi: 10.1007/s11154-023-09836-y. Online ahead of print.ABSTRACTDue to its rarity and non-specific clinical presentation, accurate diagnosis, and optimal therapeutic strategy of medullary thyroid carcinoma (MTC) remain challenging. Molecular imaging provides valuable tools for early disease detection, monitoring treatment response, and guiding personalized therapies. By enabling the visualization of molecular and cellular processes, these techniques contribute to a deeper understanding of disease mechanisms and the development of more effective clinical interventions. Different nuclear ...
Source: ENDOCR REV - September 15, 2023 Category: Endocrinology Authors: Alessio Imperiale Valentina Berti Micka ël Burgy Roberto Luigi Cazzato Arnoldo Piccardo Giorgio Treglia Source Type: research
A Case of Metastatic Papillary Thyroid Carcinoma in Neck Lymph Nodes Without Primary Tumor in Thyroid Gland
We report the case of a 63-year-old male who had a left neck level II palpable mass. A left cervical mass had previously undergone 2 central needle biopsies, but only atypical cells had been identified. His prior medical history included surgical treatment for prostate cancer 11 years ago. There was no suspicious primary tumor in the endoscopic examination. After the excisional biopsy, the pathologic finding was metastatic papillary carcinoma from the thyroid, and there were no aberrant findings in the thyroid sonography. The patient underwent a complete thyroidectomy, bilateral central neck dissection (CND), and left leve...
Source: Ear, Nose and Throat Journal - September 15, 2023 Category: ENT & OMF Authors: Sung Ha Jung Joo Hyun Park Junyoung Kim Nayeon Choi Source Type: research
Albumin nanoparticles and their folate modified counterparts for delivery of a lupine derivative to hepatocellular carcinoma
In conclusion, functionalized nanoparticles (FA-PEG-CTr-NPs) can specifically inhibit the malignant proliferation of HCC cells and are thus a promising nanoagent for the treatment of HCC.PMID:37713994 | DOI:10.1016/j.biopha.2023.115485
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Haohao Wang Di Wu Pan Wang Chunyu Gao Hongbo Teng Dong Liu Yan Zhao Rui Du Source Type: research
TMEM64 is highly expressed in hepatocellular carcinoma and promotes tumor cell proliferation and invasion
CONCLUSION: A high TMEM64 expression may serve as an independent risk factor for poor prognosis of HCC and promotes proliferation, migration, and invasion of HCC cells in vitro.PMID:37712271 | DOI:10.12122/j.issn.1673-4254.2023.08.11
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: D Cao J Cai Y Li R Dong Z Wang X Zuo Source Type: research
Germline founder variant c.1998delinsTTCT in the RET oncogene: a cohort study in 15 Belgian families
CONCLUSION: The c.1998delinsTTCT- variant in the RET gene is pathogenic and associated with a moderate risk for medullary thyroid carcinoma and rarely with other MEN2A manifestations. Active surveillance is a possible option in heterozygous gene carriers with a negative first clinical evaluation.PMID:37713609 | DOI:10.1093/ejendo/lvad126
Source: European Journal of Endocrinology - September 15, 2023 Category: Endocrinology Authors: Axelle Vuylsteke Laurens Hannes Hilde Brems Koen Devis Marleen Renard Anne Uyttebroeck Eric Legius Brigitte Decallonne Source Type: research
Necrotizing pneumonia due to Aspergillus and Salmonella after immune checkpoint inhibitor treatment: An unusual case and review of the literature
CONCLUSIONS: Awareness of unusual pathogens in the etiology of pneumonia after ICI treatment may help to avoid underdiagnosis.PMID:37714729 | DOI:10.1016/j.riam.2023.05.001
Source: Revista Iberoamericana de Micologia - September 15, 2023 Category: Biology Authors: Muhammed Cihan I şık O ğuz Karcıoğlu G ülşen Hazırolan Dolunay G ülmez Mehmet Ruhi Onur Mehmet Mahir Kunt Sevtap Arikan-Akdagli G ökhan Metan Source Type: research
Dealcoholized red wine inhibits occurrence and progression of hepatocellular carcinoma possibly by inducing cell cycle arrest and apoptosis
CONCLUSION: DRW inhibits the occurrence and progression of HCC, and this effect is mediated possibly by inducing cell cycle arrest and apoptosis.PMID:37712265 | DOI:10.12122/j.issn.1673-4254.2023.08.05
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: Y Lan K Wang Z Lan H Zhou J Sun Source Type: research
Isthmusectomy for papillarythyroid carcinoma in the isthmus: The less the better
CONCLUSIONS: Our results reveal that isthmusectomy plus BCLND may be a simple but feasible approach for selected PTCI patients, resulting in a better quality of life than total thyroidectomy plus BCLND.PMID:37714784 | DOI:10.1016/j.asjsur.2023.08.197
Source: Asian Journal of Surgery - September 15, 2023 Category: Surgery Authors: Jiaqiang Dan Jingya Tan Yao Guo Yang Xu Jin Chen Junhua Huang Source Type: research
Resveratrol Inhibits Hepatocellular Carcinoma Progression Through Regulating Exosome Secretion
CONCLUSION: Resveratrol inhibits hepatocellular carcinoma progression by regulating exosome secretion and contents.PMID:37711128 | DOI:10.2174/0929867331666230914090053
Source: Current Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Kun Tong Pingfeng Wang Ying Li Yaoyao Tong Xuejie Li Shirong Yan Pei Hu Source Type: research
