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Total 80126 results found since Jan 2013.
Effects of season, daytime, sex, and stress on the incidence, latency, frequency, severity, and duration of neonatal seizures in a rat model of birth asphyxia
This study illustrates that without a detailed analysis of all factors, the data would have erroneously indicated significant seasonal variability in the severity of neonatal seizures. Instead, the study demonstrates that even mild, short-lasting postnatal stress has a profound effect on asphyxia-induced seizures, most likely by increasing the activity of the hypothalamic-pituitary-adrenal axis. It will be interesting to examine how postnatal stress affects the treatment and adverse outcomes of birth asphyxia and neonatal seizures in the rat model used here.PMID:37729684 | DOI:10.1016/j.yebeh.2023.109415
Source: Epilepsy and Behaviour - September 20, 2023 Category: Neurology Authors: Ricardo Schmidt Bj örn Welzel Wolfgang L öscher Source Type: research
Causal relationship between addictive behaviors and epilepsy risk: A mendelian randomization study
CONCLUSION: This MR study indicated a potential genetically predicted causal association between lifetime cannabis use and higher risk of epilepsy. As for the other four addictive behaviors, no evidence of a causal relationship with the risk of epilepsy was found in this study.PMID:37729683 | DOI:10.1016/j.yebeh.2023.109443
Source: Epilepsy and Behaviour - September 20, 2023 Category: Neurology Authors: Zhen Liang Lin Qiu Yingyue Lou Zhaoshi Zheng Qi Guo Qing Zhao Songyan Liu Source Type: research
Behavior Management Training for Parents of Children with Preschool ADHD Based on Parent-Child Interactions: A Multicenter Randomized Controlled, Follow-Up Study
CONCLUSION: After continuous intervention for eight weeks, parents were able to help the children with preschool ADHD to improve their ADHD symptoms and emotional behavioral and social functioning significantly, and the efficacy was maintained at the four-month follow-up; the systemic-based parent training in behavior management (PTBM) is applicable to the treatment of preschool ADHD and is worth promoting.PMID:37727252 | PMC:PMC10506873 | DOI:10.1155/2023/3735634
Source: Behavioural Neurology - September 20, 2023 Category: Neurology Authors: Min Feng Juncai Xu Mengyao Zhai Qiaorong Wu Kangkang Chu Liping Xie Rong Luo Huiping Li Qiong Xu Xiu Xu Xiaoyan Ke Source Type: research
Relationship between 4-month functional brain network topology and 24-month neurodevelopmental outcome in children with congenital heart disease
Eur J Paediatr Neurol. 2023 Sep 11;47:47-59. doi: 10.1016/j.ejpn.2023.09.005. Online ahead of print.ABSTRACTSurvivors of complex forms of congenital heart disease (CHD)∗ are at high risk of neurodevelopmental disabilities. Neuroimaging studies have pointed to brain anomalies and immature networks in infants with CHD, yet less is known about their functional network topology and associations with neurodevelopment. To characterize the functional network topology in 4-month-old infants with repaired CHD, we compared graph theory metrics measured using resting-state functional near-infrared spectroscopy (rs-fNIRS) between in...
Source: European Journal of Paediatric Neurology - September 20, 2023 Category: Neurology Authors: Sarah Provost Sol ène Fourdain Phetsamone Vannasing Julie Tremblay Kassandra Roger Yalina Garc ía-Puente Am élie Doussau Marie-Claude Vinay Zorina Von Siebenthal Natacha Paquette Nancy Poirier Anne Gallagher Source Type: research
Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke
In this study, we found that PKD2 expression and activity were significantly upregulated in the ipsilateral side of the brain after transient focal cerebral ischemia, which coincides with the upregulation of PKD2 in primary neurons in response to in vitro ischemia, implying a potential role of PKD2 in neuronal survival in ischemic stroke. Using kinase-dead PKD2 knock-in (PKD2-KI) mice, we examined whether loss of PKD2 activity affected stroke outcomes in mice subjected to 1 h of transient middle cerebral artery occlusion (tMCAO) and 24 h of reperfusion. Our data demonstrated that PKD2-KI mice exhibited larger infarction vo...
Source: Neurobiology of Disease - September 20, 2023 Category: Neurology Authors: Jaclyn A Connelly Xuejing Zhang Yuzhou Chen Yapeng Chao Yejie Shi Tija C Jacob Q Jane Wang Source Type: research
Increased hippocampal CREB phosphorylation after retrieval of remote contextual fear memories in Carioca High-conditioned Freezing rats
Neurobiol Learn Mem. 2023 Sep 18:107828. doi: 10.1016/j.nlm.2023.107828. Online ahead of print.ABSTRACTThe participation of the hippocampal formation in consolidation and reconsolidation of contextual fear memories has been widely recognized and known to be dependent on the activation of the cAMP response element (CRE) binding protein (CREB) pathway. Recent findings have challenged the prevailing view that over time contextual fear memories migrate to neocortical circuits and no longer require the hippocampus for retrieval of remote fearful memories. It has also recently been found that this brain structure is important fo...
Source: Neurobiology of Learning and Memory - September 20, 2023 Category: Neurology Authors: Fernanda Nunes Bruna Lotufo Yury Velho Martins Lages S ílvia Maisonnette Thomas Krahe Antonio Pedro Mello Cruz J Landeira-Fernandez Source Type: research
Stress effects on spatial memory retrieval and brain c-Fos expression pattern in adults are modulated by early nicotine exposure
Neurobiol Learn Mem. 2023 Sep 18:107831. doi: 10.1016/j.nlm.2023.107831. Online ahead of print.ABSTRACTThe cognitive effects of nicotine are linked to persistent modifications in extended neural systems that regulate cognitive and emotional processes, and these changes occur during development. Additionally, acute stress has modulatory effects on cognition that involve broad neural systems and can be influenced by prior environmental challenges. The effects of nicotine and stress may be interconnected, leading to modifications in a network of shared brain substrates. Here, we explored the interaction between nicotine and s...
Source: Neurobiology of Learning and Memory - September 20, 2023 Category: Neurology Authors: Jos é L Solano Carlos Novoa Marisol R Lamprea Leonardo A Ortega Source Type: research
Linalool Attenuates Hypothalamus Proteome Disturbance Facilitated by Methamphetamine Induced Neurotoxicity in Rats
Neurotoxicology. 2023 Sep 18:S0161-813X(23)00123-7. doi: 10.1016/j.neuro.2023.09.007. Online ahead of print.ABSTRACTBACKGROUND: One of the most powerful stimulants of the central nervous system is methamphetamine (METH). Linalool has a neuroprotective effect against ischemia injury by reducing oxidative stress and apoptosis. The present study investigated whether linalool can reverse the hypothalamus neurotoxicity and proteome disturbance in METH-treated rats.BRIEF METHOD: A total of 36 male albino rats were split into two equal groups (normal and METH-treated). Three equal subgroups of normal rats were created; Control, L...
Source: Neurotoxicology - September 20, 2023 Category: Neurology Authors: Khaled M M Koriem Sara W B El-Qady Source Type: research
Spinal muscular atrophy type I associated with a novel SMN1 splicing variant that disrupts the expression of the functional transcript
DiscussionWe verified the occurrence of a non-deletion SMN1 variant and supported its pathogenicity, thus expanding the SMN1 variants spectrum. We discuss the updated SMA genetic findings in the Cypriot population, highlighting an increased percentage of intragenic variants compared to other populations.
Source: Frontiers in Neurology - September 20, 2023 Category: Neurology Source Type: research
The effects of low-intensity resistance training with blood flow restriction versus traditional resistance exercise on lower extremity muscle strength and motor functionin ischemic stroke survivors: a randomized controlled trial
CONCLUSION: LIRT-BFR produced a significant improvement in muscle strength, balance, walking capacity, and anxiety and depression in ischemic stroke patients, and the improvement are comparable to HIRT.CLINICAL TRIAL REGISTRATION: NCT05281679.PMID:37724785 | DOI:10.1080/10749357.2023.2259170
Source: Topics in Stroke Rehabilitation - September 19, 2023 Category: Neurology Authors: Ishtiaq Ahmed Rustem Mustafoglu Belgin Erhan Source Type: research
Readability of patient education material in stroke: a systematic literature review
CONCLUSION: Paper and online patient education materials exceed the reading level of stroke patients and the AMA recommended 6th grade level. Due to limitations in readability, stroke patients are not being adequately educated about their condition.PMID:37724783 | DOI:10.1080/10749357.2023.2259177
Source: Topics in Stroke Rehabilitation - September 19, 2023 Category: Neurology Authors: Aaron B Ahn Sajal Kulhari Amir Karimi Sophia Sundararajan Martha Sajatovic Source Type: research
Tilt testing
Pract Neurol. 2023 Sep 19:pn-2023-003749. doi: 10.1136/pn-2023-003749. Online ahead of print.ABSTRACTTilt testing can help to diagnose unexplained syncope, by precipitating an episode during cardiac monitoring. The Italian protocol, now most widely used, involves giving sublingual nitroglycerine after 15 min, while monitoring beat-to-beat blood pressure (BP) and recording on video. Tilt testing is time-consuming but it is clinically useful and can guide therapy. Complications are rare. Syncope types include vasovagal syncope where BP falls after >3 min of tilt-up and later the heart rate falls; classic orthostatic hypot...
Source: Practical Neurology - September 19, 2023 Category: Neurology Authors: Paul N Cooper Richard Sutton Source Type: research
Efficacy of a music-based intervention in a preclinical model of traumatic brain injury: An initial foray into a novel and non-pharmacological rehabilitative therapy
Exp Neurol. 2023 Sep 17:114544. doi: 10.1016/j.expneurol.2023.114544. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) causes neurobehavioral and cognitive impairments that negatively impact life quality for millions of individuals. Because of its pernicious effects, numerous pharmacological interventions have been evaluated to attenuate the TBI-induced deficits or to reinstate function. While many such pharmacotherapies have conferred benefits in the laboratory, successful translation to the clinic has yet to be achieved. Given the individual, medical, and societal burden of TBI, there is an urgent need for alte...
Source: Experimental Neurology - September 19, 2023 Category: Neurology Authors: Eleni H Moschonas Tyler S Ranellone Vincent J Vozzella Piper L Rennerfeldt Corina O Bondi Ellen M Annas Rachel A Bittner Dana M Tamura Rithika I Reddy Rithik R Eleti Jeffrey P Cheng Jessica M Jarvis Ericka L Fink Anthony E Kline Source Type: research
Low dose of levetiracetam counteracts amyloid β-induced alterations of hippocampal gamma oscillations by restoring fast-spiking interneuron activity
Exp Neurol. 2023 Sep 17:114545. doi: 10.1016/j.expneurol.2023.114545. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized at an early stage by memory alterations that worsen during the development of the disease. Several clinical trials in phase 3 have failed despite being able to counteract classical AD-related alterations, possibly because of the lack of recovery of the regular neuronal network activity essential for memory including low gamma oscillations (γ-Osc). Nowadays, Levetiracetam (LEV), an SV2A modulator approved for epilepsy, is being used in trials with AD patients without further support ...
Source: Experimental Neurology - September 19, 2023 Category: Neurology Authors: Arturo G Isla Hugo Balleza-Tapia Fengna Chu Gefei Chen Janne Johansson Per Nilsson Andr é Fisahn Source Type: research
Acupuncture Improves Synaptic Plasticity of SAMP8 Mice through the RhoA/ROCK Pathway
CONCLUSION: Acupuncture can improve synaptic plasticity by inhibiting the abnormal activation of the RhoA/ROCK pathway, and improve the spatial learning and memory ability of AD, so as to achieve the purpose of treating AD.PMID:37723951 | DOI:10.2174/1567205020666230828095826
Source: Current Alzheimer Research - September 19, 2023 Category: Neurology Authors: Bohong Kan Zhengjia Dong Zhenyu Tang Lan Zhao Zhen Li Source Type: research
